| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shu-Ting Zhuang, Rui Li, Shan-Shan Song, Hao-Ru Duan, Qiu-Yan L. [Effect of electroacupuncture on protein expressions of SOCS3 and IRS-1 in hypothalamus and pancreas islet morphology in diabetic fatty rats]. Zhongguo zhen jiu = Chinese acupuncture & moxibustion. vol 42. issue 9. 2022-09-08. PMID:36075599. |
to observe the effect of electroacupuncture (ea) on protein expressions of suppressor of cytokine signaling 3 (socs3) and insulin receptor substrate-1 (irs-1) in hypothalamus and morphology of pancreas islet in zucker diabetic fatty (zdf) rats, and to explore its possible mechanism on improving plasma glucose and insulin resistance of type 2 diabetes mellitus (t2dm). |
2022-09-08 |
2023-08-14 |
rat |
| Jae Hyun Cho, Kyungchan Kim, Han Chae Cho, Jaemeun Lee, Eun-Kyoung Ki. Silencing of hypothalamic FGF11 prevents diet-induced obesity. Molecular brain. vol 15. issue 1. 2022-09-05. PMID:36064426. |
lentiviral injection of fgf11 shrna into the arcuate nucleus of the mouse hypothalamus decreased weight gain and fat mass, increased brown adipose tissue thermogenesis, and improved glucose and insulin intolerances under high-fat diet conditions. |
2022-09-05 |
2023-08-14 |
mouse |
| Undurti N Da. Syntaxin interacts with arachidonic acid to prevent diabetes mellitus. Lipids in health and disease. vol 21. issue 1. 2022-08-18. PMID:35982452. |
prostaglandin e2 (pge2), the pro-inflammatory metabolite of aa, activates ventromedial hypothalamus (vmh) neurons of the hypothalamus and inhibits insulin secretion leading to reduced glucose tolerance and decreases insulin sensitivity in the skeletal muscle and liver. |
2022-08-18 |
2023-08-14 |
Not clear |
| Richard W Clayton, Robin Lovell-Badge, Christophe Galiche. The Properties and Functions of Glial Cell Types of the Hypothalamic Median Eminence. Frontiers in endocrinology. vol 13. 2022-08-15. PMID:35966104. |
for example, in mice, ablation of tanycytes (a special class of ependymal glia with stem cell-like functions) results in weight gain, feeding, insulin insensitivity and increased visceral adipose, consistent with the demonstrated ability of these cells to sense and transport both glucose and leptin, and to differentiate into neurons that control feeding and metabolism in the hypothalamus. |
2022-08-15 |
2023-08-14 |
mouse |
| Carrie R Ferrario, Julie E Finnel. Beyond the hypothalamus: roles for insulin as a regulator of neurotransmission, motivation, and feeding. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2022-08-06. PMID:35933517. |
beyond the hypothalamus: roles for insulin as a regulator of neurotransmission, motivation, and feeding. |
2022-08-06 |
2023-08-14 |
Not clear |
| Camila Libardi do Amaral, Ísis de Cássia Alves Martins, Alana Carolina Costa Veras, Fernando Moreira Simabuco, Michael Glenn Ross, Mina Desai, Leticia Martins Ignácio-Souza, Marciane Milanski, Adriana Souza Torsoni, Marcio Alberto Torson. Activation of the α7 Nicotinic Acetylcholine Receptor Prevents against Microglial-Induced Inflammation and Insulin Resistance in Hypothalamic Neuronal Cells. Cells. vol 11. issue 14. 2022-07-27. PMID:35883638. |
in this regard, our study aimed to investigate a target that is highly expressed in the hypothalamus and involved in the regulation of the inflammatory process, but still poorly investigated within the context of neuronal insulin resistance: the α7 nicotinic acetylcholine receptor (α7nachr). |
2022-07-27 |
2023-08-14 |
Not clear |
| Abdulbaset Zidane Shirif, Sanja Kovačević, Biljana Bursać, Iva Lakić, Nataša Veličković, Tanja Jevdjovic, Ana Djordjevi. Combination of chronic stress with fructose diet increases AMP-activated protein kinase phosphorylation and affects agouti-related protein and proopiomelanocortin expression in the hypothalamus of male Wistar rats. Acta biochimica Polonica. 2022-07-25. PMID:35877942. |
appetite regulation in the hypothalamus is dependent on hormonal signals from the periphery, such as insulin and leptin, and can be modulated by both sugar-rich diet and stress. |
2022-07-25 |
2023-08-14 |
rat |
| Abdulbaset Zidane Shirif, Sanja Kovačević, Biljana Bursać, Iva Lakić, Nataša Veličković, Tanja Jevdjovic, Ana Djordjevi. Combination of chronic stress with fructose diet increases AMP-activated protein kinase phosphorylation and affects agouti-related protein and proopiomelanocortin expression in the hypothalamus of male Wistar rats. Acta biochimica Polonica. 2022-07-25. PMID:35877942. |
our aim was to explore the effects of 9-week feeding with 20% fructose solution combined with 4-week chronic unpredictable stress, on appetite-regulating neuropeptides and modulatory role of leptin and insulin signalling in the hypothalamus of male wistar rats. |
2022-07-25 |
2023-08-14 |
rat |
| Matthew G Engel, Jeremy Smith, Kai Mao, Gabriela Farias Quipildor, Min-Hui Cui, Maria Gulinello, Craig A Branch, Samuel E Gandy, Derek M Huffma. Evidence for preserved insulin responsiveness in the aging rat brain. GeroScience. 2022-07-07. PMID:35798912. |
despite these stark differences, icv insulin failed to elicit any significant alteration to the bold signal in young rats, while a significant deviation of the bold signal was observed in older animals, characterized by augmentation in regions of the septal nucleus and hypothalamus, and reduction in thalamus and nucleus accumbens. |
2022-07-07 |
2023-08-14 |
rat |
| Caitlin R Coker, Melissa White, Aneesh Singal, Sarah S Bingaman, Anirban Paul, Amy C Arnold, Yuval Silberma. Minocycline Reduces Hypothalamic Microglia Activation and Improves Metabolic Dysfunction in High Fat Diet-Induced Obese Mice. Frontiers in physiology. vol 13. 2022-07-05. PMID:35784876. |
obesity is associated with insulin resistance, glucose intolerance, inflammation, and altered neuronal activity in brain regions controlling metabolic functions including food intake, energy expenditure, and glucose homeostasis, such as the hypothalamus. |
2022-07-05 |
2023-08-14 |
mouse |
| Sophia J Wiedemann, Kelly Trimigliozzi, Erez Dror, Daniel T Meier, Jose Alberto Molina-Tijeras, Leila Rachid, Christelle Le Foll, Christophe Magnan, Friederike Schulze, Marc Stawiski, Stéphanie P Häuselmann, Hélène Méreau, Marianne Böni-Schnetzler, Marc Y Donat. The cephalic phase of insulin release is modulated by IL-1β. Cell metabolism. 2022-06-24. PMID:35750050. |
moreover, il-1β activated the vagus nerve to induce insulin secretion and regulated the activity of the hypothalamus in response to cephalic stimulation. |
2022-06-24 |
2023-08-14 |
mouse |
| Hashan S M Jayarathne, Lucas K Debarba, Jacob J Jaboro, Brett C Ginsburg, Richard A Miller, Marianna Sadagursk. Neuroprotective effects of Canagliflozin: Lessons from aged genetically diverse UM-HET3 mice. Aging cell. 2022-06-16. PMID:35707855. |
here, we show that cana treatment significantly improved central insulin sensitivity in the hypothalamus and the hippocampus of 30-month-old male mice. |
2022-06-16 |
2023-08-14 |
mouse |
| Yan-Nan Liu, Yi Qin, Bin Wu, Hui Peng, Ming Li, Hai Luo, Lin-Lin Li. DNA Methylation in Polycystic Ovary Syndrome：Emerging Evidence and Challenges. Reproductive toxicology (Elmsford, N.Y.). 2022-05-13. PMID:35562068. |
at present, changes of dna methylation have been found in serum, ovarian, hypothalamus, skeletal muscle, adipose tissue of pcos patients, and these changes are closely related to insulin resistance, lipid metabolism and follicular development of pcos. |
2022-05-13 |
2023-08-13 |
Not clear |
| Nicole Aguilera, Francisca Salas-Pérez, Macarena Ortíz, Daniela Álvarez, Bárbara Echiburú, Manuel Malique. Rodent models in placental research. Implications for fetal origins of adult disease. Animal reproduction. vol 19. issue 1. 2022-05-02. PMID:35493783. |
for its part, offspring exhibit alterations in organs involved in metabolic control such as the hypothalamus, adipose tissue, liver, skeletal muscle, and pancreas altering the intake and preferences for certain foods, the metabolism of glucose and lipid, and hormonal function leading to fat accumulation, insulin resistance, fatty liver, dyslipidemia, and elevated glucose levels. |
2022-05-02 |
2023-08-13 |
mouse |
| K Keogh, D A Kenn. Gene co-expression networks contributing to reproductive development in Holstein-Friesian bull calves. Animal : an international journal of animal bioscience. vol 16. issue 5. 2022-05-02. PMID:35500509. |
in the hypothalamus, gene co-expression networks involved in biochemical signalling processes related to gonadotropin-releasing hormone (gnrh) secretion were positively associated (p < 0.05) with systemic concentrations of igf-1 and insulin. |
2022-05-02 |
2023-08-13 |
Not clear |
| Yousef M Abdulrazzaq, Salim M A Bastaki, Ernest Adeghat. Histamine H3 receptor antagonists - Roles in neurological and endocrine diseases and diabetes mellitus. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 150. 2022-04-21. PMID:35447544. |
in addition, histamine h3r antagonists stimulate insulin release, through inducing the release of acetylcholine and cause significant reduction in total body weight and triglycerides in obese subjects by causing a feeling of satiety in the hypothalamus. |
2022-04-21 |
2023-08-13 |
human |
| Jong Han Choi, Min-Seon Ki. Homeostatic Regulation of Glucose Metabolism by the Central Nervous System. Endocrinology and metabolism (Seoul, Korea). vol 37. issue 1. 2022-03-08. PMID:35255598. |
to achieve normoglycemia, specific populations of neurons and glia in the hypothalamus sense changes in the blood concentrations of glucose and of glucoregulatory hormones such as insulin, leptin, glucagon-like peptide 1, and glucagon. |
2022-03-08 |
2023-08-13 |
Not clear |
| Anup Bhusal, Md Habibur Rahman, Kyoungho Su. Hypothalamic inflammation in metabolic disorders and aging. Cellular and molecular life sciences : CMLS. 2021-12-15. PMID:34910246. |
this activation of different cell types in the hypothalamus leads to chronic, low-grade inflammation, impairing energy balance and contributing to defective feeding habits, thermogenesis, and insulin and leptin signaling, eventually leading to metabolic disorders (i.e., diabetes, obesity, and hypertension). |
2021-12-15 |
2023-08-13 |
Not clear |
| Hossein Khaleghzadeh-Ahangar, Shaghayegh Khandan, Saeideh Khosrav. Intraventricular insulin adjacent to the arcuate nucleus reduced the formalin-induced pain through dorsal raphe nucleus opioid receptors in the STZ-induced diabetic rats. Behavioural brain research. vol 418. 2021-12-11. PMID:34774584. |
one of the regions that respond to insulin and have insulin receptors is the hypothalamus, especially the arcuate nucleus. |
2021-12-11 |
2023-08-13 |
rat |
| Ying Liu, Yu-Chen Xu, Yu-Gui Cui, Shi-Wen Jiang, Fei-Yang Diao, Jia-Yin Liu, Xiang M. Androgen excess increases food intake in a rat polycystic ovary syndrome model by down-regulating hypothalamus insulin and leptin signaling pathways preceding weight gain. Neuroendocrinology. 2021-11-30. PMID:34847556. |
androgen excess increases food intake in a rat polycystic ovary syndrome model by down-regulating hypothalamus insulin and leptin signaling pathways preceding weight gain. |
2021-11-30 |
2023-08-13 |
rat |