| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fan Yang, Shuang Zhao, Pingqing Wang, Wei Xian. Hypothalamic neuroendocrine integration of reproduction and metabolism in mammals. The Journal of endocrinology. vol 258. issue 3. 2023-08-10. PMID:37561042. |
changes in the nutritional status of the body cause fluctuations in the levels of peripheral metabolic hormone signals, such as leptin, insulin, and ghrelin, which provide feedback to the hypothalamus and integrate to coordinate metabolism and fertility. |
2023-08-10 |
2023-08-16 |
Not clear |
| Caio Henrique Mazucanti, Vernon Kennedy, Hasitha U Premathilake, Maire E Doyle, Jane Tian, Qing-Rong Liu, Jennifer O'Connell, Simonetta Camandola, Josephine M Ega. AAV5-mediated manipulation of insulin expression in choroid plexus has long-term metabolic and behavioral consequences. Cell reports. vol 42. issue 8. 2023-07-29. PMID:37515772. |
transcriptomic changes in the hypothalamus, especially in synapse-related processes, are also seen in mice overexpressing insulin in cp. |
2023-07-29 |
2023-08-14 |
mouse |
| Caio Henrique Mazucanti, Vernon Kennedy, Hasitha U Premathilake, Maire E Doyle, Jane Tian, Qing-Rong Liu, Jennifer O'Connell, Simonetta Camandola, Josephine M Ega. AAV5-mediated manipulation of insulin expression in choroid plexus has long-term metabolic and behavioral consequences. Cell reports. vol 42. issue 8. 2023-07-29. PMID:37515772. |
last, activation of gq signaling in cp leads to acute akt phosphorylation in neurons of the arcuate nucleus, indicating a direct action of cp-derived insulin on the hypothalamus. |
2023-07-29 |
2023-08-14 |
mouse |
| Tamara Dakic, Tanja Jevdjovic, Iva Lakic, Aleksandra Ruzicic, Nebojsa Jasnic, Sinisa Djurasevic, Jelena Djordjevic, Predrag Vujovi. The Expression of Insulin in the Central Nervous System: What Have We Learned So Far? International journal of molecular sciences. vol 24. issue 7. 2023-04-13. PMID:37047558. |
considering that both insulin mrna and insulin were detected in the central nervous system (cns), it is now known that this hormone is also synthesized in several brain regions, including the hypothalamus, hippocampus, cerebral and cerebellar cortex, and olfactory bulb. |
2023-04-13 |
2023-08-14 |
Not clear |
| Jyoti C Patel, Kenneth D Carr, Margaret E Ric. Actions and Consequences of Insulin in the Striatum. Biomolecules. vol 13. issue 3. 2023-03-29. PMID:36979453. |
in the brain, insulin has well-established actions in the hypothalamus, as well as at the level of mesolimbic dopamine neurons in the midbrain. |
2023-03-29 |
2023-08-14 |
Not clear |
| Ana Knezovic, Marija Piknjac, Jelena Osmanovic Barilar, Ana Babic Perhoc, Davor Virag, Jan Homolak, Melita Salkovic-Petrisi. Association of Cognitive Deficit with Glutamate and Insulin Signaling in a Rat Model of Parkinson's Disease. Biomedicines. vol 11. issue 3. 2023-03-29. PMID:36979662. |
the expression of tyrosine hydroxylase (th) and proteins involved in insulin (insulin receptor - ir, phosphoinositide 3 kinase - pi3k, extracellular signal-regulated kinases-erk) and glutamate receptor (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptos-ampar, n-methyl-d-aspartate receptor - nmdar) signaling was assessed in the hippocampus (hpc), hypothalamus (hpt) and striatum (s) by immunofluorescence, western blot and enzyme-linked immunosorbent assay (elisa). |
2023-03-29 |
2023-08-14 |
rat |
| Brenda De la Cruz Concepción, Yaccil Adilene Flores Cortez, Martha Isela Barragán Bonilla, Juan Miguel Mendoza Bello, Monica Espinoza Roj. Insulin: A connection between pancreatic β cells and the hypothalamus. World journal of diabetes. vol 14. issue 2. 2023-03-17. PMID:36926659. |
insulin: a connection between pancreatic β cells and the hypothalamus. |
2023-03-17 |
2023-08-14 |
Not clear |
| Nicholas J Queen, Wei Huang, Suraj Komatineni, Anthony G Mansour, Run Xiao, Logan A Chrislip, Lei Ca. Social isolation exacerbates diet-induced obesity and peripheral inflammation in young male mice under thermoneutrality. iScience. vol 26. issue 3. 2023-03-14. PMID:36915694. |
we report si promotes weight gain, increases food intake, increases adiposity, worsens glycemic control, reduces insulin signaling, exacerbates systemic and adipose inflammatory responses, and induces a molecular signature within the hypothalamus. |
2023-03-14 |
2023-08-14 |
mouse |
| Antonella M D'Ascanio, Jamie A Mullally, William H Frishma. Cagrilintide: A Long-Acting Amylin Analog for the Treatment of Obesity. Cardiology in review. 2023-03-08. PMID:36883831. |
semaglutide, a glp-1 receptor agonist, reduces appetite via glp-1 receptors in the hypothalamus and increases the production of insulin, and reduces glucagon secretion, delaying gastric emptying. |
2023-03-08 |
2023-08-14 |
Not clear |
| Lucio Della Guardia, Roberto Codell. Exercise Restores Hypothalamic Health in Obesity by Reshaping the Inflammatory Network. Antioxidants (Basel, Switzerland). vol 12. issue 2. 2023-02-25. PMID:36829858. |
obesity and overnutrition induce inflammation, leptin-, and insulin resistance in the hypothalamus. |
2023-02-25 |
2023-08-14 |
human |
| Huihui Wang, Chengliang Zhou, Shuping Gu, Yun Su. Surrogate fostering of mice prevents prenatal estradiol-induced insulin resistance Frontiers in microbiology. vol 13. 2023-01-26. PMID:36699605. |
we previously reported that prenatal high estradiol (he) exposure induces insulin resistance in male mice by disrupting hypothalamus development. |
2023-01-26 |
2023-08-14 |
mouse |
| Isadora C Furigo, Laura Dearde. Mechanisms mediating the impact of maternal obesity on offspring hypothalamic development and later function. Frontiers in endocrinology. vol 13. 2023-01-09. PMID:36619540. |
the development of the hypothalamus is plastic and regulated by metabolic hormones such as leptin, ghrelin and insulin, making it vulnerable to disruption in an obese |
2023-01-09 |
2023-08-14 |
Not clear |
| Nida Andlib, Mohd Sajad, Rajesh Kumar, Sonu Chand Thaku. Abnormalities in sex hormones and sexual dysfunction in males with diabetes mellitus: A mechanistic insight. Acta histochemica. vol 125. issue 1. 2022-12-01. PMID:36455338. |
insulin resistance and its deficiency can impair the hypothalamus, pituitary gland, gonads, and perigonads. |
2022-12-01 |
2023-08-14 |
Not clear |
| Pedro A S Nogueira, Alexandre Moura-Assis, Ariane M Zanesco, Bruna Bombassaro, Ana L Ferraz, Marcela S Simões, Daiane F Engel, Daniela S Razolli, Joana M Gaspar, Jose Donato Junior, Licio A Vellos. The orphan G protein-coupled receptor, GPR139, is expressed in the hypothalamus and is involved in the regulation of body mass, blood glucose, and insulin. Neuroscience letters. 2022-11-08. PMID:36347339. |
the orphan g protein-coupled receptor, gpr139, is expressed in the hypothalamus and is involved in the regulation of body mass, blood glucose, and insulin. |
2022-11-08 |
2023-08-14 |
mouse |
| Pedro A S Nogueira, Alexandre Moura-Assis, Ariane M Zanesco, Bruna Bombassaro, Ana L Ferraz, Marcela S Simões, Daiane F Engel, Daniela S Razolli, Joana M Gaspar, Jose Donato Junior, Licio A Vellos. The orphan G protein-coupled receptor, GPR139, is expressed in the hypothalamus and is involved in the regulation of body mass, blood glucose, and insulin. Neuroscience letters. 2022-11-08. PMID:36347339. |
in conclusion, this study advances the characterization of gpr139 in the hypothalamus, demonstrating its involvement in the regulation of body mass, blood insulin, and glycemia. |
2022-11-08 |
2023-08-14 |
mouse |
| Yoshimitsu Ouchi, Yoshinori Komaki, Kensuke Shimizu, Natsuki Fukano, Toshihisa Sugino, Jun-Ichi Shiraishi, Vishwajit S Chowdhury, Takashi Bung. Comparison of oral administration of fructose and glucose on food intake and physiological parameters in broiler chicks. Poultry science. vol 102. issue 1. 2022-11-06. PMID:36335736. |
after treatment, measurements of food intake (at 0, 30, and 60 min), and blood glucose as well as insulin concentrations were measured over time; however, diencephalic (hypothalamus) gene expression and plasma metabolites were measured at 30 min. |
2022-11-06 |
2023-08-14 |
Not clear |
| Bingyang Xue, Yasuyoshi Ishiwata, Yohei Kawano, Hiromitsu Takahashi, Kenichi Negishi, Takao Aoyama, Masashi Nagat. Paliperidone-Induced Acute Hyperglycemia Is Caused by Adrenaline Secretion via the Activation of Hypothalamic AMP-Activated Protein Kinase. Biological & pharmaceutical bulletin. vol 45. issue 11. 2022-11-03. PMID:36328503. |
a berberine pretreatment attenuated paliperidone-induced increases in blood concentrations of glucose, adrenaline, and insulin and phosphorylated ampk concentrations in the hypothalamus. |
2022-11-03 |
2023-08-14 |
rat |
| Tamara B Dakic, Milica B Markelic, Aleksandra A Ruzicic, Tanja V Jevdjovic, Iva V Lakic, Jelena D Djordjevic, Predrag Z Vujovi. Hypothalamic insulin expression remains unaltered after short-term fasting in female rats. Endocrine. 2022-10-27. PMID:36301508. |
our previous study showed that 6-h fasting increased insulin expression in the hypothalamus of male rats. |
2022-10-27 |
2023-08-14 |
rat |
| Sara Carmo-Silva, Marisa Ferreira-Marques, Clévio Nóbrega, Mariana Botelho, Daniela Costa, Célia A Aveleira, Stefan M Pulst, Luís Pereira de Almeida, Claudia Cavada. Ataxin-2 in the hypothalamus at the crossroads between metabolism and clock genes. Journal of molecular endocrinology. 2022-09-14. PMID:36103139. |
thus, ataxin-2 in the hypothalamus is determinant for weight, insulin sensitivity and clock gene expression. |
2022-09-14 |
2023-08-14 |
mouse |
| Suchitra Chandrasekaran, Susan Melhorn, Kelsey Lw Olerich, Brendan Angelo, Ting Chow, Anny Xiang, Ellen A Schur, Kathleen A Pag. Exposure to Gestational Diabetes Mellitus Prior to 26 Weeks is Related to The Presence of Mediobasal Hypothalamic Gliosis in Children. Diabetes. 2022-09-12. PMID:36095276. |
the mediobasal hypothalamus (mbh) is involved in energy homeostasis and weight regulation, and mbh gliosis associates with obesity and insulin resistance. |
2022-09-12 |
2023-08-14 |
human |