| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ying Liu, Yu-Chen Xu, Yu-Gui Cui, Shi-Wen Jiang, Fei-Yang Diao, Jia-Yin Liu, Xiang M. Androgen excess increases food intake in a rat polycystic ovary syndrome model by down-regulating hypothalamus insulin and leptin signaling pathways preceding weight gain. Neuroendocrinology. 2021-11-30. PMID:34847556. |
androgen excess increases food intake in a rat polycystic ovary syndrome model by down-regulating hypothalamus insulin and leptin signaling pathways preceding weight gain. |
2021-11-30 |
2023-08-13 |
rat |
| Ying Liu, Yu-Chen Xu, Yu-Gui Cui, Shi-Wen Jiang, Fei-Yang Diao, Jia-Yin Liu, Xiang M. Androgen excess increases food intake in a rat polycystic ovary syndrome model by down-regulating hypothalamus insulin and leptin signaling pathways preceding weight gain. Neuroendocrinology. 2021-11-30. PMID:34847556. |
conclusions androgen excess increased food intake in rats and promoted obesity by down-regulating insulin and leptin signaling in the hypothalamus, most likely by suppressing leptin levels in the csf. |
2021-11-30 |
2023-08-13 |
rat |
| Zhengchao Dou, Joe Eun Son, Chi-Chung Hu. Frontiers in neuroscience. vol 15. 2021-11-20. PMID:34795556. |
neurons in the arcuate nucleus of the hypothalamus are largely responsible for sensing of peripheral signals such as leptin and insulin, and are critical for the regulation of food intake and energy expenditure. |
2021-11-20 |
2023-08-13 |
mouse |
| Lei Cao, Seemaab Ali, Nicholas J Quee. Hypothalamic gene transfer of BDNF promotes healthy aging. Vitamins and hormones. vol 115. 2021-11-09. PMID:33706955. |
bdnf gene transfer prevented age-associated metabolic decline by: reducing adiposity, preventing the decline of brown fat activity, increasing adiponectin while reducing leptin and insulin in circulation, improving glucose tolerance, increasing energy expenditure, alleviating hepatic steatosis, and suppressing inflammatory genes in the hypothalamus and adipose tissues. |
2021-11-09 |
2023-08-13 |
mouse |
| Stephanie Kullmann, Julia Hummel, Robert Wagner, Corinna Dannecker, Andreas Vosseler, Louise Fritsche, Ralf Veit, Konstantinos Kantartzis, Jürgen Machann, Andreas L Birkenfeld, Norbert Stefan, Hans-Ulrich Häring, Andreas Peter, Hubert Preissl, Andreas Fritsche, Martin Hen. Empagliflozin Improves Insulin Sensitivity of the Hypothalamus in Humans With Prediabetes: A Randomized, Double-Blind, Placebo-Controlled, Phase 2 Trial. Diabetes care. 2021-10-30. PMID:34716213. |
empagliflozin improves insulin sensitivity of the hypothalamus in humans with prediabetes: a randomized, double-blind, placebo-controlled, phase 2 trial. |
2021-10-30 |
2023-08-13 |
human |
| Tamara Dakic, Tanja Jevdjovic, Jelena Djordjevic, Predrag Vujovi. Short-term fasting differentially regulates PI3K/AkT/mTOR and ERK signalling in the rat hypothalamus. Mechanisms of ageing and development. vol 192. 2021-10-28. PMID:32961167. |
in order to uncover a physiological importance of the fasting-induced insulin expression in hypothalamus, we analyzed the effect of short-term food deprivation on the expression of several participants of pi3k/akt/mtor and ras/mapk signaling pathways that are typically activated by this hormone. |
2021-10-28 |
2023-08-13 |
human |
| Tamara Dakic, Tanja Jevdjovic, Jelena Djordjevic, Predrag Vujovi. Short-term fasting differentially regulates PI3K/AkT/mTOR and ERK signalling in the rat hypothalamus. Mechanisms of ageing and development. vol 192. 2021-10-28. PMID:32961167. |
our previously published and current findings suggest that the erk activation in hypothalamus was at least partially initiated by the centrally produced insulin. |
2021-10-28 |
2023-08-13 |
human |
| David Aguilar-Recarte, Xavier Palomer, Manuel Vázquez-Carrer. Uncovering the role of apolipoprotein C-III in insulin resistance. Clinica e investigacion en arteriosclerosis : publicacion oficial de la Sociedad Espanola de Arteriosclerosis. vol 33. issue 2. 2021-10-27. PMID:33303217. |
the present review focuses on the key mechanisms by which apoc-iii could promote type 2 diabetes mellitus, including exacerbation of insulin resistance in skeletal muscle, activation of β-cell apoptosis, promotion of weight gain through its effects on white adipose tissue and hypothalamus, and attenuation of the beneficial effects of high-density lipoproteins on glucose metabolism. |
2021-10-27 |
2023-08-13 |
Not clear |
| Meng-Fan Peng, Shuo Tian, Ya-Gang Song, Cai-Xia Li, Ming-San Miao, Zhen Ren, Ming L. Effects of total flavonoids from Eucommia ulmoides Oliv. leaves on polycystic ovary syndrome with insulin resistance model rats induced by letrozole combined with a high-fat diet. Journal of ethnopharmacology. vol 273. 2021-09-24. PMID:33617969. |
leaves and its extracts have many pharmacological effects, such as regulating hypothalamus pituitary ovary (hpo) axis function, estrogen like effects, correcting insulin resistance (ir), regulating lipids, and reducing weight, which are consistent with the clinical manifestations in polycystic ovary syndrome (pcos) patients. |
2021-09-24 |
2023-08-13 |
rat |
| Weikang Cai, Xuemei Zhang, Thiago M Batista, Rubén García-Martín, Samir Softic, Guoxiao Wang, Alfred K Ramirez, Masahiro Konishi, Brian T O'Neill, Jong Hun Kim, Jason K Kim, C Ronald Kah. Peripheral Insulin Regulates a Broad Network of Gene Expression in Hypothalamus, Hippocampus, and Nucleus Accumbens. Diabetes. vol 70. issue 8. 2021-09-21. PMID:34031123. |
peripheral insulin regulates a broad network of gene expression in hypothalamus, hippocampus, and nucleus accumbens. |
2021-09-21 |
2023-08-13 |
mouse |
| Weikang Cai, Xuemei Zhang, Thiago M Batista, Rubén García-Martín, Samir Softic, Guoxiao Wang, Alfred K Ramirez, Masahiro Konishi, Brian T O'Neill, Jong Hun Kim, Jason K Kim, C Ronald Kah. Peripheral Insulin Regulates a Broad Network of Gene Expression in Hypothalamus, Hippocampus, and Nucleus Accumbens. Diabetes. vol 70. issue 8. 2021-09-21. PMID:34031123. |
insulin regulates distinct pathways in the hypothalamus (htm), hippocampus, and nucleus accumbens. |
2021-09-21 |
2023-08-13 |
mouse |
| Alexander Jais, Jens C Brünin. Arcuate nucleus-dependent regulation of metabolism - pathways to obesity and diabetes mellitus. Endocrine reviews. 2021-09-07. PMID:34490882. |
particularly the arcuate nucleus of the hypothalamus (arc) is of pivotal importance for primary sensing of adiposity signals, such as leptin and insulin, and circulating nutrients, such as glucose. |
2021-09-07 |
2023-08-13 |
Not clear |
| Rui-Dong Cheng, Wen Ren, Peng Sun, Liang Tian, Li Zhang, Jie Zhang, Jue-Bao Li, Xiang-Ming Y. Spinal cord injury causes insulin resistance associated with PI3K signaling pathway in hypothalamus. Neurochemistry international. vol 140. 2021-09-02. PMID:32853751. |
spinal cord injury causes insulin resistance associated with pi3k signaling pathway in hypothalamus. |
2021-09-02 |
2023-08-13 |
rat |
| Rui-Dong Cheng, Wen Ren, Peng Sun, Liang Tian, Li Zhang, Jie Zhang, Jue-Bao Li, Xiang-Ming Y. Spinal cord injury causes insulin resistance associated with PI3K signaling pathway in hypothalamus. Neurochemistry international. vol 140. 2021-09-02. PMID:32853751. |
studies have shown that greater phosphoinositide 3-kinase (pi3k) activation in the hypothalamus leads to activation of the anti-inflammatory pathway, and the anti-inflammatory reflex may protect against insulin resistance and type 2 diabetes. |
2021-09-02 |
2023-08-13 |
rat |
| Rui-Dong Cheng, Wen Ren, Peng Sun, Liang Tian, Li Zhang, Jie Zhang, Jue-Bao Li, Xiang-Ming Y. Spinal cord injury causes insulin resistance associated with PI3K signaling pathway in hypothalamus. Neurochemistry international. vol 140. 2021-09-02. PMID:32853751. |
the reduced activity of the pi3k signaling pathway in the hypothalamus may lead to peripheral inflammation, which might be the mechanism underlying the development of insulin resistance and type 2 diabetes following sci. |
2021-09-02 |
2023-08-13 |
rat |
| Martin Heni, Robert Wagner, Caroline Willmann, Benjamin Assad Jaghutriz, Andreas Vosseler, Christian Kübler, Verena Hund, Klaus Scheffler, Andreas Peter, Hans-Ulrich Häring, Hubert Preissl, Stephanie Kullmann, Andreas Fritsch. Insulin Action in the Hypothalamus Increases Second-Phase Insulin Secretion in Humans. Neuroendocrinology. vol 110. issue 11-12. 2021-08-27. PMID:31689708. |
insulin action in the hypothalamus increases second-phase insulin secretion in humans. |
2021-08-27 |
2023-08-13 |
Not clear |
| Martin Heni, Robert Wagner, Caroline Willmann, Benjamin Assad Jaghutriz, Andreas Vosseler, Christian Kübler, Verena Hund, Klaus Scheffler, Andreas Peter, Hans-Ulrich Häring, Hubert Preissl, Stephanie Kullmann, Andreas Fritsch. Insulin Action in the Hypothalamus Increases Second-Phase Insulin Secretion in Humans. Neuroendocrinology. vol 110. issue 11-12. 2021-08-27. PMID:31689708. |
an important brain region for this process is the hypothalamus, an area that can develop insulin resistance. |
2021-08-27 |
2023-08-13 |
Not clear |
| A O Shpakov, K V Derkach, E V Surkova, A I Bespalo. [Perspectives of application of intranasally administered insulin for correction of metabolic and hormonal disorders in diabetes mellitus and metabolic syndrome]. Problemy endokrinologii. vol 65. issue 5. 2021-08-25. PMID:32202743. |
in the course of numerous studies of intranasally administered insulin in animal models of diabetes mellitus, not only stabilization of carbohydrate homeostasis was shown, but also a positive effect in the form of restoration of the functional activity of insulin signaling pathways in the hypothalamus and other parts of the brain. |
2021-08-25 |
2023-08-13 |
human |
| Zubin He, Guochao Yin, Qingdi Quentin Li, Qiongfang Zeng, Jinliang Dua. Diabetes Mellitus Causes Male Reproductive Dysfunction: A Review of the Evidence and Mechanisms. In vivo (Athens, Greece). vol 35. issue 5. 2021-08-23. PMID:34410936. |
in addition, insulin deficiency and resistance in diabetes can damage the hypothalamus, pituitary gland, gonads, and perigonads. |
2021-08-23 |
2023-08-13 |
Not clear |
| Rafael C Gaspar, Susana C B R Nakandakari, Vitor R Muñoz, Renan F L Vieira, Adelino S R da Silva, Dennys E Cintra, Leandro P de Moura, Eduardo R Ropelle, José Rodrigo Paul. Acute physical exercise increases PI3K-p110α protein content in the hypothalamus of obese mice. Journal of anatomy. vol 238. issue 3. 2021-08-13. PMID:33094520. |
furthermore, leptin signalling in the hypothalamus can communicate with insulin signalling through the activation of phosphoinositide 3-kinase (pi3k). |
2021-08-13 |
2023-08-13 |
mouse |