| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Maggie C Evans, Jennifer W Hill, Greg M Anderso. Role of insulin in the neuroendocrine control of reproduction. Journal of neuroendocrinology. vol 33. issue 4. 2021-04-19. PMID:33523515. |
infertility associated with insulin resistance is characterised by abnormal hormone secretion by the hypothalamus, pituitary gland and gonads. |
2021-04-19 |
2023-08-13 |
mouse |
| Sasha Rawlinson, Zane B Andrew. Hypothalamic insulin signalling as a nexus regulating mood and metabolism. Journal of neuroendocrinology. vol 33. issue 4. 2021-04-19. PMID:33634518. |
specifically, we hypothesise that the insulin receptor in the hypothalamus, classically known as the homeostatic centre of the brain, plays a causal role in linking metabolic and behavioural effects of insulin signalling. |
2021-04-19 |
2023-08-13 |
Not clear |
| Sasha Rawlinson, Zane B Andrew. Hypothalamic insulin signalling as a nexus regulating mood and metabolism. Journal of neuroendocrinology. vol 33. issue 4. 2021-04-19. PMID:33634518. |
in this review, we discuss insulin signalling in the hypothalamus as a critical point of neural integration controlling metabolism and mood. |
2021-04-19 |
2023-08-13 |
Not clear |
| Denise D Belsham, Prasad S Dalv. Insulin signalling in hypothalamic neurones. Journal of neuroendocrinology. vol 33. issue 4. 2021-04-16. PMID:33227171. |
the hypothalamus is a key region in the brain that responds to circulating insulin by engaging a complex signalling cascade resulting in the ultimate release of neuropeptides that control hunger and feeding. |
2021-04-16 |
2023-08-13 |
Not clear |
| Shih-Yi Lin, Ching-Ping Yang, Ya-Yu Wang, Chiao-Wan Hsiao, Wen-Ying Chen, Su-Lan Liao, Yu-Li Lo, Yih-Hsin Chang, Chen-Jee Hong, Chun-Jung Che. Interleukin-4 Improves Metabolic Abnormalities in Leptin-Deficient and High-Fat Diet Mice. International journal of molecular sciences. vol 21. issue 12. 2021-03-22. PMID:32585823. |
145e and hfd mice showed a number of abnormalities: obesity, hyperglycemia, hyperinsulinemia, insulin resistance, dyslipidemia, liver injury, and adiposity with concurrent inflammation, decreases in akt, signal transducer and activator of transcription 3 (stat3), and stat6 phosphorylation in the hypothalamus, liver, and epididymal fat. |
2021-03-22 |
2023-08-13 |
mouse |
| Jeanne Guitton, Cécile L Bandet, Mohamed L Mariko, Sophie Tan-Chen, Olivier Bourron, Yacir Benomar, Eric Hajduch, Hervé Le Stunf. Sphingosine-1-Phosphate Metabolism in the Regulation of Obesity/Type 2 Diabetes. Cells. vol 9. issue 7. 2021-03-04. PMID:32668665. |
in this review, the current knowledge on s1p metabolism in regulating insulin signaling in pancreatic β cell fate and in the regulation of feeding by the hypothalamus in the context of obesity and t2d is summarized. |
2021-03-04 |
2023-08-13 |
Not clear |
| Jian Qiu, Martha A Bosch, Chungang Zhang, Oline K Rønnekleiv, Martin J Kell. Estradiol Protects Neuropeptide Y/Agouti-Related Peptide Neurons against Insulin Resistance in Females. Neuroendocrinology. vol 110. issue 1-2. 2021-02-15. PMID:31212279. |
a key diagnostic of the metabolic syndrome is insulin resistance in both peripheral tissues and brain, especially in the hypothalamus. |
2021-02-15 |
2023-08-13 |
mouse |
| Claude Knauf, Anne Abot, Eve Wemelle, Patrice D Can. Targeting the Enteric Nervous System to Treat Metabolic Disorders? "Enterosynes" as Therapeutic Gut Factors. Neuroendocrinology. vol 110. issue 1-2. 2021-02-15. PMID:31280267. |
in turn, the hypothalamus sends an aberrant efferent message that provokes a state of insulin resistance, which is characteristic of a t2d state. |
2021-02-15 |
2023-08-13 |
mouse |
| Huan Wu, Li Chen, Zhao-Qing Zhang, Bang-Guo Chen, Feng-Xia Liang, Wei Li. [Effect of electroacupuncture on insulin sensitivity and TLR4/ IκBα/ NF-κB signaling in hypothalamus of obese rats with insulin resistance]. Zhen ci yan jiu = Acupuncture research. vol 46. issue 1. 2021-02-10. PMID:33559423. |
[effect of electroacupuncture on insulin sensitivity and tlr4/ iκbα/ nf-κb signaling in hypothalamus of obese rats with insulin resistance]. |
2021-02-10 |
2023-08-13 |
rat |
| Serpil Taheri, Zuleyha Karaca, Minoo Rassoulzadegan, Ecmel Mehmetbeyoglu, Gokmen Zararsiz, Elif Funda Sener, Kezban Korkmaz Bayram, Esra Tufan, Mustafa Caglar Sahin, Mert Kahraman Marasli, Mehmet Memis, Halit Canatan, Figen Ozturk, Fatih Tanriverdi, Kursad Unluhizarci, Fahrettin Kelestimu. The Characterization of Sex Differences in Hypoglycemia-Induced Activation of HPA Axis on the Transcriptomic Level. Cellular and molecular neurobiology. 2021-02-05. PMID:33544274. |
after insulin injection, expression levels of 192 micrornas and 41 mrnas associated with the hpa, gh and hypothalamic-pituitary-gonadal (hpg) axes were determined by real-time rt-pcr in the hypothalamus, pituitary and adrenal tissues, as well as blood samples (raw data accession: https://drive.google.com/drive/folders/10qi00natjxoepcnkxsjnqbjebfa6zghk?usp=sharing ). |
2021-02-05 |
2023-08-13 |
mouse |
| Yukiko Fu, Kentaro Kaneko, Hsiao-Yun Lin, Qianxing Mo, Yong Xu, Takayoshi Suganami, Peter Ravn, Makoto Fukud. Gut Hormone GIP Induces Inflammation and Insulin Resistance in the Hypothalamus. Endocrinology. vol 161. issue 9. 2021-01-04. PMID:32603429. |
gut hormone gip induces inflammation and insulin resistance in the hypothalamus. |
2021-01-04 |
2023-08-13 |
mouse |
| Yukiko Fu, Kentaro Kaneko, Hsiao-Yun Lin, Qianxing Mo, Yong Xu, Takayoshi Suganami, Peter Ravn, Makoto Fukud. Gut Hormone GIP Induces Inflammation and Insulin Resistance in the Hypothalamus. Endocrinology. vol 161. issue 9. 2021-01-04. PMID:32603429. |
high-fat diet (hfd) feeding increases the gene expression of proinflammatory mediators and decreases insulin actions in the hypothalamus. |
2021-01-04 |
2023-08-13 |
mouse |
| Yukiko Fu, Kentaro Kaneko, Hsiao-Yun Lin, Qianxing Mo, Yong Xu, Takayoshi Suganami, Peter Ravn, Makoto Fukud. Gut Hormone GIP Induces Inflammation and Insulin Resistance in the Hypothalamus. Endocrinology. vol 161. issue 9. 2021-01-04. PMID:32603429. |
additionally, centrally administered gip reduced anorectic actions of insulin in the brain and diminished insulin-induced phosphorylation of protein kinase b and glycogen synthase kinase 3β in the hypothalamus. |
2021-01-04 |
2023-08-13 |
mouse |
| Yukiko Fu, Kentaro Kaneko, Hsiao-Yun Lin, Qianxing Mo, Yong Xu, Takayoshi Suganami, Peter Ravn, Makoto Fukud. Gut Hormone GIP Induces Inflammation and Insulin Resistance in the Hypothalamus. Endocrinology. vol 161. issue 9. 2021-01-04. PMID:32603429. |
collectively, these findings reveal a previously unrecognized role for brain gip signaling in diet-induced inflammation and insulin resistance in the hypothalamus. |
2021-01-04 |
2023-08-13 |
mouse |
| Chanya Inprasit, Yu-Chuen Huang, Yi-Wen Li. Evidence for acupoint catgut embedding treatment and TRPV1 gene deletion increasing weight control in murine model. International journal of molecular medicine. vol 45. issue 3. 2020-11-30. PMID:31922226. |
similar patterns were observed in adipose tissue mass, glucose, leptin and insulin plasma levels, and protein molecule density of trpv1 and its associated molecules in the hypothalamus and nucleus tractus solitarii. |
2020-11-30 |
2023-08-13 |
mouse |
| Elizabeth M Rhea, Surabhi Nirkhe, Steven Nguyen, Sarah Pemberton, Theo K Bammler, Richard Beyer, Michael L Niehoff, John E Morley, Susan A Farr, William A Bank. Molecular Mechanisms of Intranasal Insulin in SAMP8 Mice. Journal of Alzheimer's disease : JAD. vol 71. issue 4. 2020-11-06. PMID:31561374. |
using the samp8 mouse model of ad, we investigated the impact of inl insulin on protein and gene expression in brain regions including the olfactory bulb, hypothalamus, and hippocampus. |
2020-11-06 |
2023-08-13 |
mouse |
| Zsuzsanna Winkler, Dániel Kuti, Ágnes Polyák, Balázs Juhász, Krisztina Gulyás, Nikolett Lénárt, Ádám Dénes, Szilamér Ferenczi, Krisztina J Kovác. Hypoglycemia-activated Hypothalamic Microglia Impairs Glucose Counterregulatory Responses. Scientific reports. vol 9. issue 1. 2020-10-20. PMID:30996341. |
bolus insulin administration to fasted mice resulted in hypoglycemia, which increased hypothalamo-pituitary-adrenal (hpa) axis- and sympathetic activity, increased transcription of neuropeptide y (npy) and agouti-related peptide (agrp) in the hypothalamic arcuate nucleus and activated iba1+ microglia in the hypothalamus. |
2020-10-20 |
2023-08-13 |
mouse |
| Yuling Lian, Fangui Zhao, Wenjun Wan. Use of Bao Gui capsule in treatment of a polycystic ovary syndrome rat model. Molecular medicine reports. vol 21. issue 3. 2020-10-19. PMID:32016479. |
serum levels of follicle‑stimulating hormone (fsh), luteinizing hormone (lh), testosterone (t), estradiol (e2), insulin, leptin, and interleukin (il)‑1β, il‑6 and tumor necrosis factor‑α (tnf‑α) in the hypothalamus were determined by elisa. |
2020-10-19 |
2023-08-13 |
rat |
| Yuling Lian, Fangui Zhao, Wenjun Wan. Use of Bao Gui capsule in treatment of a polycystic ovary syndrome rat model. Molecular medicine reports. vol 21. issue 3. 2020-10-19. PMID:32016479. |
these results suggest that bgc may effectively improve hyperandrogenism, insulin resistance, endometrial receptivity and the low‑grade chronic inflammation in the hypothalamus. |
2020-10-19 |
2023-08-13 |
rat |
| S Galoi. NEW BLOOD PRESSURE TARGETS IN NON-DIABETIC PATIENTS AND INSULIN RESISTANCE IN BRAIN. Acta endocrinologica (Bucharest, Romania : 2005). vol 12. issue 1. 2020-10-01. PMID:31258812. |
in limited area of the human brain, insulin acts in modulation of body weight by food intake and modification of metabolism: hypothalamus (the central regulator of whole- body energy homeostasis and of food intake), prefrontal cortex (inhibitory control of eating), hippocampus (memory) and the fusiform gyrus (recognition of food, positive emotions, reward). |
2020-10-01 |
2023-08-13 |
human |