| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| G Battaglia, S Y Yeh, E O'Hearn, M E Molliver, M J Kuhar, E B De Souz. 3,4-Methylenedioxymethamphetamine and 3,4-methylenedioxyamphetamine destroy serotonin terminals in rat brain: quantification of neurodegeneration by measurement of [3H]paroxetine-labeled serotonin uptake sites. The Journal of pharmacology and experimental therapeutics. vol 242. issue 3. 1987-11-05. PMID:2443644. |
marked reductions (30-60%) in the concentration of 5-hydroxyindoleacetic acid were observed in cerebral cortex, hippocampus, striatum, hypothalamus and midbrain at 2 weeks after a 4-day treatment regimen of mdma or mda; less consistent reductions in serotonin (5-ht) content were observed in these brain regions. |
1987-11-05 |
2023-08-11 |
rat |
| A M Copland, D J Balfou. The effects of diazepam on brain 5-HT and 5-HIAA in stressed and unstressed rats. Pharmacology, biochemistry, and behavior. vol 27. issue 4. 1987-10-29. PMID:2443932. |
acute diazepam (25 mg/kg) increased (p less than 0.05) hippocampal 5-hydroxyindoleacetic acid; its withdrawal from unstressed rats after 40 days reduced (p less than 0.01) hypothalamic 5-hydroxytryptamine. |
1987-10-29 |
2023-08-11 |
rat |
| H Hörtnagl, P E Potter, I Hani. Effect of cholinergic deficit induced by ethylcholine aziridinium on serotonergic parameters in rat brain. Neuroscience. vol 22. issue 1. 1987-10-22. PMID:2442662. |
as with acetylcholine, the decrease in serotonin content was most pronounced in the hippocampus, ranged from 19.4 +/- 2.9% to 53.4 +/- 4.1%, and even persisted at 28 days after injection of 3 and 5 nmoles of the toxin/ventricle, although serotonin levels returned towards normal at that time point after injection of 1 or 2 nmoles of the toxin/ventricle. |
1987-10-22 |
2023-08-11 |
rat |
| A G Silina, A G Sverdlov. [Effect of super-high doses of gamma-radiation on the level and metabolism of serotonin in the rat brain]. Radiobiologiia. vol 27. issue 4. 1987-10-22. PMID:2442793. |
as early as 60 mi after gamma-irradiation of wistar rats with a dose of 150 gy the content of serotonin and 5-hydroxyindoleacetic acid decreases in the midbrain, hippocampus, and cerebral hemisphere cortex. |
1987-10-22 |
2023-08-11 |
rat |
| R Andrade, R A Nicol. Novel anxiolytics discriminate between postsynaptic serotonin receptors mediating different physiological responses on single neurons of the rat hippocampus. Naunyn-Schmiedeberg's archives of pharmacology. vol 336. issue 1. 1987-10-22. PMID:2888027. |
novel anxiolytics discriminate between postsynaptic serotonin receptors mediating different physiological responses on single neurons of the rat hippocampus. |
1987-10-22 |
2023-08-11 |
rat |
| R Andrade, R A Nicol. Novel anxiolytics discriminate between postsynaptic serotonin receptors mediating different physiological responses on single neurons of the rat hippocampus. Naunyn-Schmiedeberg's archives of pharmacology. vol 336. issue 1. 1987-10-22. PMID:2888027. |
since the buspirone induced hyperpolarization was also accompanied by a surmountable antagonism of 5-ht responses, these results indicate that buspirone behaves as a partial agonist at a subpopulation of 5-ht receptors in the ca1 region of the hippocampus. |
1987-10-22 |
2023-08-11 |
rat |
| D G Morga. The dopamine and serotonin systems during aging in human and rodent brain. A brief review. Progress in neuro-psychopharmacology & biological psychiatry. vol 11. issue 2-3. 1987-10-15. PMID:2819950. |
the density of s-2 serotonin receptors declines 20-50% with age in human frontal cortex and hippocampus, and by 30% in mouse cortex. |
1987-10-15 |
2023-08-11 |
mouse |
| G P Reynolds, S J Pearso. Decreased glutamic acid and increased 5-hydroxytryptamine in Huntington's disease brain. Neuroscience letters. vol 78. issue 2. 1987-09-30. PMID:2442679. |
5-ht and 5-hiaa were significantly increased in all areas except the hippocampus. |
1987-09-30 |
2023-08-11 |
human |
| G Maura, M Ulivi, M Raiter. (-)-Propranolol and (+/-)-cyanopindolol are mixed agonists-antagonists at serotonin autoreceptors in the hippocampus of the rat brain. Neuropharmacology. vol 26. issue 7A. 1987-09-30. PMID:3627379. |
(-)-propranolol and (+/-)-cyanopindolol are mixed agonists-antagonists at serotonin autoreceptors in the hippocampus of the rat brain. |
1987-09-30 |
2023-08-11 |
rat |
| G Maura, M Ulivi, M Raiter. (-)-Propranolol and (+/-)-cyanopindolol are mixed agonists-antagonists at serotonin autoreceptors in the hippocampus of the rat brain. Neuropharmacology. vol 26. issue 7A. 1987-09-30. PMID:3627379. |
the effects of (-)-propranolol, (+)-propranolol and (+/-)-cyanopindolol on the release of [3h]5-hydroxytryptamine [( 3h]5-ht) were investigated in synaptosomes from the hippocampus of the rat, depolarized in superfusion with 15 mm kcl. |
1987-09-30 |
2023-08-11 |
rat |
| D J Mokler, S E Robinson, J A Rosecran. (+/-)3,4-Methylenedioxymethamphetamine (MDMA) produces long-term reductions in brain 5-hydroxytryptamine in rats. European journal of pharmacology. vol 138. issue 2. 1987-09-25. PMID:2887440. |
mdma produced significant depletions of 5-ht and its metabolite 5-hiaa in the hippocampus and the frontal cortex. |
1987-09-25 |
2023-08-11 |
rat |
| D J Mokler, S E Robinson, J A Rosecran. (+/-)3,4-Methylenedioxymethamphetamine (MDMA) produces long-term reductions in brain 5-hydroxytryptamine in rats. European journal of pharmacology. vol 138. issue 2. 1987-09-25. PMID:2887440. |
5-ht was depleted to 30% of control value in the hippocampus following a single dose. |
1987-09-25 |
2023-08-11 |
rat |
| B Lerer, J Warner, E Friedman, G Vincent, E Gamz. Cortical cholinergic impairment and behavioral deficits produced by kainic acid lesions of rat magnocellular basal forebrain. Behavioral neuroscience. vol 99. issue 4. 1987-09-25. PMID:3843733. |
cortical dopamine levels were unchanged; serotonin levels were unchanged in hippocampus and parietal cortex but decreased in frontal cortex. |
1987-09-25 |
2023-08-11 |
human |
| M Ohno, T Yamamoto, S Uek. Clonidine attenuates wet-dog shaking induced by hippocampal stimulation in rats. European journal of pharmacology. vol 137. issue 2-3. 1987-09-24. PMID:3609139. |
although clonidine has been reported to inhibit the activity not only of noradrenergic but also of serotonergic neurons, a 5-hydroxytryptamine (5-ht) antagonist, cinanserin at doses up to 32 mg/kg had no significant effect on hippocampal stimulation-induced wds. |
1987-09-24 |
2023-08-11 |
rat |
| G Lombardi, O Gandolfi, R Dall'Olio, D E Pellegrini-Giampietro, M Beni, V Carla, A Consolazione, F Moron. Lesioning and recovery of the serotoninergic projections to the hippocampus. Brain research. vol 411. issue 2. 1987-08-28. PMID:2440519. |
the time course of the changes of the hippocampal 5-hydroxytryptamine (5-ht) system after a lesion of the dorsal afferents to this brain area was studied by measuring the content of 5-ht and of 5-hydroxyindoleacetic acid (5-hiaa) in the dorsal, medial and ventral hippocampus. |
1987-08-28 |
2023-08-11 |
Not clear |
| G Lombardi, O Gandolfi, R Dall'Olio, D E Pellegrini-Giampietro, M Beni, V Carla, A Consolazione, F Moron. Lesioning and recovery of the serotoninergic projections to the hippocampus. Brain research. vol 411. issue 2. 1987-08-28. PMID:2440519. |
the contents of 5-ht and of 5-hiaa are higher in the ventral than in the dorsal hippocampus. |
1987-08-28 |
2023-08-11 |
Not clear |
| G Lombardi, O Gandolfi, R Dall'Olio, D E Pellegrini-Giampietro, M Beni, V Carla, A Consolazione, F Moron. Lesioning and recovery of the serotoninergic projections to the hippocampus. Brain research. vol 411. issue 2. 1987-08-28. PMID:2440519. |
seven days after the lesion the 5-ht content decreases by 78% in the dorsal and by 50% in the ventral hippocampus. |
1987-08-28 |
2023-08-11 |
Not clear |
| G Lombardi, O Gandolfi, R Dall'Olio, D E Pellegrini-Giampietro, M Beni, V Carla, A Consolazione, F Moron. Lesioning and recovery of the serotoninergic projections to the hippocampus. Brain research. vol 411. issue 2. 1987-08-28. PMID:2440519. |
these results suggest that important changes occur in the 5-ht innervation of the hippocampus after a mechanical lesion: among these we showed a slow collateral sprouting, an increased utilization of the amine and a supersensitivity of 5-ht receptors. |
1987-08-28 |
2023-08-11 |
Not clear |
| T D Steele, D E Nichols, G K Yi. Stereochemical effects of 3,4-methylenedioxymethamphetamine (MDMA) and related amphetamine derivatives on inhibition of uptake of [3H]monoamines into synaptosomes from different regions of rat brain. Biochemical pharmacology. vol 36. issue 14. 1987-08-19. PMID:2886126. |
both stereoisomers of mdma, mda and mbdb were potent inhibitors of [3h]serotonin uptake into hippocampal synaptosomes, but only s-(+)-amphetamine produced an appreciable inhibition of [3h]serotonin uptake. |
1987-08-19 |
2023-08-11 |
rat |
| F C Zhou, S Auerbach, E Azmiti. Denervation of serotonergic fibers in the hippocampus induced a trophic factor which enhances the maturation of transplanted serotonergic neurons but not norepinephrine neurons. Journal of neuroscience research. vol 17. issue 3. 1987-08-11. PMID:3037093. |
the trophic effects of specific denervation on the growth and survival of fetal serotonergic (5-ht) or norepinephrinergic (ne) neurons grafted into the hippocampus were assessed by means of two transplantation paradigms. |
1987-08-11 |
2023-08-11 |
Not clear |