| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T Tsubokawa, Y Katayama, S Miyazaki, H Ogawa, M Iwasaki, S Shibanoki, K Ishikaw. Supranormal levels of serotonin and its metabolite after raphe cell transplantation in serotonin-denervated rat hippocampus. Brain research bulletin. vol 20. issue 3. 1988-06-16. PMID:2452672. |
these data indicate that a large amount of 5-ht is released from nerve terminals of transplanted raphe cells, and suggest that the supranormal levels of 5-ht and 5-hiaa after raphe cell transplantation are neurochemical correlates of 5-ht hyper-innervation of the hippocampus which has been reported previously. |
1988-06-16 |
2023-08-11 |
rat |
| K J Reinikainen, L Paljärvi, M Huuskonen, H Soininen, M Laakso, P J Riekkine. A post-mortem study of noradrenergic, serotonergic and GABAergic neurons in Alzheimer's disease. Journal of the neurological sciences. vol 84. issue 1. 1988-06-13. PMID:2452858. |
serotonin (5-ht) levels were significantly lowered in the hippocampal cortex, hippocampus, caudate nucleus and putamen and the concentrations of 5-hiaa, a metabolite of 5-ht, were reduced in 3 cortical areas, thalamus and putamen in patients with ad/sdat. |
1988-06-13 |
2023-08-11 |
Not clear |
| A S Dmitriev, G K Tropnikov. [Effect of low-frequency whole-body vertical vibration on the serotoninergic system of the brain and spinal cord]. Kosmicheskaia biologiia i aviakosmicheskaia meditsina. vol 22. issue 1. 1988-06-09. PMID:3361835. |
acute vibration led to 5-ht activation which was most significant in the hippocampus, diencephalon, cerebellum and in the sacrolumbar cord. |
1988-06-09 |
2023-08-11 |
rat |
| A S Dmitriev, G K Tropnikov. [Effect of low-frequency whole-body vertical vibration on the serotoninergic system of the brain and spinal cord]. Kosmicheskaia biologiia i aviakosmicheskaia meditsina. vol 22. issue 1. 1988-06-09. PMID:3361835. |
as compared to the controls, vibration produced a smaller accumulation of 5-ht in the hippocampus and a larger accumulation in the cerebellum, diencephalon, medulla oblongata and spinal cord. |
1988-06-09 |
2023-08-11 |
rat |
| A Cudennec, D Duverger, T Nishikawa, A McRae-Degueurce, E T MacKenzie, B Scatto. Influence of ascending serotonergic pathways on glucose use in the conscious rat brain. I. Effects of electrolytic or neurotoxic lesions of the dorsal and/or median raphé nucleus. Brain research. vol 444. issue 2. 1988-06-02. PMID:3359293. |
the efficacy of both electrolytic and neurotoxic lesions was verified, in each animal, by neurochemical microassay of 5-hydroxytryptamine and its metabolite in samples of striatum, hippocampus and prefrontal cortex. |
1988-06-02 |
2023-08-11 |
rat |
| H Yamamoto, T Kat. Effects on brain cholecystokinin-8-sulfate and serotonin in adult rats after neonatal reduction of catecholamines. Neuroscience research. vol 5. issue 3. 1988-05-26. PMID:2451793. |
in contrast, neonatal norepinephrine (ne) depletion did not affect either cck-8si or serotonin in the frontal cortex, anterior cingulate cortex or hippocampus. |
1988-05-26 |
2023-08-11 |
rat |
| J L Yakel, L O Trussell, M B Jackso. Three serotonin responses in cultured mouse hippocampal and striatal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 8. issue 4. 1988-05-26. PMID:2965756. |
three serotonin responses in cultured mouse hippocampal and striatal neurons. |
1988-05-26 |
2023-08-11 |
mouse |
| J L Yakel, L O Trussell, M B Jackso. Three serotonin responses in cultured mouse hippocampal and striatal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 8. issue 4. 1988-05-26. PMID:2965756. |
serotonin (5-ht) produced 3 different types of responses in neurons of mouse hippocampal and striatal cell cultures. |
1988-05-26 |
2023-08-11 |
mouse |
| J L Yakel, L O Trussell, M B Jackso. Three serotonin responses in cultured mouse hippocampal and striatal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 8. issue 4. 1988-05-26. PMID:2965756. |
5-methoxy-n,n-dimethyltryptamine also produced this response in both striatal and hippocampal cultures and had no effect on the other 5-ht currents observed in this study. |
1988-05-26 |
2023-08-11 |
mouse |
| H Y Wang, E Friedma. Chronic lithium: desensitization of autoreceptors mediating serotonin release. Psychopharmacology. vol 94. issue 3. 1988-05-13. PMID:3128806. |
the effect of chronic lithium treatment on k+-induced release of preloaded [3h] serotonin [( 3h]5-ht) from brain slices and its regulation by the presynaptic serotonin autoreceptors were investigated in superfused cortical, hippocampal and hypothalamic brain slices. |
1988-05-13 |
2023-08-11 |
Not clear |
| M Carli, R Invernizzi, L Cervo, R Samani. Neurochemical and behavioural studies with RU-24969 in the rat. Psychopharmacology. vol 94. issue 3. 1988-05-13. PMID:3128812. |
ru-24969 0.62 mg/kg significantly reduced 5-ht synthesis in the nucleus accumbens and hypothalamus, while with 1.25 and 2.5 mg/kg the effect was also seen in striatum, hippocampus, brainstem and cortex. |
1988-05-13 |
2023-08-11 |
rat |
| R Andrade, R A Nicol. Pharmacologically distinct actions of serotonin on single pyramidal neurones of the rat hippocampus recorded in vitro. The Journal of physiology. vol 394. 1988-05-12. PMID:3443977. |
pharmacologically distinct actions of serotonin on single pyramidal neurones of the rat hippocampus recorded in vitro. |
1988-05-12 |
2023-08-11 |
rat |
| R Andrade, R A Nicol. Pharmacologically distinct actions of serotonin on single pyramidal neurones of the rat hippocampus recorded in vitro. The Journal of physiology. vol 394. 1988-05-12. PMID:3443977. |
the actions of serotonin (5-ht) on pyramidal cells of the ca1 region of the rat hippocampus were characterized using intracellular recording in in vitro brain slices. |
1988-05-12 |
2023-08-11 |
rat |
| L Bacciottini, D E Pellegrini-Giampietro, F Bongianni, G de Luca, M Beni, V Politi, F Moron. Biochemical and behavioural studies on indole-pyruvic acid: a keto-analogue of tryptophan. Pharmacological research communications. vol 19. issue 11. 1988-04-25. PMID:2451257. |
acute or repeated administrations of ipa (20 or 50 mg/kg) increased the utilization of 5-ht in the cortex, hippocampus, diencephalon and brain-stem of rats fed a standard laboratory diet. |
1988-04-25 |
2023-08-11 |
rat |
| S E File, P F Curle, H A Baldwin, M J Nea. Anxiety in the rat is associated with decreased release of 5-HT and glycine from the hippocampus. Neuroscience letters. vol 83. issue 3. 1988-04-19. PMID:3441314. |
anxiety in the rat is associated with decreased release of 5-ht and glycine from the hippocampus. |
1988-04-19 |
2023-08-11 |
rat |
| B A McMillen, J K Chamberlain, J P DaVanz. Effects of housing and muricidal behavior on serotonergic receptors and interactions with novel anxiolytic drugs. Journal of neural transmission. vol 71. issue 2. 1988-04-18. PMID:2894404. |
binding of [3h]-5-hydroxytryptamine (5ht) to 5ht1a receptors decreased in septum of both groups of isolated rats and binding to 5ht1b receptors decreased 50% in hippocampus of isolated and aggregated muricidal rats. |
1988-04-18 |
2023-08-11 |
mouse |
| H Gozlan, M Ponchant, G Daval, D Verge, F Menard, A Vanhove, J P Beaucourt, M Hamo. 125I-Bolton-Hunter-8-methoxy-2-[N-propyl-N-propylamino]tetralin as a new selective radioligand of 5-HT1A sites in the rat brain. In vitro binding and autoradiographic studies. The Journal of pharmacology and experimental therapeutics. vol 244. issue 2. 1988-04-12. PMID:2964524. |
in vitro binding assays with 125i-[8-methoxy-2-[n-propyl-n-(3'-iodo-4'-hydroxyphenyl)-propionamido -n'- propylamino] tetralin] (125i-bh-8-meo-n-pat), a 125i-labeled derivative of the potent serotonin (5-ht) agonist 8-hydroxy-2-[di-n-propylamino]tetralin [( 3h]-8-oh-dpat), showed that this compound recognized specific sites with nanomolar affinity for 5-ht and 5-ht1a ligands such as spiroxatrine, ipsapirone, buspirone and gepirone in rat hippocampal membranes. |
1988-04-12 |
2023-08-11 |
rat |
| H Gozlan, M Ponchant, G Daval, D Verge, F Menard, A Vanhove, J P Beaucourt, M Hamo. 125I-Bolton-Hunter-8-methoxy-2-[N-propyl-N-propylamino]tetralin as a new selective radioligand of 5-HT1A sites in the rat brain. In vitro binding and autoradiographic studies. The Journal of pharmacology and experimental therapeutics. vol 244. issue 2. 1988-04-12. PMID:2964524. |
comparison of the binding characteristics of 125i-bh-8-meo-n-pat with those of [3h]-8-oh-dpat revealed striking similarities: at the hippocampal level, both binding sites exhibited nanomolar affinity for their respective ligands and the same bmax; their pharmacological profiles defined by the inhibition of each bound ligand by a series of 26 serotonin, dopamine- or norepinephrine-related agonists and antagonists were identical; and their regional distributions examined by membrane binding assays and autoradiography of labeled brain sections were highly correlated. |
1988-04-12 |
2023-08-11 |
rat |
| D M Stone, K M Merchant, G R Hanson, J W Gib. Immediate and long-term effects of 3,4-methylenedioxymethamphetamine on serotonin pathways in brain of rat. Neuropharmacology. vol 26. issue 12. 1988-04-07. PMID:2893986. |
fifteen min after subcutaneous injection of mdma (10 mg/kg), the enzymatic activity of tryptophan hydroxylase (the rate-limiting enzyme for the biosynthesis of serotonin) was significantly decreased in the frontal cortex; by 1 hr after the injection, the activity of tryptophan hydroxylase had significantly declined in the neostriatum, hippocampus and hypothalamus as well. |
1988-04-07 |
2023-08-11 |
rat |
| T Mennini, E Mocaer, S Garattin. Tianeptine, a selective enhancer of serotonin uptake in rat brain. Naunyn-Schmiedeberg's archives of pharmacology. vol 336. issue 5. 1988-03-30. PMID:3437921. |
the biochemical effect of tianeptine in vivo after acute or repeated treatment indicates an enhanced serotonin uptake in cortex and hippocampus but not in mesencephalon, with no effect on noradrenaline or dopamine uptake. |
1988-03-30 |
2023-08-11 |
rat |