| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R Andrade, R A Nicol. Pharmacologically distinct actions of serotonin on single pyramidal neurones of the rat hippocampus recorded in vitro. The Journal of physiology. vol 394. 1988-05-12. PMID:3443977. |
the actions of serotonin (5-ht) on pyramidal cells of the ca1 region of the rat hippocampus were characterized using intracellular recording in in vitro brain slices. |
1988-05-12 |
2023-08-11 |
rat |
| L Bacciottini, D E Pellegrini-Giampietro, F Bongianni, G de Luca, M Beni, V Politi, F Moron. Biochemical and behavioural studies on indole-pyruvic acid: a keto-analogue of tryptophan. Pharmacological research communications. vol 19. issue 11. 1988-04-25. PMID:2451257. |
acute or repeated administrations of ipa (20 or 50 mg/kg) increased the utilization of 5-ht in the cortex, hippocampus, diencephalon and brain-stem of rats fed a standard laboratory diet. |
1988-04-25 |
2023-08-11 |
rat |
| S E File, P F Curle, H A Baldwin, M J Nea. Anxiety in the rat is associated with decreased release of 5-HT and glycine from the hippocampus. Neuroscience letters. vol 83. issue 3. 1988-04-19. PMID:3441314. |
anxiety in the rat is associated with decreased release of 5-ht and glycine from the hippocampus. |
1988-04-19 |
2023-08-11 |
rat |
| B A McMillen, J K Chamberlain, J P DaVanz. Effects of housing and muricidal behavior on serotonergic receptors and interactions with novel anxiolytic drugs. Journal of neural transmission. vol 71. issue 2. 1988-04-18. PMID:2894404. |
binding of [3h]-5-hydroxytryptamine (5ht) to 5ht1a receptors decreased in septum of both groups of isolated rats and binding to 5ht1b receptors decreased 50% in hippocampus of isolated and aggregated muricidal rats. |
1988-04-18 |
2023-08-11 |
mouse |
| H Gozlan, M Ponchant, G Daval, D Verge, F Menard, A Vanhove, J P Beaucourt, M Hamo. 125I-Bolton-Hunter-8-methoxy-2-[N-propyl-N-propylamino]tetralin as a new selective radioligand of 5-HT1A sites in the rat brain. In vitro binding and autoradiographic studies. The Journal of pharmacology and experimental therapeutics. vol 244. issue 2. 1988-04-12. PMID:2964524. |
in vitro binding assays with 125i-[8-methoxy-2-[n-propyl-n-(3'-iodo-4'-hydroxyphenyl)-propionamido -n'- propylamino] tetralin] (125i-bh-8-meo-n-pat), a 125i-labeled derivative of the potent serotonin (5-ht) agonist 8-hydroxy-2-[di-n-propylamino]tetralin [( 3h]-8-oh-dpat), showed that this compound recognized specific sites with nanomolar affinity for 5-ht and 5-ht1a ligands such as spiroxatrine, ipsapirone, buspirone and gepirone in rat hippocampal membranes. |
1988-04-12 |
2023-08-11 |
rat |
| H Gozlan, M Ponchant, G Daval, D Verge, F Menard, A Vanhove, J P Beaucourt, M Hamo. 125I-Bolton-Hunter-8-methoxy-2-[N-propyl-N-propylamino]tetralin as a new selective radioligand of 5-HT1A sites in the rat brain. In vitro binding and autoradiographic studies. The Journal of pharmacology and experimental therapeutics. vol 244. issue 2. 1988-04-12. PMID:2964524. |
comparison of the binding characteristics of 125i-bh-8-meo-n-pat with those of [3h]-8-oh-dpat revealed striking similarities: at the hippocampal level, both binding sites exhibited nanomolar affinity for their respective ligands and the same bmax; their pharmacological profiles defined by the inhibition of each bound ligand by a series of 26 serotonin, dopamine- or norepinephrine-related agonists and antagonists were identical; and their regional distributions examined by membrane binding assays and autoradiography of labeled brain sections were highly correlated. |
1988-04-12 |
2023-08-11 |
rat |
| D M Stone, K M Merchant, G R Hanson, J W Gib. Immediate and long-term effects of 3,4-methylenedioxymethamphetamine on serotonin pathways in brain of rat. Neuropharmacology. vol 26. issue 12. 1988-04-07. PMID:2893986. |
fifteen min after subcutaneous injection of mdma (10 mg/kg), the enzymatic activity of tryptophan hydroxylase (the rate-limiting enzyme for the biosynthesis of serotonin) was significantly decreased in the frontal cortex; by 1 hr after the injection, the activity of tryptophan hydroxylase had significantly declined in the neostriatum, hippocampus and hypothalamus as well. |
1988-04-07 |
2023-08-11 |
rat |
| T Mennini, E Mocaer, S Garattin. Tianeptine, a selective enhancer of serotonin uptake in rat brain. Naunyn-Schmiedeberg's archives of pharmacology. vol 336. issue 5. 1988-03-30. PMID:3437921. |
the biochemical effect of tianeptine in vivo after acute or repeated treatment indicates an enhanced serotonin uptake in cortex and hippocampus but not in mesencephalon, with no effect on noradrenaline or dopamine uptake. |
1988-03-30 |
2023-08-11 |
rat |
| P Soubrie, P Martin, S el Mestikawy, M Hamo. Delayed behavioral response to antidepressant drugs following selective damage to the hippocampal noradrenergic innervation in rats. Brain research. vol 437. issue 2. 1988-03-25. PMID:3124930. |
after behavioral testing, animals were sacrificed and [3h]noradrenaline uptake was assayed in synaptosomal preparations from the hippocampus, the cerebral cortex and the septum, [3h]serotonin uptake being assessed in hippocampal synaptosomes. |
1988-03-25 |
2023-08-11 |
rat |
| P Soubrie, P Martin, S el Mestikawy, M Hamo. Delayed behavioral response to antidepressant drugs following selective damage to the hippocampal noradrenergic innervation in rats. Brain research. vol 437. issue 2. 1988-03-25. PMID:3124930. |
the 6-ohda infusion was found not to alter hippocampal [3h]serotonin uptake but to decrease (30%) [3h]noradrenaline uptake in the cerebral cortex. |
1988-03-25 |
2023-08-11 |
rat |
| A Dumuis, M Sebben, J Bockaer. Pharmacology of 5-hydroxytryptamine-1A receptors which inhibit cAMP production in hippocampal and cortical neurons in primary culture. Molecular pharmacology. vol 33. issue 2. 1988-03-24. PMID:2828913. |
serotonin (5-hydroxytryptamine, 5-ht) inhibited the formation of camp promoted by vasoactive intestinal polypeptide, plus forskolin, in mouse hippocampal and cortical neurons in primary culture. |
1988-03-24 |
2023-08-11 |
mouse |
| A Dumuis, M Sebben, J Bockaer. Pharmacology of 5-hydroxytryptamine-1A receptors which inhibit cAMP production in hippocampal and cortical neurons in primary culture. Molecular pharmacology. vol 33. issue 2. 1988-03-24. PMID:2828913. |
the rank order of potencies of classical 5-ht1 agonists in inhibiting camp formation in hippocampal neurons was 8-hydroxy-2-(di-n-propylamino)tetralin (8-oh-dpat) greater than 5-carboxamidotryptamine (5-ct) greater than d-lysergic acid diethylamide greater than 5-ht greater than 5-methoxy-n,n-dimethyltryptamine (5-meo-n,n-dmt) greater than ru 24969 greater than ipsapirone greater than bufotenine greater than buspirone [half-maximal efficacy (ec50) = 7, 18, 30, 52, 90, 102, 100, 110, and 128 nm, respectively]. |
1988-03-24 |
2023-08-11 |
mouse |
| A Ebel, G Fuhrmann, J Kempf, M T Strosser, E Kemp. Influence of mouse genotype on responses on central neurotransmitters to long-term alcohol exposure in striatum and hippocampus. Alcohol and alcoholism (Oxford, Oxfordshire). Supplement. vol 1. 1988-03-23. PMID:2892498. |
a striking strain dependency in response of central neuromediators (dopamine, serotonin, acetylcholine activities and somatostatin) to various periods of alcohol treatment has been noted in striatum and hippocampus in mice. |
1988-03-23 |
2023-08-11 |
mouse |
| M B Speisky, H Kalan. Retention of ethanol tolerance by desglycinamide-arginine-vasopressin occurs in the absence of changes in hippocampal serotonin synthesis. Alcohol and alcoholism (Oxford, Oxfordshire). Supplement. vol 1. 1988-03-23. PMID:3426715. |
retention of ethanol tolerance by desglycinamide-arginine-vasopressin occurs in the absence of changes in hippocampal serotonin synthesis. |
1988-03-23 |
2023-08-11 |
rat |
| M B Speisky, H Kalan. Retention of ethanol tolerance by desglycinamide-arginine-vasopressin occurs in the absence of changes in hippocampal serotonin synthesis. Alcohol and alcoholism (Oxford, Oxfordshire). Supplement. vol 1. 1988-03-23. PMID:3426715. |
while the mechanism underlying this effect is unknown, we have reported that specific depletion of hippocampal serotonin (5-ht) prevents the prolongation of tolerance by dgavp. |
1988-03-23 |
2023-08-11 |
rat |
| M B Speisky, H Kalan. Retention of ethanol tolerance by desglycinamide-arginine-vasopressin occurs in the absence of changes in hippocampal serotonin synthesis. Alcohol and alcoholism (Oxford, Oxfordshire). Supplement. vol 1. 1988-03-23. PMID:3426715. |
the present study explored possible presynaptic interactions between dgavp and 5-ht terminals in the hippocampus, in relation to tolerance retention. |
1988-03-23 |
2023-08-11 |
rat |
| M B Speisky, H Kalan. Retention of ethanol tolerance by desglycinamide-arginine-vasopressin occurs in the absence of changes in hippocampal serotonin synthesis. Alcohol and alcoholism (Oxford, Oxfordshire). Supplement. vol 1. 1988-03-23. PMID:3426715. |
when administered acutely, dgavp had no effect on the rates of hippocampal or septal 5-ht synthesis in naive rats, as assessed by the nsd 1015 method. |
1988-03-23 |
2023-08-11 |
rat |
| M B Speisky, H Kalan. Retention of ethanol tolerance by desglycinamide-arginine-vasopressin occurs in the absence of changes in hippocampal serotonin synthesis. Alcohol and alcoholism (Oxford, Oxfordshire). Supplement. vol 1. 1988-03-23. PMID:3426715. |
moreover, chronic dgavp treatment that maintained tolerance did not change the in vivo rate of 5-ht synthesis in the hippocampus or septum. |
1988-03-23 |
2023-08-11 |
rat |
| M B Speisky, H Kalan. Retention of ethanol tolerance by desglycinamide-arginine-vasopressin occurs in the absence of changes in hippocampal serotonin synthesis. Alcohol and alcoholism (Oxford, Oxfordshire). Supplement. vol 1. 1988-03-23. PMID:3426715. |
similarly, no significant differences were found in the levels of hippocampal 5-ht or 5-hiaa. |
1988-03-23 |
2023-08-11 |
rat |
| M B Speisky, H Kalan. Retention of ethanol tolerance by desglycinamide-arginine-vasopressin occurs in the absence of changes in hippocampal serotonin synthesis. Alcohol and alcoholism (Oxford, Oxfordshire). Supplement. vol 1. 1988-03-23. PMID:3426715. |
while the lack of changes in hippocampal 5-ht synthesis argues against a presynaptic dgavp-5-ht interaction, the possibility remains of a peptide modulation of 5-ht postsynaptic actions. |
1988-03-23 |
2023-08-11 |
rat |