| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Michelle M Karth, Brittany J Baugher, Nicole Daly, Melinda D Karth, Stephen C Gironda, Benjamin D Sach. Brain 5-HT Deficiency Prevents Antidepressant-Like Effects of High-Fat-Diet and Blocks High-Fat-Diet-Induced GSK3β Phosphorylation in the Hippocampus. Frontiers in molecular neuroscience. vol 12. 2020-09-30. PMID:31920532. |
brain 5-ht deficiency prevents antidepressant-like effects of high-fat-diet and blocks high-fat-diet-induced gsk3β phosphorylation in the hippocampus. |
2020-09-30 |
2023-08-13 |
mouse |
| Michelle M Karth, Brittany J Baugher, Nicole Daly, Melinda D Karth, Stephen C Gironda, Benjamin D Sach. Brain 5-HT Deficiency Prevents Antidepressant-Like Effects of High-Fat-Diet and Blocks High-Fat-Diet-Induced GSK3β Phosphorylation in the Hippocampus. Frontiers in molecular neuroscience. vol 12. 2020-09-30. PMID:31920532. |
however, genetic brain 5-ht deficiency blocks hfd-induced reductions in forced swim immobility and prevents hfd-induced increases in hippocampal gsk3β phosphorylation despite having no significant effects on hfd-induced changes in body weight or anxiety-like behavior. |
2020-09-30 |
2023-08-13 |
mouse |
| Jun Zhao, Huiling Tian, Hongtao Song, Xu Wang, Tong Luo, Liya Ai, Yumin Fang, Jianghao Zhao, Saiyin Chao-Ke-Tu, Zhigang L. Effect of Electroacupuncture on Reuptake of Serotonin via miRNA-16 Expression in a Rat Model of Depression. Evidence-based complementary and alternative medicine : eCAM. vol 2019. 2020-09-30. PMID:31929820. |
the current study aimed to investigate the effects and mechanisms of electroacupuncture (ea) treatment applied to bai hui (gv20) and yin tang (gv29) acupoints (1 ma, 2 hz, continuous wave, 20 minutes) for 28 days in a rat model of chronic unpredictable mild stress (cums) on reuptake of serotonin (5-hydroxytryptamine (5-ht)) and mirna-16 levels in the hippocampus and serum. |
2020-09-30 |
2023-08-13 |
rat |
| Jun Zhao, Huiling Tian, Hongtao Song, Xu Wang, Tong Luo, Liya Ai, Yumin Fang, Jianghao Zhao, Saiyin Chao-Ke-Tu, Zhigang L. Effect of Electroacupuncture on Reuptake of Serotonin via miRNA-16 Expression in a Rat Model of Depression. Evidence-based complementary and alternative medicine : eCAM. vol 2019. 2020-09-30. PMID:31929820. |
after ea treatment for 4 weeks, behavioral changes and indices including 5-ht transporter (sert), 5-ht, and mirna-16 levels in the hippocampus and serum were examined. |
2020-09-30 |
2023-08-13 |
rat |
| Jun Zhao, Huiling Tian, Hongtao Song, Xu Wang, Tong Luo, Liya Ai, Yumin Fang, Jianghao Zhao, Saiyin Chao-Ke-Tu, Zhigang L. Effect of Electroacupuncture on Reuptake of Serotonin via miRNA-16 Expression in a Rat Model of Depression. Evidence-based complementary and alternative medicine : eCAM. vol 2019. 2020-09-30. PMID:31929820. |
significantly increased 5-ht levels were observed, and mirna-16 levels were significantly decreased in the hippocampus and serum of depressed rats. |
2020-09-30 |
2023-08-13 |
rat |
| Jun Zhao, Huiling Tian, Hongtao Song, Xu Wang, Tong Luo, Liya Ai, Yumin Fang, Jianghao Zhao, Saiyin Chao-Ke-Tu, Zhigang L. Effect of Electroacupuncture on Reuptake of Serotonin via miRNA-16 Expression in a Rat Model of Depression. Evidence-based complementary and alternative medicine : eCAM. vol 2019. 2020-09-30. PMID:31929820. |
in conclusion, the antidepressant effects of ea treatment may be affected via inhibition of 5-ht reuptake, upregulation of 5-ht levels, and inhibition of mirna-16 expression in the hippocampus and serum. |
2020-09-30 |
2023-08-13 |
rat |
| Zhiying Hu, Yang Yang, Keqiang Gao, John A Rudd, Marong Fan. Ovarian hormones ameliorate memory impairment, cholinergic deficit, neuronal apoptosis and astrogliosis in a rat model of Alzheimer's disease. Experimental and therapeutic medicine. vol 11. issue 1. 2020-09-30. PMID:26889223. |
in addition, treatment with e2 and p4 was associated with increased expression levels of choline acetyltransferase and 5-hydroxytryptamine receptor 2a (5-ht2a), and decreased expression levels of the glial fibrillary acidic protein in the hippocampus of the rats. |
2020-09-30 |
2023-08-13 |
rat |
| Ping Yang, Liang Li, Xue-Jun Liu, Xiong Cai, Mei-Zhen Sun, Jun-Feng He, Guang Zeng, Hui-Yong Huan. Effect of Chaihu-Shugan-San on the mRNA expression of the 5-HT1A receptor and cellular proliferation in the hippocampus of epileptic rats with depression. Experimental and therapeutic medicine. vol 11. issue 1. 2020-09-30. PMID:26889228. |
the mrna expression levels of the 5-hydroxytryptamine 1a (5-ht1a) receptor and the number of 5-bromo-2'-deoxyuridine (brdu)-labeled cells in the hippocampal dentate gyrus were detected using reverse transcription-quantitative polymerase chain reaction and immunohistochemical analysis, respectively. |
2020-09-30 |
2023-08-13 |
rat |
| Yuan Hu, Yu-Nin Wang, Gang-Qiang Zhang, Xian-Zhe Dong, Wan-Wan Liu, Ping Li. Gan-Dan-Liang-Yi-Tang alleviates p-chlorophenylalanine-induced insomnia through modification of the serotonergic and immune system. Experimental and therapeutic medicine. vol 12. issue 5. 2020-09-30. PMID:27882122. |
gdlyt was also able to alleviate insomnia induced by pcpa in the rodent models, and increased 5-hydroxytryptamine levels in the prefrontal cortex, hippocampus, hypothalamus and corpus striatum of pcpa-treated rats. |
2020-09-30 |
2023-08-13 |
mouse |
| Dasiel O Borroto-Escuela, Caitlin M DuPont, Xiang Li, David Savelli, Davide Lattanzi, Ipsit Srivastava, Manuel Narváez, Michael Di Palma, Elisa Barbieri, Yuniesky Andrade-Talavera, Riccardo Cuppini, Yuji Odagaki, Miklos Palkovits, Patrizia Ambrogini, Maria Lindskog, Kjell Fux. Disturbances in the FGFR1-5-HT1A Heteroreceptor Complexes in the Raphe-Hippocampal 5-HT System Develop in a Genetic Rat Model of Depression. Frontiers in cellular neuroscience. vol 11. 2020-09-30. PMID:29066953. |
the fgfr1-5-ht1a heteroreceptor complexes are involved in neuroplasticity in the rat hippocampus and in the mesencephalic raphe 5-ht nerve cells. |
2020-09-30 |
2023-08-13 |
rat |
| Flóra Gölöncsér, Mária Baranyi, Diána Balázsfi, Kornél Demeter, József Haller, Tamás F F Freund, Dóra Zelena, Beáta Sperlág. Regulation of Hippocampal 5-HT Release by P2X7 Receptors in Response to Optogenetic Stimulation of Median Raphe Terminals of Mice. Frontiers in molecular neuroscience. vol 10. 2020-09-30. PMID:29075178. |
regulation of hippocampal 5-ht release by p2x7 receptors in response to optogenetic stimulation of median raphe terminals of mice. |
2020-09-30 |
2023-08-13 |
mouse |
| Jung-Wan Cho, Sun-Young Jung, Sang-Won Lee, Sam-Jun Lee, Tae-Beom Seo, Young-Pyo Kim, Dae-Young Ki. Treadmill exercise ameliorates social isolation-induced depression through neuronal generation in rat pups. Journal of exercise rehabilitation. vol 13. issue 6. 2020-09-30. PMID:29326893. |
expression of 5-ht and tph in the dorsal raphe and expression of bdnf and trkb in the hippocampus were decreased by social isolation. |
2020-09-30 |
2023-08-13 |
rat |
| Yong Li, Qian Jiao, Xixun Du, Mingxia Bi, Shuaishuai Han, Lingling Jiao, Hong Jian. Investigation of Behavioral Dysfunctions Induced by Monoamine Depletions in a Mouse Model of Parkinson's Disease. Frontiers in cellular neuroscience. vol 12. 2020-09-30. PMID:30135645. |
although there was no obvious change in the number of 5-htergic neurons in the dorsal raphe nucleus after pcpa treatment, the levels of 5-ht and its metabolite in the frontal cortex and hippocampus were reduced, respectively. |
2020-09-30 |
2023-08-13 |
mouse |
| Yan-Ping Wu, Hua-Ying Gao, Shu-Hua Ouyang, Hiroshi Kurihara, Rong-Rong He, Yi-Fang L. Predator stress-induced depression is associated with inhibition of hippocampal neurogenesis in adult male mice. Neural regeneration research. vol 14. issue 2. 2020-09-30. PMID:30531013. |
the concentrations of hippocampal 5-hydroxytryptamine and 5-hydroxyindoleacetic acid were measured using high-performance liquid chromatography-electrochemical detection. |
2020-09-30 |
2023-08-13 |
mouse |
| Ali A El-Sol. Management of nightmares in patients with posttraumatic stress disorder: current perspectives. Nature and science of sleep. vol 10. 2020-09-30. PMID:30538593. |
although the characteristics of these distressing dreams may vary with the type of traumatic event, the pathophysiology exposes central dysfunction of brain structures at the level of the hippocampus, amygdala, and locus coeruleus, modulated by neurochemical imbalance in nor-adrenergic, dopaminergic, and serotonin pathways. |
2020-09-30 |
2023-08-13 |
human |
| Jonas Waider, Sandy Popp, Boris Mlinar, Alberto Montalbano, Francesco Bonfiglio, Benjamin Aboagye, Elisabeth Thuy, Raphael Kern, Christopher Thiel, Naozumi Araragi, Evgeniy Svirin, Angelika G Schmitt-Böhrer, Renato Corradetti, Christopher A Lowry, Klaus-Peter Lesc. Serotonin Deficiency Increases Context-Dependent Fear Learning Through Modulation of Hippocampal Activity. Frontiers in neuroscience. vol 13. 2020-09-30. PMID:31068767. |
serotonin deficiency increases context-dependent fear learning through modulation of hippocampal activity. |
2020-09-30 |
2023-08-13 |
Not clear |
| Efstathios Garoflos, Theofanis Panagiotaropoulos, Stavroula Pondiki, Antonios Stamatakis, Eleni Philippidis, Fotini Stylianopoulo. Cellular mechanisms underlying the effects of an early experience on cognitive abilities and affective states. Annals of general psychiatry. vol 4. 2020-09-29. PMID:15876359. |
in the present study we investigated the effects of neonatal handling, an animal model of early experience, on spatial learning and memory, on hippocampal glucocorticoid (gr), mineralocorticoid (mr) and type 1a serotonin (5-ht1a) receptors, as well as brain derived neurotrophic factor (bdnf), and on circulating leptin levels, of male rats. |
2020-09-29 |
2023-08-12 |
rat |
| Charles V Vorhees, Devon L Graham, Robyn M Amos-Kroohs, Amanda A Braun, Curtis E Grace, Tori L Schaefer, Matthew R Skelton, Keith M Erikson, Michael Aschner, Michael T William. Effects of developmental manganese, stress, and the combination of both on monoamines, growth, and corticosterone. Toxicology reports. vol 1. 2020-09-29. PMID:25574457. |
mn increased hippocampal dopamine at p11 and p29 and 5-ht at p29 regardless of housing or sex. |
2020-09-29 |
2023-08-13 |
rat |
| Liping Huang, Minzhen Deng, Yongqi Fang, Ling L. Dynamic changes of five neurotransmitters and their related enzymes in various rat tissues following β-asarone and levodopa co-administration. Experimental and therapeutic medicine. vol 10. issue 4. 2020-09-29. PMID:26622527. |
by contrast, no statistically significant differences were observed in the serotonin (5-ht) levels among the plasma, hippocampus, cortex and striatum. |
2020-09-29 |
2023-08-13 |
rat |
| Mario F Juruena, Bruno Agustini, Anthony J Cleare, Allan H Youn. A translational approach to clinical practice via stress-responsive glucocorticoid receptor signaling. Stem cell investigation. vol 4. 2020-09-29. PMID:28275643. |
there is evidence that the expression and function of gr in the hippocampus, mainly mr, is regulated by the stimulation of 5-ht receptors. |
2020-09-29 |
2023-08-13 |
human |