| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Deblina Dey, Vipan K Parihar, Gergely G Szabo, Peter M Klein, Jenny Tran, Jonathan Moayyad, Faizy Ahmed, Quynh-Anh Nguyen, Alexandria Murry, David Merriott, Brandon Nguyen, Jodi Goldman, Maria C Angulo, Daniele Piomelli, Ivan Soltesz, Janet E Baulch, Charles L Limol. Neurological Impairments in Mice Subjected to Irradiation and Chemotherapy. Radiation research. vol 193. issue 5. 2020-09-14. PMID:32134362. |
relevant to the known roles of the serotonin axis in mood disorders, we found that 5ht1a serotonin receptor levels were decreased by ∼50% in the hippocampus at both early and late time points, and a 37% decrease in serotonin levels was observed at 15 weeks postirradiation. |
2020-09-14 |
2023-08-13 |
mouse |
| Eduardo Silva de Assis Brasil, Cristiane Regina Guerino Furini, Fernanda da Silva Rodrigues, Eduarda Godfried Nachtigall, Jonny Anderson Kielbovicz Behling, Bruna Freitas Saenger, Clarissa Penha Farias, Jociane de Carvalho Myskiw, Ivan Izquierd. The blockade of the serotoninergic receptors 5-HT5A, 5-HT6 and 5-HT7 in the basolateral amygdala, but not in the hippocampus facilitate the extinction of fear memory. Behavioural brain research. vol 372. 2020-09-10. PMID:31233821. |
the serotonin (5-ht) system is positioned to modulate the extinction circuitry via ascending 5-ht projections that innervate certain brain structures including the hippocampus and the basolateral amygdala (bla). |
2020-09-10 |
2023-08-13 |
rat |
| Rong Yang, Meng-Qi Zhang, Ying Xue, Rui Yang, Mi-Mi Tan. Dietary of n-3 polyunsaturated fatty acids influence neurotransmitter systems of rats exposed to unpredictable chronic mild stress. Behavioural brain research. vol 376. 2020-09-03. PMID:31445977. |
repeated cums caused depressive-like behaviors of rats, associated with the alteration of neurotransmitters in brain, including the decreasing da level, the increasing ne and gaba level, and the increasing 5-ht turnover rate in hippocampus, which could be partly alleviated by sufficient n-3 pufas supplementation. |
2020-09-03 |
2023-08-13 |
rat |
| Eugenia Z Poh, Dorothee Hahne, Jessica Moretti, Alan R Harvey, Michael W Clarke, Jennifer Rodge. Simultaneous quantification of dopamine, serotonin, their metabolites and amino acids by LC-MS/MS in mouse brain following repetitive transcranial magnetic stimulation. Neurochemistry international. vol 131. 2020-09-03. PMID:31518601. |
fo8-rtms induced a significant reduction in cortical 5-ht turnover rates, hippocampal dopac and an increase in striatal dopac concentrations. |
2020-09-03 |
2023-08-13 |
mouse |
| Aya Abdalla, Alyssa West, Yunju Jin, Rachel A Saylor, Beidi Qiang, Edsel Peña, David J Linden, H Frederik Nijhout, Michael C Reed, Janet Best, Parastoo Hashem. Fast serotonin voltammetry as a versatile tool for mapping dynamic tissue architecture: I. Responses at carbon fibers describe local tissue physiology. Journal of neurochemistry. vol 153. issue 1. 2020-08-31. PMID:31419307. |
evoked and ambient serotonin in these brain areas, the ca2 region of the hippocampus and the medial prefrontal cortex, are compared to ambient and evoked serotonin in the substantia nigra pars reticulata, an area well established previously for serotonin measurements with fast voltammetry. |
2020-08-31 |
2023-08-13 |
mouse |
| Jake Rogers, Feng Chen, Davor Stanic, Farheen Farzana, Shanshan Li, Ariel M Zeleznikow-Johnston, Jess Nithianantharajah, Leonid Churilov, Paul A Adlard, Laurence Lanfumey, Anthony J Hannan, Thibault Renoi. Paradoxical effects of exercise on hippocampal plasticity and cognition in mice with a heterozygous null mutation in the serotonin transporter gene. British journal of pharmacology. vol 176. issue 17. 2020-08-28. PMID:31167040. |
paradoxical effects of exercise on hippocampal plasticity and cognition in mice with a heterozygous null mutation in the serotonin transporter gene. |
2020-08-28 |
2023-08-13 |
mouse |
| C Escudero, F Giuliani, M Mulle Bernedo, Roberto Yunes, R Cabrer. Allopregnanolone reversion of estrogen and progesterone memory impairment: interplay with serotonin release. Journal of neural transmission (Vienna, Austria : 1996). vol 126. issue 10. 2020-08-24. PMID:31377952. |
ovariectomized rats injected subcutaneously with estrogen and progesterone were subsequently injected in the dorsal hippocampus with vehicle, allopregnanolone alone or allopregnanolone shortly after 8oh-dpat, a predominantly 5ht |
2020-08-24 |
2023-08-13 |
rat |
| Qiaohui Lu, Akihiro Mouri, Yang Yang, Kazuo Kunisawa, Tomoaki Teshigawara, Mami Hirakawa, Yuko Mori, Yasuko Yamamoto, Zou Libo, Toshitaka Nabeshima, Kuniaki Sait. Chronic unpredictable mild stress-induced behavioral changes are coupled with dopaminergic hyperfunction and serotonergic hypofunction in mouse models of depression. Behavioural brain research. vol 372. 2020-08-19. PMID:31288060. |
the level of serotonin and protein levels of tryptophan hydroxylase (tph) and th were decreased by cums in the hippocampus (hpc) and prefrontal cortex (pfc). |
2020-08-19 |
2023-08-13 |
mouse |
| Hwa Chul Shin, Byung Gon Jo, Chan-Yong Lee, Kang-Woo Lee, Uk Namgun. Hippocampal activation of 5-HT The European journal of neuroscience. vol 50. issue 1. 2020-08-14. PMID:30735600. |
hippocampal activation of 5-ht a growing body of evidence shows that the electrical stimulation of the vagus nerve can improve mental illness including depression. |
2020-08-14 |
2023-08-13 |
rat |
| Chia-Li Wei, Sabrina Wang, Jui-Ting Yen, Yun-Fang Cheng, Chia-Li Liao, Chih-Chieh Hsu, Chien-Chen Wu, Ying-Chieh Tsa. Antidepressant-like activities of live and heat-killed Lactobacillus paracasei PS23 in chronic corticosterone-treated mice and possible mechanisms. Brain research. vol 1711. 2020-08-04. PMID:30684456. |
in addition, live ps23 also reverses corticosterone-reduced serotonin levels in hippocampus, prefrontal cortex and striatum; whereas heat-killed ps23 reverses corticosterone-reduced dopamine levels in hippocampus and prefrontal cortex. |
2020-08-04 |
2023-08-13 |
mouse |
| Ahmed Draoui, Omar El Hiba, El Khiat Abdelaati, Abdellatif Abbaoui, Radouane El Fari, Mohamed Aitihya, Halima Gamran. Differential impairment of short working and spatial memories in a rat model of progressive Parkinson's disease onset: A focus on the prodromal stage. Brain research bulletin. vol 150. 2020-07-24. PMID:31228545. |
our data show a differential deterioration of short-term working memory without the long-term spatial memory being changed which was accompanied by a significant decrease in serotonin innervation of the bla and a striking change in both density and morphology of the astrocyte at the level of the hippocampus. |
2020-07-24 |
2023-08-13 |
rat |
| Ahmed Draoui, Omar El Hiba, El Khiat Abdelaati, Abdellatif Abbaoui, Radouane El Fari, Mohamed Aitihya, Halima Gamran. Differential impairment of short working and spatial memories in a rat model of progressive Parkinson's disease onset: A focus on the prodromal stage. Brain research bulletin. vol 150. 2020-07-24. PMID:31228545. |
such deficit could arise from the loss of 5-ht innervation in bla and/or the astroglial morpho-functional changes within the hippocampus leading to possible neurophysiological disturbances of the different neighboring neuronal populations involved in short working memory. |
2020-07-24 |
2023-08-13 |
rat |
| Lokesh Agrawal, Sunil Kumar Vimal, Takashi Shig. Role of serotonin 4 receptor in the growth of hippocampal neurons during the embryonic development in mice. Neuropharmacology. vol 158. 2020-07-20. PMID:31325432. |
role of serotonin 4 receptor in the growth of hippocampal neurons during the embryonic development in mice. |
2020-07-20 |
2023-08-13 |
mouse |
| Per Plenge, Ara M Abramyan, Gunnar Sørensen, Arne Mørk, Pia Weikop, Ulrik Gether, Benny Bang-Andersen, Lei Shi, Claus J Lolan. The mechanism of a high-affinity allosteric inhibitor of the serotonin transporter. Nature communications. vol 11. issue 1. 2020-07-17. PMID:32198394. |
the sert inhibition by lu af60097 is demonstrated by the potentiated imipramine binding and increased hippocampal serotonin level in rats. |
2020-07-17 |
2023-08-13 |
rat |
| Abdeslam Mouihate, Samah Kalakh, Rawan AlMutairi, Abdelrahman Alashqa. Prenatal Inflammation Dampens Neurogenesis and Enhances Serotonin Transporter Expression in the Hippocampus of Adult Female Rats. Medical principles and practice : international journal of the Kuwait University, Health Science Centre. vol 28. issue 4. 2020-06-30. PMID:30884483. |
prenatal inflammation dampens neurogenesis and enhances serotonin transporter expression in the hippocampus of adult female rats. |
2020-06-30 |
2023-08-13 |
rat |
| Zhi-Long Zhang, Yu-Gang Gao, Pu Zang, Pei-Pei Gu, Yan Zhao, Zhong-Mei He, Hong-Yan Zh. [Research progress on mechanism of gastrodin and p-hydroxybenzyl alcohol on central nervous system]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 45. issue 2. 2020-06-23. PMID:32237313. |
they alleviate hippocampal neuronal toxicity mainly by regulating a variety of neurotransmitters, such as acetylcholine, glutamic acid(glu), γ-aminobutyric acid(gaba), serotonin(5-ht), dopamine(da), norepinephrine(ne), 5-indoleacetic acid(5-hiaa), high vanillic acid(hva) and dihydroxyphenylacetic acid(dopac), pro-inflammatory cell growth factors, such as il-1β, il-6 and tnf-α and relevant receptor functions, and exert neuropharmacological effects by effectively increasing mrna expressions of brain neurotrophic factors, such as bdnf and gdnf, and further inhibiting the apoptosis of damaged neurons. |
2020-06-23 |
2023-08-13 |
Not clear |
| Juliane Zemdegs, Hugo Martin, Hiranya Pintana, Sebastien Bullich, Stella Manta, Marie A Marqués, Cédric Moro, Sophie Layé, Fabien Ducrocq, Nipon Chattipakorn, Siriporn C Chattipakorn, Claire Rampon, Luc Pénicaud, Xavier Fioramonti, Bruno P Guiar. Metformin Promotes Anxiolytic and Antidepressant-Like Responses in Insulin-Resistant Mice by Decreasing Circulating Branched-Chain Amino Acids. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 39. issue 30. 2020-06-17. PMID:31160539. |
our results indicated that hfd-fed mice displayed impairment in the electrical activity of dorsal raphe 5-ht neurons, attenuated hippocampal extracellular 5-ht concentrations and anxiety, one of the most visible and early symptoms of depression. |
2020-06-17 |
2023-08-13 |
mouse |
| Pollyana C Leal, José Marcos M Bispo, Rovena C G J Engelberth, Kayo Diogenes de A Silva, Ywlliane R Meurer, Alessandra M Ribeiro, Regina H Silva, Murilo Marchioro, José R Santo. Serotonergic dysfunction in a model of parkinsonism induced by reserpine. Journal of chemical neuroanatomy. vol 96. 2020-06-15. PMID:30597197. |
after st, 5-ht immunoreactivity decreased in hippocampal subareas (ca1 and ca3) and medial prefrontal cortex (mpfc) compared to vehicle. |
2020-06-15 |
2023-08-13 |
rat |
| Jiacheng Lin, Zejia Song, Xiaolei Chen, Riji Zhao, Jiawen Chen, Huifeng Chen, Xiaodan Yang, Zhongping W. Trans-cinnamaldehyde shows anti-depression effect in the forced swimming test and possible involvement of the endocannabinoid system. Biochemical and biophysical research communications. vol 518. issue 2. 2020-06-15. PMID:31421826. |
moreover, tca elevated the level of 5-ht and decreased the ratio of glu/gaba in mice hippocampus. |
2020-06-15 |
2023-08-13 |
mouse |
| Abdelaati El Khiat, Lahcen Tamegart, Ahmed Draoui, Radouane El Fari, Souad Sellami, Hanane Rais, Omar El Hiba, Halima Gamran. Kinetic deterioration of short memory in rat with acute hepatic encephalopathy: Involvement of astroglial and neuronal dysfunctions. Behavioural brain research. vol 367. 2020-06-08. PMID:30928460. |
while for the behavioral study, we used t-maze test to assess short working memory using the percentage of alternation behavior, together with an immunohistochemical analysis of the glial fibrillary acidic protein (gfap) as the key marker of astrocytes in the hippocampus, as well as serotonin (5-ht) for 5-htergic neurons within the dorsal raphe nucleus (drn). |
2020-06-08 |
2023-08-13 |
rat |