| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bombi Lee, Mijung Yeom, Insop Shim, Hyejung Lee, Dae-Hyun Hah. Umbelliferone modulates depression-like symptoms by altering monoamines in a rat post-traumatic stress disorder model. Journal of natural medicines. vol 74. issue 2. 2020-06-05. PMID:31755013. |
umb treatment attenuated the sps-induced decrease in serotonin (5-ht) concentrations in the hippocampus and amygdala. |
2020-06-05 |
2023-08-13 |
rat |
| Bombi Lee, Mijung Yeom, Insop Shim, Hyejung Lee, Dae-Hyun Hah. Umbelliferone modulates depression-like symptoms by altering monoamines in a rat post-traumatic stress disorder model. Journal of natural medicines. vol 74. issue 2. 2020-06-05. PMID:31755013. |
the increased 5-ht concentration during umb treatment was partially due to a decrease in the ratio of 5-hydroxyindoleacetic acid/5-ht in the hippocampus of rats with ptsd. |
2020-06-05 |
2023-08-13 |
rat |
| Christine Gebhardt, Valentina Mosienko, Natalia Alenina, Doris Albrech. Priming of LTP in amygdala and hippocampus by prior paired pulse facilitation paradigm in mice lacking brain serotonin. Hippocampus. vol 29. issue 7. 2020-06-01. PMID:30457189. |
priming of ltp in amygdala and hippocampus by prior paired pulse facilitation paradigm in mice lacking brain serotonin. |
2020-06-01 |
2023-08-13 |
mouse |
| Huanhuan Li, Yutong Liu, Xiaoqing Gao, Lifen Liu, Siyiti Amuti, Dandan Wu, Fen Jiang, Liang Huang, Geying Wang, Jiujiang Zeng, Bin Ma, Qionglan Yua. Neuroplastin 65 modulates anxiety- and depression-like behavior likely through adult hippocampal neurogenesis and central 5-HT activity. The FEBS journal. vol 286. issue 17. 2020-05-26. PMID:31034748. |
neuroplastin 65 modulates anxiety- and depression-like behavior likely through adult hippocampal neurogenesis and central 5-ht activity. |
2020-05-26 |
2023-08-13 |
mouse |
| Huanhuan Li, Yutong Liu, Xiaoqing Gao, Lifen Liu, Siyiti Amuti, Dandan Wu, Fen Jiang, Liang Huang, Geying Wang, Jiujiang Zeng, Bin Ma, Qionglan Yua. Neuroplastin 65 modulates anxiety- and depression-like behavior likely through adult hippocampal neurogenesis and central 5-HT activity. The FEBS journal. vol 286. issue 17. 2020-05-26. PMID:31034748. |
in addition, the level of 5-hydroxytryptamine (5-ht) in the hippocampus was reduced. |
2020-05-26 |
2023-08-13 |
mouse |
| Debapriya Garabadu, Neha Srivastava, Yogesh Murt. Calotropis procera attenuates chronic unpredictable mild stress-induced depression in experimental animals. Metabolic brain disease. vol 34. issue 6. 2020-05-14. PMID:31346860. |
further, ecp (200 mg/kg) mitigated cums-induced decrease in serotonin (5-ht), increase in 5-hydroxy indole acetic acid (5-hiaa) and increase in the ratio of 5-hiaa/5-ht in hippocampus and pre-frontal cortex. |
2020-05-14 |
2023-08-13 |
rat |
| Vishnu N Thakare, Rajesh R Patil, Anupama A Suralkar, Valmik D Dhakane, Bhoomika M Pate. Protocatechuic acid attenuate depressive-like behavior in olfactory bulbectomized rat model: behavioral and neurobiochemical investigations. Metabolic brain disease. vol 34. issue 3. 2020-05-11. PMID:30848471. |
behavioral (ambulatory and rearing activity and immobility time), neurochemical [serotonin (5-ht), dopamine (da), norepinephrine (ne) and brain derived neurotrophic factor (bdnf) expression], biochemical (mda formation, il-6, tnf-α and antioxidants) changes in hippocampus and cerebral cortex along with serum corticosterone were investigated. |
2020-05-11 |
2023-08-13 |
rat |
| Vishnu N Thakare, Rajesh R Patil, Anupama A Suralkar, Valmik D Dhakane, Bhoomika M Pate. Protocatechuic acid attenuate depressive-like behavior in olfactory bulbectomized rat model: behavioral and neurobiochemical investigations. Metabolic brain disease. vol 34. issue 3. 2020-05-11. PMID:30848471. |
experimental findings reveals that obx subjected rats showed alteration in behaviors like, increase in immobility time, ambulatory and rearing behaviors significantly, reduced bdnf level, 5-ht, da,ne and antioxidant parameters along with increased serum corticosterone, mda formation, il-6, and tnf-α in hippocampus and cerebral cortex compared to sham operated rats. |
2020-05-11 |
2023-08-13 |
rat |
| Vishnu N Thakare, Rajesh R Patil, Anupama A Suralkar, Valmik D Dhakane, Bhoomika M Pate. Protocatechuic acid attenuate depressive-like behavior in olfactory bulbectomized rat model: behavioral and neurobiochemical investigations. Metabolic brain disease. vol 34. issue 3. 2020-05-11. PMID:30848471. |
administration of pca significantly attenuated behavioral and neurobiochemical alterations, thus, its antidepressant-like activity is largely mediated through modulation of neurotransmitter, endocrine and immunologic systems, mainly by improvements of bdnf, 5-ht, da, ne, reduced mda, il-6, and tnf-α in hippocampus and cerebral cortex. |
2020-05-11 |
2023-08-13 |
rat |
| Naif E Al Omairi, Ashraf Y Al-Brakati, Rami B Kassab, Maha S Lokman, Ehab Kotb Elmahallawy, Hatem K Amin, Ahmed E Abdel Monei. Soursop fruit extract mitigates scopolamine-induced amnesia and oxidative stress via activating cholinergic and Nrf2/HO-1 pathways. Metabolic brain disease. vol 34. issue 3. 2020-05-11. PMID:30919246. |
sco-treatment increased acetylcholine esterase activity and decreased hippocampal levels of acetylcholine, serotonin, dopamine, norepinephrine, and histamine. |
2020-05-11 |
2023-08-13 |
rat |
| Rubén García-Cabrerizo, M Julia García-Fuste. Methamphetamine binge administration dose-dependently enhanced negative affect and voluntary drug consumption in rats following prolonged withdrawal: role of hippocampal FADD. Addiction biology. vol 24. issue 2. 2020-05-08. PMID:29282816. |
in particular, rats treated repeatedly with methamphetamine (7.5 mg/kg) showed (1) enhanced negative affect-increased anhedonia associated with behavioral despair, (2) increased voluntary methamphetamine consumption, (3) enhanced neurotoxicity-decreased dopamine and metabolites in striatum and decreased serotonin in hippocampus, (4) altered neuroplasticity markers-decreased fadd protein and increased p-fadd/fadd balance selectively in hippocampus and (5) higher consumption rates of methamphetamine that were associated with lower fadd content in hippocampus. |
2020-05-08 |
2023-08-13 |
rat |
| Emilie Puginier, Rahul Bharatiya, Abdeslam Chagraoui, Julien Manem, Yoon H Cho, Maurice Garret, Philippe De Deurwaerdèr. Early neurochemical modifications of monoaminergic systems in the R6/1 mouse model of Huntington's disease. Neurochemistry international. vol 128. 2020-04-24. PMID:31054882. |
the metabolite of 5-ht was also lower in r6/1 mice, mainly in the substantia nigra and hippocampus. |
2020-04-24 |
2023-08-13 |
mouse |
| Kinga Krzysztoforska, Agnieszka Piechal, Kamilla Blecharz-Klin, Justyna Pyrzanowska, Ilona Joniec-Maciejak, Dagmara Mirowska-Guzel, Ewa Widy-Tyszkiewic. Administration of protocatechuic acid affects memory and restores hippocampal and cortical serotonin turnover in rat model of oral D-galactose-induced memory impairment. Behavioural brain research. vol 368. 2020-04-23. PMID:30978406. |
administration of protocatechuic acid affects memory and restores hippocampal and cortical serotonin turnover in rat model of oral d-galactose-induced memory impairment. |
2020-04-23 |
2023-08-13 |
rat |
| Kinga Krzysztoforska, Agnieszka Piechal, Kamilla Blecharz-Klin, Justyna Pyrzanowska, Ilona Joniec-Maciejak, Dagmara Mirowska-Guzel, Ewa Widy-Tyszkiewic. Administration of protocatechuic acid affects memory and restores hippocampal and cortical serotonin turnover in rat model of oral D-galactose-induced memory impairment. Behavioural brain research. vol 368. 2020-04-23. PMID:30978406. |
d-gal significantly impaired cognitive performance during the acquisition and recall of mwm compared to control rats and changed concentrations of cortical serotonin as well as its cortical and hippocampal turnover. |
2020-04-23 |
2023-08-13 |
rat |
| Toshiaki Ishii, Ken-Ichi Kinoshita, Yoshikage Muro. Serotonin 5-HT International journal of molecular sciences. vol 20. issue 21. 2020-04-13. PMID:31717815. |
serotonin 5-ht previously, we found that 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp)-induced parkinson's disease (pd) model mice (pd mice) showed facilitation of hippocampal memory extinction via reduced cyclic adenosine monophosphate (camp)/camp-dependent response element-binding protein (creb) signaling, which may cause cognitive impairment in pd. |
2020-04-13 |
2023-08-13 |
mouse |
| Floriana Volpicelli, L Speranza, S Pulcrano, R De Gregorio, M Crispino, C De Sanctis, M Leopoldo, E Lacivita, U di Porzio, G C Bellenchi, C Perrone-Capan. The microRNA-29a Modulates Serotonin 5-HT7 Receptor Expression and Its Effects on Hippocampal Neuronal Morphology. Molecular neurobiology. vol 56. issue 12. 2020-04-02. PMID:31292861. |
the microrna-29a modulates serotonin 5-ht7 receptor expression and its effects on hippocampal neuronal morphology. |
2020-04-02 |
2023-08-13 |
mouse |
| Floriana Volpicelli, L Speranza, S Pulcrano, R De Gregorio, M Crispino, C De Sanctis, M Leopoldo, E Lacivita, U di Porzio, G C Bellenchi, C Perrone-Capan. The microRNA-29a Modulates Serotonin 5-HT7 Receptor Expression and Its Effects on Hippocampal Neuronal Morphology. Molecular neurobiology. vol 56. issue 12. 2020-04-02. PMID:31292861. |
indeed, it downregulates 5-ht7r gene expression in cultured hippocampal neurons, while the expression of other serotonin receptors is not affected. |
2020-04-02 |
2023-08-13 |
mouse |
| Yun-Ju Huang, Kuan-Hung Lu, Yu-En Lin, Suraphan Panyod, Hsin-Yu Wu, Wan-Ting Chang, Lee-Yan Shee. Garlic essential oil mediates acute and chronic mild stress-induced depression in rats via modulation of monoaminergic neurotransmission and brain-derived neurotrophic factor levels. Food & function. vol 10. issue 12. 2020-04-01. PMID:31735946. |
geo (25 mg per kg bw) effectively decreased the frontal cortex turnover ratio of serotonin (5-ht) and dopamine (da), thus increasing the 5-ht and da levels, with no hippocampal effects. |
2020-04-01 |
2023-08-13 |
rat |
| Peng Chen, Maofang Hei, Lili Kong, Yinyin Liu, Yu Yang, Haibo Mu, Xiuyun Zhang, Shanting Zhao, Jinyou Dua. One water-soluble polysaccharide from Ginkgo biloba leaves with antidepressant activities via modulation of the gut microbiome. Food & function. vol 10. issue 12. 2020-04-01. PMID:31742291. |
consistent with the improvement of depression-like behavior above, gps mice had elevated serotonin and dopamine levels in multiple brain regions including the hippocampus, cerebral cortex and olfactory bulb, relative to unpredictable chronic mild stress (ucms) treatment mice. |
2020-04-01 |
2023-08-13 |
mouse |
| Dariusz Zurawek, Piotr Gruca, Lucyna Antkiewicz-Michaluk, Marta Dziedzicka-Wasylewsk. Resilient Phenotype in Chronic Mild Stress Paradigm Is Associated with Altered Expression Levels of miR-18a-5p and Serotonin 5-HT Molecular neurobiology. vol 56. issue 11. 2020-03-12. PMID:31098953. |
resilient phenotype in chronic mild stress paradigm is associated with altered expression levels of mir-18a-5p and serotonin 5-ht disturbed serotonergic signaling in the hippocampus observed in many individuals vulnerable to stress has been suggested as one of the primary factors contributing to the development of depression. |
2020-03-12 |
2023-08-13 |
human |