| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ning Jiang, Hong Huang, Haixia Wang, Jingwei Lv, Guirong Zeng, Qiong Wang, Yu Bao, Ying Chen, Xin-Min Li. The antidepressant-like effects of Shen Yuan: Dependence on hippocampal BDNF-TrkB signaling activation in chronic social defeat depression-like mice. Phytotherapy research : PTR. 2021-01-21. PMID:33474783. |
sy decreased the serum levels of cort and increased hippocampal neurotransmitters (5-ht, da, and ne) in csds mice. |
2021-01-21 |
2023-08-13 |
mouse |
| Mennat-Allah M Hassan, Amany M Gad, Esther T Menze, Osama A Badary, Reem N El-Nag. Protective effects of morin against depressive-like behavior prompted by chronic unpredictable mild stress in rats: Possible role of inflammasome-related pathways. Biochemical pharmacology. vol 180. 2021-01-11. PMID:32652141. |
the morin-treated groups showed a great improvement in the biochemical parameters in both the cortex and hippocampus, where it significantly elevated the serotonin, epinephrine, and norepinephrine levels. |
2021-01-11 |
2023-08-13 |
rat |
| Katsunori Kobayashi, Yasunori Mikahara, Yuka Murata, Daiki Morita, Sumire Matsuura, Eri Segi-Nishida, Hidenori Suzuk. Predominant Role of Serotonin at the Hippocampal Mossy Fiber Synapse with Redundant Monoaminergic Modulation. iScience. vol 23. issue 4. 2021-01-10. PMID:32283526. |
predominant role of serotonin at the hippocampal mossy fiber synapse with redundant monoaminergic modulation. |
2021-01-10 |
2023-08-13 |
mouse |
| Katsunori Kobayashi, Yasunori Mikahara, Yuka Murata, Daiki Morita, Sumire Matsuura, Eri Segi-Nishida, Hidenori Suzuk. Predominant Role of Serotonin at the Hippocampal Mossy Fiber Synapse with Redundant Monoaminergic Modulation. iScience. vol 23. issue 4. 2021-01-10. PMID:32283526. |
we here show that endogenous monoamines can potentiate mf synaptic transmission in mouse hippocampal slices by activating the serotonin 5-ht |
2021-01-10 |
2023-08-13 |
mouse |
| Mei Huang, Wenqi He, Lakshmi Rajagopal, Andrea Kudwa, Dimitri E Grigoriadis, Herbert Y Meltze. Effects of NBI-98782, a selective vesicular monoamine transporter 2 (VMAT2) inhibitor, on neurotransmitter efflux and phencyclidine-induced locomotor activity: Relevance to tardive dyskinesia and antipsychotic action. Pharmacology, biochemistry, and behavior. vol 190. 2021-01-07. PMID:32084491. |
acute nbi-98782 and tetrabenazine decreased mpfc, dstr, hippocampus, and nac da, 5-ht, and ne efflux, while increasing that of dopac, hva, and 5-hiaa. |
2021-01-07 |
2023-08-13 |
mouse |
| Yi-Fan Jiang, Jian Liu, Jie Yang, Yuan Guo, Wei Hu, Jin Zhang, Xue-Mei La, Wen Xie, Hui-Sheng Wang, Li Zhan. Involvement of the Dorsal Hippocampus 5-HT1A Receptors in the Regulation of Depressive-Like Behaviors in Hemiparkinsonian Rats. Neuropsychobiology. vol 79. issue 3. 2021-01-04. PMID:31940619. |
lines of evidence have indicated that the hippocampus and serotonin 1a (5-ht1a) receptors are related to the regulation of depression. |
2021-01-04 |
2023-08-13 |
rat |
| Mariana de Souza Aranha Garcia-Gomes, Dennis Albert Zanatto, Orfa Yineth Galvis-Alonso, Jorge Mejia, Ana Tada Fonseca Brasil Antiorio, Pedro Kenzo Yamamoto, Márcia Carolina Millán Olivato, Thaísa Meira Sandini, Jorge Camilo Flório, Ivo Lebrun, Silvia Maria Gomes Massironi, Sandra Regina Alexandre-Ribeiro, Maria Martha Bernardi, Susan Ienne, Tiago Antonio de Souza, Maria Lúcia Zaidan Dagli, Claudia Madalena Cabrera Mor. Behavioral and neurochemical characterization of the spontaneous mutation tremor, a new mouse model of audiogenic seizures. Epilepsy & behavior : E&B. vol 105. 2020-12-29. PMID:32109856. |
comparing with wild type (wt) mice, the tremor mice showed higher hippocampal gene expression of egr3 and gabra1 and increased concentrations of noradrenalin (nor; p = .0012), serotonin (5ht; p = .0083), 5-hydroxyindoleacetic acid (5-hiaa; p = .0032), γ-amino butyric acid (gaba; p = .0123), glutamate (p = .0217) and aspartate (p = .0124). |
2020-12-29 |
2023-08-13 |
mouse |
| Suhyeon Kim, Ki-Bae Hong, Singeun Kim, Hyung Joo Suh, Kyungae J. Creatine and taurine mixtures alleviate depressive-like behaviour in Drosophila melanogaster and mice via regulating Akt and ERK/BDNF pathways. Scientific reports. vol 10. issue 1. 2020-12-21. PMID:32647316. |
in behavioural assessments, movement and sucrose preference of the cre/tau group increased to a similar level as in the positive control group; hippocampal catecholamine and serotonin levels increased significantly. |
2020-12-21 |
2023-08-13 |
mouse |
| Brittany E Dong, Hao Chen, Kazuko Sakat. BDNF deficiency and enriched environment treatment affect neurotransmitter gene expression differently across ages. Journal of neurochemistry. vol 154. issue 1. 2020-12-04. PMID:32222968. |
high-throughput quantitative reverse transcription polymerase chain reaction measured expression of 81 genes for dopamine, adrenaline, serotonin, gamma aminobutyric acid, glutamate, acetylcholine, and bdnf systems in the frontal cortex (fc) and hippocampus. |
2020-12-04 |
2023-08-13 |
mouse |
| Zhilan Peng, Cai Zhang, Ling Yan, Yongping Zhang, Zhiyou Yang, Jiajia Wang, Cai Son. EPA is More Effective than DHA to Improve Depression-Like Behavior, Glia Cell Dysfunction and Hippcampal Apoptosis Signaling in a Chronic Stress-Induced Rat Model of Depression. International journal of molecular sciences. vol 21. issue 5. 2020-12-01. PMID:32150824. |
lower hippocampal noradrenaline and 5-hydroxytryptamine concentrations in cums rats were also reversed by both epa and dha supplement. |
2020-12-01 |
2023-08-13 |
rat |
| Christopher B German. The Psilocybin-Telomere Hypothesis: An empirically falsifiable prediction concerning the beneficial neuropsychopharmacological effects of psilocybin on genetic aging. Medical hypotheses. vol 134. 2020-11-23. PMID:31634774. |
in order to substantiate the 'psilocybin-telomere hypothesis' potential neuropsychopharmacological, endocrinological, and genetic mechanisms of action are discussed (e.g., hpa-axis reactivity, hippocampal neurogenesis, neurotropic growth factors such as bdnf, 5-ht |
2020-11-23 |
2023-08-13 |
human |
| Mercedes Rose, Alain Filiatreault, Josée Guénette, Andrew Williams, Errol M Thomso. Ozone increases plasma kynurenine-tryptophan ratio and impacts hippocampal serotonin receptor and neurotrophic factor expression: Role of stress hormones. Environmental research. vol 185. 2020-11-20. PMID:32278163. |
hippocampal expression of serotonin receptors exhibited differential regulation following exposure, and expression of key neurotrophic factors (brain-derived neurotrophic factor, vascular endothelial growth factor a, insulin-like growth factor-1, tyrosine kinase receptor b, b-cell lymphoma 2) was decreased. |
2020-11-20 |
2023-08-13 |
rat |
| Ernest Dallé, William M U Daniels, Musa V Mabandl. Long-Term Treatment with Fluvoxamine Decreases Nonmotor Symptoms and Dopamine Depletion in a Postnatal Stress Rat Model of Parkinson's Disease. Oxidative medicine and cellular longevity. vol 2020. 2020-11-17. PMID:32273939. |
a 6-ohda lesion effect was evidenced by impairment in the limb-use asymmetry test as well as decreased dopamine (da) and serotonin levels in the striatum, prefrontal cortex, and hippocampus. |
2020-11-17 |
2023-08-13 |
rat |
| O Gokdemir, C Cetinkaya, H Gumus, I Aksu, M Kiray, M Ates, A Kiray, B Baykara, B Baykara, A R Sisman, N Uysa. The effect of exercise on anxiety- and depression-like behavior of aged rats. Biotechnic & histochemistry : official publication of the Biological Stain Commission. vol 95. issue 1. 2020-11-13. PMID:31264480. |
we assessed serum corticosterone levels; number of amygdala, hippocampus and prefrontal cortex cells; tissue serotonin and serotonin 1a (5-ht1a) levels. |
2020-11-13 |
2023-08-13 |
rat |
| O Gokdemir, C Cetinkaya, H Gumus, I Aksu, M Kiray, M Ates, A Kiray, B Baykara, B Baykara, A R Sisman, N Uysa. The effect of exercise on anxiety- and depression-like behavior of aged rats. Biotechnic & histochemistry : official publication of the Biological Stain Commission. vol 95. issue 1. 2020-11-13. PMID:31264480. |
the tissue serotonin levels in amygdala and hippocampus were higher in ssris + exercise group compared to the aged, exercised and ssris groups. |
2020-11-13 |
2023-08-13 |
rat |
| L Cai, W T Li, L L Zhang, X Q Lu, M Chen, Y Li. Long noncoding RNA GAS5 enhanced by curcumin relieves poststroke depression by targeting miR-10b/BDNF in rats. Journal of biological regulators and homeostatic agents. vol 34. issue 3. 2020-11-03. PMID:32627518. |
in the present study, the therapeutic effect of curcumin on rats with psd was detected by open field tests and tail suspension tests, as well as the examination of corticosterone and corticotropin-releasing hormone (crh) levels in the serum and neurotransmitter 5-hydroxytryptamine (5-ht), 5-hydroxyindoleacetic acid (5-hiaa) and dopamine (da) levels in the hippocampus. |
2020-11-03 |
2023-08-13 |
rat |
| Hanqing Wang, Yue Tong, Dong Xiao, Baomei Xi. Involvement of mTOR-related signaling in antidepressant effects of Sophoraflavanone G on chronically stressed mice. Phytotherapy research : PTR. vol 34. issue 9. 2020-10-23. PMID:32246575. |
the levels of il-6, il-1β, and tnf-α in the hippocampus were significantly reduced, and the quantity of 5-ht and ne was raised considerably in sg-treated group compared with the cums-exposed group. |
2020-10-23 |
2023-08-13 |
mouse |
| Xialin Sun, Tingwen Zhang, Yan Zhao, Enbo Cai, Hongyan Zhu, Shuangli Li. Panaxynol attenuates CUMS-induced anxiety and depressive-like behaviors via regulating neurotransmitters, synapses and the HPA axis in mice. Food & function. vol 11. issue 2. 2020-10-19. PMID:32048672. |
meanwhile, pal promotes the release of 5-ht and da in the hippocampus and improves synaptic plasticity in the hippocampus, allowing neurotransmitters to function more effectively. |
2020-10-19 |
2023-08-13 |
mouse |
| Jinpeng Wang, Baihong Zheng, Dan Zhou, Jie Xing, Honghua Li, Jiayu Li, Zehui Zhang, Beilin Zhang, Ping L. Supplementation of Diet With Different n-3/n-6 PUFA Ratios Ameliorates Autistic Behavior, Reduces Serotonin, and Improves Intestinal Barrier Impairments in a Valproic Acid Rat Model of Autism. Frontiers in psychiatry. vol 11. 2020-10-10. PMID:33033482. |
our results showed that rats with prenatal administration of vpa took less response time to sniff three odorants in the olfactory habituation/dishabituation tests, had lower frequency of pinning and following patterns, and had decreased hippocampal 5-hydroxytryptamine (5-ht), increased serum 5-ht and downregulated expression of tight junction protein (occludin and claudin-1) in the colon. |
2020-10-10 |
2023-08-13 |
rat |
| Jinpeng Wang, Baihong Zheng, Dan Zhou, Jie Xing, Honghua Li, Jiayu Li, Zehui Zhang, Beilin Zhang, Ping L. Supplementation of Diet With Different n-3/n-6 PUFA Ratios Ameliorates Autistic Behavior, Reduces Serotonin, and Improves Intestinal Barrier Impairments in a Valproic Acid Rat Model of Autism. Frontiers in psychiatry. vol 11. 2020-10-10. PMID:33033482. |
however, supplementation of n-3/n-6 pufas (1:5) in the vpa treated rats ameliorated the autistic behaviors, increased hippocampal 5-ht and tight junction expression in the colon, and decreased serum 5-ht. |
2020-10-10 |
2023-08-13 |
rat |