| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chengping Luo, Huimin Fan, Shaojun Li, Yuling Zo. Therapeutic of Candesartan and Music Therapy in Diabetic Retinopathy with Depression in Rats. Evidence-based complementary and alternative medicine : eCAM. vol 2021. 2021-04-10. PMID:33833815. |
angiotensin ii (ang ii) in peripheral blood and neurotransmitters, including serotonin (5-ht), dopamine (da), and norepinephrine (ne) in the hippocampus, was measured by enzyme linked immunosorbent assay (elisa). |
2021-04-10 |
2023-08-13 |
rat |
| Chengping Luo, Huimin Fan, Shaojun Li, Yuling Zo. Therapeutic of Candesartan and Music Therapy in Diabetic Retinopathy with Depression in Rats. Evidence-based complementary and alternative medicine : eCAM. vol 2021. 2021-04-10. PMID:33833815. |
compared with the control group, the apoptosis of retinal cells was significantly higher, the contents of 5-ht, da, and ne in the hippocampus were significantly lower, ang ii level in peripheral blood was significantly higher, and the expression of bdnf and c-fos in the hippocampus decreased significantly in the model group. |
2021-04-10 |
2023-08-13 |
rat |
| Carina Meinke, Meagan A Quinlan, Krista C Paffenroth, Fiona E Harrison, Cristina Fenollar-Ferrer, Rania M Katamish, Isabel Stillman, Sammanda Ramamoorthy, Randy D Blakel. Serotonin Transporter Ala276 Mouse: Novel Model to Assess the Neurochemical and Behavioral Impact of Thr276 Phosphorylation In Vivo. Neurochemical research. 2021-04-08. PMID:33830406. |
similarly, no genotype differences were evident in midbrain or hippocampal 5-ht levels, midbrain and hippocampal sert mrna or midbrain protein levels, nor in midbrain synaptosomal 5-ht uptake kinetics. |
2021-04-08 |
2023-08-13 |
mouse |
| Jodi L Pawluski, Rafaella Paravatou, Alan Even, Gael Cobraiville, Marianne Fillet, Nikolaos Kokras, Christina Dalla, Thierry D Charlie. Effect of sertraline on central serotonin and hippocampal plasticity in pregnant and non-pregnant rats. Neuropharmacology. vol 166. 2021-04-02. PMID:31935392. |
effect of sertraline on central serotonin and hippocampal plasticity in pregnant and non-pregnant rats. |
2021-04-02 |
2023-08-13 |
rat |
| Jodi L Pawluski, Rafaella Paravatou, Alan Even, Gael Cobraiville, Marianne Fillet, Nikolaos Kokras, Christina Dalla, Thierry D Charlie. Effect of sertraline on central serotonin and hippocampal plasticity in pregnant and non-pregnant rats. Neuropharmacology. vol 166. 2021-04-02. PMID:31935392. |
results show that pregnant females have significantly higher serum levels of sertraline compared to non-pregnant females but that rates of serotonin turnover in the hippocampus and pfc are similar between pregnant and non-pregnant females. |
2021-04-02 |
2023-08-13 |
rat |
| Nikolay N Dygalo, Tatyana S Kalinina, Galina T Shishkin. Stress-induced expression pattern of glutamate signaling genes associated with anhedonia. Stress (Amsterdam, Netherlands). vol 23. issue 6. 2021-03-24. PMID:32814471. |
main features of the expression patterns include the decrease in mrna levels for ampa and nmda subunits in the midbrain and hippocampus that is consistent with the hypothesis that "monoamine (serotonin)-glutamate/gaba long neural circuit" involved in mood regulation. |
2021-03-24 |
2023-08-13 |
human |
| Eleni Siopi, Grégoire Chevalier, Lida Katsimpardi, Soham Saha, Mathilde Bigot, Carine Moigneu, Gérard Eberl, Pierre-Marie Lled. Changes in Gut Microbiota by Chronic Stress Impair the Efficacy of Fluoxetine. Cell reports. vol 30. issue 11. 2021-03-23. PMID:32187541. |
the fecal transfer induces despair-like behavior, decreases neurogenesis in the hippocampus (hpc), and impairs the antidepressant and neurogenic effects of a standard selective serotonin (5-ht) reuptake inhibitor, fluoxetine (flx). |
2021-03-23 |
2023-08-13 |
mouse |
| Feng Zhu, Ruijin Guo, Wei Wang, Yanmei Ju, Qi Wang, Qingyan Ma, Qiang Sun, Yajuan Fan, Yuying Xie, Zai Yang, Zhuye Jie, Binbin Zhao, Liang Xiao, Lin Yang, Tao Zhang, Bing Liu, Liyang Guo, Xiaoyan He, Yunchun Chen, Ce Chen, Chengge Gao, Xun Xu, Huanming Yang, Jian Wang, Yonghui Dang, Lise Madsen, Susanne Brix, Karsten Kristiansen, Huijue Jia, Xiancang M. Transplantation of microbiota from drug-free patients with schizophrenia causes schizophrenia-like abnormal behaviors and dysregulated kynurenine metabolism in mice. Molecular psychiatry. vol 25. issue 11. 2021-03-15. PMID:31391545. |
these mice also showed elevation of the kynurenine-kynurenic acid pathway of tryptophan degradation in both periphery and brain, as well as increased basal extracellular dopamine in prefrontal cortex and 5-hydroxytryptamine in hippocampus, compared with their counterparts receiving feces from healthy controls. |
2021-03-15 |
2023-08-13 |
mouse |
| Yotam Sagi, Lucian Medrihan, Katia George, Miles Barney, Kathryn A McCabe, Paul Greengar. Emergence of 5-HT5A signaling in parvalbumin neurons mediates delayed antidepressant action. Molecular psychiatry. vol 25. issue 6. 2021-03-09. PMID:30804492. |
here we show, in mice, that hippocampal parvalbumin interneurons express functionally silent serotonin 5a receptors, which translocate to the cell membrane and become active upon chronic, but not acute, treatment with a selective serotonin reuptake inhibitor (ssri). |
2021-03-09 |
2023-08-13 |
mouse |
| Zainab Eydipour, Mohammad Nasehi, Salar Vaseghi, Seyed Hamid Jamaldini, Mohammad-Reza Zarrindas. The role of 5-HT4 serotonin receptors in the CA1 hippocampal region on memory acquisition impairment induced by total (TSD) and REM sleep deprivation (RSD). Physiology & behavior. vol 215. 2021-03-04. PMID:31863855. |
the role of 5-ht4 serotonin receptors in the ca1 hippocampal region on memory acquisition impairment induced by total (tsd) and rem sleep deprivation (rsd). |
2021-03-04 |
2023-08-13 |
Not clear |
| Melodi A Bowman, Melissa Vitela, Kyra M Clarke, Wouter Koek, Lynette C Daw. Serotonin Transporter and Plasma Membrane Monoamine Transporter Are Necessary for the Antidepressant-Like Effects of Ketamine in Mice. International journal of molecular sciences. vol 21. issue 20. 2021-02-25. PMID:33066466. |
using high-speed chronoamperometry to measure real-time clearance of serotonin from ca3 region of hippocampus in vivo, we found ketamine robustly inhibited serotonin clearance in wild-type mice, an effect that was lost in mice constitutively lacking sert or pmat. |
2021-02-25 |
2023-08-13 |
mouse |
| Wen Shan Yang, Zhen-Guo Shi, Xian-Zhe Dong, Ping Liu, Meng-Li Chen, Yuan H. Involvement of 5-HT-BDNF signaling axis in mediating synergistic antidepressant-like effects after combined administration of two oligosaccharide esters. Food science & nutrition. vol 9. issue 2. 2021-02-19. PMID:33598202. |
moreover, combined treatment of diss and tfsa also demonstrated enhanced levels of 5-hydroxytryptamine (5-ht), and stronger increase in the phosphorylation levels of creb, bdnf, and crtc1 proteins in the hippocampus. |
2021-02-19 |
2023-08-13 |
Not clear |
| Christina Veit, Andrew M Janczak, Birgit Ranheim, Judit Vas, Anna Valros, Dale A Sandercock, Petteri Piepponen, Daniela Dulgheriu, Janicke Nordgree. The Effect of LPS and Ketoprofen on Cytokines, Brain Monoamines, and Social Behavior in Group-Housed Pigs. Frontiers in veterinary science. vol 7. 2021-02-16. PMID:33585605. |
serotonin concentrations in the hypothalamus and noradrenaline concentrations in the hippocampus of sl pigs were significantly lower compared to those in kl pigs. |
2021-02-16 |
2023-08-13 |
Not clear |
| N A Krupina, N N Khlebnikova, V B Narkevich, P L Naplekova, V S Kudri. The Levels of Monoamines and Their Metabolites in the Brain Structures of Rats Subjected to Two- and Three-Month-Long Social Isolation. Bulletin of experimental biology and medicine. vol 168. issue 5. 2021-02-03. PMID:32249401. |
two-monthlong social isolation was accompanied by a reduction in serotonin content and its increased turnover judging from the 5-hiaa/5-ht ratio in the hippocampus; three-month-long isolation was associated with increased levels of serotonin and reduction in its turnover in the amygdala. |
2021-02-03 |
2023-08-13 |
rat |
| Xiaoxia Huang, Wu Li, Bangyan You, Wanpei Tang, Tingsheng Gan, Chao Feng, Congfa Li, Ruili Yan. Serum Metabonomic Study on the Antidepressant-like Effects of Ellagic Acid in a Chronic Unpredictable Mild Stress-Induced Mouse Model. Journal of agricultural and food chemistry. vol 68. issue 35. 2021-02-03. PMID:32786855. |
furthermore, ea attenuated the cums-induced hippocampal damage and significantly increased the brain-derived neurotrophic factor (bdnf) and the serotonin (5-ht) levels as well as suppressed the inflammatory response. |
2021-02-03 |
2023-08-13 |
mouse |
| Tao Yang, Xubo Wang, Lei Liu, Hanwen Chen, Na Wan. Ginkgolide-Platinum(II) Complex GPt(II) Exhibits Therapeutic Effect on Depression in Mice via Upregulation of DA and 5-HT Neurotransmitters. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2021-02-02. PMID:32484164. |
treatment of mice with gpt(ii) significantly elevated dopamine, bdnf, and serotonin levels in hippocampus tissues. |
2021-02-02 |
2023-08-13 |
mouse |
| Javed Iqbal, Frank Adu-Nti, Xuejiao Wang, Hui Qiao, Xin-Ming M. Sex difference in depression: Which animal models mimic it. Behavioral neuroscience. vol 134. issue 3. 2021-02-01. PMID:32223277. |
furthermore, to explore the underlying mechanisms, we used quantitative reverse transcriptase polymerase chain reaction to examine and compare the messenger rna (mrna) levels of various transcripts previously shown to be involved in psychiatric disorders in rna-sequencing/microarray studies including serotonin receptor-7, early growth response-2, histone deacetylase-2, roundabout guidance receptor-2 (robo2), serum/glucocorticoid regulated kinase-2, orthodenticle homeobox-2, parathyroid hormone-2 receptor, and neuronal pas domain protein-4 in the hippocampus after exposure of rats to scvs and cums. |
2021-02-01 |
2023-08-13 |
human |
| Lixing Chen, Zengyu Yao, Shanshan Qu, Jialing Zhang, Jiping Zhang, Zhinan Zhang, Yong Huang, Zheng Zhon. Electroacupuncture improves synaptic plasticity by regulating the 5-HT1A receptor in hippocampus of rats with chronic unpredictable mild stress. The Journal of international medical research. vol 48. issue 5. 2021-02-01. PMID:32363965. |
to investigate the antidepressant effects of electroacupuncture (ea) on chronic unpredictable mild stress (cums) in rats, as well as the effects of ea on hippocampal neurons, synaptic morphology, and 5-hydroxytryptamine (ht) receptor expression. |
2021-02-01 |
2023-08-13 |
rat |
| Salma A El-Marasy, Sally A El Awdan, Azza Hassan, Omar A Ahmed-Farid, Hanan A Ogal. Anti-depressant effect of cerebrolysin in reserpine-induced depression in rats: Behavioral, biochemical, molecular and immunohistochemical evidence. Chemico-biological interactions. vol 334. 2021-01-25. PMID:33279466. |
cbl elevated nor-epinephrine (ne), serotonin (5-ht), and dopamine (da) and reduced 5-hydroxyindoleacetic acid (5-htaa), 3,4-dihydroxyphenylacetic acid (dopac), and homovanillic acid (hva) cortical and hippocampal contents. |
2021-01-25 |
2023-08-13 |
rat |
| J M Carpenter, H E Gordon, H D Ludwig, J J Wagner, D A Harn, T Norberg, N M Filipo. Neurochemical and neuroinflammatory perturbations in two Gulf War Illness models: Modulation by the immunotherapeutic LNFPIII. Neurotoxicology. vol 77. 2021-01-22. PMID:31866310. |
serotonergic (5-ht) and dopaminergic (da) dyshomeostasis caused by gwi chemicals was apparent in multiple brain regions, primarily in the nucleus accumbens (5-ht) and hippocampus (5-ht, da) for both models. |
2021-01-22 |
2023-08-13 |
mouse |