| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S A Farr, K Uezu, J F Flood, J E Morle. Septo-hippocampal drug interactions in post-trial memory processing. Brain research. vol 847. issue 2. 1999-12-21. PMID:10575091. |
ketanserin, a serotonin type 2 receptor antagonist at a dose of 0.5 ng, had no measurable effect on retention, but it reduced the dose of bicuculline, in the septum, or arecoline in the hippocampus that was needed to improve retention. |
1999-12-21 |
2023-08-12 |
mouse |
| S A Farr, K Uezu, J F Flood, J E Morle. Septo-hippocampal drug interactions in post-trial memory processing. Brain research. vol 847. issue 2. 1999-12-21. PMID:10575091. |
the results of this study are compatible with models that propose that serotonin innervation from the median raphe drives gaba interneurons in the medial septum that synapse on cholinergic neurons projecting to the hippocampus. |
1999-12-21 |
2023-08-12 |
mouse |
| S Benmansour, M Cecchi, D A Morilak, G A Gerhardt, M A Javors, G G Gould, A Fraze. Effects of chronic antidepressant treatments on serotonin transporter function, density, and mRNA level. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 23. 1999-12-17. PMID:10575045. |
high-speed in vivo electrochemical recordings were used to assess the ability of the ssri fluvoxamine to modulate the clearance of locally applied serotonin in the ca3 region of hippocampus in drug- or vehicle-treated rats. |
1999-12-17 |
2023-08-12 |
rat |
| S Benmansour, M Cecchi, D A Morilak, G A Gerhardt, M A Javors, G G Gould, A Fraze. Effects of chronic antidepressant treatments on serotonin transporter function, density, and mRNA level. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 23. 1999-12-17. PMID:10575045. |
the serotonin content of the hippocampus was unaffected by paroxetine or sertraline treatment, ruling out neurotoxicity as a possible explanation for the ssri-induced decrease in sert binding and alteration in 5-ht clearance. |
1999-12-17 |
2023-08-12 |
rat |
| Y J Karten, S M Nair, L van Essen, R Sibug, M Joël. Long-term exposure to high corticosterone levels attenuates serotonin responses in rat hippocampal CA1 neurons. Proceedings of the National Academy of Sciences of the United States of America. vol 96. issue 23. 1999-12-13. PMID:10557342. |
in the present animal study, we tested one possible mechanism, i.e., that long-term exposure to high corticosterone levels alters functional responses to serotonin in the hippocampus, an important area in the etiology of depression. |
1999-12-13 |
2023-08-12 |
rat |
| H Sarhan, G Fillio. Differential sensitivity of 5-HT1B auto and heteroreceptors. Naunyn-Schmiedeberg's archives of pharmacology. vol 360. issue 4. 1999-12-10. PMID:10551275. |
the effect of the native and rodent-selective 5-ht1b receptor agonists (5-hydroxytryptamine (5-ht) and cp93,129) on the k+-evoked overflows of [3h]5-ht, [3h]dopamine (da) and [3h]acetylcholine (ach) was studied in synaptosome preparations obtained from rat brain striatum or hippocampus loaded with radiolabeled neurotransmitter. |
1999-12-10 |
2023-08-12 |
rat |
| H Sarhan, G Fillio. Differential sensitivity of 5-HT1B auto and heteroreceptors. Naunyn-Schmiedeberg's archives of pharmacology. vol 360. issue 4. 1999-12-10. PMID:10551275. |
results show that under the same experimental conditions, 5-ht and cp93,129 exhibited significantly higher potencies in inhibiting the k+-evoked overflow of [3h]5-ht from synaptosomes of rat striatum (ic50=2.0+/-1.8 nm and 20.5+/-3.1 nm, respectively) than in inhibiting the k+-evoked overflow of [3h]da from synaptosomes of the same cerebral region (ic50= 0.8+/-0.2 microm and 1.8+/-0.4 microm, respectively), or [3h]ach from synaptosomes of hippocampus (ic50=1.7+/-0.8 microm for cp93,129). |
1999-12-10 |
2023-08-12 |
rat |
| A Rex, J P Voigt, H Fin. Behavioral and neurochemical differences between Fischer 344 and Harlan-Wistar rats raised identically. Behavior genetics. vol 29. issue 3. 1999-12-02. PMID:10547925. |
in a separate microdialysis study, the relationship between behavioral variations to biochemical differences was assessed, with serotonin (5-ht) release in the ventral hippocampus being measured during the elevated plus-maze test. |
1999-12-02 |
2023-08-12 |
rat |
| A Rex, J P Voigt, H Fin. Behavioral and neurochemical differences between Fischer 344 and Harlan-Wistar rats raised identically. Behavior genetics. vol 29. issue 3. 1999-12-02. PMID:10547925. |
exposure to the elevated plus-maze induced an increase in hippocampal 5-ht in the (more anxious) fischer rats but not in the (less anxious) wistar rats. |
1999-12-02 |
2023-08-12 |
rat |
| J Dong, C De Montigny, P Blie. Assessment of the serotonin reuptake blocking property of YM992: electrophysiological studies in the rat hippocampus and dorsal raphe. Synapse (New York, N.Y.). vol 34. issue 4. 1999-11-30. PMID:10529722. |
assessment of the serotonin reuptake blocking property of ym992: electrophysiological studies in the rat hippocampus and dorsal raphe. |
1999-11-30 |
2023-08-12 |
rat |
| J Dong, C De Montigny, P Blie. Assessment of the serotonin reuptake blocking property of YM992: electrophysiological studies in the rat hippocampus and dorsal raphe. Synapse (New York, N.Y.). vol 34. issue 4. 1999-11-30. PMID:10529722. |
in a third series of experiments, the sensitivity of pre- and postsynaptic 5-ht(1a) receptors in the dorsal raphe and the dorsal hippocampus were assessed. |
1999-11-30 |
2023-08-12 |
rat |
| J Dong, C De Montigny, P Blie. Assessment of the serotonin reuptake blocking property of YM992: electrophysiological studies in the rat hippocampus and dorsal raphe. Synapse (New York, N.Y.). vol 34. issue 4. 1999-11-30. PMID:10529722. |
as did the selective 5-ht reuptake inhibitor fluvoxamine, ym992 markedly increased the effectiveness of the electrical stimulation of ascending 5-ht fibres on firing activity of the postsynaptic hippocampus pyramidal neurons. |
1999-11-30 |
2023-08-12 |
rat |
| J Dong, C De Montigny, P Blie. Assessment of the serotonin reuptake blocking property of YM992: electrophysiological studies in the rat hippocampus and dorsal raphe. Synapse (New York, N.Y.). vol 34. issue 4. 1999-11-30. PMID:10529722. |
this enhancement of 5-ht neurotransmission by ym992 was attributable to a desensitization of the terminal 5-ht(1b) autoreceptors since the postsynaptic 5-ht(1a) receptors in the hippocampus remained normosensitive. |
1999-11-30 |
2023-08-12 |
rat |
| T Fujii, S Ohba, K Nakai, K Fujimoto, T Suzuki, K Kawashim. Enhancement of the serotonin-mediated acetylcholine release by repeated desmethylimipramine treatment in the hippocampus of freely moving rats. Japanese journal of pharmacology. vol 80. issue 4. 1999-11-24. PMID:10496330. |
hippocampal 5-ht content of acutely dmi-treated rats was significantly higher than that of saline-treated control rats, while no difference was observed between the repeatedly dmi- and saline-treated rats. |
1999-11-24 |
2023-08-12 |
rat |
| S Gasparini, D DiFrancesc. Action of serotonin on the hyperpolarization-activated cation current (Ih) in rat CA1 hippocampal neurons. The European journal of neuroscience. vol 11. issue 9. 1999-11-24. PMID:10510173. |
action of serotonin on the hyperpolarization-activated cation current (ih) in rat ca1 hippocampal neurons. |
1999-11-24 |
2023-08-12 |
rat |
| E Germani, M L Suck, A M Di Giulio, A Gori. Perinatal supplementation of low doses of ethanol enhances 5-HT restoration in the central nervous system. Journal of neuroscience research. vol 58. issue 3. 1999-11-23. PMID:10518119. |
the loss of 5-ht is particularly relevant in lumbar spinal cord, occipital cortex, and hippocampus. |
1999-11-23 |
2023-08-12 |
rat |
| C W Stewart, W Slikke. Hyperthermia-enhanced serotonin (5-HT) depletion resulting from D-fenfluramine (D-Fen) exposure does not evoke a glial-cell response in the central nervous system of rats. Brain research. vol 839. issue 2. 1999-11-17. PMID:10519050. |
likewise, in the striatum and hippocampus, 5-ht concentrations ranged from 13 to 53% and 6 to 40%, respectively. |
1999-11-17 |
2023-08-12 |
rat |
| R Suhr, E Balse, A Haaf, C Kelche, J C Cassel, R Jackisc. Modulation of acetylcholine and 5-hydroxytryptamine release in hippocampal slices of rats with fimbria-fornix lesions and intrahippocampal grafts containing cholinergic and/or serotonergic neurons. Brain research bulletin. vol 50. issue 1. 1999-11-10. PMID:10507467. |
modulation of acetylcholine and 5-hydroxytryptamine release in hippocampal slices of rats with fimbria-fornix lesions and intrahippocampal grafts containing cholinergic and/or serotonergic neurons. |
1999-11-10 |
2023-08-12 |
rat |
| R Suhr, E Balse, A Haaf, C Kelche, J C Cassel, R Jackisc. Modulation of acetylcholine and 5-hydroxytryptamine release in hippocampal slices of rats with fimbria-fornix lesions and intrahippocampal grafts containing cholinergic and/or serotonergic neurons. Brain research bulletin. vol 50. issue 1. 1999-11-10. PMID:10507467. |
hippocampal slices of these rats (5-9 month after surgery) were preincubated with [3h]choline or [3h]5-ht, superfused continuously (in the presence of hemicholinium-3 or fluvoxamine) and stimulated electrically (360 pulses, 2 ms, 3 hz, 26-28 ma) in order to study the presynaptic modulation of acetylcholine (ach) and serotonin (5-ht) release. |
1999-11-10 |
2023-08-12 |
rat |
| R Suhr, E Balse, A Haaf, C Kelche, J C Cassel, R Jackisc. Modulation of acetylcholine and 5-hydroxytryptamine release in hippocampal slices of rats with fimbria-fornix lesions and intrahippocampal grafts containing cholinergic and/or serotonergic neurons. Brain research bulletin. vol 50. issue 1. 1999-11-10. PMID:10507467. |
it is concluded that despite substantial lesion- and graft-induced changes in the amount of ach and 5-ht released by hippocampal slices of lesion-only or grafted rats, the presynaptic modulation of these transmitters is only slightly affected by changes in the neuronal environment. |
1999-11-10 |
2023-08-12 |
rat |