| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J Stemmelin, C Lazarus, S Cassel, C Kelche, J C Casse. Immunohistochemical and neurochemical correlates of learning deficits in aged rats. Neuroscience. vol 96. issue 2. 2000-04-20. PMID:10683568. |
alterations related to aging consisted of reduced concentration of acetylcholine, norepinephrine and serotonin in the striatum, serotonin in the occipital cortex, dopamine and norepinephrine in the dorsal hippocampus, and norepinephrine in the ventral hippocampus. |
2000-04-20 |
2023-08-12 |
rat |
| J Stemmelin, C Lazarus, S Cassel, C Kelche, J C Casse. Immunohistochemical and neurochemical correlates of learning deficits in aged rats. Neuroscience. vol 96. issue 2. 2000-04-20. PMID:10683568. |
in the second experiment, water maze performance was correlated with the concentration of; (i) acetylcholine and serotonin in the striatum; (ii) serotonin and norepinephrine in the dorsal hippocampus; (iii) norepinephrine in the frontoparietal cortex and; (iv) with other functional markers such as the 5-hydroxyindoleacetic acid/serotonin ratio in the striatum, 3,4-dihydroxyphenylacetic acid/dopamine ratio in the dorsal hippocampus, 5-hydroxyindoleacetic acid/serotonin and homovanillic acid/dopamine ratios in the frontoparietal cortex, and 3,4-dihydroxyphenylacetic acid/dopamine ratio in the occipital cortex. |
2000-04-20 |
2023-08-12 |
rat |
| C Stenfors, H Yu, S B Ros. Enhanced 5-HT metabolism and synthesis rate by the new selective r5-HT1B receptor antagonist, NAS-181 in the rat brain. Neuropharmacology. vol 39. issue 4. 2000-04-20. PMID:10728876. |
5-ht metabolism, measured as the ratio 5-hydroxyindoleacetic acid (5-hiaa)/5-ht, was dose-dependently increased in all four brain regions analysed (hypothalamus, hippocampus, frontal cortex and striatum) at doses 0.1 to 20 mg/kg s.c. nas-181. |
2000-04-20 |
2023-08-12 |
rat |
| C Stenfors, H Yu, S B Ros. Enhanced 5-HT metabolism and synthesis rate by the new selective r5-HT1B receptor antagonist, NAS-181 in the rat brain. Neuropharmacology. vol 39. issue 4. 2000-04-20. PMID:10728876. |
5-ht synthesis rate measured as the accumulation of 5-hydroxytryptophan (5-htp) after inhibition of the aromatic amino acid decarboxylase activity was also elevated by nas-181 at doses 0.3 to 20 mg/kg s.c. nas-181 competitively antagonised the decrease in 5-ht metabolism evoked by the r5-ht1b receptor agonist, anpirtoline, in hypothalamus, hippocampus and frontal cortex. |
2000-04-20 |
2023-08-12 |
rat |
| J Farisse, P Boulenguez, A Sémont, F Héry, N Barden, M Faudon, M Hér. Regional serotonin metabolism under basal and restraint stress conditions in the brain of transgenic mice with impaired glucocorticoid receptor function. Neuroendocrinology. vol 70. issue 6. 2000-04-14. PMID:10657734. |
our results support the hypothesis of a tonic activation of serotonin turnover by corticosterone through gr in the mouse hippocampus. |
2000-04-14 |
2023-08-12 |
mouse |
| J Farisse, P Boulenguez, A Sémont, F Héry, N Barden, M Faudon, M Hér. Regional serotonin metabolism under basal and restraint stress conditions in the brain of transgenic mice with impaired glucocorticoid receptor function. Neuroendocrinology. vol 70. issue 6. 2000-04-14. PMID:10657734. |
moreover, stress-induced stimulation of serotonin metabolism in the brain stem and hippocampus appears to be delayed in tg mice compared to control mice. |
2000-04-14 |
2023-08-12 |
mouse |
| L Matzen, C van Amsterdam, W Rautenberg, H E Greiner, J Harting, C A Seyfried, H Böttche. 5-HT reuptake inhibitors with 5-HT(1B/1D) antagonistic activity: a new approach toward efficient antidepressants. Journal of medicinal chemistry. vol 43. issue 6. 2000-04-13. PMID:10737747. |
binding experiments in rat frontal cortex using [(125)i]iodocyanopindolol, in calf striatum using [(3)h]5-ht, and in rat hippocampus using [(3)h]8-oh-dpat as radioligands, respectively, revealed significantly higher affinity at the 5-ht(1b) receptor as compared to the affinities for the 5-ht(1a) and 5-ht(1d) receptors for a number of compounds, among them 4-(5-fluoro-1h-indol-3-yl)piperidine-1-carboxylic acid [4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]amide (5), the corresponding 4-fluoro-1h-indol-3-yl analogue 21a, and the corresponding 6-fluoro-1h-indol-3-yl analogue 21b. |
2000-04-13 |
2023-08-12 |
rat |
| M Konstandi, E Johnson, M A Lang, M Malamas, M Marselo. Noradrenaline, dopamine, serotonin: different effects of psychological stress on brain biogenic amines in mice and rats. Pharmacological research. vol 41. issue 3. 2000-04-12. PMID:10675287. |
on the other hand, 5-ht was suppressed in the mouse striatum and in the rat hypothalamus and amygdala, while 5-ht turnover was markedly decreased in the hippocampus and dorsal cortex of rats alone. |
2000-04-12 |
2023-08-12 |
mouse |
| N Ginovart, W Hassoun, D Le Bars, D Weissmann, V Levie. In vivo characterization of p-[(18)F]MPPF, a fluoro analog of WAY-100635 for visualization of 5-HT(1a) receptors. Synapse (New York, N.Y.). vol 35. issue 3. 2000-04-11. PMID:10657026. |
the highest uptakes of radioactivity were observed in the hippocampus and cingulate cortex, regions known to be rich in 5-ht(1a) receptors, whereas lower levels of radioactivity were observed in the cerebellum. |
2000-04-11 |
2023-08-12 |
human |
| N Ginovart, W Hassoun, D Le Bars, D Weissmann, V Levie. In vivo characterization of p-[(18)F]MPPF, a fluoro analog of WAY-100635 for visualization of 5-HT(1a) receptors. Synapse (New York, N.Y.). vol 35. issue 3. 2000-04-11. PMID:10657026. |
specific binding in the hippocampus and the cingulate cortex was markedly reduced following injection of unlabeled way-100635 and pindolol but was unaffected by treatment with alpha1, 5-ht(2), or reuptake inhibitor agents indicating reversibility and selectivity of p-[(18)f]mppf binding to 5-ht(1a) receptors. |
2000-04-11 |
2023-08-12 |
human |
| M V Pletnikov, S A Rubin, G J Schwartz, K M Carbone, T H Mora. Effects of neonatal rat Borna disease virus (BDV) infection on the postnatal development of the brain monoaminergic systems. Brain research. Developmental brain research. vol 119. issue 2. 2000-04-11. PMID:10675767. |
tissue content of norepinephrine (ne), dopamine (da) and its metabolite, 3,4-dihydroxyphenol acetic acid (dopac), and serotonin (5-ht) and its metabolite, 5-hydroxyindole-3-acetic acid (5-hiaa) were assayed by means of hplc-ec in frontal cortex, cerebellum, hippocampus, hypothalamus and striatum of neonatally bdv-infected and sham-inoculated male lewis rats of 8, 14, 21, 60 and 90 days of age. |
2000-04-11 |
2023-08-12 |
rat |
| M V Pletnikov, S A Rubin, G J Schwartz, K M Carbone, T H Mora. Effects of neonatal rat Borna disease virus (BDV) infection on the postnatal development of the brain monoaminergic systems. Brain research. Developmental brain research. vol 119. issue 2. 2000-04-11. PMID:10675767. |
in hippocampus, neonatally bdv-infected rats had lower 5-ht levels at pnd 8 and significantly elevated levels at pnd 21 and onwards. |
2000-04-11 |
2023-08-12 |
rat |
| J M Brezun, A Daszut. Serotonergic reinnervation reverses lesion-induced decreases in PSA-NCAM labeling and proliferation of hippocampal cells in adult rats. Hippocampus. vol 10. issue 1. 2000-04-11. PMID:10706215. |
they emphasize the critical role played by 5-ht in the neuronal organization of the hippocampus. |
2000-04-11 |
2023-08-12 |
rat |
| A Semont, M Fache, L Ouafik, M Hery, M Faudon, F Her. Effect of serotonin inhibition on glucocorticoid and mineralocorticoid expression in various brain structures. Neuroendocrinology. vol 69. issue 2. 2000-03-31. PMID:9986925. |
the present study examined the short-term (48 h) effects of parachlorophenylalanine (pcpa), a drug which specifically inhibits 5-ht synthesis, on corticosteroid receptor levels and on the expression of their respective messenger ribonucleic acids (mrna) in the rat hippocampus, hypothalamus and brain stem. |
2000-03-31 |
2023-08-12 |
rat |
| A Semont, M Fache, L Ouafik, M Hery, M Faudon, F Her. Effect of serotonin inhibition on glucocorticoid and mineralocorticoid expression in various brain structures. Neuroendocrinology. vol 69. issue 2. 2000-03-31. PMID:9986925. |
short-term inhibition of 5-ht synthesis by pcpa significantly increased the number of hippocampal mr-binding sites. |
2000-03-31 |
2023-08-12 |
rat |
| A Semont, M Fache, L Ouafik, M Hery, M Faudon, F Her. Effect of serotonin inhibition on glucocorticoid and mineralocorticoid expression in various brain structures. Neuroendocrinology. vol 69. issue 2. 2000-03-31. PMID:9986925. |
in pcpa-treated rats, restoration of control 5-ht levels by injection of its immediate precursor, 5-hydroxytryptophan (5-htp) brings the number of hippocampal mr-binding sites back to control levels. |
2000-03-31 |
2023-08-12 |
rat |
| A Semont, M Fache, L Ouafik, M Hery, M Faudon, F Her. Effect of serotonin inhibition on glucocorticoid and mineralocorticoid expression in various brain structures. Neuroendocrinology. vol 69. issue 2. 2000-03-31. PMID:9986925. |
the increase in hippocampal mr binding sites was correlated with an induction of their messengers, suggesting that 5-ht modulates the synthesis of mr protein. |
2000-03-31 |
2023-08-12 |
rat |
| A Semont, M Fache, L Ouafik, M Hery, M Faudon, F Her. Effect of serotonin inhibition on glucocorticoid and mineralocorticoid expression in various brain structures. Neuroendocrinology. vol 69. issue 2. 2000-03-31. PMID:9986925. |
this study shows that 5-ht inhibits hippocampal mineralocorticoid receptor synthesis and that this effect is not mediated by changes in corticosterone hormone secretion, and illustrates the existence of complex mechanisms for corticosteroid receptor regulation in the hippocampus. |
2000-03-31 |
2023-08-12 |
rat |
| D C Mathangi, A Namasivaya. Effect of chronic cyanide intoxication on memory in albino rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 38. issue 1. 2000-03-22. PMID:10685013. |
cyanide reduced the memory along with reduction in the levels of dopamine and 5-hydroxytryptamine in the hippocampus. |
2000-03-22 |
2023-08-12 |
rat |
| O Lehmann, H Jeltsch, O Lehnardt, L Pain, C Lazarus, J C Casse. Combined lesions of cholinergic and serotonergic neurons in the rat brain using 192 IgG-saporin and 5,7-dihydroxytryptamine: neurochemical and behavioural characterization. The European journal of neuroscience. vol 12. issue 1. 2000-03-16. PMID:10651861. |
5,7-dht lesions reduced the concentration of serotonin by 60% in the frontoparietal cortex and 80% in the hippocampus and striatum. |
2000-03-16 |
2023-08-12 |
rat |