| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A C Linthorst, C Flachskamm, N Barden, F Holsboer, J M Reu. Glucocorticoid receptor impairment alters CNS responses to a psychological stressor: an in vivo microdialysis study in transgenic mice. The European journal of neuroscience. vol 12. issue 1. 2000-03-16. PMID:10651883. |
through a microdialysis probe in the hippocampus, serotonin (5-ht), 5-hydroxyindoleacetic acid (5-hiaa) and free corticosterone [as an index of hypothalamic-pituitary-adrenocortical (hpa) axis activity] were monitored. |
2000-03-16 |
2023-08-12 |
mouse |
| A C Linthorst, C Flachskamm, N Barden, F Holsboer, J M Reu. Glucocorticoid receptor impairment alters CNS responses to a psychological stressor: an in vivo microdialysis study in transgenic mice. The European journal of neuroscience. vol 12. issue 1. 2000-03-16. PMID:10651883. |
a positive correlation between baseline hippocampal extracellular levels of 5-ht and 5-hiaa and the time spent performing active behaviours was observed in both genotypes. |
2000-03-16 |
2023-08-12 |
mouse |
| A C Linthorst, C Flachskamm, N Barden, F Holsboer, J M Reu. Glucocorticoid receptor impairment alters CNS responses to a psychological stressor: an in vivo microdialysis study in transgenic mice. The European journal of neuroscience. vol 12. issue 1. 2000-03-16. PMID:10651883. |
in both mouse lines, exposure to a rat increased hippocampal extracellular levels of 5-ht and 5-hiaa. |
2000-03-16 |
2023-08-12 |
mouse |
| J M Brezun, A Daszut. Serotonin may stimulate granule cell proliferation in the adult hippocampus, as observed in rats grafted with foetal raphe neurons. The European journal of neuroscience. vol 12. issue 1. 2000-03-16. PMID:10651896. |
serotonin may stimulate granule cell proliferation in the adult hippocampus, as observed in rats grafted with foetal raphe neurons. |
2000-03-16 |
2023-08-12 |
rat |
| M Barrionuevo, N Aguirre, J D Del Río, B Lashera. Serotonergic deficits and impaired passive-avoidance learning in rats by MDEA: a comparison with MDMA. Pharmacology, biochemistry, and behavior. vol 65. issue 2. 2000-03-14. PMID:10672974. |
a single dose of mdea (10, 20, or 40 mg/kg ip) induced a dose-related hyperthermia, but only the highest dose significantly reduced 5-ht content and 5-ht transporter density in the frontal cortex and in the hippocampus 7 days later. |
2000-03-14 |
2023-08-12 |
rat |
| Y Liao, H Böttcher, J Harting, H Greiner, C van Amsterdam, T Cremers, S Sundell, J März, W Rautenberg, H Wikströ. New selective and potent 5-HT(1B/1D) antagonists: chemistry and pharmacological evaluation of N-piperazinylphenyl biphenylcarboxamides and biphenylsulfonamides. Journal of medicinal chemistry. vol 43. issue 3. 2000-03-13. PMID:10669578. |
a biochemical study of 2 with in vivo microdialysis in the rat brain showed that it is capable of augmenting citalopram (a selective serotonin reuptake inhibitor, ssri) induced 5-ht release in rat ventral hippocampus, while preventing the decrease in acetylcholine release elicited by citalopram administration. |
2000-03-13 |
2023-08-12 |
rat |
| M Reuben, P B Clark. Nicotine-evoked [3H]5-hydroxytryptamine release from rat striatal synaptosomes. Neuropharmacology. vol 39. issue 2. 2000-03-09. PMID:10670424. |
nicotine increased 5-ht release from striatal synaptosomes (maximally by 15-30%) but not from cerebral cortex or hippocampal synaptosomes. |
2000-03-09 |
2023-08-12 |
rat |
| A Otano, A García-Osta, S Ballaz, D Frechilla, J Del Rí. Facilitation by 8-OH-DPAT of passive avoidance performance in rats after inactivation of 5-HT(1A) receptors. British journal of pharmacology. vol 128. issue 8. 2000-03-02. PMID:10588924. |
in the hippocampus of eedq-treated rats, 5-ht(7) receptors were less inactivated than 5-ht(1a) receptors and significant increases were found in 5-ht(1a) but not in 5-ht(7) receptor mrna levels. |
2000-03-02 |
2023-08-12 |
rat |
| M Jähkel, O Rilke, R Koch, J Oehle. Open field locomotion and neurotransmission in mice evaluated by principal component factor analysis-effects of housing condition, individual activity disposition and psychotropic drugs. Progress in neuro-psychopharmacology & biological psychiatry. vol 24. issue 1. 2000-03-02. PMID:10659984. |
pca of considerable locomotion and neurochemical data revealed interrelationships between striatal dopamine metabolism and f1-activity, between cortical dopamine and serotonin metabolism and f2-exploration as well as between cerebellar, hippocampal and striatal serotonin metabolism and f3-irritation. |
2000-03-02 |
2023-08-12 |
mouse |
| L Palego, A Giromella, D Marazziti, G Giannaccini, F Borsini, F Bigazzi, A G Naccarato, A Lucacchini, G B Cassano, M R Mazzon. Lack of stereoselectivity of 8-hydroxy-2(di-N-propylamino)tetralin-mediated inhibition of forskolin-stimulated adenylyl cyclase activity in human pre- and post-synaptic brain regions. Neurochemistry international. vol 36. issue 3. 2000-03-02. PMID:10676857. |
the stereoselectivity of the serotonin1a (5-ht1a) receptor compound 8-hydroxy-2(di-n-propylamino)tetralin (8-oh-dpat) on forskolin-stimulated adenylyl cyclase activity was investigated in membranes from human 5-ht pre-synaptic (raphe nuclei) and post-synaptic (hippocampus and prefrontal cortex) regions of autopsy brains. |
2000-03-02 |
2023-08-12 |
human |
| S Wirth, O Lehmann, F Bertrand, C Lazarus, H Jeltsch, J C Casse. Preserved olfactory short-term memory after combined cholinergic and serotonergic lesions using 192 IgG-saporin and 5,7-dihydroxytryptamine in rats. Neuroreport. vol 11. issue 2. 2000-02-29. PMID:10674484. |
compared with animals undergoing sham operations, 5,7-dht reduced the concentration of serotonin by 60-80% in the frontoparietal cortex, hippocampus, striatum and the olfactory bulbs. |
2000-02-29 |
2023-08-12 |
rat |
| E Meller, H Li, K D Carr, J M Hille. 5-Hydroxytryptamine(1A) receptor-stimulated [(35)S]GTPgammaS binding in rat brain: absence of regional differences in coupling efficiency. The Journal of pharmacology and experimental therapeutics. vol 292. issue 2. 2000-02-22. PMID:10640306. |
in hippocampal membranes, the selective 5-hydroxytryptamine (5-ht(1a)) receptor agonists 8-hydroxy-dipropylaminotetralin (8-oh-dpat) and n,n-dipropyl-5-carboxamidotryptamine (n,n-dp-5-ct) stimulated guanosine-5'-o-(3-thio)triphosphate ([(35)s]gtpgammas) binding by 130 to 140%; binding stimulated by nonselective agonists (5-ht and 5-ct) was approximately 30% greater. |
2000-02-22 |
2023-08-12 |
rat |
| E Meller, H Li, K D Carr, J M Hille. 5-Hydroxytryptamine(1A) receptor-stimulated [(35)S]GTPgammaS binding in rat brain: absence of regional differences in coupling efficiency. The Journal of pharmacology and experimental therapeutics. vol 292. issue 2. 2000-02-22. PMID:10640306. |
in autoradiographic sections, r-(+)-8-oh-dpat stimulated [(35)s]gtpgammas binding in 5-ht(1a) receptor-rich regions (dorsal hippocampus, 123%; lateral septum, 111%; midhippocampus, 110%; dorsal raphe nucleus, 83%; medial prefrontal cortex, approximately 60%). |
2000-02-22 |
2023-08-12 |
rat |
| E Meller, H Li, K D Carr, J M Hille. 5-Hydroxytryptamine(1A) receptor-stimulated [(35)S]GTPgammaS binding in rat brain: absence of regional differences in coupling efficiency. The Journal of pharmacology and experimental therapeutics. vol 292. issue 2. 2000-02-22. PMID:10640306. |
partial irreversible blockade of 5-ht(1a) receptors in brain sections (phenoxybenzamine, 10 microm) reduced the maximal response without altering the ec(50) in both the hippocampus and dorsal raphe. |
2000-02-22 |
2023-08-12 |
rat |
| E Meller, H Li, K D Carr, J M Hille. 5-Hydroxytryptamine(1A) receptor-stimulated [(35)S]GTPgammaS binding in rat brain: absence of regional differences in coupling efficiency. The Journal of pharmacology and experimental therapeutics. vol 292. issue 2. 2000-02-22. PMID:10640306. |
despite prior evidence that dorsal raphe somatodendritic 5-ht(1a) autoreceptors exhibit high receptor/effector coupling efficiency (receptor reserve) compared with postsynaptic receptors in hippocampus, there was no evidence of a difference at the level of receptor/g protein coupling. |
2000-02-22 |
2023-08-12 |
rat |
| F Bai, S S Lau, T J Monk. Glutathione and N-acetylcysteine conjugates of alpha-methyldopamine produce serotonergic neurotoxicity: possible role in methylenedioxyamphetamine-mediated neurotoxicity. Chemical research in toxicology. vol 12. issue 12. 2000-02-17. PMID:10604863. |
we have shown that intracerebroventricular (icv) injection of 2,5-bis(glutathion-s-yl)-alpha-methyldopamine [2, 5-bis(glutathion-s-yl)-alpha-meda] causes decreases in serotonin concentrations in the striatum, cortex, and hippocampus, and neurobehavioral effects similar to those seen following mda and mdma administration. |
2000-02-17 |
2023-08-12 |
Not clear |
| M J Millan, A Newman-Tancredi, V Audinot, D Cussac, F Lejeune, J P Nicolas, F Cogé, J P Galizzi, J A Boutin, J M Rivet, A Dekeyne, A Gober. Agonist and antagonist actions of yohimbine as compared to fluparoxan at alpha(2)-adrenergic receptors (AR)s, serotonin (5-HT)(1A), 5-HT(1B), 5-HT(1D) and dopamine D(2) and D(3) receptors. Significance for the modulation of frontocortical monoaminergic transmission and depressive states. Synapse (New York, N.Y.). vol 35. issue 2. 2000-02-17. PMID:10611634. |
while fluparoxan selectively enhances hippocampal noradrenaline (nad) turnover, yohimbine also enhances striatal dopamine (da) turnover and suppresses striatal turnover of 5-ht. |
2000-02-17 |
2023-08-12 |
human |
| M K Osterlund, D H Overstreet, Y L Hur. The flinders sensitive line rats, a genetic model of depression, show abnormal serotonin receptor mRNA expression in the brain that is reversed by 17beta-estradiol. Brain research. Molecular brain research. vol 74. issue 1-2. 2000-02-15. PMID:10640686. |
the fsl animals were shown to express significantly lower levels of the 5-ht(2a) receptor transcripts in the perirhinal cortex, piriform cortex, and medial anterodorsal amygdala and higher levels in the ca 2-3 region of the hippocampus. |
2000-02-15 |
2023-08-12 |
rat |
| M B Assié, C Cosi, W Koe. Correlation between low/high affinity ratios for 5-HT(1A) receptors and intrinsic activity. European journal of pharmacology. vol 386. issue 1. 2000-02-11. PMID:10611469. |
we examined the affinity of a series of compounds for 5-hydroxytryptamine(1a) (5-ht(1a)) receptor sites labeled with 0.2 nm [3h](+/-)-8-hydroxy-2-(di-n-propylamino)tetralin ([3h]8-oh-dpat) (high affinity), or with 0.25 nm [3h]4-(2'-methoxy-)-phenyl-1-[2'-(n-2"-pyridyl)-p-fluorobenzamido] eth yl-piperazine ([3h]p-mppf) in the presence of 100 microm guanylylimidodiphosphate (gpp(nh)p) (low affinity) in rat hippocampal membranes. |
2000-02-11 |
2023-08-12 |
rat |
| L A Mamounas, C A Altar, M E Blue, D R Kaplan, L Tessarollo, W E Lyon. BDNF promotes the regenerative sprouting, but not survival, of injured serotonergic axons in the adult rat brain. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 2. 2000-02-09. PMID:10632606. |
bdnf also encouraged the regrowth of the 5-ht plexus in the hippocampus, but only in those lamina where 5-ht axons normally ramify. |
2000-02-09 |
2023-08-12 |
rat |