| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Newman-Tancredi, J Rivet, C Chaput, M Touzard, L Verrièle, M J Milla. The 5HT(1A) receptor ligand, S15535, antagonises G-protein activation: a [35S]GTPgammaS and [3H]S15535 autoradiography study. European journal of pharmacology. vol 384. issue 2-3. 2000-02-03. PMID:10611431. |
[3h]s15535 binding was highest in hippocampus, frontal cortex, entorhinal cortex, lateral septum, interpeduncular nucleus and dorsal raphe, consistent with specific labelling of 5-ht(1a) receptors. |
2000-02-03 |
2023-08-12 |
rat |
| A Brambilla, A Baschirotto, N Grippa, F Borsin. Effect of flibanserin (BIMT 17), fluoxetine, 8-OH-DPAT and buspirone on serotonin synthesis in rat brain. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 10. issue 1. 2000-02-02. PMID:10647099. |
in male rats, the effects of the administration of the novel serotonergic agent flibanserin on the synthesis of 5-ht were evaluated in the frontal cortex (fc), hippocampus (hip) and brainstem (br). |
2000-02-02 |
2023-08-12 |
rat |
| F Pollier, S Sarre, S Aguerre, G Ebinger, P Mormède, Y Michotte, F Chaoulof. Serotonin reuptake inhibition by citalopram in rat strains differing for their emotionality. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 22. issue 1. 2000-01-28. PMID:10633492. |
hippocampal, but not midbrain or striatal, [3h]citalopram binding at 5-ht transporters was lower in wky rats than in shrs. |
2000-01-28 |
2023-08-12 |
rat |
| F Pollier, S Sarre, S Aguerre, G Ebinger, P Mormède, Y Michotte, F Chaoulof. Serotonin reuptake inhibition by citalopram in rat strains differing for their emotionality. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 22. issue 1. 2000-01-28. PMID:10633492. |
however, neither [3h]5-ht reuptake kinetics nor the potencies of citalopram (1-1000 nm) to inhibit [3h]5-ht reuptake into hippocampal and striatal synaptosomes differed between strains. |
2000-01-28 |
2023-08-12 |
rat |
| F Pollier, S Sarre, S Aguerre, G Ebinger, P Mormède, Y Michotte, F Chaoulof. Serotonin reuptake inhibition by citalopram in rat strains differing for their emotionality. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 22. issue 1. 2000-01-28. PMID:10633492. |
thus, although lew rats displayed a 3-4 fold higher baseline level of extracellular 5-ht in the hippocampus, compared with shrs and wky rats, local perfusion with 1 microm citalopram promoted relative increases in extracellular 5-ht levels over baseline that were similar in all strains. |
2000-01-28 |
2023-08-12 |
rat |
| F Pollier, S Sarre, S Aguerre, G Ebinger, P Mormède, Y Michotte, F Chaoulof. Serotonin reuptake inhibition by citalopram in rat strains differing for their emotionality. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 22. issue 1. 2000-01-28. PMID:10633492. |
administration of 3.3 mg/kg citalopram (1 h beforehand) decreased to similar extents [3h]5-ht reuptake into hippocampal synaptosomes from shrs and wky rats. |
2000-01-28 |
2023-08-12 |
rat |
| H Thomas, H Fink, T R Sohr, M Voit. Lesion of the median raphe nucleus: a combined behavioral and microdialysis study in rats. Pharmacology, biochemistry, and behavior. vol 65. issue 1. 2000-01-28. PMID:10638630. |
neurochemically, microinjection of 5,7-dht into the mrn resulted in 87.5% depletion of hippocampal 5-ht content. |
2000-01-28 |
2023-08-12 |
rat |
| H Thomas, H Fink, T R Sohr, M Voit. Lesion of the median raphe nucleus: a combined behavioral and microdialysis study in rats. Pharmacology, biochemistry, and behavior. vol 65. issue 1. 2000-01-28. PMID:10638630. |
using the in vivo microdialysis technique, the exposure of 5,7-dht-lesioned rats to the elevated plus-maze failed to increase extracellular 5-ht release (94%) in the hippocampus, as shown in sham-lesioned (150%) or untreated controls (194%). |
2000-01-28 |
2023-08-12 |
rat |
| H Thomas, H Fink, T R Sohr, M Voit. Lesion of the median raphe nucleus: a combined behavioral and microdialysis study in rats. Pharmacology, biochemistry, and behavior. vol 65. issue 1. 2000-01-28. PMID:10638630. |
evoked a 10-fold increase in hippocampal extracellular 5-ht levels in sham-lesioned animals, whereas in 5,7-dht lesioned rats 5-ht was only slightly increased. |
2000-01-28 |
2023-08-12 |
rat |
| W E Lyons, L A Mamounas, G A Ricaurte, V Coppola, S W Reid, S H Bora, C Wihler, V E Koliatsos, L Tessaroll. Brain-derived neurotrophic factor-deficient mice develop aggressiveness and hyperphagia in conjunction with brain serotonergic abnormalities. Proceedings of the National Academy of Sciences of the United States of America. vol 96. issue 26. 2000-01-27. PMID:10611369. |
however, young adult bdnf(+/-) mice show a blunted c-fos induction by the specific serotonin releaser-uptake inhibitor dexfenfluramine and alterations in the expression of several 5-ht receptors in the cortex, hippocampus, and hypothalamus. |
2000-01-27 |
2023-08-12 |
mouse |
| C Drogou, M Chennaoui, L Forestier, B Grimaldi, G Fillion, Y Guezenne. Application of the polymerase chain reaction to the RNase protection assay for 5-HT(1B) receptor mRNA levels measurement in rat brain tissues. Brain research. Brain research protocols. vol 4. issue 3. 2000-01-24. PMID:10592341. |
since the 5-ht(1b) receptors are the predominant auto- and heteroreceptors located on serotonergic and non-serotonergic terminals where they regulate the neuronal release of neurotransmitters and the protocol described here permits the determination of 5-ht(1b) receptor mrna levels in the rat cerebellum, striatum, hippocampus and frontal cortex, this protocol is helpful in understanding the involvement of 5-ht(1b) receptors in various physiological phenomena. |
2000-01-24 |
2023-08-12 |
rat |
| N Aguirre, M Barrionuevo, M J Ramírez, J Del Río, B Lashera. Alpha-lipoic acid prevents 3,4-methylenedioxy-methamphetamine (MDMA)-induced neurotoxicity. Neuroreport. vol 10. issue 17. 2000-01-19. PMID:10619665. |
), induced significant hyperthermia in rats and reduced 5-hydroxytryptamine (5-ht) content and [3h]paroxetine-labeled 5-ht transporter density in the frontal cortex, striatum and hippocampus by 40-60% 1 week later. |
2000-01-19 |
2023-08-12 |
rat |
| M Héry, A Sémont, M P Fache, M Faudon, F Hér. The effects of serotonin on glucocorticoid receptor binding in rat raphe nuclei and hippocampal cells in culture. Journal of neurochemistry. vol 74. issue 1. 2000-01-18. PMID:10617146. |
the effects of serotonin on glucocorticoid receptor binding in rat raphe nuclei and hippocampal cells in culture. |
2000-01-18 |
2023-08-12 |
rat |
| M Héry, A Sémont, M P Fache, M Faudon, F Hér. The effects of serotonin on glucocorticoid receptor binding in rat raphe nuclei and hippocampal cells in culture. Journal of neurochemistry. vol 74. issue 1. 2000-01-18. PMID:10617146. |
the purpose of this study was to determine and compare the roles of 5-ht in the regulation of glucocorticoid receptor (gr) binding in the raphe nuclei and in the hippocampus. |
2000-01-18 |
2023-08-12 |
rat |
| M Héry, A Sémont, M P Fache, M Faudon, F Hér. The effects of serotonin on glucocorticoid receptor binding in rat raphe nuclei and hippocampal cells in culture. Journal of neurochemistry. vol 74. issue 1. 2000-01-18. PMID:10617146. |
the effects of 5-ht, 5-ht agonists, and the 5-ht reuptake inhibitor citalopram on gr binding sites were studied in primary cultures of the fetal raphe nuclei and the hippocampus. |
2000-01-18 |
2023-08-12 |
rat |
| M Héry, A Sémont, M P Fache, M Faudon, F Hér. The effects of serotonin on glucocorticoid receptor binding in rat raphe nuclei and hippocampal cells in culture. Journal of neurochemistry. vol 74. issue 1. 2000-01-18. PMID:10617146. |
exposure of hippocampal cells to 5-ht, (+/-)-2,5-dimethoxy-4-iodoamphetamine (doi; a 5-ht2 agonist), or citalopram resulted in an increase in number of gr binding sites. |
2000-01-18 |
2023-08-12 |
rat |
| B D Youngblood, G N Smagin, P D Elkins, D H Ryan, R B Harri. The effects of paradoxical sleep deprivation and valine on spatial learning and brain 5-HT metabolism. Physiology & behavior. vol 67. issue 5. 2000-01-12. PMID:10604833. |
in contrast, the valine diet did not prevent increases in brain trp or 5-ht metabolism in remsd rats, and increased hypothalamic and brain stem trp concentrations and the hippocampal 5-hiaa/5-ht ratio in tc rats. |
2000-01-12 |
2023-08-12 |
rat |
| M K Osterlund, C Halldin, Y L Hur. Effects of chronic 17beta-estradiol treatment on the serotonin 5-HT(1A) receptor mRNA and binding levels in the rat brain. Synapse (New York, N.Y.). vol 35. issue 1. 2000-01-05. PMID:10579806. |
radioligand autoradiographic studies using the selective 5-ht(1a) receptor antagonist [(3)h]way-100635 revealed reduced receptor binding in the amygdala, hippocampus, perirhinal cortex, and motor cortex after estradiol treatment, whereas no changes were observed in the piriform or retrosplenial cortex. |
2000-01-05 |
2023-08-12 |
rat |
| T J Sexton, C McEvoy, J F Neumaie. (+) 3,4-methylenedioxymethamphetamine ('ecstasy') transiently increases striatal 5-HT1B binding sites without altering 5-HT1B mRNA in rat brain. Molecular psychiatry. vol 4. issue 6. 2000-01-03. PMID:10578240. |
[3h]-citalopram binding to serotonin transporters in hippocampus was reduced in the high dose protocol, indicating degeneration of forebrain serotonergic fibers. |
2000-01-03 |
2023-08-12 |
rat |
| S A Farr, K Uezu, J F Flood, J E Morle. Septo-hippocampal drug interactions in post-trial memory processing. Brain research. vol 847. issue 2. 1999-12-21. PMID:10575091. |
to determine if serotonin and gaba regulate post-trial memory processing of the cholinergic projection from the septum to the hippocampus, mice were trained on footshock avoidance in a t-maze. |
1999-12-21 |
2023-08-12 |
mouse |