| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| E Hajós-Korcsok, S F McTavish, T Shar. Effect of a selective 5-hydroxytryptamine reuptake inhibitor on brain extracellular noradrenaline: microdialysis studies using paroxetine. European journal of pharmacology. vol 407. issue 1-2. 2000-12-29. PMID:11050296. |
in summary, despite its selectivity as a 5-ht reuptake inhibitor, paroxetine increased extracellular levels of noradrenaline in rat hippocampus following repeated administration. |
2000-12-29 |
2023-08-12 |
rat |
| P J Kenny, S E File, M J Nea. Evidence for a complex influence of nicotinic acetylcholine receptors on hippocampal serotonin release. Journal of neurochemistry. vol 75. issue 6. 2000-12-28. PMID:11080192. |
evidence for a complex influence of nicotinic acetylcholine receptors on hippocampal serotonin release. |
2000-12-28 |
2023-08-12 |
rat |
| P J Kenny, S E File, M J Nea. Evidence for a complex influence of nicotinic acetylcholine receptors on hippocampal serotonin release. Journal of neurochemistry. vol 75. issue 6. 2000-12-28. PMID:11080192. |
the effects of nicotine on 5-hydroxytryptamine (5-ht) release from serotonergic nerve endings in rat dorsal hippocampal slices were studied. |
2000-12-28 |
2023-08-12 |
rat |
| P Rosel, B Arranz, L San, J Vallejo, J M Crespo, M Urretavizcaya, M A Navarr. Altered 5-HT(2A) binding sites and second messenger inositol trisphosphate (IP(3)) levels in hippocampus but not in frontal cortex from depressed suicide victims. Psychiatry research. vol 99. issue 3. 2000-12-27. PMID:11068198. |
altered 5-ht(2a) binding sites and second messenger inositol trisphosphate (ip(3)) levels in hippocampus but not in frontal cortex from depressed suicide victims. |
2000-12-27 |
2023-08-12 |
human |
| P Rosel, B Arranz, L San, J Vallejo, J M Crespo, M Urretavizcaya, M A Navarr. Altered 5-HT(2A) binding sites and second messenger inositol trisphosphate (IP(3)) levels in hippocampus but not in frontal cortex from depressed suicide victims. Psychiatry research. vol 99. issue 3. 2000-12-27. PMID:11068198. |
the binding parameters of 5-ht(2a) and levels of its second messenger, 1,4,5-trisphosphate (ip(3)), were simultaneously studied in frontal cortex and hippocampus from the brains of 18 control subjects and 18 depressed suicide victims. |
2000-12-27 |
2023-08-12 |
human |
| P Rosel, B Arranz, L San, J Vallejo, J M Crespo, M Urretavizcaya, M A Navarr. Altered 5-HT(2A) binding sites and second messenger inositol trisphosphate (IP(3)) levels in hippocampus but not in frontal cortex from depressed suicide victims. Psychiatry research. vol 99. issue 3. 2000-12-27. PMID:11068198. |
the reported results may indicate a significant hypersensitivity of the 5-ht(2a) postsynaptic receptor located in the hippocampus from depressed suicide victims, giving rise to an enhancement of its intracellular signaling system with higher ip(3) production. |
2000-12-27 |
2023-08-12 |
human |
| M J Millan, F Lejeune, A Gobert, M Brocco, A Auclair, C Bosc, J M Rivet, J M Lacoste, A Cordi, A Dekeyn. S18616, a highly potent spiroimidazoline agonist at alpha(2)-adrenoceptors: II. Influence on monoaminergic transmission, motor function, and anxiety in comparison with dexmedetomidine and clonidine. The Journal of pharmacology and experimental therapeutics. vol 295. issue 3. 2000-12-20. PMID:11082458. |
in freely moving rats, s18616 decreased extracellular levels of norepinephrine (ne), serotonin (5-ht), and dopamine (da) in frontal cortex and hippocampus. |
2000-12-20 |
2023-08-12 |
mouse |
| T D Smith, R Kuczenski, K George-Friedman, J D Malley, S L Foot. In vivo microdialysis assessment of extracellular serotonin and dopamine levels in awake monkeys during sustained fluoxetine administration. Synapse (New York, N.Y.). vol 38. issue 4. 2000-12-14. PMID:11044893. |
thus, the effects of chronic oral flu administration on neocortical and hippocampal ec 5-ht, and on caudate ec 5-ht and dopamine (da), were examined in awake monkeys (macaca fascicularis) using in vivo microdialysis (10.0 mg/kg; 3, 7, 14, and 21 days). |
2000-12-14 |
2023-08-12 |
monkey |
| T D Smith, R Kuczenski, K George-Friedman, J D Malley, S L Foot. In vivo microdialysis assessment of extracellular serotonin and dopamine levels in awake monkeys during sustained fluoxetine administration. Synapse (New York, N.Y.). vol 38. issue 4. 2000-12-14. PMID:11044893. |
on day 3, 5-ht was significantly increased above baseline levels in hippocampus (hc) and caudate. |
2000-12-14 |
2023-08-12 |
monkey |
| H Inou. Effects of naltrexone on the accumulation of L-3, 4-dihydroxyphenylalanine and 5-hydroxy-L-tryptophan and on the firing rate induced by acute ethanol administration. European journal of pharmacology. vol 406. issue 3. 2000-12-11. PMID:11040344. |
the widespread inhibitory action of naltrexone also decreased the ethanol-induced stimulation of hippocampal serotonin synthesis. |
2000-12-11 |
2023-08-12 |
rat |
| B S McEwe. Effects of adverse experiences for brain structure and function. Biological psychiatry. vol 48. issue 8. 2000-12-07. PMID:11063969. |
both forms of structural remodeling of the hippocampus appear to be reversible and are mediated by glucocorticoid hormones working in concert with excitatory amino acids (eaa) and n-methyl-d-aspartate (nmda) receptors, along with transmitters such as serotonin and the gaba-benzodiazepine system. |
2000-12-07 |
2023-08-12 |
human |
| S Nakad. [Effects of (+/-)-pindolol over increased extracellular 5-HT level induced by fluvoxamine: regional difference in effect among the raphe, dorsal hippocampus and prefrontal cortex as measured by in vivo microdialysis technique]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. vol 20. issue 2. 2000-11-30. PMID:11062862. |
[effects of (+/-)-pindolol over increased extracellular 5-ht level induced by fluvoxamine: regional difference in effect among the raphe, dorsal hippocampus and prefrontal cortex as measured by in vivo microdialysis technique]. |
2000-11-30 |
2023-08-12 |
rat |
| S Nakad. [Effects of (+/-)-pindolol over increased extracellular 5-HT level induced by fluvoxamine: regional difference in effect among the raphe, dorsal hippocampus and prefrontal cortex as measured by in vivo microdialysis technique]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. vol 20. issue 2. 2000-11-30. PMID:11062862. |
we have used freely moving rats to measure the extracellular level of 5-ht and dopamine (da) in the raphe, dorsal hippocampus and prefrontal cortex using an in vivo microdialysis technique. |
2000-11-30 |
2023-08-12 |
rat |
| Y Shirayama, K Hashimoto, M Iyo, K Watanabe, T Higuchi, Y Minab. 3,4-methylenedioxymethamphetamine (MDMA, ecstasy)-induced egr-1 mRNA in rat brain: pharmacological manipulation. European journal of pharmacology. vol 402. issue 3. 2000-11-28. PMID:10958887. |
furthermore, the expression of egr-1 mrna in the prefrontal cortex, striatum and hippocampal dentate gyrus after administration of mdma (10 mg/kg) was blocked significantly by pretreatment with nmda receptor antagonist (5r, 10s)-(+)-5-methyl-10,11-dihydro-5h-dibenzo[a,b]-cyclohepten-5, 10-imine ((+)-mk801; 1 mg/kg), dopamine d(1) receptor antagonist sch 23390 (1 mg/kg) or 5-ht uptake inhibitor paroxetine (5 mg/kg), but not by 5-ht(2a) receptor antagonist sr46349b (5 mg/kg). |
2000-11-28 |
2023-08-12 |
rat |
| Y Shirayama, K Hashimoto, M Iyo, K Watanabe, T Higuchi, Y Minab. 3,4-methylenedioxymethamphetamine (MDMA, ecstasy)-induced egr-1 mRNA in rat brain: pharmacological manipulation. European journal of pharmacology. vol 402. issue 3. 2000-11-28. PMID:10958887. |
these results suggest that mdma alters the expression of egr-1 mrna in several regions of rat brain, and that the expression of egr-1 mrna by mdma in the prefrontal cortex, striatum and hippocampal dentate gyrus appears to be mediated, at least in part, by nmda receptor, dopamine d(1) receptor and 5-ht transporter. |
2000-11-28 |
2023-08-12 |
rat |
| C Hébert, A Habimana, R Elie, T A Reade. Effects of chronic antidepressant treatments on 5-HT and NA transporters in rat brain: an autoradiographic study. Neurochemistry international. vol 38. issue 1. 2000-11-20. PMID:10913689. |
identified cortical areas, hippocampal divisions and nuclei raphe dorsalis, raphe medialis and locus coeruleus were examined by quantitative autoradiography using either [3h]citalopram to label 5-ht transporters, or [3h]nisoxetine for na uptake sites. |
2000-11-20 |
2023-08-12 |
rat |
| F Chaoulof. Serotonin, stress and corticoids. Journal of psychopharmacology (Oxford, England). vol 14. issue 2. 2000-11-16. PMID:10890308. |
the aim of the present review is to provide an overview of the effects of different acute and repeated/chronic stressors on serotonin (5-ht) release and reuptake, extracellular 5-ht levels, and 5-ht pre- and postsynaptic receptors in areas tightly linked to the control of fear and anxiety, namely the dorsal and median raphe nuclei, the frontal cortex, the amygdala and the hippocampus. |
2000-11-16 |
2023-08-12 |
human |
| S Hjorth, H J Bengtsson, A Kullberg, D Carlzon, H Peilot, S B Auerbac. Serotonin autoreceptor function and antidepressant drug action. Journal of psychopharmacology (Oxford, England). vol 14. issue 2. 2000-11-16. PMID:10890313. |
in particular, emerging data suggest that somatodendritic 5-ht1a autoreceptor- and nerve terminal 5-ht1b autoreceptor-mediated feedback may be relatively more important in the control of 5-ht output in dorsal raphe-frontal cortex and median raphe-dorsal hippocampus systems, respectively. |
2000-11-16 |
2023-08-12 |
rat |
| J A Casal, M D Corzo, L F Pérez, J A Alvarez, M Aldegunde, J C Tuto. Pharmacological modification of the serotonergic transmitter system and beta-N-acetylhexosaminidase activity in rats. Life sciences. vol 67. issue 19. 2000-11-16. PMID:11065183. |
in the group of animals treated with 5-hydroxytryptophan, in the different dissected brain regions (brain stem, cortex and hippocampus) significantly higher levels of serotonin and 5-hydroxyindolacetic acid were found, and significantly lower in the group treated with p-chlorophenylalanine, than in the control group. |
2000-11-16 |
2023-08-12 |
rat |
| E Consogno, C Dorigo, G Racagni, M Popol. Modification of presynaptic CaM kinase II affinity for ATP in hippocampus after long term blockade of serotonin reuptake. Life sciences. vol 67. issue 16. 2000-11-15. PMID:11072872. |
modification of presynaptic cam kinase ii affinity for atp in hippocampus after long term blockade of serotonin reuptake. |
2000-11-15 |
2023-08-12 |
Not clear |