| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J F Neumaier, T J Sexton, M W Hamblin, S G Bec. Corticosteroids regulate 5-HT(1A) but not 5-HT(1B) receptor mRNA in rat hippocampus. Brain research. Molecular brain research. vol 82. issue 1-2. 2001-02-22. PMID:11042358. |
5-ht(1a) and 5-ht(1b) mrnas were measured by in situ hybridization in hippocampus and raphe nuclei. |
2001-02-22 |
2023-08-12 |
rat |
| J F Neumaier, T J Sexton, M W Hamblin, S G Bec. Corticosteroids regulate 5-HT(1A) but not 5-HT(1B) receptor mRNA in rat hippocampus. Brain research. Molecular brain research. vol 82. issue 1-2. 2001-02-22. PMID:11042358. |
none of the experimental manipulations altered 5-ht(1b) mrna levels in the hippocampus or dorsal raphe, and also had no effect on 5-ht(1a) mrna in dorsal or median raphe. |
2001-02-22 |
2023-08-12 |
rat |
| J F Neumaier, T J Sexton, M W Hamblin, S G Bec. Corticosteroids regulate 5-HT(1A) but not 5-HT(1B) receptor mRNA in rat hippocampus. Brain research. Molecular brain research. vol 82. issue 1-2. 2001-02-22. PMID:11042358. |
however, 5-ht(1a) mrna levels were regulated in a complex manner in the different subfields of hippocampus. |
2001-02-22 |
2023-08-12 |
rat |
| J F Neumaier, T J Sexton, M W Hamblin, S G Bec. Corticosteroids regulate 5-HT(1A) but not 5-HT(1B) receptor mRNA in rat hippocampus. Brain research. Molecular brain research. vol 82. issue 1-2. 2001-02-22. PMID:11042358. |
we conclude that both mr and gr play an integrated role in regulating 5-ht(1a) mrna levels in hippocampus while having no effect on 5-ht(1b) mrna levels under these conditions. |
2001-02-22 |
2023-08-12 |
rat |
| Q Li, C Wichems, A Heils, K P Lesch, D L Murph. Reduction in the density and expression, but not G-protein coupling, of serotonin receptors (5-HT1A) in 5-HT transporter knock-out mice: gender and brain region differences. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 21. 2001-02-22. PMID:11050108. |
5-ht(1a) receptor mrna was reduced significantly in the dorsal raphe region, but not in the hypothalamus or hippocampus, of female 5-htt +/- and 5-htt -/- mice. |
2001-02-22 |
2023-08-12 |
mouse |
| N Jolimay, L Franck, X Langlois, M Hamon, M Darmo. Dominant role of the cytosolic C-terminal domain of the rat 5-HT1B receptor in axonal-apical targeting. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 24. 2001-02-22. PMID:11124988. |
in the present study, the role of the cytosolic c-terminal tail of the receptors was further investigated by transfecting truncated receptors and 5-ht(1a)r/5-ht(1b)r chimeras in both the epithelial llc-pk1 cells and rat hippocampal neurons in primary culture. |
2001-02-22 |
2023-08-12 |
rat |
| N Jolimay, L Franck, X Langlois, M Hamon, M Darmo. Dominant role of the cytosolic C-terminal domain of the rat 5-HT1B receptor in axonal-apical targeting. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 24. 2001-02-22. PMID:11124988. |
in addition, a domain within the third intracytoplasmic loop of the 5-ht(1b)r, responsible for its golgi sequestration in llc-pk1 cells, appeared to act as another axonal targeting signal in hippocampal neurons. |
2001-02-22 |
2023-08-12 |
rat |
| A Dekeyne, M Brocco, A Adhumeau, A Gobert, M J Milla. The selective serotonin (5-HT)1A receptor ligand, S15535, displays anxiolytic-like effects in the social interaction and Vogel models and suppresses dialysate levels of 5-HT in the dorsal hippocampus of freely-moving rats. A comparison with other anxiolytic agents. Psychopharmacology. vol 152. issue 1. 2001-02-15. PMID:11041316. |
the selective serotonin (5-ht)1a receptor ligand, s15535, displays anxiolytic-like effects in the social interaction and vogel models and suppresses dialysate levels of 5-ht in the dorsal hippocampus of freely-moving rats. |
2001-02-15 |
2023-08-12 |
rat |
| M B Assié, W Koe. Estimation of apparent pA2 values for WAY 100635 at 5-HT1A receptors regulating 5-hydroxytryptamine release in anaesthetised rats. European journal of pharmacology. vol 409. issue 2. 2001-02-15. PMID:11104831. |
the present study was aimed at estimating apparent pa2 values for way 100635 to antagonise 5-ht1a receptor agonist-induced decrease in 5-ht release in rat hippocampus. |
2001-02-15 |
2023-08-12 |
rat |
| M B Assié, W Koe. Estimation of apparent pA2 values for WAY 100635 at 5-HT1A receptors regulating 5-hydroxytryptamine release in anaesthetised rats. European journal of pharmacology. vol 409. issue 2. 2001-02-15. PMID:11104831. |
administration of cumulative doses of (+/-)-8-hydroxy-2-(di-n-propylamino)tetralin (8-oh-dpat) (0.01-40 mg/kg), 1[2-(4-fluorobenzoylamino)ethyl]-4-(7-methoxynaphtyl)pipe razine (s 14506) (0.00063-2.5 mg/kg), or buspirone (0.16-40 mg/kg), dose-dependently decreased the extracellular concentrations of 5-ht in the ventral hippocampus. |
2001-02-15 |
2023-08-12 |
rat |
| Z Sarnyai, E L Sibille, C Pavlides, R J Fenster, B S McEwen, M Tot. Impaired hippocampal-dependent learning and functional abnormalities in the hippocampus in mice lacking serotonin(1A) receptors. Proceedings of the National Academy of Sciences of the United States of America. vol 97. issue 26. 2001-02-15. PMID:11121072. |
impaired hippocampal-dependent learning and functional abnormalities in the hippocampus in mice lacking serotonin(1a) receptors. |
2001-02-15 |
2023-08-12 |
mouse |
| Z Sarnyai, E L Sibille, C Pavlides, R J Fenster, B S McEwen, M Tot. Impaired hippocampal-dependent learning and functional abnormalities in the hippocampus in mice lacking serotonin(1A) receptors. Proceedings of the National Academy of Sciences of the United States of America. vol 97. issue 26. 2001-02-15. PMID:11121072. |
the hippocampus is a major limbic target of the brainstem serotonergic neurons that modulate fear, anxiety, and learning through postsynaptic serotonin(1a) receptors (5-ht(1a) receptors). |
2001-02-15 |
2023-08-12 |
mouse |
| Z Sarnyai, E L Sibille, C Pavlides, R J Fenster, B S McEwen, M Tot. Impaired hippocampal-dependent learning and functional abnormalities in the hippocampus in mice lacking serotonin(1A) receptors. Proceedings of the National Academy of Sciences of the United States of America. vol 97. issue 26. 2001-02-15. PMID:11121072. |
because chronic stress selectively down-regulates the 5-ht(1a) receptors in the hippocampus, we hypothesized that mice lacking these receptors may exhibit abnormalities reminiscent of symptoms of stress-related psychiatric disorders. |
2001-02-15 |
2023-08-12 |
mouse |
| Z Sarnyai, E L Sibille, C Pavlides, R J Fenster, B S McEwen, M Tot. Impaired hippocampal-dependent learning and functional abnormalities in the hippocampus in mice lacking serotonin(1A) receptors. Proceedings of the National Academy of Sciences of the United States of America. vol 97. issue 26. 2001-02-15. PMID:11121072. |
in particular, a hippocampal deficit in the 5-ht(1a) receptor could contribute to the cognitive abnormalities often seen in these disorders. |
2001-02-15 |
2023-08-12 |
mouse |
| Z Sarnyai, E L Sibille, C Pavlides, R J Fenster, B S McEwen, M Tot. Impaired hippocampal-dependent learning and functional abnormalities in the hippocampus in mice lacking serotonin(1A) receptors. Proceedings of the National Academy of Sciences of the United States of America. vol 97. issue 26. 2001-02-15. PMID:11121072. |
to test whether a deficit in 5-ht(1a) receptors impairs hippocampus-related functions, we studied hippocampal-dependent learning and memory, synaptic plasticity in the hippocampus, and limbic neuronal excitability in 5-ht(1a)-knockout (ko) mice. |
2001-02-15 |
2023-08-12 |
mouse |
| Z Sarnyai, E L Sibille, C Pavlides, R J Fenster, B S McEwen, M Tot. Impaired hippocampal-dependent learning and functional abnormalities in the hippocampus in mice lacking serotonin(1A) receptors. Proceedings of the National Academy of Sciences of the United States of America. vol 97. issue 26. 2001-02-15. PMID:11121072. |
furthermore, paired-pulse facilitation in the dentate gyrus of the hippocampus was impaired in 5-ht(1a)-ko mice. |
2001-02-15 |
2023-08-12 |
mouse |
| Z Sarnyai, E L Sibille, C Pavlides, R J Fenster, B S McEwen, M Tot. Impaired hippocampal-dependent learning and functional abnormalities in the hippocampus in mice lacking serotonin(1A) receptors. Proceedings of the National Academy of Sciences of the United States of America. vol 97. issue 26. 2001-02-15. PMID:11121072. |
these results demonstrate that 5-ht(1a) receptors are required for maintaining normal hippocampal functions and implicate a role for the 5-ht(1a) receptor in hippocampal-related symptoms, such as cognitive disturbances, in stress-related disorders. |
2001-02-15 |
2023-08-12 |
mouse |
| C P Bopaiah, N Pradhan, B S Venkatara. Pharmacological study on antidepressant activity of 50% ethanol extract of a formulated ayurvedic product in rats. Journal of ethnopharmacology. vol 72. issue 3. 2001-02-08. PMID:10996280. |
the effects on the forced swimming test were assessed along with the levels of dopamine (da), serotonin (5-ht) and its metabolites homovanillic acid (hva) and 5-hydroxyindoleaceticacid (5-hiaa) in striatum, frontal cortex, hippocampus, hypothalamus and brain stem after 21 days of chronic oral administration of the extract (500 and 1500 mg/kg-body weight). |
2001-02-08 |
2023-08-12 |
rat |
| C P Bopaiah, N Pradhan, B S Venkatara. Pharmacological study on antidepressant activity of 50% ethanol extract of a formulated ayurvedic product in rats. Journal of ethnopharmacology. vol 72. issue 3. 2001-02-08. PMID:10996280. |
the 500 mg/kg extract treated group had significantly increased the levels of da in frontal cortex, hypothalamus and hippocampus whereas the 5-ht in hypothalamus (p<0.05). |
2001-02-08 |
2023-08-12 |
rat |
| D H Kim, J S Jung, J J Yan, H W Suh, B K Son, Y H Kim, D K Son. Increased plasma corticosterone, aggressiveness and brain monoamine changes induced by central injection of pertussis toxin. European journal of pharmacology. vol 409. issue 1. 2001-02-08. PMID:11099701. |
brain monoamines and their metabolites levels were changed on day 1 and 6 after pertussis toxin injection (0.2 microg/mouse): in the hypothalamus, levels of dopamine and 3,4-dihydroxyphenylacetic acid were increased, norepinephrine level decreased, and 5-hydroxyindole acetic acid (5-hiaa) level was markedly increased, with no changes in 5-hydroxytryptamine (5-ht) level, whereas in the hippocampus, 5-ht level was significantly decreased, with no changes in 5-hiaa and catecholamines. |
2001-02-08 |
2023-08-12 |
mouse |