| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A L Mize, A M Poisner, R H Alpe. Estrogens act in rat hippocampus and frontal cortex to produce rapid, receptor-mediated decreases in serotonin 5-HT(1A) receptor function. Neuroendocrinology. vol 73. issue 3. 2001-06-21. PMID:11307035. |
studies were designed to determine if 17beta-estradiol also acts in vitro on estrogen receptors in the hippocampus and frontal cortex to decrease 5-ht(1a) receptor function. |
2001-06-21 |
2023-08-12 |
rat |
| A L Mize, A M Poisner, R H Alpe. Estrogens act in rat hippocampus and frontal cortex to produce rapid, receptor-mediated decreases in serotonin 5-HT(1A) receptor function. Neuroendocrinology. vol 73. issue 3. 2001-06-21. PMID:11307035. |
the nonestradiol estrogen diethylstilbestrol also decreased 5-ht(1a) receptor function while the less potent estrogens 17alpha-estradiol and estriol were inactive at 5 x 10(-8) m. the estrogen receptor antagonist ici 182,780 potently and completely blocked the effects of 17beta-estradiol on 5-ht(1a) receptor function with an apparent k(b) of approximately 10(-9) m. these data demonstrate clearly that estrogens can act on estrogen receptors located in hippocampus and frontal cortex of ovariectomized rats to produce rapid heterologous decreases in 5-ht(1a) receptor function. |
2001-06-21 |
2023-08-12 |
rat |
| C Mannoury la Cour, C Boni, N Hanoun, K P Lesch, M Hamon, L Lanfume. Functional consequences of 5-HT transporter gene disruption on 5-HT(1a) receptor-mediated regulation of dorsal raphe and hippocampal cell activity. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 6. 2001-06-07. PMID:11245702. |
functional consequences of 5-ht transporter gene disruption on 5-ht(1a) receptor-mediated regulation of dorsal raphe and hippocampal cell activity. |
2001-06-07 |
2023-08-12 |
mouse |
| C Mannoury la Cour, C Boni, N Hanoun, K P Lesch, M Hamon, L Lanfume. Functional consequences of 5-HT transporter gene disruption on 5-HT(1a) receptor-mediated regulation of dorsal raphe and hippocampal cell activity. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 6. 2001-06-07. PMID:11245702. |
the consequences of the absence of 5-ht reuptake on the functional properties of 5-ht(1a) receptors were examined in the dorsal raphe nucleus and the hippocampus of knock-out mice lacking the serotonin transporter (5-htt). |
2001-06-07 |
2023-08-12 |
mouse |
| C Mannoury la Cour, C Boni, N Hanoun, K P Lesch, M Hamon, L Lanfume. Functional consequences of 5-HT transporter gene disruption on 5-HT(1a) receptor-mediated regulation of dorsal raphe and hippocampal cell activity. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 6. 2001-06-07. PMID:11245702. |
these data showed that 5-htt gene knock-out induced a marked desensitization of 5-ht(1a) autoreceptors in the dorsal raphe nucleus without altering postsynaptic 5-ht(1a) receptor functioning in the hippocampus. |
2001-06-07 |
2023-08-12 |
mouse |
| C Becamel, A Figge, S Poliak, A Dumuis, E Peles, J Bockaert, H Lubbert, C Ullme. Interaction of serotonin 5-hydroxytryptamine type 2C receptors with PDZ10 of the multi-PDZ domain protein MUPP1. The Journal of biological chemistry. vol 276. issue 16. 2001-05-31. PMID:11150294. |
the highest mupp1 mrna levels were found in all cerebral cortical layers, the hippocampus, the granular layer of the dentate gyrus, as well as the choroid plexus, where 5-ht(2c) receptors are highly enriched. |
2001-05-31 |
2023-08-12 |
rat |
| A Romaniuk, M Koprowska, M Krotewicz, M Strzelczuk, M Wieczore. Effects of 8-OHDPAT administration into the dorsal raphe nucleus and dorsal hippocampus on fear behavior and regional brain monoamines distribution in rats. Behavioural brain research. vol 120. issue 1. 2001-05-31. PMID:11173084. |
the effects of r(+)-8-hydroxy-dipropylaminotetralin (8-ohdpat) administration into the dorsal raphe nucleus (drn) or bilaterally into the dorsal hippocampus (hip) on fear behavior in a modified version of the light-dark transitions test and regional brain monoamines (na, da, 5-ht) and their metabolites (mhpg, dopac, 5-hiaa) in the hypothalamus, midbrain central gray matter, amygdala, hippocampus and pons were examined. |
2001-05-31 |
2023-08-12 |
rat |
| A Romaniuk, M Koprowska, M Krotewicz, M Strzelczuk, M Wieczore. Effects of 8-OHDPAT administration into the dorsal raphe nucleus and dorsal hippocampus on fear behavior and regional brain monoamines distribution in rats. Behavioural brain research. vol 120. issue 1. 2001-05-31. PMID:11173084. |
hplc analysis showed reduction of 5-ht content in the midbrain and amygdala, reduction of 5-hiaa content in pons, increased 5-hiaa/5-ht ratio in the hippocampus and increased dopac/da ratio in the hypothalamus, midbrain, hippocampus and pons without affecting the mhpg/na ratio and na content. |
2001-05-31 |
2023-08-12 |
rat |
| K Tekes, K Magya. Effect of MAO inhibitors on the high-affinity reuptake of biogenic amines in rat subcortical regions. Neurobiology (Budapest, Hungary). vol 8. issue 3-4. 2001-05-31. PMID:11225517. |
hippocampal 5ht reuptake was slightly inhibited by clorgyline (ic50 205.0 mumol/l), while the other mao-inhibitors were devoid of potency. |
2001-05-31 |
2023-08-12 |
rat |
| E E Irvine, S Cheeta, S E Fil. Development of tolerance to nicotine's anxiogenic effect in the social interaction test. Brain research. vol 894. issue 1. 2001-05-31. PMID:11245819. |
this suggests that tolerance to the anxiogenic effect of nicotine administered into the dorsal hippocampus could be mediated by a reduction in the nicotine enhancement of 5-ht release in this area. |
2001-05-31 |
2023-08-12 |
rat |
| B Mirnikjoo, S E Brown, H F Kim, L B Marangell, J D Sweatt, E J Weebe. Protein kinase inhibition by omega-3 fatty acids. The Journal of biological chemistry. vol 276. issue 14. 2001-05-24. PMID:11152679. |
we found that omega-3 fatty acids could prevent serotonin receptor-induced mapk activation in hippocampal slice preparations. |
2001-05-24 |
2023-08-12 |
Not clear |
| D Gomez-Merino, F Béquet, M Berthelot, M Chennaoui, C Y Guezenne. Site-dependent effects of an acute intensive exercise on extracellular 5-HT and 5-HIAA levels in rat brain. Neuroscience letters. vol 301. issue 2. 2001-05-24. PMID:11248443. |
this in vivo microdialysis study is the first to examine the impact of an acute intensive treadmill running (2 h at 25 m.min(-1), which is close to exhaustion time), on extracellular 5-hydroxytryptamine (5-ht) and 5-hydroxyindoleacetic acid (5-hiaa) levels in two different brain areas in rats, the ventral hippocampus and the frontal cortex. |
2001-05-24 |
2023-08-12 |
rat |
| D Gomez-Merino, F Béquet, M Berthelot, M Chennaoui, C Y Guezenne. Site-dependent effects of an acute intensive exercise on extracellular 5-HT and 5-HIAA levels in rat brain. Neuroscience letters. vol 301. issue 2. 2001-05-24. PMID:11248443. |
hippocampal and cortical 5-ht levels increased significantly after 90 min of exercise and were maximal in the first 30 min of recovery. |
2001-05-24 |
2023-08-12 |
rat |
| D Gomez-Merino, F Béquet, M Berthelot, M Chennaoui, C Y Guezenne. Site-dependent effects of an acute intensive exercise on extracellular 5-HT and 5-HIAA levels in rat brain. Neuroscience letters. vol 301. issue 2. 2001-05-24. PMID:11248443. |
thereafter, cortical 5-ht levels followed a rapid and significant decrease when hippocampal levels are still maximal. |
2001-05-24 |
2023-08-12 |
rat |
| J Segieth, B Pearce, L Fowler, P S Whitto. Regulatory role of nitric oxide over hippocampal 5-HT release in vivo. Naunyn-Schmiedeberg's archives of pharmacology. vol 363. issue 3. 2001-05-24. PMID:11284445. |
regulatory role of nitric oxide over hippocampal 5-ht release in vivo. |
2001-05-24 |
2023-08-12 |
rat |
| J Segieth, B Pearce, L Fowler, P S Whitto. Regulatory role of nitric oxide over hippocampal 5-HT release in vivo. Naunyn-Schmiedeberg's archives of pharmacology. vol 363. issue 3. 2001-05-24. PMID:11284445. |
previous work has shown that n-methyl-d-aspartate (nmda) receptor activation decreases 5-hydroxytryptamine (5-ht) release in the hippocampus of freely moving rats. |
2001-05-24 |
2023-08-12 |
rat |
| J Segieth, B Pearce, L Fowler, P S Whitto. Regulatory role of nitric oxide over hippocampal 5-HT release in vivo. Naunyn-Schmiedeberg's archives of pharmacology. vol 363. issue 3. 2001-05-24. PMID:11284445. |
given the association between nmda receptor function and nitric oxide (no) production with the regulation of 5-ht release in other brain regions, we have studied this in rat hippocampus. |
2001-05-24 |
2023-08-12 |
rat |
| J Segieth, B Pearce, L Fowler, P S Whitto. Regulatory role of nitric oxide over hippocampal 5-HT release in vivo. Naunyn-Schmiedeberg's archives of pharmacology. vol 363. issue 3. 2001-05-24. PMID:11284445. |
nmda (100 microm) decreased hippocampal 5-ht release by approximately 70% and this was reversed by the nmda receptor antagonist 2-amino-5-phosphonopentanoic acid (ap5; 10 microm). |
2001-05-24 |
2023-08-12 |
rat |
| J Segieth, B Pearce, L Fowler, P S Whitto. Regulatory role of nitric oxide over hippocampal 5-HT release in vivo. Naunyn-Schmiedeberg's archives of pharmacology. vol 363. issue 3. 2001-05-24. PMID:11284445. |
our data support a role for no in modulating both basal and nmda-evoked changes in 5-ht release in the hippocampus, however, the association appears to be complex. |
2001-05-24 |
2023-08-12 |
rat |
| S Hayley, T Borowski, Z Merali, H Anisma. Central monoamine activity in genetically distinct strains of mice following a psychogenic stressor: effects of predator exposure. Brain research. vol 892. issue 2. 2001-05-17. PMID:11172776. |
likewise, the 5-ht metabolite, 5-hiaa, was elevated in hippocampus, prefrontal cortex and central amygdala, and to some extent dopac accumulation was increased in the prefrontal cortex. |
2001-05-17 |
2023-08-12 |
mouse |