| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Y Kawata, M Okada, T Murakami, A Kamata, G Zhu, S Kanek. Pharmacological discrimination between effects of carbamazepine on hippocampal basal, Ca(2+)- and K(+)-evoked serotonin release. British journal of pharmacology. vol 133. issue 4. 2001-08-23. PMID:11399673. |
to elucidate mechanisms of hippocampal serotonin release and possible mechanisms of clinical action of carbamazepine (cbz), we determined interaction between antagonists of n-type (omega-conotoxin gvia:gvia), p-type (omega-agatoxin iva:iva) ca(2+) channels, na(+) channel (tetrodotoxin: ttx) and cbz on hippocampal basal, ca(2+)- and k(+)-evoked serotonin releases, using microdialysis in freely moving rats. |
2001-08-23 |
2023-08-12 |
rat |
| S Hume, E Hirani, J Opacka-Juffry, R Myers, C Townsend, V Pike, P Grasb. Effect of 5-HT on binding of [(11)C] WAY 100635 to 5-HT(IA) receptors in rat brain, assessed using in vivo microdialysis nd PET after fenfluramine. Synapse (New York, N.Y.). vol 41. issue 2. 2001-08-23. PMID:11400181. |
resulted in a approximately 5-fold increase in extracellular 5-ht in medial prefrontal cortex and a approximately 15-fold increase in lateral hippocampus, maximal at approximately 40 min after injection. |
2001-08-23 |
2023-08-12 |
human |
| C Rocher, A M Gardie. Effects of repeated systemic administration of d-Fenfluramine on serotonin and glutamate release in rat ventral hippocampus: comparison with methamphetamine using in vivo microdialysis. Naunyn-Schmiedeberg's archives of pharmacology. vol 363. issue 4. 2001-08-16. PMID:11330336. |
effects of repeated systemic administration of d-fenfluramine on serotonin and glutamate release in rat ventral hippocampus: comparison with methamphetamine using in vivo microdialysis. |
2001-08-16 |
2023-08-12 |
rat |
| C Rocher, A M Gardie. Effects of repeated systemic administration of d-Fenfluramine on serotonin and glutamate release in rat ventral hippocampus: comparison with methamphetamine using in vivo microdialysis. Naunyn-Schmiedeberg's archives of pharmacology. vol 363. issue 4. 2001-08-16. PMID:11330336. |
at 2-h intervals, simultaneously on extracellular levels of glutamate [gluext] and 5-ht [5-htext] in the ventral hippocampus (vhpc) using in vivo microdialysis in conscious rats. |
2001-08-16 |
2023-08-12 |
rat |
| C Rocher, A M Gardie. Effects of repeated systemic administration of d-Fenfluramine on serotonin and glutamate release in rat ventral hippocampus: comparison with methamphetamine using in vivo microdialysis. Naunyn-Schmiedeberg's archives of pharmacology. vol 363. issue 4. 2001-08-16. PMID:11330336. |
these data highlight marked in vivo differences between meth and d-fenfluramine in their effects on extracellular levels of 5-ht and glu in the rat ventral hippocampus following their repeated systemic administration. |
2001-08-16 |
2023-08-12 |
rat |
| J Sprouse, J Braselton, L Reynolds, T Clarke, H Rollem. Activation of postsynaptic 5-HT(1A) receptors by fluoxetine despite the loss of firing-dependent serotonergic input: electrophysiological and neurochemical studies. Synapse (New York, N.Y.). vol 41. issue 1. 2001-08-09. PMID:11354013. |
within the same dose range, increases in hippocampal extracellular 5-ht approaching 300% above basal levels were achieved. |
2001-08-09 |
2023-08-12 |
Not clear |
| J Sprouse, J Braselton, L Reynolds, T Clarke, H Rollem. Activation of postsynaptic 5-HT(1A) receptors by fluoxetine despite the loss of firing-dependent serotonergic input: electrophysiological and neurochemical studies. Synapse (New York, N.Y.). vol 41. issue 1. 2001-08-09. PMID:11354013. |
both the changes in hippocampal neuronal activity and extracellular 5-ht are evident at doses of fluoxetine in excess of that required to inhibit dorsal raphe cell firing (ed(50) = 1.1 mg/kg i.v.). |
2001-08-09 |
2023-08-12 |
Not clear |
| M J Millan, A Gobert, F Lejeune, A Newman-Tancredi, J M Rivet, A Auclair, J L Peglio. S33005, a novel ligand at both serotonin and norepinephrine transporters: I. Receptor binding, electrophysiological, and neurochemical profile in comparison with venlafaxine, reboxetine, citalopram, and clomipramine. The Journal of pharmacology and experimental therapeutics. vol 298. issue 2. 2001-08-09. PMID:11454918. |
in hippocampus, levels of 5-ht and ne were similarly elevated, while in nucleus accumbens and striatum, levels of 5-ht were increased whereas da was unaffected. |
2001-08-09 |
2023-08-12 |
human |
| A M Gardier, A C Trillat, I Malagié, D David, M Hascoët, M C Colombel, P Jolliet, C Jacquot, R Hen, M Bouri. [5-HT1B serotonin receptors and antidepressant effects of selective serotonin reuptake inhibitors ]. Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie. vol 324. issue 5. 2001-08-02. PMID:11417564. |
increased extracellular serotonin levels [5-ht]ext in the ventral hippocampus and frontal cortex of wild-type and mutant mice. |
2001-08-02 |
2023-08-12 |
mouse |
| A M Gardier, A C Trillat, I Malagié, D David, M Hascoët, M C Colombel, P Jolliet, C Jacquot, R Hen, M Bouri. [5-HT1B serotonin receptors and antidepressant effects of selective serotonin reuptake inhibitors ]. Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie. vol 324. issue 5. 2001-08-02. PMID:11417564. |
however, in the ventral hippocampus, paroxetine at the two doses studied induced a larger increase in [5-ht]ext in knockout than in wild-type mice. |
2001-08-02 |
2023-08-12 |
mouse |
| A M Gardier, A C Trillat, I Malagié, D David, M Hascoët, M C Colombel, P Jolliet, C Jacquot, R Hen, M Bouri. [5-HT1B serotonin receptors and antidepressant effects of selective serotonin reuptake inhibitors ]. Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie. vol 324. issue 5. 2001-08-02. PMID:11417564. |
in addition, either the absence of the 5-ht1b receptor or its blockade with the mixed 5-ht1b/1d receptor antagonist, gr 127935, potentiates the effect of a single administration of paroxetine on [5-ht]ext more in the ventral hippocampus than in the frontal cortex. |
2001-08-02 |
2023-08-12 |
mouse |
| A M Gardier, A C Trillat, I Malagié, D David, M Hascoët, M C Colombel, P Jolliet, C Jacquot, R Hen, M Bouri. [5-HT1B serotonin receptors and antidepressant effects of selective serotonin reuptake inhibitors ]. Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie. vol 324. issue 5. 2001-08-02. PMID:11417564. |
taken together these data demonstrate that 5-ht1b autoreceptors appear to limit the effects of ssri on dialysate 5-ht levels particularly in the hippocampus while presynaptic 5-ht1b heteroreceptors are likely to be required for the antidepressant activity of ssris. |
2001-08-02 |
2023-08-12 |
mouse |
| G Milligan, E Kellett, C Dacquet, V Dubreuil, E Jacoby, M J Millan, G Lavielle, M Speddin. S 14506: novel receptor coupling at 5-HT(1A) receptors. Neuropharmacology. vol 40. issue 3. 2001-07-19. PMID:11166326. |
in hippocampal membranes, the specific binding of [(3)h]-s 14506 (k(d)=0.79+/-0.2 nm; b(max)=400+/-32 fmol/mg protein) to 5-ht(1a) receptors resembled that of an antagonist in that it was increased by gppnhp, whereas gppnhp reduced the binding of the classic agonist [(3)h]-8-oh-dpat (k(d)=1.5+/-0.5 nm; b(max)=303+/-20 fmol/mg protein). |
2001-07-19 |
2023-08-12 |
Not clear |
| X Moreau, R Jeanningros, P Mazzola-Pomiett. Chronic effects of triiodothyronine in combination with imipramine on 5-HT transporter, 5-HT(1A) and 5-HT(2A) receptors in adult rat brain. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 24. issue 6. 2001-07-19. PMID:11331145. |
since brain serotonin (5-ht) changes have been implicated in the mode of action of tca drugs, the effects of a chronic (7 or 21 days) administration of imipramine (10 mg/kg/day) and of a low dose of t3 (4 microg/kg/day), given alone or in combination, were investigated on the density of midbrain 5-ht transporters and of hippocampal 5-ht(1a) and cortical 5-ht(2a) receptors in adult wistar rats. |
2001-07-19 |
2023-08-12 |
rat |
| C C Beaufour, C Le Bihan, M Hamon, M H Thiébo. Extracellular serotonin is enhanced in the striatum, but not in the dorsal hippocampus or prefrontal cortex, in rats subjected to an operant conflict procedure. Behavioral neuroscience. vol 115. issue 1. 2001-07-12. PMID:11256436. |
extracellular serotonin is enhanced in the striatum, but not in the dorsal hippocampus or prefrontal cortex, in rats subjected to an operant conflict procedure. |
2001-07-12 |
2023-08-12 |
rat |
| C C Beaufour, C Le Bihan, M Hamon, M H Thiébo. Extracellular serotonin is enhanced in the striatum, but not in the dorsal hippocampus or prefrontal cortex, in rats subjected to an operant conflict procedure. Behavioral neuroscience. vol 115. issue 1. 2001-07-12. PMID:11256436. |
compared with baseline, hippocampal and cortical extracellular levels of serotonin (5-htext) did not change, regardless of operant period (punished or nonpunished) and drug. |
2001-07-12 |
2023-08-12 |
rat |
| B N Srinivas, M N Subhash, K Y Vino. Cortical 5-HT(1A) receptor downregulation by antidepressants in rat brain. Neurochemistry international. vol 38. issue 7. 2001-07-12. PMID:11290382. |
it was observed that chronic exposure to tricyclic antidepressants (tcas) results in significant downregulation of total [3h]5-ht binding sites in cortex (42-76%) and hippocampus (35-67%). |
2001-07-12 |
2023-08-12 |
rat |
| B N Srinivas, M N Subhash, K Y Vino. Cortical 5-HT(1A) receptor downregulation by antidepressants in rat brain. Neurochemistry international. vol 38. issue 7. 2001-07-12. PMID:11290382. |
interestingly, in hippocampus imipramine treatment increased the 5-ht(1a) receptor density (14%). |
2001-07-12 |
2023-08-12 |
rat |
| B N Srinivas, M N Subhash, K Y Vino. Cortical 5-HT(1A) receptor downregulation by antidepressants in rat brain. Neurochemistry international. vol 38. issue 7. 2001-07-12. PMID:11290382. |
5-ht sensitive adenylyl cyclase (ac) activity was significantly increased in cortex with imipramine (72%) and clomipramine (17%) treatment, whereas in hippocampus only imipramine treatment significantly increased ac activity (50%). |
2001-07-12 |
2023-08-12 |
rat |
| E E Irvine, S Cheeta, C Lovelock, S E Fil. Tolerance to midazolam's anxiolytic effects after short-term nicotine treatment. Neuropharmacology. vol 40. issue 5. 2001-07-12. PMID:11311899. |
the decrease in benzodiazepine binding could explain tolerance to the effects of midazolam when administered to the dorsal hippocampus, but other mechanisms, such as indirect effects on the serotonergic (5-ht) system, might be involved in tolerance to the effects of dorsal raphé nucleus administration. |
2001-07-12 |
2023-08-12 |
rat |