| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L H Parsons, T M Kerr, L H Tecot. 5-HT(1A) receptor mutant mice exhibit enhanced tonic, stress-induced and fluoxetine-induced serotonergic neurotransmission. Journal of neurochemistry. vol 77. issue 2. 2001-05-17. PMID:11299323. |
here we examined the impact of serotonin(1a) receptor deletion on forebrain serotonin neurotransmission using in vivo microdialysis in the frontal cortex and ventral hippocampus of serotonin(1a) receptor mutant and wild-type mice. |
2001-05-17 |
2023-08-12 |
mouse |
| L H Parsons, T M Kerr, L H Tecot. 5-HT(1A) receptor mutant mice exhibit enhanced tonic, stress-induced and fluoxetine-induced serotonergic neurotransmission. Journal of neurochemistry. vol 77. issue 2. 2001-05-17. PMID:11299323. |
baseline dialysate serotonin levels were significantly elevated in mutant animals as compared with wild-types both in frontal cortex (mutant = 0.44 +/- 0.05 n m; wild-type = 0.28 +/- 0.03 n m) and hippocampus (mutant = 0.46 +/- 0.07 n m; wild-type = 0.27 +/- 0.04 n m). |
2001-05-17 |
2023-08-12 |
mouse |
| L H Parsons, T M Kerr, L H Tecot. 5-HT(1A) receptor mutant mice exhibit enhanced tonic, stress-induced and fluoxetine-induced serotonergic neurotransmission. Journal of neurochemistry. vol 77. issue 2. 2001-05-17. PMID:11299323. |
there was no phenotypic difference in the effect of this stressor on serotonin levels in the hippocampus. |
2001-05-17 |
2023-08-12 |
mouse |
| L H Parsons, T M Kerr, L H Tecot. 5-HT(1A) receptor mutant mice exhibit enhanced tonic, stress-induced and fluoxetine-induced serotonergic neurotransmission. Journal of neurochemistry. vol 77. issue 2. 2001-05-17. PMID:11299323. |
fluoxetine produced significantly greater increases in dialysate 5-ht content in serotonin(1a) receptor mutants as compared with wild-types, with two- and three-fold greater responses being observed in the hippocampus and frontal cortex, respectively. |
2001-05-17 |
2023-08-12 |
mouse |
| L H Parsons, T M Kerr, L H Tecot. 5-HT(1A) receptor mutant mice exhibit enhanced tonic, stress-induced and fluoxetine-induced serotonergic neurotransmission. Journal of neurochemistry. vol 77. issue 2. 2001-05-17. PMID:11299323. |
these results indicate that deletion of central serotonin(1a) receptors results in a tonic disinhibition of central serotonin neurotransmission, with a greater dysregulation of serotonin release in the frontal cortex than ventral hippocampus under conditions of stress or increased interstitial serotonin levels. |
2001-05-17 |
2023-08-12 |
mouse |
| K Isogawa, J Akiyoshi, T Hikichi, Y Yamamoto, T Tsutsumi, H Nagayam. Effect of corticotropin releasing factor receptor 1 antagonist on extracellular norepinephrine, dopamine and serotonin in hippocampus and prefrontal cortex of rats in vivo. Neuropeptides. vol 34. issue 3-4. 2001-05-03. PMID:11021986. |
effect of corticotropin releasing factor receptor 1 antagonist on extracellular norepinephrine, dopamine and serotonin in hippocampus and prefrontal cortex of rats in vivo. |
2001-05-03 |
2023-08-12 |
rat |
| K Isogawa, J Akiyoshi, T Hikichi, Y Yamamoto, T Tsutsumi, H Nagayam. Effect of corticotropin releasing factor receptor 1 antagonist on extracellular norepinephrine, dopamine and serotonin in hippocampus and prefrontal cortex of rats in vivo. Neuropeptides. vol 34. issue 3-4. 2001-05-03. PMID:11021986. |
cp-154,526 reduced the extracellular concentration of norepinephrine (ne) from 30 min to 180 min and 5-hydroxytryptamine (5-ht) from 30 min to 60 min after injection in the hippocampus. |
2001-05-03 |
2023-08-12 |
rat |
| K Isogawa, J Akiyoshi, T Hikichi, Y Yamamoto, T Tsutsumi, H Nagayam. Effect of corticotropin releasing factor receptor 1 antagonist on extracellular norepinephrine, dopamine and serotonin in hippocampus and prefrontal cortex of rats in vivo. Neuropeptides. vol 34. issue 3-4. 2001-05-03. PMID:11021986. |
the present results indicate that crf1 receptor antagonist produced a decrease in dialysate concentration of ne and 5-ht, but not da, in the hippocampus. |
2001-05-03 |
2023-08-12 |
rat |
| K Isogawa, J Akiyoshi, T Hikichi, Y Yamamoto, T Tsutsumi, H Nagayam. Effect of corticotropin releasing factor receptor 1 antagonist on extracellular norepinephrine, dopamine and serotonin in hippocampus and prefrontal cortex of rats in vivo. Neuropeptides. vol 34. issue 3-4. 2001-05-03. PMID:11021986. |
these results suggest that the crh-1 receptor antagonist suppresses the release of ne and 5-ht in the hippocampus. |
2001-05-03 |
2023-08-12 |
rat |
| J Hensler, H Durga. Regulation of 5-HT(1A) receptor-stimulated [35S]-GtpgammaS binding as measured by quantitative autoradiography following chronic agonist administration. British journal of pharmacology. vol 132. issue 2. 2001-05-03. PMID:11159711. |
5-ht(1a) receptor-stimulated [(35)s]-gtpgammas binding was significantly attenuated in the ca(1) region of the hippocampus after 7, but not 14 days of 8-oh-dpat administration. |
2001-05-03 |
2023-08-12 |
rat |
| M Errico, R A Crozier, M R Plummer, D S Cowe. 5-HT(7) receptors activate the mitogen activated protein kinase extracellular signal related kinase in cultured rat hippocampal neurons. Neuroscience. vol 102. issue 2. 2001-05-03. PMID:11166122. |
5-ht(7) receptors activate the mitogen activated protein kinase extracellular signal related kinase in cultured rat hippocampal neurons. |
2001-05-03 |
2023-08-12 |
rat |
| M Errico, R A Crozier, M R Plummer, D S Cowe. 5-HT(7) receptors activate the mitogen activated protein kinase extracellular signal related kinase in cultured rat hippocampal neurons. Neuroscience. vol 102. issue 2. 2001-05-03. PMID:11166122. |
the hippocampus is highly innervated by serotonergic neurons and appears to be an ideal region of the brain for studying the antidepressant role of 5-hydroxytryptamine. |
2001-05-03 |
2023-08-12 |
rat |
| M Errico, R A Crozier, M R Plummer, D S Cowe. 5-HT(7) receptors activate the mitogen activated protein kinase extracellular signal related kinase in cultured rat hippocampal neurons. Neuroscience. vol 102. issue 2. 2001-05-03. PMID:11166122. |
in the present study we found that 5-ht(7) receptors, expressed by cultured rat hippocampal neurons, couple to stimulation of the mitogen-activated protein kinase extracellular signal-regulated kinases erk1 and erk2. |
2001-05-03 |
2023-08-12 |
rat |
| M Errico, R A Crozier, M R Plummer, D S Cowe. 5-HT(7) receptors activate the mitogen activated protein kinase extracellular signal related kinase in cultured rat hippocampal neurons. Neuroscience. vol 102. issue 2. 2001-05-03. PMID:11166122. |
that 5-ht(7) receptors couple to activation of extracellular signal-regulated kinase in hippocampal neurons suggests a possible role for 5-ht(7) receptors in mediating some of the actions of antidepressants that increase 5-hydroxytryptamine. |
2001-05-03 |
2023-08-12 |
rat |
| K Matthews, J W Dalley, C Matthews, T H Tsai, T W Robbin. Periodic maternal separation of neonatal rats produces region- and gender-specific effects on biogenic amine content in postmortem adult brain. Synapse (New York, N.Y.). vol 40. issue 1. 2001-05-03. PMID:11170216. |
serotonin levels were reduced in dorsal hippocampus of rms rats of both sexes and in the mpfc of male rms rats. |
2001-05-03 |
2023-08-12 |
human |
| T Inoue, F Wang, A Moriguchi, K Shirakawa, N Matsuoka, T Got. FK960, a novel potential anti-dementia drug, enhances high K(+)-evoked release of somatostatin from rat hippocampal slices. Brain research. vol 892. issue 1. 2001-05-03. PMID:11172755. |
on the other hands, fk960 had no effects on the release of neurotransmitters such as acetylcholine, 5-ht, d-aspartate or gaba from hippocampal slices. |
2001-05-03 |
2023-08-12 |
rat |
| K E Sabol, J T Roach, S L Broom, C Ferreira, M M Prea. Long-term effects of a high-dose methamphetamine regimen on subsequent methamphetamine-induced dopamine release in vivo. Brain research. vol 892. issue 1. 2001-05-03. PMID:11172757. |
tissue concentrations of serotonin were also significantly depleted in striatum, nucleus accumbens/olfactory tubercle, hippocampus, somatosensory cortex, but not septum, hypothalamus or ventral mid-brain. |
2001-05-03 |
2023-08-12 |
rat |
| Y Levkovitz, M Sega. Aging affects transcranial magnetic modulation of hippocampal evoked potentials. Neurobiology of aging. vol 22. issue 2. 2001-05-03. PMID:11182475. |
likewise, tms increased ltp expression in the young but not the old rats, and reduced the efficacy of serotonin modulation of reactivity of the hippocampus, in the young but not the old rats. |
2001-05-03 |
2023-08-12 |
rat |
| A Dugar, B J Keck, L W Maines, S Miller, R Njai, J M Lakosk. Compensatory responses in the aging hippocampal serotonergic system following neurodegenerative injury with 5,7-dihydroxytryptamine. Synapse (New York, N.Y.). vol 39. issue 2. 2001-04-19. PMID:11180498. |
this study utilized a multidisciplinary approach to examine injury-induced compensatory responses in the aging hippocampal serotonin transporter (5-htt), a membrane protein implicated in a variety of neurodegenerative disorders. |
2001-04-19 |
2023-08-12 |
rat |
| S M Ravi, B M Prabhu, T R Raju, P N Bind. Long-term effects of postnatal aluminium exposure on acetylcholinesterase activity and biogenic amine neurotransmitters in rat brain. Indian journal of physiology and pharmacology. vol 44. issue 4. 2001-04-12. PMID:11214504. |
on the sixtieth day, the rats from both the groups were sacrificed and ache activity, levels of dopamine, noradrenaline and serotonin were estimated in the cerebral cortex, hippocampus, septum, brainstem and striatum. |
2001-04-12 |
2023-08-12 |
human |