| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R Christensen, A B Marcussen, G Wörtwein, G M Knudsen, S Azna. Abeta(1-42) injection causes memory impairment, lowered cortical and serum BDNF levels, and decreased hippocampal 5-HT(2A) levels. Experimental neurology. vol 210. issue 1. 2008-05-02. PMID:18053988. |
these results indicate that the abeta(1-42) associated memory deficit is associated with an impaired bdnf regulation, which is reflected in lower cortical bdnf levels, and changes in hippocampal 5-ht(2a) receptor levels. |
2008-05-02 |
2023-08-12 |
rat |
| Alfred Meurs, Ralph Clinckers, Guy Ebinger, Yvette Michotte, Ilse Smolder. Seizure activity and changes in hippocampal extracellular glutamate, GABA, dopamine and serotonin. Epilepsy research. vol 78. issue 1. 2008-05-02. PMID:18054462. |
seizure activity and changes in hippocampal extracellular glutamate, gaba, dopamine and serotonin. |
2008-05-02 |
2023-08-12 |
human |
| Alfred Meurs, Ralph Clinckers, Guy Ebinger, Yvette Michotte, Ilse Smolder. Seizure activity and changes in hippocampal extracellular glutamate, GABA, dopamine and serotonin. Epilepsy research. vol 78. issue 1. 2008-05-02. PMID:18054462. |
our aim was to better characterise the relationship between seizure activity and changes in hippocampal glutamate, gaba, dopamine and serotonin by comparing three limbic seizure models which differ only in the pharmacological mechanism used to induce seizures. |
2008-05-02 |
2023-08-12 |
human |
| Alfred Meurs, Ralph Clinckers, Guy Ebinger, Yvette Michotte, Ilse Smolder. Seizure activity and changes in hippocampal extracellular glutamate, GABA, dopamine and serotonin. Epilepsy research. vol 78. issue 1. 2008-05-02. PMID:18054462. |
seizure-related behavioural changes were scored and hippocampal extracellular glutamate, gaba, dopamine and serotonin concentrations were monitored. |
2008-05-02 |
2023-08-12 |
human |
| Alfred Meurs, Ralph Clinckers, Guy Ebinger, Yvette Michotte, Ilse Smolder. Seizure activity and changes in hippocampal extracellular glutamate, GABA, dopamine and serotonin. Epilepsy research. vol 78. issue 1. 2008-05-02. PMID:18054462. |
hippocampal serotonin concentration increased following pilocarpine and picrotoxin, but not dhpg. |
2008-05-02 |
2023-08-12 |
human |
| Alfred Meurs, Ralph Clinckers, Guy Ebinger, Yvette Michotte, Ilse Smolder. Seizure activity and changes in hippocampal extracellular glutamate, GABA, dopamine and serotonin. Epilepsy research. vol 78. issue 1. 2008-05-02. PMID:18054462. |
our results suggest a direct relationship between seizure activity and increased hippocampal extracellular concentrations of glutamate, gaba and dopamine, but not serotonin. |
2008-05-02 |
2023-08-12 |
human |
| Tatjana Bordukalo-Niksić, Gordana Mokrović, Branimir Jernej, Lipa Cicin-Sai. Expression of 5HT-1A and 5HT-1B receptor genes in brains of Wistar-Zagreb 5HT rats. Collegium antropologicum. vol 32 Suppl 1. 2008-05-01. PMID:18405056. |
results suggest that constitutional alteration of 5ht homeostasis, induced by selective breeding for the extremes of platelet 5htt activity, did not cause measurable changes in the expression of central 5ht-1a (hippocampus) and 5ht-1b (striatum) receptors in the mentioned rat sublines under physiological conditions. |
2008-05-01 |
2023-08-12 |
rat |
| Cai Song, Mehar S Manku, David F Horrobi. Long-chain polyunsaturated fatty acids modulate interleukin-1beta-induced changes in behavior, monoaminergic neurotransmitters, and brain inflammation in rats. The Journal of nutrition. vol 138. issue 5. 2008-05-01. PMID:18424607. |
aa also increased the turnover of dopamine (da), noradrenaline (na), and serotonin (5-ht) in the amygdala and increased the prostaglandin (pg)e(2) level in the hippocampus. |
2008-05-01 |
2023-08-12 |
rat |
| Cai Song, Mehar S Manku, David F Horrobi. Long-chain polyunsaturated fatty acids modulate interleukin-1beta-induced changes in behavior, monoaminergic neurotransmitters, and brain inflammation in rats. The Journal of nutrition. vol 138. issue 5. 2008-05-01. PMID:18424607. |
il-1 administration slowed rat learning in the water maze and increased anxiety-like behavior, changes which were associated with increased homovanillic acid and 5-ht turnover, decreased na in the hippocampus and amygdala, decreased da in the frontal cortex, and decreased il-10 in limbic brain regions. |
2008-05-01 |
2023-08-12 |
rat |
| Lucinéia Dos Santos, Telma G C S de Andrade, Hélio Zangrossi Junio. 5-HT1A receptors in the dorsal hippocampus mediate the anxiogenic effect induced by the stimulation of 5-HT neurons in the median raphe nucleus. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 18. issue 4. 2008-04-23. PMID:17728111. |
5-ht1a receptors in the dorsal hippocampus mediate the anxiogenic effect induced by the stimulation of 5-ht neurons in the median raphe nucleus. |
2008-04-23 |
2023-08-12 |
rat |
| Lucinéia Dos Santos, Telma G C S de Andrade, Hélio Zangrossi Junio. 5-HT1A receptors in the dorsal hippocampus mediate the anxiogenic effect induced by the stimulation of 5-HT neurons in the median raphe nucleus. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 18. issue 4. 2008-04-23. PMID:17728111. |
we evaluated the involvement of dorsal hippocampus (dh) 5-ht1a receptors in the mediation of the behavioral effects caused by the pharmacological manipulation of 5-ht neurons in the median raphe nucleus (mrn). |
2008-04-23 |
2023-08-12 |
rat |
| Bruno P Guiard, Denis J P David, Thierry Deltheil, Franck Chenu, Erwan Le Maître, Thibault Renoir, Isabelle Leroux-Nicollet, Pierre Sokoloff, Laurence Lanfumey, Michel Hamon, Anne M Andrews, René Hen, Alain M Gardie. Brain-derived neurotrophic factor-deficient mice exhibit a hippocampal hyperserotonergic phenotype. The international journal of neuropsychopharmacology. vol 11. issue 1. 2008-04-15. PMID:17559709. |
heterozygous mutants bdnf +/- mice were utilized to investigate the influence of bdnf on the serotonin (5-ht) system and the activity of the serotonin transporter (sert) in the hippocampus. |
2008-04-15 |
2023-08-12 |
mouse |
| Bruno P Guiard, Denis J P David, Thierry Deltheil, Franck Chenu, Erwan Le Maître, Thibault Renoir, Isabelle Leroux-Nicollet, Pierre Sokoloff, Laurence Lanfumey, Michel Hamon, Anne M Andrews, René Hen, Alain M Gardie. Brain-derived neurotrophic factor-deficient mice exhibit a hippocampal hyperserotonergic phenotype. The international journal of neuropsychopharmacology. vol 11. issue 1. 2008-04-15. PMID:17559709. |
the zero net flux method of quantitative microdialysis revealed that bdnf +/- heterozygous mice have increased basal extracellular 5-ht levels in the hippocampus and decreased 5-ht reuptake capacity. |
2008-04-15 |
2023-08-12 |
mouse |
| Bruno P Guiard, Denis J P David, Thierry Deltheil, Franck Chenu, Erwan Le Maître, Thibault Renoir, Isabelle Leroux-Nicollet, Pierre Sokoloff, Laurence Lanfumey, Michel Hamon, Anne M Andrews, René Hen, Alain M Gardie. Brain-derived neurotrophic factor-deficient mice exhibit a hippocampal hyperserotonergic phenotype. The international journal of neuropsychopharmacology. vol 11. issue 1. 2008-04-15. PMID:17559709. |
in keeping with these results, the selective serotonin reuptake inhibitor paroxetine failed to increase hippocampal extracellular 5-ht levels in bdnf +/- mice while it produced robust effects in wild-type littermates. |
2008-04-15 |
2023-08-12 |
mouse |
| Bruno P Guiard, Denis J P David, Thierry Deltheil, Franck Chenu, Erwan Le Maître, Thibault Renoir, Isabelle Leroux-Nicollet, Pierre Sokoloff, Laurence Lanfumey, Michel Hamon, Anne M Andrews, René Hen, Alain M Gardie. Brain-derived neurotrophic factor-deficient mice exhibit a hippocampal hyperserotonergic phenotype. The international journal of neuropsychopharmacology. vol 11. issue 1. 2008-04-15. PMID:17559709. |
a significant decrease in [3h]citalopram-binding-site density in the ca3 subregion of the ventral hippocampus and a significant reduction in [3h]5-ht uptake in hippocampal synaptosomes, revealed mainly a decrease in sert function. |
2008-04-15 |
2023-08-12 |
mouse |
| A Rex, J P Voigt, K M Wicke, H Fin. In vivo/ex vivo and behavioural study on central effects of 5-HT1B/1D and 5-HT1A antagonists in guinea pigs. Pharmacology, biochemistry, and behavior. vol 88. issue 3. 2008-04-09. PMID:17888505. |
we investigated effects of the 5-ht1b/1d antagonist gr127935, the 5-ht1a antagonist way 100635 and a combination of both in guinea pigs on the behaviour in the forced swimming test and on extracellular 5-ht in the hippocampus and the prefrontal cortex using in vivo microdialysis. |
2008-04-09 |
2023-08-12 |
Not clear |
| A Rex, J P Voigt, K M Wicke, H Fin. In vivo/ex vivo and behavioural study on central effects of 5-HT1B/1D and 5-HT1A antagonists in guinea pigs. Pharmacology, biochemistry, and behavior. vol 88. issue 3. 2008-04-09. PMID:17888505. |
tissue content of 5-ht, 5-hiaa and 5-ht turnover (ratio 5-hiaa/5-ht) were determined in a sample containing i) the median and dorsal raphe nuclei, ii) the frontal cortex, or iii) the ventral hippocampus ex vivo. |
2008-04-09 |
2023-08-12 |
Not clear |
| A Rex, J P Voigt, K M Wicke, H Fin. In vivo/ex vivo and behavioural study on central effects of 5-HT1B/1D and 5-HT1A antagonists in guinea pigs. Pharmacology, biochemistry, and behavior. vol 88. issue 3. 2008-04-09. PMID:17888505. |
way 100635 decreased 5-ht in the hippocampus (-40%), too. |
2008-04-09 |
2023-08-12 |
Not clear |
| A Rex, J P Voigt, K M Wicke, H Fin. In vivo/ex vivo and behavioural study on central effects of 5-HT1B/1D and 5-HT1A antagonists in guinea pigs. Pharmacology, biochemistry, and behavior. vol 88. issue 3. 2008-04-09. PMID:17888505. |
way 100635 and gr127935 and their combination increased hippocampal 5-hiaa and 5-ht turnover twofold, compared to controls. |
2008-04-09 |
2023-08-12 |
Not clear |
| M Cachard-Chastel, S Devers, S Sicsic, M Langlois, F Lezoualc'h, A M Gardier, C Belzun. Prucalopride and donepezil act synergistically to reverse scopolamine-induced memory deficit in C57Bl/6j mice. Behavioural brain research. vol 187. issue 2. 2008-04-07. PMID:18061284. |
it is known that 5-ht(4) receptor agonists increase sappalpha levels in the cortex and hippocampus of mice as well as in a model of alzheimer's disease (ad). |
2008-04-07 |
2023-08-12 |
mouse |