| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Brian A Hoshaw, Tiffany I Hill, James J Crowley, Jessica E Malberg, Xavier Khawaja, Sharon Rosenzweig-Lipson, Lee E Schechter, Irwin Luck. Antidepressant-like behavioral effects of IGF-I produced by enhanced serotonin transmission. European journal of pharmacology. vol 594. issue 1-3. 2008-11-25. PMID:18675266. |
administration of igf-i increased basal serotonin levels in the ventral hippocampus and altered the effects of acute citalopram. |
2008-11-25 |
2023-08-12 |
rat |
| Beth Levant, Marlies K Ozias, Paul F Davis, Michelle Winter, Kristin L Russell, Susan E Carlson, Gregory A Reed, Kenneth E McCarso. Decreased brain docosahexaenoic acid content produces neurobiological effects associated with depression: Interactions with reproductive status in female rats. Psychoneuroendocrinology. vol 33. issue 9. 2008-11-25. PMID:18707812. |
in parous dams with decreased brain dha, the density of 5-ht(1a) receptors in the hippocampus was increased, corticosterone response to an intense stressor was increased, and the latency to immobility in the forced swim test was decreased compared to parous dams with normal dha. |
2008-11-25 |
2023-08-12 |
rat |
| Yukiko Misumi, Takako Yamato, Toshio Obata, Masahiro Aomin. Effects of ion channel blockers on basal hippocampal monoamine levels in freely moving diabetic and non-diabetic rats. The International journal of neuroscience. vol 118. issue 6. 2008-11-18. PMID:18465423. |
extracellular levels of serotonin and dopamine were measured in the hippocampus of awake, freely moving streptozotocin-induced diabetic rats, spontaneously diabetic rats, and non-diabetic rats, using in vivo microdialysis. |
2008-11-18 |
2023-08-12 |
rat |
| Trisha A Jenkin. Effect of angiotensin-related antihypertensives on brain neurotransmitter levels in rats. Neuroscience letters. vol 444. issue 2. 2008-11-18. PMID:18718508. |
in addition chronic candesartan infusion produced a significant increase in the levels of hippocampal noradrenaline and serotonin; and frontal cortex serotonin content. |
2008-11-18 |
2023-08-12 |
rat |
| Thomas Frodl, Peter Zill, Thomas Baghai, Cornelius Schüle, Rainer Rupprecht, Thomas Zetzsche, Brigitta Bondy, Maximilian Reiser, Hans-Jürgen Möller, Eva M Meisenzah. Reduced hippocampal volumes associated with the long variant of the tri- and diallelic serotonin transporter polymorphism in major depression. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 147B. issue 7. 2008-11-17. PMID:18286634. |
reduced hippocampal volumes associated with the long variant of the tri- and diallelic serotonin transporter polymorphism in major depression. |
2008-11-17 |
2023-08-12 |
Not clear |
| Thomas Frodl, Peter Zill, Thomas Baghai, Cornelius Schüle, Rainer Rupprecht, Thomas Zetzsche, Brigitta Bondy, Maximilian Reiser, Hans-Jürgen Möller, Eva M Meisenzah. Reduced hippocampal volumes associated with the long variant of the tri- and diallelic serotonin transporter polymorphism in major depression. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 147B. issue 7. 2008-11-17. PMID:18286634. |
the polymorphism of the serotonin transporter gene (5-httlpr) was found to be associated with reduced hippocampal volume in major depression. |
2008-11-17 |
2023-08-12 |
Not clear |
| Hans S Crombag, Jennifer M Bossert, Eisuke Koya, Yavin Shaha. Review. Context-induced relapse to drug seeking: a review. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. vol 363. issue 1507. 2008-11-17. PMID:18640922. |
we then summarize results from pharmacological and neuroanatomical studies on the role of several neurotransmitter systems (dopamine, glutamate, serotonin and opioids) and brain areas (ventral tegmental area, accumbens shell, dorsal striatum, basolateral amygdala, prefrontal cortex, dorsal hippocampus and lateral hypothalamus) in context-induced reinstatement. |
2008-11-17 |
2023-08-12 |
rat |
| Weixing Wang, Xinying Hu, Zhiyu Zhao, Peng Liu, Yuchi Hu, Jianping Zhou, Dongfeng Zhou, Zhibin Wang, Dean Guo, Hongzhu Gu. Antidepressant-like effects of liquiritin and isoliquiritin from Glycyrrhiza uralensis in the forced swimming test and tail suspension test in mice. Progress in neuro-psychopharmacology & biological psychiatry. vol 32. issue 5. 2008-11-05. PMID:18289754. |
it was found that these two compounds significantly increased the concentrations of the main neurotransmitters 5-ht and ne in the hippocampus, hypothalamus and cortex. |
2008-11-05 |
2023-08-12 |
mouse |
| Weixing Wang, Xinying Hu, Zhiyu Zhao, Peng Liu, Yuchi Hu, Jianping Zhou, Dongfeng Zhou, Zhibin Wang, Dean Guo, Hongzhu Gu. Antidepressant-like effects of liquiritin and isoliquiritin from Glycyrrhiza uralensis in the forced swimming test and tail suspension test in mice. Progress in neuro-psychopharmacology & biological psychiatry. vol 32. issue 5. 2008-11-05. PMID:18289754. |
liquiritin and isoliquiritin also significantly reduced the ratio of 5-hiaa/5-ht in the hippocampus, hypothalamus and cortex, slowing down 5-ht metabolism compared with mice treated with vehicle+stress. |
2008-11-05 |
2023-08-12 |
mouse |
| Weixing Wang, Xinying Hu, Zhiyu Zhao, Peng Liu, Yuchi Hu, Jianping Zhou, Dongfeng Zhou, Zhibin Wang, Dean Guo, Hongzhu Gu. Antidepressant-like effects of liquiritin and isoliquiritin from Glycyrrhiza uralensis in the forced swimming test and tail suspension test in mice. Progress in neuro-psychopharmacology & biological psychiatry. vol 32. issue 5. 2008-11-05. PMID:18289754. |
in conclusion, liquiritin and isoliquiritin produced significant antidepressant-like effects, and their mechanism of action may be due to increased 5-ht and ne in the mouse hippocampus, hypothalamus and cortex. |
2008-11-05 |
2023-08-12 |
mouse |
| Kevin C F Fone, M Veronica Porkes. Behavioural and neurochemical effects of post-weaning social isolation in rodents-relevance to developmental neuropsychiatric disorders. Neuroscience and biobehavioral reviews. vol 32. issue 6. 2008-11-05. PMID:18423591. |
these alterations are associated with hyperfunction of mesolimbic dopaminergic systems, enhanced presynaptic dopamine (da) and serotonergic (5-ht) function in the nucleus accumbens (nacc), hypofunction of mesocortical da and attenuated 5-ht function in the prefrontal cortex and hippocampus. |
2008-11-05 |
2023-08-12 |
rat |
| Ricardo Mostany, Elsa M Valdizán, Angel Pazo. A role for nuclear beta-catenin in SNRI antidepressant-induced hippocampal cell proliferation. Neuropharmacology. vol 55. issue 1. 2008-11-05. PMID:18511088. |
these results suggest that the hippocampal proliferative effect of chronic venlafaxine, only evident when both serotonin (5-ht) and noradrenaline/norepinephrine (ne) reuptake systems are inhibited, requires a strong activation of intracellular signaling through wnt (beta-catenin translocation) and akt/pkb pathways. |
2008-11-05 |
2023-08-12 |
rat |
| Ebany J Martinez, Bethany L Kolb, Angela Bell, Daniel D Savage, Andrea M Alla. Moderate perinatal arsenic exposure alters neuroendocrine markers associated with depression and increases depressive-like behaviors in adult mouse offspring. Neurotoxicology. vol 29. issue 4. 2008-11-05. PMID:18573533. |
compared to controls, offspring exposed to 50 parts per billion arsenic during the perinatal period had significantly elevated serum corticosterone levels, reduced whole hippocampal crfr 1 protein level and elevated dorsal hippocampal serotonin 5ht 1a receptor binding and receptor-effector coupling. |
2008-11-05 |
2023-08-12 |
mouse |
| Yoav Noam, Wytse J Wadman, Johannes A van Hoof. On the voltage-dependent Ca2+ block of serotonin 5-HT3 receptors: a critical role of intracellular phosphates. The Journal of physiology. vol 586. issue 15. 2008-11-04. PMID:18566001. |
finally, atp was found to be critical for voltage-dependent channel block also in hippocampal interneurons that natively express 5-ht(3) receptors. |
2008-11-04 |
2023-08-12 |
Not clear |
| Prem Prakash Tripathi, Luca Giovanni Di Giovannantonio, Alessandro Viegi, Wolfgang Wurst, Antonio Simeone, Yuri Bozz. Serotonin hyperinnervation abolishes seizure susceptibility in Otx2 conditional mutant mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 37. 2008-11-03. PMID:18784307. |
adult en1(cre/+); otx2(flox/flox) mice showed increased serotonin (5-ht) levels in the pons, ventral midbrain, hippocampus (ca3 subfield), and cerebral cortex, as indicated by hplc and immunohistochemistry. |
2008-11-03 |
2023-08-12 |
mouse |
| Laura Saenz del Burgo, Roser Cortes, Guadalupe Mengod, Jon Zarate, Enrique Echevarria, Joan Salle. Distribution and neurochemical characterization of neurons expressing GIRK channels in the rat brain. The Journal of comparative neurology. vol 510. issue 6. 2008-10-27. PMID:18698588. |
double-labeling experiments show that girk subunits are present in most of the 5-ht(1a) receptor-expressing cells in hippocampus, cerebral cortex, septum, and dorsal raphe nucleus. |
2008-10-27 |
2023-08-12 |
human |
| D A F Robertson, J E Beattie, I C Reid, D J K Balfou. Influence of 5,7-dihydroxytryptamine lesions of the rat fornix-fimbria and cingulum bundles on spontaneous activity in an aversive maze. Journal of psychopharmacology (Oxford, England). vol 22. issue 3. 2008-10-23. PMID:18208913. |
this study explored the putative role of the principal 5-hydroxytryptamine (5-ht) neurones that project to the hippocampus from the median raphe nucleus in this response to an aversive environment by lesioning the 5-ht fibres that project through the fornix/fimbria and cingulum bundles. |
2008-10-23 |
2023-08-12 |
rat |
| D A F Robertson, J E Beattie, I C Reid, D J K Balfou. Influence of 5,7-dihydroxytryptamine lesions of the rat fornix-fimbria and cingulum bundles on spontaneous activity in an aversive maze. Journal of psychopharmacology (Oxford, England). vol 22. issue 3. 2008-10-23. PMID:18208913. |
it is concluded that exposure to an explicitly aversive environment elicits a brief stimulation of the 5-ht neurones that project to the hippocampus from the median raphe nucleus and that this stimulation inhibits the initial burst of exploratory activity that is observed in animals placed in a less aversive novel environment. |
2008-10-23 |
2023-08-12 |
rat |
| O Mnie-Filali, M El Mansari, H Scarna, L Zimmer, C Sánchez, N Haddjer. [Escitalopram: a selective inhibitor and allosteric modulator of the serotonin transporter]. L'Encephale. vol 33. issue 6. 2008-10-23. PMID:18789789. |
for instance, microdialysis studies have shown that escitalopram increased the extracellular 5-ht levels in the frontal cortex and the ventral hippocampus, and this effect was prevented by concomitant injection of r-citalopram. |
2008-10-23 |
2023-08-12 |
rat |
| Xiaoying Lu, Brendon Ross, Manuel Sanchez-Alavez, Eric P Zorrilla, Tamas Bartfa. Phenotypic analysis of GalR2 knockout mice in anxiety- and depression-related behavioral tests. Neuropeptides. vol 42. issue 4. 2008-10-20. PMID:18554714. |
we have previously shown that chronic antidepressant treatments increase the binding of a galr2-preferring ligand, galanin (2-11), to the dorsal raphe nucleus (drn) of the rat, which, along with the finding that intra-drn infusion of galanin (2-11) increases the release of serotonin in the hippocampus, suggests that galr2 signaling might exert antidepressant-like actions by modulating ascending serotonergic outflow. |
2008-10-20 |
2023-08-12 |
mouse |