| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Terence Y C Pang, Xin Du, Michelle S Zajac, Monique L Howard, Anthony J Hanna. Altered serotonin receptor expression is associated with depression-related behavior in the R6/1 transgenic mouse model of Huntington's disease. Human molecular genetics. vol 18. issue 4. 2009-02-27. PMID:19008301. |
the baseline behaviors of hd mice were similar to the behavioral phenotypes of serotonin (5-ht) receptor and transporter null mutants, and gene expression of specific serotonin receptors were subsequently found to be reduced in the hippocampus and cortex of hd mice. |
2009-02-27 |
2023-08-12 |
mouse |
| Terence Y C Pang, Xin Du, Michelle S Zajac, Monique L Howard, Anthony J Hanna. Altered serotonin receptor expression is associated with depression-related behavior in the R6/1 transgenic mouse model of Huntington's disease. Human molecular genetics. vol 18. issue 4. 2009-02-27. PMID:19008301. |
environmental enrichment normalized the fst behavioral response of female hd mice corresponding with increased gene expression of specific 5-ht receptors in the hippocampus and cortex. |
2009-02-27 |
2023-08-12 |
mouse |
| Elena Puerta, Isabel Hervias, Beatriz Goñi-Allo, Berta Lasheras, Joaquin Jordan, Norberto Aguirr. Phosphodiesterase 5 inhibitors prevent 3,4-methylenedioxymethamphetamine-induced 5-HT deficits in the rat. Journal of neurochemistry. vol 108. issue 3. 2009-02-24. PMID:19187094. |
oral administration of sildenafil citrate (1.5 or 8 mg/kg) increased brain cgmp levels and protected in a dose-dependent manner against 5-hydroxytryptamine depletions caused by mdma (3 x 5 mg/kg, i.p., every 2 h) in the striatum, frontal cortex and hippocampus without altering the acute hyperthermic response to mdma. |
2009-02-24 |
2023-08-12 |
rat |
| Daniel Anthony Johnson, Colin David Ingram, Emma Jane Grant, Mark Craighead, Sarah Elizabeth Gartsid. Glucocorticoid receptor antagonism augments fluoxetine-induced downregulation of the 5-HT transporter. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 34. issue 2. 2009-02-23. PMID:18496518. |
[(3)h]-citalopram binding (an index of 5-ht transporter (5-htt) expression) was only slightly affected by org 34850 alone: decreased in cortex and midbrain and increased in hippocampus. |
2009-02-23 |
2023-08-12 |
rat |
| Mei Huang, Zhu Li, Jin Dai, Mohammed Shahid, Erik H F Wong, Herbert Y Meltze. Asenapine increases dopamine, norepinephrine, and acetylcholine efflux in the rat medial prefrontal cortex and hippocampus. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 33. issue 12. 2009-02-20. PMID:18418367. |
atypical antipsychotic drugs, which are more potent direct acting antagonists of brain serotonin (5-ht)(2a) than dopamine (da) d(2) receptors, preferentially enhance da and acetylcholine (ach) efflux in the rat medial prefrontal cortex (mpfc) and hippocampus (hip), compared with the nucleus accumbens (nac). |
2009-02-20 |
2023-08-12 |
rat |
| I G Kapitza, T S Kalinina, L N Nerobkova, T A Voronina, P M Klodt, V B Narkevich, V S Kudri. Relationship between the severity of hypokinesia induced by neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and neurochemical changes in brain structures of C57Bl/6 mice. Bulletin of experimental biology and medicine. vol 146. issue 1. 2009-02-19. PMID:19145349. |
severe hypokinesia was accompanied by an increase in serotonin content and decrease in the rate of serotonin biodegradation in the striatum, hippocampus, and frontal cortex. |
2009-02-19 |
2023-08-12 |
mouse |
| Michal Reichenstein, Moshe Rehavi, Albert Pinhaso. Involvement of pituitary adenylate cyclase activating polypeptide (PACAP) and its receptors in the mechanism of antidepressant action. Journal of molecular neuroscience : MN. vol 36. issue 1-3. 2009-02-17. PMID:18592413. |
in rat hippocampal neurons, prolonged (72-hour) treatment with selective serotonin reuptake inhibitors paroxetine and citalopram significantly up-regulated bdnf and pacap expression and down-regulated pacap receptor (pac1 and vpac2) expression; the tricyclic antidepressant imipramine had an opposite effect. |
2009-02-17 |
2023-08-12 |
rat |
| b' V B Narkevich, V S Kudrin, P M Klodt, A A Pokrovski\\xc4\\xad, M M Kozlovskaia, A I Ma\\xc4\\xadski\\xc4\\xad, K S Raevski\\xc4\\xa. [Effects of heptapeptide selank on the content of monoamines and their metabolites in the brain of BALB/C and C57Bl/6 mice: a comparative study]. Eksperimental\'naia i klinicheskaia farmakologiia. vol 71. issue 5. 2009-02-03. PMID:19093364.' |
significant interstrain differences in the content of norepinephrine (ne), dopamine (da), serotonin (5-ht) as well as in the levels of their metabolites in hippocampus, hypothalamus, striatum and frontal cortex of c57bl/6 and balb/c mice were demonstrated. |
2009-02-03 |
2023-08-12 |
mouse |
| b' V B Narkevich, V S Kudrin, P M Klodt, A A Pokrovski\\xc4\\xad, M M Kozlovskaia, A I Ma\\xc4\\xadski\\xc4\\xad, K S Raevski\\xc4\\xa. [Effects of heptapeptide selank on the content of monoamines and their metabolites in the brain of BALB/C and C57Bl/6 mice: a comparative study]. Eksperimental\'naia i klinicheskaia farmakologiia. vol 71. issue 5. 2009-02-03. PMID:19093364.' |
in particular, the content of 5-ht and its metabolite 5-oxyindolacetic acid (5-hiaa) in hippocampus of balb/c mice (with passive stress response) was higher than in the same structure of c57bl/6 (stress-susceptible) animals. |
2009-02-03 |
2023-08-12 |
mouse |
| b' V B Narkevich, V S Kudrin, P M Klodt, A A Pokrovski\\xc4\\xad, M M Kozlovskaia, A I Ma\\xc4\\xadski\\xc4\\xad, K S Raevski\\xc4\\xa. [Effects of heptapeptide selank on the content of monoamines and their metabolites in the brain of BALB/C and C57Bl/6 mice: a comparative study]. Eksperimental\'naia i klinicheskaia farmakologiia. vol 71. issue 5. 2009-02-03. PMID:19093364.' |
selank induced a decrease in 5-ht and 5-hiaa levels in the hippocampus of balb/c mice, but did not affect these parameters in c57bl/6 animals. |
2009-02-03 |
2023-08-12 |
mouse |
| Birgitte R Kornum, Nanna M Lind, Nic Gillings, Lisbeth Marner, Flemming Andersen, Gitte M Knudse. Evaluation of the novel 5-HT4 receptor PET ligand [11C]SB207145 in the Göttingen minipig. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 29. issue 1. 2009-01-30. PMID:18797470. |
the binding potentials calculated for striatum, midbrain, and cortex from the pet data were highly correlated with 5-ht(4) receptor concentrations determined in brain homogenates from the same regions, except for hippocampus where pet-measurements significantly underestimate the 5-ht(4) receptor binding, probably because of partial volume effects. |
2009-01-30 |
2023-08-12 |
human |
| Emi Fukuda, Shun Hamada, Sonoko Hasegawa, Shota Katori, Makoto Sanbo, Tsuyoshi Miyakawa, Toshifumi Yamamoto, Hideko Yamamoto, Takahiro Hirabayashi, Takeshi Yag. Down-regulation of protocadherin-alpha A isoforms in mice changes contextual fear conditioning and spatial working memory. The European journal of neuroscience. vol 28. issue 7. 2009-01-30. PMID:18973563. |
in addition, the amount of 5-hydroxytryptamine increased in the hippocampus of the hypomorphic pcdh-alpha a mutant mice but not in recovery pcdh-alpha(deltab/deltab). |
2009-01-30 |
2023-08-12 |
mouse |
| Emi Fukuda, Shun Hamada, Sonoko Hasegawa, Shota Katori, Makoto Sanbo, Tsuyoshi Miyakawa, Toshifumi Yamamoto, Hideko Yamamoto, Takahiro Hirabayashi, Takeshi Yag. Down-regulation of protocadherin-alpha A isoforms in mice changes contextual fear conditioning and spatial working memory. The European journal of neuroscience. vol 28. issue 7. 2009-01-30. PMID:18973563. |
these results suggested that the level of pcdh-alpha a isoforms in the brain has an important role in regulating learning and memory functions and the amount of 5-hydroxytryptamine in the hippocampus. |
2009-01-30 |
2023-08-12 |
mouse |
| Takashi Yamada, Duk-Young Jung, Rumi Sawada, Atsuko Matsuoka, Ryusuke Nakaoka, Toshie Tsuchiy. Effects intracerebral microinjection and intraperitoneal injection of [60]fullerene on brain functions differ in rats. Journal of nanoscience and nanotechnology. vol 8. issue 8. 2009-01-29. PMID:19049160. |
in particular, serotonin turnover rates were increased in the hypothalamus, cerebral cortex, striatum, and hippocampus, and dopamine turnover rates were increased in the hypothalamus, cerebral cortex, and striatum. |
2009-01-29 |
2023-08-12 |
rat |
| Mark J Millan, Alain Gobert, Fany Panayi, Jean-Michel Rivet, Anne Dekeyne, Mauricette Brocco, Jean-Claude Ortuno, Benjamin Di Car. The melanin-concentrating hormone1 receptor antagonists, SNAP-7941 and GW3430, enhance social recognition and dialysate levels of acetylcholine in the frontal cortex of rats. The international journal of neuropsychopharmacology. vol 11. issue 8. 2009-01-26. PMID:18466669. |
the snap-7941 effect was specific, as it did not increase levels of ach in ventral and dorsal hippocampus: moreover, it did not modify levels of noradrenaline, dopamine, serotonin and glutamate in fcx. |
2009-01-26 |
2023-08-12 |
rat |
| Herbert Y Meltzer, Mei Huan. In vivo actions of atypical antipsychotic drug on serotonergic and dopaminergic systems. Progress in brain research. vol 172. 2009-01-15. PMID:18772033. |
this appears to be mediated mainly through the combined effect of relatively more potent blockade of 5-ht(2a) receptors, located on cortical and hippocampal glutamatergic and gabaergic neurons, as well as cell bodies of the mesolimbic and mesocortical dopamine (da) neurons, and weaker blockade of d(2) receptors in the ventral and dorsal striatum and pyramidal neurons in cortical areas, as well as the cell bodies of da neurons. |
2009-01-15 |
2023-08-12 |
Not clear |
| G Perez-Garcia, A Menese. Memory formation, amnesia, improved memory and reversed amnesia: 5-HT role. Behavioural brain research. vol 195. issue 1. 2009-01-12. PMID:18221797. |
thus, specific 5-ht receptors were expressed in trained animals relative to untrained in brain areas such as cortex, hippocampus and amygdala. |
2009-01-12 |
2023-08-12 |
rat |
| Agata Cifariello, Assunta Pompili, Antonella Gasbarr. 5-HT(7) receptors in the modulation of cognitive processes. Behavioural brain research. vol 195. issue 1. 2009-01-12. PMID:18243350. |
in addition, 5-ht localized in "cognitive pathways" with hippocampus and frontal cortex as the main target structures, is involved in learning and memory processes. |
2009-01-12 |
2023-08-12 |
Not clear |
| Sven Ove Ogren, Therese M Eriksson, Elin Elvander-Tottie, Claudio D'Addario, Joanna C Ekström, Per Svenningsson, Björn Meister, Jan Kehr, Oliver Stied. The role of 5-HT(1A) receptors in learning and memory. Behavioural brain research. vol 195. issue 1. 2009-01-12. PMID:18394726. |
the ascending serotonin (5-ht) neurons innervate the cerebral cortex, hippocampus, septum and amygdala, all representing brain regions associated with various domains of cognition. |
2009-01-12 |
2023-08-12 |
Not clear |
| Sven Ove Ogren, Therese M Eriksson, Elin Elvander-Tottie, Claudio D'Addario, Joanna C Ekström, Per Svenningsson, Björn Meister, Jan Kehr, Oliver Stied. The role of 5-HT(1A) receptors in learning and memory. Behavioural brain research. vol 195. issue 1. 2009-01-12. PMID:18394726. |
the 5-ht(1a) receptors are in the position to influence the activity of glutamatergic, cholinergic and possibly gabaergic neurons in the cerebral cortex, hippocampus and in the septohippocampal projection, thereby affecting declarative and non-declarative memory functions. |
2009-01-12 |
2023-08-12 |
Not clear |