| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wendy Adams, Snezana Kusljic, Maarten van den Buus. Serotonin depletion in the dorsal and ventral hippocampus: effects on locomotor hyperactivity, prepulse inhibition and learning and memory. Neuropharmacology. vol 55. issue 6. 2009-04-14. PMID:18634810. |
stereotaxic microinjection of the serotonin neurotoxin 5,7-dihydroxytryptamine (5,7-dht) into the mrn or one of its main projections regions, the dorsal hippocampus, induced a marked enhancement of phencyclidine-induced locomotor hyperactivity and a disruption of prepulse inhibition (ppi) in rats. |
2009-04-14 |
2023-08-12 |
rat |
| Wendy Adams, Snezana Kusljic, Maarten van den Buus. Serotonin depletion in the dorsal and ventral hippocampus: effects on locomotor hyperactivity, prepulse inhibition and learning and memory. Neuropharmacology. vol 55. issue 6. 2009-04-14. PMID:18634810. |
the results provide new insight into the role of serotonin in the dorsal hippocampus in aspects of schizophrenia. |
2009-04-14 |
2023-08-12 |
rat |
| T Deltheil, B P Guiard, J Cerdan, D J David, K F Tanaka, C Repérant, J-P Guilloux, F Coudoré, R Hen, A M Gardie. Behavioral and serotonergic consequences of decreasing or increasing hippocampus brain-derived neurotrophic factor protein levels in mice. Neuropharmacology. vol 55. issue 6. 2009-04-14. PMID:18761360. |
(1) in heterozygous bdnf+/- mice in which brain bdnf protein levels were decreased by half, an enhancement of basal extracellular 5-ht levels (5-htext) that induced a down-regulation of sert, i.e., a decrease in its capacity to reuptake 5-ht, was found in the hippocampus. |
2009-04-14 |
2023-08-12 |
mouse |
| T Deltheil, B P Guiard, J Cerdan, D J David, K F Tanaka, C Repérant, J-P Guilloux, F Coudoré, R Hen, A M Gardie. Behavioral and serotonergic consequences of decreasing or increasing hippocampus brain-derived neurotrophic factor protein levels in mice. Neuropharmacology. vol 55. issue 6. 2009-04-14. PMID:18761360. |
such a correlation between neurochemical and behavioral effects of [bdnf+ssri] co-administration suggests that its antidepressant-like activity is linked to the activation of 5-ht neurotransmission in the adult hippocampus. |
2009-04-14 |
2023-08-12 |
mouse |
| T Deltheil, B P Guiard, J Cerdan, D J David, K F Tanaka, C Repérant, J-P Guilloux, F Coudoré, R Hen, A M Gardie. Behavioral and serotonergic consequences of decreasing or increasing hippocampus brain-derived neurotrophic factor protein levels in mice. Neuropharmacology. vol 55. issue 6. 2009-04-14. PMID:18761360. |
however, the decreased capacity of sert to reuptake 5-ht was not associated to an increase in basal 5-htext in the hippocampus of wt mice. |
2009-04-14 |
2023-08-12 |
mouse |
| T Deltheil, B P Guiard, J Cerdan, D J David, K F Tanaka, C Repérant, J-P Guilloux, F Coudoré, R Hen, A M Gardie. Behavioral and serotonergic consequences of decreasing or increasing hippocampus brain-derived neurotrophic factor protein levels in mice. Neuropharmacology. vol 55. issue 6. 2009-04-14. PMID:18761360. |
interestingly, using in situ hybridization experiments indicated that trkb receptor mrna was expressed in the hippocampus and dorsal raphe nucleus in adult mice suggesting that the neurochemical and behavioral effects of intra-hippocampal bdnf injection can mobilize both pre- and post-synaptic elements of the brain 5-ht neurotransmission. |
2009-04-14 |
2023-08-12 |
mouse |
| Nicolas Narboux-Nême, Luigi Michele Pavone, Luigi Avallone, Xiaoxi Zhuang, Patricia Gaspa. Serotonin transporter transgenic (SERTcre) mouse line reveals developmental targets of serotonin specific reuptake inhibitors (SSRIs). Neuropharmacology. vol 55. issue 6. 2009-04-14. PMID:18789954. |
this fate map of serotonin transporter expressing cells emphasizes the broad expression of sert in non-serotonin neurons during development and clarifies the localization of sert expression in the hippocampus and limbic cortex. |
2009-04-14 |
2023-08-12 |
mouse |
| Bettina Bert, Jörg-Peter Voigt, Heike Kusserow, Franz Theuring, André Rex, Heidrun Fin. Increasing the number of 5-HT(1A)-receptors in cortex and hippocampus does not induce mnemonic deficits in mice. Pharmacology, biochemistry, and behavior. vol 92. issue 1. 2009-04-13. PMID:19010345. |
increasing the number of 5-ht(1a)-receptors in cortex and hippocampus does not induce mnemonic deficits in mice. |
2009-04-13 |
2023-08-12 |
mouse |
| Bettina Bert, Jörg-Peter Voigt, Heike Kusserow, Franz Theuring, André Rex, Heidrun Fin. Increasing the number of 5-HT(1A)-receptors in cortex and hippocampus does not induce mnemonic deficits in mice. Pharmacology, biochemistry, and behavior. vol 92. issue 1. 2009-04-13. PMID:19010345. |
recently, we introduced a mouse line overexpressing the 5-ht(1a)-receptor in the hippocampus and cortex. |
2009-04-13 |
2023-08-12 |
mouse |
| Bettina Bert, Jörg-Peter Voigt, Heike Kusserow, Franz Theuring, André Rex, Heidrun Fin. Increasing the number of 5-HT(1A)-receptors in cortex and hippocampus does not induce mnemonic deficits in mice. Pharmacology, biochemistry, and behavior. vol 92. issue 1. 2009-04-13. PMID:19010345. |
overall, the cortical and hippocampal overexpression of the 5-ht(1a)-receptor had no major effect on cognitive functions in mice, suggesting that changes in the 5-ht(1a)-receptor density are not necessarily accompanied with alterations of learning and memory processes. |
2009-04-13 |
2023-08-12 |
mouse |
| Alfredo Briones-Aranda, Mariano Castillo-Salazar, Ofir Picaz. Adrenalectomy modifies the hippocampal 5-HT(1A) receptors and the anxiolytic-like effect of 8-OH-DPAT in rats. Pharmacology, biochemistry, and behavior. vol 92. issue 1. 2009-04-13. PMID:19095004. |
adrenalectomy modifies the hippocampal 5-ht(1a) receptors and the anxiolytic-like effect of 8-oh-dpat in rats. |
2009-04-13 |
2023-08-12 |
rat |
| Alfredo Briones-Aranda, Mariano Castillo-Salazar, Ofir Picaz. Adrenalectomy modifies the hippocampal 5-HT(1A) receptors and the anxiolytic-like effect of 8-OH-DPAT in rats. Pharmacology, biochemistry, and behavior. vol 92. issue 1. 2009-04-13. PMID:19095004. |
the influence of 15 min of forced swimming was explored on sham and adrenalectomized rats by measuring the 5-ht(1a) receptor density in raphe and hippocampus. |
2009-04-13 |
2023-08-12 |
rat |
| Michael T Klein, Milt Teitle. Guinea pig hippocampal 5-HT(1E) receptors: a tool for selective drug development. Journal of neurochemistry. vol 109. issue 1. 2009-04-13. PMID:19200348. |
guinea pig hippocampal 5-ht(1e) receptors: a tool for selective drug development. |
2009-04-13 |
2023-08-12 |
mouse |
| Michael T Klein, Milt Teitle. Guinea pig hippocampal 5-HT(1E) receptors: a tool for selective drug development. Journal of neurochemistry. vol 109. issue 1. 2009-04-13. PMID:19200348. |
in hippocampal homogenates, where 5-ht(1e) receptor density was sufficiently high for radioligand binding analysis, 100 nm 5-carboxyamidotryptamine, 30 nm ritanserin, and 100 nm ly344864 were used to mask [(3)h]5-ht binding at non-5-ht(1e) receptors. |
2009-04-13 |
2023-08-12 |
mouse |
| Juan C Brenes, Michael Padilla, Jaime Fornaguer. A detailed analysis of open-field habituation and behavioral and neurochemical antidepressant-like effects in postweaning enriched rats. Behavioural brain research. vol 197. issue 1. 2009-04-10. PMID:18786573. |
third, behavior in the forced-swimming test was analyzed and afterward, the tissue levels of hippocampal norepinephrine and serotonin were assessed. |
2009-04-10 |
2023-08-12 |
rat |
| Juan C Brenes, Michael Padilla, Jaime Fornaguer. A detailed analysis of open-field habituation and behavioral and neurochemical antidepressant-like effects in postweaning enriched rats. Behavioural brain research. vol 197. issue 1. 2009-04-10. PMID:18786573. |
we found that rearing conditions (i) differed on locomotor habituation and on sensory-motor exploration at the first minute and during the 10-min session without modifying the plus-maze behavior; (ii) affected differentially the grooming time, its sequential components, and the relationship between grooming and locomotor parameters; (iii) modified forced-swimming behavior and the hippocampal concentration of norepinephrine, serotonin, and its turnover; and (iv) produced different correlation patterns between both neurotransmitters and forced-swimming behaviors. |
2009-04-10 |
2023-08-12 |
rat |
| Y Claustre, M Leonetti, V Santucci, I Bougault, C Desvignes, L Rouquier, N Aubin, P Keane, S Busch, Y Chen, V Palejwala, M Tocci, P Yamdagni, M Didier, P Avenet, G Le Fur, F Oury-Donat, B Scatton, R Steinber. Effects of the beta3-adrenoceptor (Adrb3) agonist SR58611A (amibegron) on serotonergic and noradrenergic transmission in the rodent: relevance to its antidepressant/anxiolytic-like profile. Neuroscience. vol 156. issue 2. 2009-04-09. PMID:18691638. |
increased the synthesis of 5-ht and tryptophan (trp) levels in several rodent brain areas (cortex, hippocampus, hypothalamus, striatum). |
2009-04-09 |
2023-08-12 |
mouse |
| Wen-Lei Li, Hui-Hui Cai, Bin Wang, Ling Chen, Qi-Gang Zhou, Chun-Xia Luo, Na Liu, Xin-Sheng Ding, Dong-Ya Zh. Chronic fluoxetine treatment improves ischemia-induced spatial cognitive deficits through increasing hippocampal neurogenesis after stroke. Journal of neuroscience research. vol 87. issue 1. 2009-04-08. PMID:18711744. |
fluoxetine, a selective serotonin reuptake inhibitor, can enhance neurogenesis in the hippocampus in physiological situations and some neurological diseases. |
2009-04-08 |
2023-08-12 |
mouse |
| R Ramakrishnan, R Sheeladevi, A Namasivaya. Regulation of protein kinases and coregulatory interplay of S-100beta and serotonin transporter on serotonin levels in diabetic rat brain. Journal of neuroscience research. vol 87. issue 1. 2009-04-08. PMID:18711746. |
although the 5-ht levels in hippocampus (hc) and hypothalamus (ht) were not altered, the pkc-alpha expression and pkc activity showed increases (p < 0.05) in level in hc. |
2009-04-08 |
2023-08-12 |
rat |
| V L Misener, L Gomez, K G Wigg, P Luca, N King, E Kiss, G Daróczi, K Kapornai, Z Tamas, L Mayer, J Gádoros, I Baji, J L Kennedy, M Kovacs, A Vetró, C L Bar. Cytokine Genes TNF, IL1A, IL1B, IL6, IL1RN and IL10, and childhood-onset mood disorders. Neuropsychobiology. vol 58. issue 2. 2009-04-08. PMID:18832862. |
support for this is found in multiple lines of evidence, such as the effects of cytokines on the activities of the hypothalamic-pituitary-adrenal axis, serotonin and brain-derived neurotrophic factor, and hippocampal function, all of which are implicated in the etiology of depression. |
2009-04-08 |
2023-08-12 |
Not clear |