| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zaiquan Dong, Qinglian Xie, Feiyu Xu, Xiaoling Shen, Yanni Hao, Jin Li, Haizhen Xu, Qiang Peng, Weihong Kuan. Neferine alleviates chronic stress-induced depression by regulating monoamine neurotransmitter secretion and gut microbiota structure. Frontiers in pharmacology. vol 13. 2022-09-19. PMID:36120376. |
moreover, both nef and flu treatments induced significant increases in the levels of anti-depressant neurotransmitters, including dopamine (da), serotonin (5-ht), and norepinephrine (ne), and also reduced pathological damage to the hippocampus of the depressed mice. |
2022-09-19 |
2023-08-14 |
mouse |
| Weiping Xiao, Jiaying Li, Xinjie Gao, Heng Yang, Jiabin Su, Ruiyuan Weng, Yanqin Gao, Wei Ni, Yuxiang G. Involvement of the gut-brain axis in vascular depression via tryptophan metabolism: A benefit of short chain fatty acids. Experimental neurology. 2022-09-13. PMID:36100045. |
a promoted conversion of tryptophan (trp) into kynurenine (kyn) instead of 5-hydroxytryptamine (5-ht) was observed in the hippocampus and gut of bccao rats. |
2022-09-13 |
2023-08-14 |
rat |
| Weiping Xiao, Jiaying Li, Xinjie Gao, Heng Yang, Jiabin Su, Ruiyuan Weng, Yanqin Gao, Wei Ni, Yuxiang G. Involvement of the gut-brain axis in vascular depression via tryptophan metabolism: A benefit of short chain fatty acids. Experimental neurology. 2022-09-13. PMID:36100045. |
enzyme-linked immunosorbent assays and quantitative rt-pcr suggested that scfa supplementation suppressed the conversion of trp to kyn and rescued the reduction in 5-ht levels in the hippocampus and gut. |
2022-09-13 |
2023-08-14 |
rat |
| Bongjun Sur, Bombi Le. Luteolin reduces fear, anxiety, and depression in rats with post-traumatic stress disorder. Animal cells and systems. vol 26. issue 4. 2022-09-01. PMID:36046028. |
also, administration of lu restored the increased norepinephrine and decreased serotonin levels in the structures within the fear circuit, medial prefrontal cortex, and hippocampus. |
2022-09-01 |
2023-08-14 |
rat |
| Jiabin Hong, Xiaoxun Lu, Jieyu Wang, Mengzhu Jiang, Qian Liu, Juntong Lin, Wenjing Sun, Jing Zhang, Yanwei Shi, Xiaoshan Li. Triphenyl phosphate disturbs placental tryptophan metabolism and induces neurobehavior abnormal in male offspring. Ecotoxicology and environmental safety. vol 243. 2022-08-25. PMID:36007322. |
consistent with the increased 5-ht, the nissl body was reduced in the hippocampus of treatment group. |
2022-08-25 |
2023-08-14 |
mouse |
| Ehsan Hosseini, Mahsa Farid Habibi, Shirin Babri, Gisou Mohaddes, Hajar Abkhezr, Hamed Heydar. Maternal stress induced anxiety-like behavior exacerbated by electromagnetic fields radiation in female rats offspring. PloS one. vol 17. issue 8. 2022-08-23. PMID:35998127. |
the results of the current study, clarified that elf-emf can induce anxiety-like behavior which may be attributed to an increase in the pnmdar2/nmdar2 ratio and 24(s)-ohc in the hippocampus, and prenatal stress may contribute to anxiety via a decrease in serotonin and an increase in corticosterone in the hippocampus. |
2022-08-23 |
2023-08-14 |
rat |
| Wenfei Wang, Yichun Wang, Qiuting Guo, Huiting Li, Zhaoqiang Wang, Jia Li, Taotao Li, Tiantian Tang, Yujiao Wang, Yanzhuo Jia, Yao Wang, Junbo Zou, Yajun Shi, Dongyan Guo, Ming Yang, Xiaofei Zhang, Jing Su. Valerian essential oil for treating insomnia Frontiers in nutrition. vol 9. 2022-08-22. PMID:35990355. |
valerian essential oil was given orally for treatment and the contents of 5-hydroxytryptamine receptor 1 a (5-ht1ar), γ-aminobutyric acid (gaba), cyclic adenosine monophosphate (camp), and protein kinase a (pka) in the hippocampus of rats in each group were detected by enzyme-linked immunosorbent assay (elisa), western blot, polymerase chain reaction (pcr), and immunohistochemistry. |
2022-08-22 |
2023-08-14 |
rat |
| Laura Durieux, Karine Herbeaux, Christopher Borcuk, Cécile Hildenbrand, Virginie Andry, Yannick Goumon, Alexandra Barbelivien, Chantal Mathis, Demian Bataglia, Monique Majchrzak, Lucas Lecourtie. Functional brain-wide network mapping during acute stress exposure in rats: Interaction between the lateral habenula and cortical, amygdalar, hypothalamic and monoaminergic regions. The European journal of neuroscience. 2022-08-22. PMID:35993349. |
it has been known for decades that the main structures engaged during the stress response are the medial prefrontal cortex, the amygdala, the hippocampus, the hypothalamus, the monoaminergic systems (noradrenaline, dopamine, serotonin), and the periaqueductal gray. |
2022-08-22 |
2023-08-14 |
rat |
| Cong Lu, Zhen Wei, Yongquan Wang, Shuying Li, Litao Tong, Xinmin Liu, Bei Fan, Fengzhong Wan. Soy isoflavones alleviate lipopolysaccharide-induced depressive-like behavior by suppressing neuroinflammation, mediating tryptophan metabolism and promoting synaptic plasticity. Food & function. 2022-08-22. PMID:35993820. |
additionally, si administration regulated tryptophan (trp) metabolism by increasing 5-hydroxytryptamine (5-ht) levels, inhibiting the release of kynurenine (kyn) in the cortex and hippocampus, and elevating the expressions of synaptic plasticity-related protein markers such as postsynaptic density-95 (psd-95) and synaptophysin (syn). |
2022-08-22 |
2023-08-14 |
mouse |
| Eduardo Solórzano Hernández, José Miguel Cervantes Alfaro, Rosalinda Figueroa Rosales, Blanca Erika Gutiérrez Guzmán, Miguel Ángel López Vázquez, María Esther Olvera Corté. Septal medial/diagonal band of Broca citalopram infusion reduces place learning efficiency and alters septohippocampal theta learning-related activity in rats. Behavioural brain research. 2022-08-13. PMID:35963580. |
the suppression of hippocampal theta expression and the modulation of hippocampal learning and memory are attributed to serotonin. |
2022-08-13 |
2023-08-14 |
rat |
| Eduardo Solórzano Hernández, José Miguel Cervantes Alfaro, Rosalinda Figueroa Rosales, Blanca Erika Gutiérrez Guzmán, Miguel Ángel López Vázquez, María Esther Olvera Corté. Septal medial/diagonal band of Broca citalopram infusion reduces place learning efficiency and alters septohippocampal theta learning-related activity in rats. Behavioural brain research. 2022-08-13. PMID:35963580. |
these results support a role of serotonin, in acting on the ms/dbb in the fine tuning of hippocampal learning and memory efficiency through the modulation of learning-related theta activity power and septohipocampal synchronization. |
2022-08-13 |
2023-08-14 |
rat |
| Melodi A Bowman, Jorge A Gomez, Nathan C Mitchell, Anne M Wells, Melissa Vitela, Kyra M Clarke, Rebecca E Horton, Wouter Koek, Lynette C Daw. Faster Serotonin Clearance in CA3 Region of Hippocampus and Antidepressant-like Effect of Decynium-22 in Juvenile Mice Are Putatively Linked to Increased Plasma Membrane Monoamine Transporter Function: Implications for Efficacy of Antidepressants in Juveniles. Cells. vol 11. issue 15. 2022-08-12. PMID:35954298. |
faster serotonin clearance in ca3 region of hippocampus and antidepressant-like effect of decynium-22 in juvenile mice are putatively linked to increased plasma membrane monoamine transporter function: implications for efficacy of antidepressants in juveniles. |
2022-08-12 |
2023-08-14 |
mouse |
| Melodi A Bowman, Jorge A Gomez, Nathan C Mitchell, Anne M Wells, Melissa Vitela, Kyra M Clarke, Rebecca E Horton, Wouter Koek, Lynette C Daw. Faster Serotonin Clearance in CA3 Region of Hippocampus and Antidepressant-like Effect of Decynium-22 in Juvenile Mice Are Putatively Linked to Increased Plasma Membrane Monoamine Transporter Function: Implications for Efficacy of Antidepressants in Juveniles. Cells. vol 11. issue 15. 2022-08-12. PMID:35954298. |
using in vivo high-speed chronoamperometry, we found that juveniles clear serotonin from the ca3 region of the hippocampus ~2-fold faster than adult mice. |
2022-08-12 |
2023-08-14 |
mouse |
| Andréa V Maglione, Bruna P P do Nascimento, Miriam O Ribeiro, Talytha J L de Souza, Renata E C da Silva, Monica A Sato, Carlos A A Penatti, Luiz R G Britto, Janaina S de Souza, Rui M B Maciel, Rodrigo Rodrigues da Conceição, Roberto Laureano-Melo, Gisele Giannocc. Triiodothyronine Treatment reverses Depression-Like Behavior in a triple-transgenic animal model of Alzheimer's Disease. Metabolic brain disease. 2022-08-11. PMID:35951206. |
when compared to control hippocampal samples, the t3 group exhibited attenuated glycogen synthase kinase-3 (gsk3), metalloproteinase 10 (adam10), amyloid-beta precursor-protein (app), serotonin transporter (sert), 5ht1a receptor, monocarboxylate transporter 8 (mct8) and bone morphogenetic protein 7 (bmp-7) gene expression, whereas augmented superoxide dismutase 2 (sod2) and hairless gene expression. |
2022-08-11 |
2023-08-14 |
mouse |
| Wenjing Yan, Hulin Zhu, Pengbo Zhang, Ting Sun, Shuai Gong, Guoxiu Sun, Zeqiang Re. Heterotopic 4T1 breast cancer transplantation induces hippocampal inflammation and depressive-like behaviors in mice. Metabolic brain disease. 2022-08-10. PMID:35947291. |
immunohistochemistry studies revealed reduced levels of serotonin, norepinephrine, and bdnf in the hippocampus and serum. |
2022-08-10 |
2023-08-14 |
mouse |
| Harleen Kaur Dhillon, Tanveer Singh, Rajesh Kumar Goe. Ferulic acid inhibits catamenial epilepsy through modulation of female hormones. Metabolic brain disease. 2022-08-06. PMID:35932441. |
four to six hours following tst, animals were euthanized, and discrete brain parts (cortex and hippocampus) were separated for estimation of norepinephrine, serotonin, and dopamine as well as glutamic acid decarboxylase (gad) enzyme activity. |
2022-08-06 |
2023-08-14 |
mouse |
| Gyllyandeson de Araújo Delmondes, Maria Janice Pereira Lopes, Isaac Moura Araújo, Alex de Sousa Borges, Paulo Ricardo Batista, Henrique Douglas Melo Coutinho, Irwin Rose Alencar de Menezes, José Maria Barbosa-Filho, Cícero Francisco Bezerra Felipe, Marta Regina Kerntop. Possible mechanisms involved in the neuroprotective effect of Trans,trans-farnesol on pilocarpine-induced seizures in mice. Chemico-biological interactions. 2022-08-05. PMID:35931201. |
in this same model, pretreatment with the lowest dose of the compound decreased the hippocampal concentrations of thiobarbituric acid and nitrite, and partially restored striatal concentrations of noradrenaline, dopamine, and serotonin. |
2022-08-05 |
2023-08-14 |
mouse |
| Lauren Malave, Milenna T van Dijk, Christoph Anacke. Early life adversity shapes neural circuit function during sensitive postnatal developmental periods. Translational psychiatry. vol 12. issue 1. 2022-08-01. PMID:35915071. |
we provide converging evidence from human and animal studies on how ela alters the functional development of brain regions, neural circuits, and neurotransmitter systems that are crucial for cognition and affective behavior, including the hippocampus, the hypothalamus-pituitary-adrenal (hpa) axis, neural networks of fear responses and cognition, and the serotonin (5-ht) system. |
2022-08-01 |
2023-08-14 |
human |
| V N Zorina, A Ya Bespalov, K A Krasnov, A S Melekhova, V L Reinu. [Prospects for the development of new prolonged forms of valproic acid derivatives for the relief of convulsive syndrome]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. vol 122. issue 7. 2022-07-29. PMID:35904287. |
the antiepileptic, mood stabilizing and neuroprotective properties of valproate due to pre- and postsynaptic modulation of gaba-ergic transmission, regulation of glutamate activity, serotonin and dopamine levels in the hippocampus, modulation of sodium, calcium and potassium channels, epigenetic effects on the body are described. |
2022-07-29 |
2023-08-14 |
Not clear |
| Catharina S Hamann, Julian Bankmann, Hanna Mora Maza, Johannes Kornhuber, Iulia Zoicas, Angelika Schmitt-Böhre. Social Fear Affects Limbic System Neuronal Activity and Gene Expression. International journal of molecular sciences. vol 23. issue 15. 2022-07-28. PMID:35897794. |
sfc+ mice also showed alterations in the expression of npy and serotonin system-related genes in the paraventricular nucleus of the hypothalamus, basolateral amygdala, septum and dorsal raphe nucleus, but not in the dorsal hippocampus. |
2022-07-28 |
2023-08-14 |
mouse |