| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Joanna Kowalczyk, Modestos Nakos-Bimpos, Alexia Polissidis, Christina Dalla, Nikolaos Kokras, Krystyna Skalicka-Woźniak, Barbara Budzyńsk. Imperatorin Influences Depressive-like Behaviors: A Preclinical Study on Behavioral and Neurochemical Sex Differences. Molecules (Basel, Switzerland). vol 27. issue 4. 2022-02-25. PMID:35208969. |
there were no evident changes observed with respect to noradrenaline and serotonin metabolite levels in the male hippocampus. |
2022-02-25 |
2023-08-13 |
mouse |
| Amina E Essawy, Soad Ahmed El-Sayed, Ehab Tousson, Horeya S Abd El-Gawad, Reem Hasaballah Alhasani, Heba-Tallah Abd Elrahim Abd Elkade. Anti-kindling effect of Ginkgo biloba leaf extract and L-carnitine in the pentylenetetrazol model of epilepsy. Environmental science and pollution research international. 2022-02-23. PMID:35194715. |
the oxidative stress, antioxidant, and neurochemical parameters, viz., malondialdehyde (mda), nitric oxide (no), reduced glutathione (gsh), superoxide dismutase (sod), catalase (cat), glutathione peroxidase (gpx), acetylcholine esterase (ache), dopamine (da), norepinephrine (ne), and serotonin (5-ht), in the hippocampal and hypothalamic regions have been evaluated. |
2022-02-23 |
2023-08-13 |
rat |
| Qiliang Chen, Candong Li, Enxiang Tao, Tetsuya Asakawa, Yuanyuan Zhan. Exploration of a Brain-Liver-Communication-Related Mechanism Involved in the Experimental Perimenopausal Depression Rat Model using Chaihu-Shugan-San. Neurochemical research. 2022-02-22. PMID:35190952. |
we observed the behavioural performances of depression and anxiety, serum concentrations of biochemical indices, serum estrogen two levels, hippocampal 5-ht and ne levels and the morphological changes in liver tissues. |
2022-02-22 |
2023-08-13 |
rat |
| Alexandre Magno da Nobrega Marinho, Bruno Lobão-Soares, Hugo Alexandre Sousa Targino, Yago José Fernandes Vasconcellos, Ricardo Guarnieri, Carlos Gilberto Carlott. Decreased hippocampal serotonin 5HT Epilepsy & behavior : E&B. vol 129. 2022-02-21. PMID:35189481. |
decreased hippocampal serotonin 5ht mesial temporal lobe epilepsy related to hippocampal sclerosis (mtle-hs) is a surgically remediable epilepsy with a relatively high prevalence and psychiatric comorbidities. |
2022-02-21 |
2023-08-13 |
Not clear |
| Safa Ghaheri, Ali Niapour, Nona Sakhaie, Farshid Sadegzadeh, Hakimeh Saadat. Postnatal depletion of serotonin affects the morphology of neurons and the function of the hippocampus in male rats. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 2022-02-19. PMID:35181916. |
postnatal depletion of serotonin affects the morphology of neurons and the function of the hippocampus in male rats. |
2022-02-19 |
2023-08-13 |
rat |
| Safa Ghaheri, Ali Niapour, Nona Sakhaie, Farshid Sadegzadeh, Hakimeh Saadat. Postnatal depletion of serotonin affects the morphology of neurons and the function of the hippocampus in male rats. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 2022-02-19. PMID:35181916. |
here we aimed to examine the effects of the para- chlorophenylalanine (pcpa; 100mg/kg/daily, s.c during the postnatal days 10-20), a reversible inhibitor of 5-ht synthesis, on the serotonin level of the hippocampal and prefrontal cortex. |
2022-02-19 |
2023-08-13 |
rat |
| Safa Ghaheri, Ali Niapour, Nona Sakhaie, Farshid Sadegzadeh, Hakimeh Saadat. Postnatal depletion of serotonin affects the morphology of neurons and the function of the hippocampus in male rats. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 2022-02-19. PMID:35181916. |
our results indicated that the administration of pcpa led to a decrease in serotonin levels in the hippocampus and prefrontal cortex. |
2022-02-19 |
2023-08-13 |
rat |
| Safa Ghaheri, Ali Niapour, Nona Sakhaie, Farshid Sadegzadeh, Hakimeh Saadat. Postnatal depletion of serotonin affects the morphology of neurons and the function of the hippocampus in male rats. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 2022-02-19. PMID:35181916. |
postnatal serotonin depletion also induced subtle alterations in the neuronal populations of the hippocampus and impaired spatial memory in the adulthood period of life. |
2022-02-19 |
2023-08-13 |
rat |
| Ying-Xiao Li, Kai-Chun Cheng, Chao-Tien Hsu, Juei-Tang Cheng, Ting-Ting Yan. Major Plant in Herbal Mixture Gan-Mai-Da-Zao for the Alleviation of Depression in Rat Models. Plants (Basel, Switzerland). vol 11. issue 3. 2022-02-15. PMID:35161241. |
the expression levels of the serotonin transporter (5-htt) and brain-derived neurotrophic factor (bdnf) in the hippocampus of the rats with depression were markedly increased by gmdz. |
2022-02-15 |
2023-08-13 |
rat |
| Xiaoyue Wei, Kezhu Wang, Jinfeng Gao, Shijian Chen, Siying Zeng, Yuhong Zha. FG7142 combined with restraint stress induces anxiogenic-like effects via downregulation gamma-aminobutyric acid type A receptor subunit alpha1 and 5-hydroxytryptamine 1A receptors expression in the hippocampus. Neuroreport. vol 33. issue 3. 2022-02-09. PMID:35139062. |
fg7142 combined with restraint stress induces anxiogenic-like effects via downregulation gamma-aminobutyric acid type a receptor subunit alpha1 and 5-hydroxytryptamine 1a receptors expression in the hippocampus. |
2022-02-09 |
2023-08-13 |
Not clear |
| Khalid A El-Saiy, Rabab H Sayed, Ayman E El-Sahar, Esraa A Kandi. Modulation of histone deacetylase, the ubiquitin proteasome system, and autophagy underlies the neuroprotective effects of venlafaxine in a rotenone-induced Parkinson's disease model in rats. Chemico-biological interactions. 2022-02-01. PMID:35104487. |
moreover, venlafaxine hampered depressive symptoms and improved hippocampal noradrenaline and serotonin levels. |
2022-02-01 |
2023-08-13 |
rat |
| Ana Paula Farias Waltrick, Alvaro Henrique Bernardo de Lima Silva, Milene Cristina de Carvalho, Bruna Aparecida Comotti de Oliveira, Katya Naliwaiko, Joice Maria da Cunha, Janaina Menezes Zanovel. Preventive treatment with fish oil facilitates the antidepressant-like effect of antidepressant drugs in type-1 diabetes mellitus rats: implication of serotonergic system. Neuroscience letters. 2022-01-29. PMID:35090949. |
in addition, confirming these assumptions, the decreased 5-ht levels in the hippocampus from induced-t1dm rats were increased after treatment with flx (highest dose) or imi (both doses), being this increase more pronounced in animal pretreated with fo. |
2022-01-29 |
2023-08-13 |
rat |
| Bingqian Zhou, Ge Jin, Xiaoqi Pang, Qi Mo, Jie Bao, Tiaotiao Liu, Jingyi Wu, Runxiang Xie, Xiang Liu, Jinghua Liu, Hongwei Yang, Xin Xu, Bangmao Wang, Hailong Ca. Lactobacillus rhamnosus GG colonization in early life regulates gut-brain axis and relieves anxiety-like behavior in adulthood. Pharmacological research. 2022-01-22. PMID:35065201. |
mechanically, lgg colonization activated epithelial growth factor receptor (egfr) and enhanced serotonin transporter (sert) expression and modulated serotonergic system in the intestine, and increased brain-derived neurotrophic factor and γ-aminobutyric acid receptor levels in the hippocampus and amygdala. |
2022-01-22 |
2023-08-13 |
mouse |
| Qi Wang, Ya-Nan Sun, Chun-Ming Zou, Te-Li Zhang, Zhu Li, Min Liu, Bi-Ying Shi, Shan-Shan Shi, Chun-Yue Yu, Tai-Ming We. Regulation of the kynurenine/serotonin pathway by berberine and the underlying effect in the hippocampus of the chronic unpredictable mild stress mice. Behavioural brain research. 2022-01-20. PMID:35051489. |
this study was to investigate the hypothesis that bbr treats depressive-like behavior by shifting the balance of the kynurenine (kyn)/serotonin (5-ht) pathway toward the 5-ht pathway through downregulated indoleamine 2,3-dioxygenase 1 (ido1), monoamine oxidase a (maoa) and upregulated dopamine decarboxylase (ddc) in hippocampus. |
2022-01-20 |
2023-08-13 |
mouse |
| Guo-Liang Dai, Xin-Yi Yang, Shan-Shan Chen, Yi-Qing Wang, Mei-Chen Liu, Yang Cao, Fei-Ran Li, Cheng-Yao Ma, Wen-Zheng J. [Effects of Jiaotai Pills on CUMS-induced depression model in mice based on changes of SIRT1 expression in hippocampus]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 46. issue 24. 2022-01-07. PMID:34994144. |
liquid chromatography-tandem mass spectrometry(lc-ms/ms) was used to detect the levels of dopamine(da), 5-hydroxytryptamine(5-ht), and norepinephrine(ne) in the hippocampus and serum of mice. |
2022-01-07 |
2023-08-13 |
mouse |
| Guo-Liang Dai, Xin-Yi Yang, Shan-Shan Chen, Yi-Qing Wang, Mei-Chen Liu, Yang Cao, Fei-Ran Li, Cheng-Yao Ma, Wen-Zheng J. [Effects of Jiaotai Pills on CUMS-induced depression model in mice based on changes of SIRT1 expression in hippocampus]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 46. issue 24. 2022-01-07. PMID:34994144. |
in the hippocampus and serum, the levels of il-1β, il-6, tnf-α, and mda were increased(p<0.01), and the activity of sod and the levels of gsh, da, 5-ht, ne, and bdnf were reduced(p<0.01). |
2022-01-07 |
2023-08-13 |
mouse |
| Guo-Liang Dai, Xin-Yi Yang, Shan-Shan Chen, Yi-Qing Wang, Mei-Chen Liu, Yang Cao, Fei-Ran Li, Cheng-Yao Ma, Wen-Zheng J. [Effects of Jiaotai Pills on CUMS-induced depression model in mice based on changes of SIRT1 expression in hippocampus]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 46. issue 24. 2022-01-07. PMID:34994144. |
the treatment with high-dose jiaotai pills increased the sucrose preference rate, movement distance, and the number of crossing centers(p<0.05), reduced tail suspension time and swimming immobility time(p<0.01), elevated hippocampal sirt1 expression level(p<0.01), decreased hippocampal and serum il-1β, il-6, tnf-α, and mda levels(p<0.01), potentiated sod activity, and up-regulated gsh, da, 5-ht, ne, and bdnf levels in the hippocampus and serum(p<0.05, p<0.01) in model mice. |
2022-01-07 |
2023-08-13 |
mouse |
| Xueting Zhang, Kazufumi Yoshihara, Noriyuki Miyata, Tomokazu Hata, Altanzul Altaisaikhan, Shu Takakura, Yasunari Asano, Satoshi Izuno, Nobuyuki Sud. Dietary tryptophan, tyrosine, and phenylalanine depletion induce reduced food intake and behavioral alterations in mice. Physiology & behavior. vol 244. 2021-12-11. PMID:34800493. |
the ttp-deprived group showed a reduction in ttp levels in the serum, concomitant with decreases in both phenylalanine and tyrosine levels in the hippocampus, as well as serotonin, norepinephrine, and dopamine concentrations in some regions of the brain. |
2021-12-11 |
2023-08-13 |
mouse |
| Tatiana de Queiroz Oliveira, Adriano José Maia Chaves Filho, Paloma Marinho Jucá, Michelle Verde Ramos Soares, Natássia Lopes Cunha, Charliene Freire Xavier Vieira, Carlos Venício Jataí Gadelha Filho, Glautemberg de Almeida Viana, Gabriela Mariângela Farias De Oliveira, Danielle Silveira Macedo, Silvânia Maria Mendes Vasconcelo. Lipoic acid prevents mirtazapine-induced weight gain in mice without impairs its antidepressant-like action in a neuroendocrine model of depression. Behavioural brain research. vol 419. 2021-12-10. PMID:34798169. |
also, hippocampus (hc) protein expression of the serotonin transporter (sert), synaptophysin, protein kinase b-akt (total and phosphorylated) and the cytokines il-4 and il-6 were investigated. |
2021-12-10 |
2023-08-13 |
mouse |
| Nirupa Goel, Tristan J Philippe, Judy Chang, Maya E Koblanski, Victor Via. Cellular and serotonergic correlates of habituated neuroendocrine responses in male and female rats. Psychoneuroendocrinology. vol 136. 2021-12-10. PMID:34891046. |
relative to their singly restrained counterparts, males displayed an increase in 5-ht 1 a receptor expression in the raphe nucleus after repeated restraint, whereas females showed a decrease in 5-ht 1 a mrna levels in the hippocampus and in the zona incerta, representing the most proximal of cell groups expressing the 5-ht 1 a receptor in the vicinity of the pvh. |
2021-12-10 |
2023-08-13 |
rat |