| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuko Adachi, Kazuki Ota, Isao Minami, Tetsuya Yamada, Takayuki Watanab. Lower insulin secretion is associated with hippocampal and parahippocampal gyrus atrophy in elderly patients with type 2 diabetes mellitus. Journal of diabetes investigation. vol 12. issue 10. 2021-10-22. PMID:33783982. |
lower insulin secretion is associated with hippocampal and parahippocampal gyrus atrophy in elderly patients with type 2 diabetes mellitus. |
2021-10-22 |
2023-08-13 |
Not clear |
| Reza Sardar, Javad Hami, Mansoureh Soleimani, Mohammad-Taghi Joghataei, Reza Shirazi, Fereshteh Golab, Zeinab Namjoo, Zahra Zandie. Maternal diabetes-induced alterations in the expression of brain-derived neurotrophic factor in the developing rat hippocampus. Journal of chemical neuroanatomy. vol 114. 2021-10-05. PMID:33745942. |
in the current study, we evaluated the effects of maternal diabetes and insulin treatment on expression and distribution pattern of bdnf in the hippocampus of neonatal rats at the first two postnatal weeks. |
2021-10-05 |
2023-08-13 |
rat |
| Reza Sardar, Javad Hami, Mansoureh Soleimani, Mohammad-Taghi Joghataei, Reza Shirazi, Fereshteh Golab, Zeinab Namjoo, Zahra Zandie. Maternal diabetes-induced alterations in the expression of brain-derived neurotrophic factor in the developing rat hippocampus. Journal of chemical neuroanatomy. vol 114. 2021-10-05. PMID:33745942. |
we found no differences in hippocampal expression of bdnf between diabetics with normal control or insulin treated neonatal rats at postnatal day (p0) (p > 0.05 each). |
2021-10-05 |
2023-08-13 |
rat |
| Patricia Soriano Roque, Mehdi Hooshmandi, Laura Neagu-Lund, Shelly Yin, Noosha Yousefpour, Hiroaki Sato, Tamaki Sato, Yosuke Nakadate, Akiko Kawakami, Soroush Tahmasebi, Alfredo Ribeiro-da-Silva, Christos G Gkogkas, Masha Prager-Khoutorsky, Thomas Schricker, Linda Wykes, Arkady Khoutorsk. Intranasal insulin rescues repeated anesthesia-induced deficits in synaptic plasticity and memory and prevents apoptosis in neonatal mice via mTORC1. Scientific reports. vol 11. issue 1. 2021-10-04. PMID:34326413. |
moreover, intranasal insulin prevented anesthesia-induced apoptosis of hippocampal cells, which is thought to underlie cognitive impairment. |
2021-10-04 |
2023-08-13 |
mouse |
| Patricia Soriano Roque, Mehdi Hooshmandi, Laura Neagu-Lund, Shelly Yin, Noosha Yousefpour, Hiroaki Sato, Tamaki Sato, Yosuke Nakadate, Akiko Kawakami, Soroush Tahmasebi, Alfredo Ribeiro-da-Silva, Christos G Gkogkas, Masha Prager-Khoutorsky, Thomas Schricker, Linda Wykes, Arkady Khoutorsk. Intranasal insulin rescues repeated anesthesia-induced deficits in synaptic plasticity and memory and prevents apoptosis in neonatal mice via mTORC1. Scientific reports. vol 11. issue 1. 2021-10-04. PMID:34326413. |
our study demonstrates that intranasal insulin prevents general anesthesia-induced apoptosis of hippocampal cells, and deficits in synaptic plasticity and memory, and suggests that the rescue effect is mediated via mtorc1/4e-bp2 signaling. |
2021-10-04 |
2023-08-13 |
mouse |
| Fábio J Sousa, Raquel G Correia, Alexandra F Cruz, Joana M Martins, Matilde S Rodrigues, Catarina A Gomes, António F Ambrósio, Filipa I Baptist. Sex differences in offspring neurodevelopment, cognitive performance and microglia morphology associated with maternal diabetes: Putative targets for insulin therapy. Brain, behavior, & immunity - health. vol 5. 2021-10-01. PMID:34589855. |
notably, insulin administration to diabetic dams may also modulate offspring development in a way that differs from what is observed in physiological conditions, since it promoted the expedited acquisition of developmental milestones and of discrimination ability at memory test, also inducing a hyper-ramification of male and female hippocampal microglia. |
2021-10-01 |
2023-08-13 |
Not clear |
| Alfonso Diaz, Guadalupe Muñoz-Arenas, Berenice Venegas, Rubén Vázquez-Roque, Gonzalo Flores, Jorge Guevara, Enrique Gonzalez-Vergara, Samuel Treviñ. Metforminium Decavanadate (MetfDeca) Treatment Ameliorates Hippocampal Neurodegeneration and Recognition Memory in a Metabolic Syndrome Model. Neurochemical research. vol 46. issue 5. 2021-09-27. PMID:33559829. |
it has recently been proposed that metformin decavanadate (metfdeca) exerts insulin mimetic effects that enhance metabolism in ms animals; however, what effects it can cause on the hippocampal neurons of rats with ms are unknown. |
2021-09-27 |
2023-08-13 |
rat |
| Weikang Cai, Xuemei Zhang, Thiago M Batista, Rubén García-Martín, Samir Softic, Guoxiao Wang, Alfred K Ramirez, Masahiro Konishi, Brian T O'Neill, Jong Hun Kim, Jason K Kim, C Ronald Kah. Peripheral Insulin Regulates a Broad Network of Gene Expression in Hypothalamus, Hippocampus, and Nucleus Accumbens. Diabetes. vol 70. issue 8. 2021-09-21. PMID:34031123. |
peripheral insulin regulates a broad network of gene expression in hypothalamus, hippocampus, and nucleus accumbens. |
2021-09-21 |
2023-08-13 |
mouse |
| Weikang Cai, Xuemei Zhang, Thiago M Batista, Rubén García-Martín, Samir Softic, Guoxiao Wang, Alfred K Ramirez, Masahiro Konishi, Brian T O'Neill, Jong Hun Kim, Jason K Kim, C Ronald Kah. Peripheral Insulin Regulates a Broad Network of Gene Expression in Hypothalamus, Hippocampus, and Nucleus Accumbens. Diabetes. vol 70. issue 8. 2021-09-21. PMID:34031123. |
insulin regulates distinct pathways in the hypothalamus (htm), hippocampus, and nucleus accumbens. |
2021-09-21 |
2023-08-13 |
mouse |
| Liangyu Peng, Xin Fang, Fangxia Xu, Shuai Liu, Yue Qian, Xiangdan Gong, Xin Zhao, Zhengliang Ma, Tianjiao Xia, Xiaoping G. Amelioration of Hippocampal Insulin Resistance Reduces Tau Hyperphosphorylation and Cognitive Decline Induced by Isoflurane in Mice. Frontiers in aging neuroscience. vol 13. 2021-09-14. PMID:34512303. |
amelioration of hippocampal insulin resistance reduces tau hyperphosphorylation and cognitive decline induced by isoflurane in mice. |
2021-09-14 |
2023-08-13 |
mouse |
| Liangyu Peng, Xin Fang, Fangxia Xu, Shuai Liu, Yue Qian, Xiangdan Gong, Xin Zhao, Zhengliang Ma, Tianjiao Xia, Xiaoping G. Amelioration of Hippocampal Insulin Resistance Reduces Tau Hyperphosphorylation and Cognitive Decline Induced by Isoflurane in Mice. Frontiers in aging neuroscience. vol 13. 2021-09-14. PMID:34512303. |
administration of 25% glucose to metformin-pretreated mice induced hyperglycemia, but surprisingly did not reverse the benefits of metformin on hippocampal insulin signaling and fear memory following isoflurane anesthesia. |
2021-09-14 |
2023-08-13 |
mouse |
| Nazia Siddiqui, Javed Ali, Suhel Parvez, Saima Zameer, Abul Kalam Najmi, Mohd Akhta. Linagliptin, a DPP-4 inhibitor, ameliorates Aβ (1-42) peptides induced neurodegeneration and brain insulin resistance (BIR) via insulin receptor substrate-1 (IRS-1) in rat model of Alzheimer's disease. Neuropharmacology. vol 195. 2021-09-13. PMID:34119519. |
linagliptin, a dpp-4 inhibitor is hypothesized to increase glp-1 level, which then crosses blood brain barrier (bbb), decreases amyloid-beta (aβ) and insulin resistance in hippocampus. |
2021-09-13 |
2023-08-13 |
rat |
| Yahong Cheng, Xin Zeng, Qianting Mai, Xinying Bai, Yuan Jiang, Jinjin Li, Shiqi Fan, Hong Din. Insulin injections inhibits PTZ-induced mitochondrial dysfunction, oxidative stress and neurological deficits via the SIRT1/PGC-1α/SIRT3 pathway. Biochimica et biophysica acta. Molecular basis of disease. vol 1867. issue 6. 2021-09-10. PMID:33727197. |
additionally, insulin pretreatment upregulated bcl-2, downregulated bax, and then played a neuroprotective role against hippocampal neuron apoptosis. |
2021-09-10 |
2023-08-13 |
mouse |
| Guianfranco Mazzei, Ryohei Ikegami, Nona Abolhassani, Naoki Haruyama, Kunihiko Sakumi, Takashi Saito, Takaomi C Saido, Yusaku Nakabepp. A high-fat diet exacerbates the Alzheimer's disease pathology in the hippocampus of the App Aging cell. vol 20. issue 8. 2021-09-10. PMID:34245097. |
a high-fat diet exacerbates the alzheimer's disease pathology in the hippocampus of the app insulin resistance and diabetes mellitus are major risk factors for alzheimer's disease (ad), and studies with transgenic mouse models of ad have provided supportive evidence with some controversies. |
2021-09-10 |
2023-08-13 |
mouse |
| Pegah Javadpour, Sahar Askari, Fatemeh Sadat Rashidi, Leila Dargahi, Abolhassan Ahmadiani, Rasoul Ghasem. Imipramine alleviates memory impairment and hippocampal apoptosis in STZ-induced sporadic Alzheimer's rat model: Possible contribution of MAPKs and insulin signaling. Behavioural brain research. vol 408. 2021-09-02. PMID:33775777. |
imipramine alleviates memory impairment and hippocampal apoptosis in stz-induced sporadic alzheimer's rat model: possible contribution of mapks and insulin signaling. |
2021-09-02 |
2023-08-13 |
rat |
| Clarissa Branco Haas, Afonso Kopczynski de Carvalho, Alexandre Pastoris Muller, Bart J L Eggen, Luis Valmor Portel. Insulin activates microglia and increases COX-2/IL-1β expression in young but not in aged hippocampus. Brain research. vol 1741. 2021-09-01. PMID:32422127. |
insulin activates microglia and increases cox-2/il-1β expression in young but not in aged hippocampus. |
2021-09-01 |
2023-08-13 |
rat |
| Clarissa Branco Haas, Afonso Kopczynski de Carvalho, Alexandre Pastoris Muller, Bart J L Eggen, Luis Valmor Portel. Insulin activates microglia and increases COX-2/IL-1β expression in young but not in aged hippocampus. Brain research. vol 1741. 2021-09-01. PMID:32422127. |
in this study we investigated whether insulin affected microglia in the hippocampus of young and aged rats. |
2021-09-01 |
2023-08-13 |
rat |
| Clarissa Branco Haas, Afonso Kopczynski de Carvalho, Alexandre Pastoris Muller, Bart J L Eggen, Luis Valmor Portel. Insulin activates microglia and increases COX-2/IL-1β expression in young but not in aged hippocampus. Brain research. vol 1741. 2021-09-01. PMID:32422127. |
insulin (20 mu) or vehicle for five days and evaluated microglial inflammatory markers in the hippocampus of young (3 months) wistar rats. |
2021-09-01 |
2023-08-13 |
rat |
| Hilaree N Frazier, Katie L Anderson, Adam O Ghoweri, Ruei-Lung Lin, Tara R Hawkinson, Gabriel J Popa, Pradoldej Sompol, Michael D Mendenhall, Christopher M Norris, Olivier Thibaul. Molecular elevation of insulin receptor signaling improves memory recall in aged Fischer 344 rats. Aging cell. vol 19. issue 10. 2021-08-26. PMID:32852134. |
as demonstrated by increased hippocampal insulin receptor density following learning in animal models and decreased insulin signaling, receptor density, and memory decline in aging and alzheimer's diseases, numerous studies have emphasized the importance of insulin in learning and memory processes. |
2021-08-26 |
2023-08-13 |
human |
| Hilaree N Frazier, Katie L Anderson, Adam O Ghoweri, Ruei-Lung Lin, Tara R Hawkinson, Gabriel J Popa, Pradoldej Sompol, Michael D Mendenhall, Christopher M Norris, Olivier Thibaul. Molecular elevation of insulin receptor signaling improves memory recall in aged Fischer 344 rats. Aging cell. vol 19. issue 10. 2021-08-26. PMID:32852134. |
these results provide new insights into the potential impact of increasing neuronal insulin signaling in the hippocampus of aged animals and support the efficacy of molecularly elevating insulin receptor activity in vivo in the absence of the ligand to directly study this process. |
2021-08-26 |
2023-08-13 |
human |