| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hui Yang, Lin Tang, Zhan Qu, Shi-Hui Lei, Wei Li, Yu-Hong Wan. Hippocampal insulin resistance and the Sirtuin 1 signaling pathway in diabetes-induced cognitive dysfunction. Neural regeneration research. vol 16. issue 12. 2021-08-26. PMID:33907035. |
hippocampal insulin resistance and the sirtuin 1 signaling pathway in diabetes-induced cognitive dysfunction. |
2021-08-26 |
2023-08-13 |
rat |
| Hui Yang, Lin Tang, Zhan Qu, Shi-Hui Lei, Wei Li, Yu-Hong Wan. Hippocampal insulin resistance and the Sirtuin 1 signaling pathway in diabetes-induced cognitive dysfunction. Neural regeneration research. vol 16. issue 12. 2021-08-26. PMID:33907035. |
at 8 weeks after streptozotocin injection, the morris water maze test and western blot assays confirmed that the diabetic model rats had learning and memory deficits, insulin resistance, and sirtuin 1 expression could be detected in the hippocampus. |
2021-08-26 |
2023-08-13 |
rat |
| Hui Yang, Lin Tang, Zhan Qu, Shi-Hui Lei, Wei Li, Yu-Hong Wan. Hippocampal insulin resistance and the Sirtuin 1 signaling pathway in diabetes-induced cognitive dysfunction. Neural regeneration research. vol 16. issue 12. 2021-08-26. PMID:33907035. |
the results showed that insulin administration improved the impaired cognitive function of diabetic model rats and increased the expression levels of phosphorylated insulin receptor, phosphorylated insulin receptor substrate 1, and sirtuin 1 in the hippocampus. |
2021-08-26 |
2023-08-13 |
rat |
| Fei Gao, Dingying Wu, Lingling Guo, Lixue Wang, Min Hao, Ling Li, Dongmei Ni, Haojie Ha. Liraglutide inhibits the progression of prediabetes in rats by reducing Raf-1 kinase inhibitor protein. Annals of translational medicine. vol 9. issue 14. 2021-08-26. PMID:34430598. |
the cleavage product of raf-1 kinase inhibitor protein (rkip), hippocampal cholinergic neurostimulating peptide (hcnp) is involved in the promotion of insulin secretion. |
2021-08-26 |
2023-08-13 |
rat |
| Hayma Hammoud, Olga Netsyk, Atieh S Tafreshiha, Sergiy V Korol, Zhe Jin, Jin-Ping Li, Bryndis Birni. Insulin differentially modulates GABA signalling in hippocampal neurons and, in an age-dependent manner, normalizes GABA-activated currents in the tg-APPSwe mouse model of Alzheimer's disease. Acta physiologica (Oxford, England). vol 232. issue 2. 2021-08-18. PMID:33559388. |
insulin differentially modulates gaba signalling in hippocampal neurons and, in an age-dependent manner, normalizes gaba-activated currents in the tg-appswe mouse model of alzheimer's disease. |
2021-08-18 |
2023-08-13 |
mouse |
| Hayma Hammoud, Olga Netsyk, Atieh S Tafreshiha, Sergiy V Korol, Zhe Jin, Jin-Ping Li, Bryndis Birni. Insulin differentially modulates GABA signalling in hippocampal neurons and, in an age-dependent manner, normalizes GABA-activated currents in the tg-APPSwe mouse model of Alzheimer's disease. Acta physiologica (Oxford, England). vol 232. issue 2. 2021-08-18. PMID:33559388. |
we examined if tonic γ-aminobutyric acid (gaba)-activated currents in primary hippocampal neurons were modulated by insulin in wild-type and tg-appswe mice, an alzheimer's disease (ad) model. |
2021-08-18 |
2023-08-13 |
mouse |
| Sophia Frangou, Fahim Abbasi, Katie Watson, Shalaila S Haas, Mathilde Antoniades, Amirhossein Modabbernia, Alison Myoraku, Thalia Robakis, Natalie Rasgo. Hippocampal volume reduction is associated with direct measure of insulin resistance in adults. Neuroscience research. 2021-08-17. PMID:34352294. |
hippocampal volume reduction is associated with direct measure of insulin resistance in adults. |
2021-08-17 |
2023-08-13 |
Not clear |
| Sophia Frangou, Fahim Abbasi, Katie Watson, Shalaila S Haas, Mathilde Antoniades, Amirhossein Modabbernia, Alison Myoraku, Thalia Robakis, Natalie Rasgo. Hippocampal volume reduction is associated with direct measure of insulin resistance in adults. Neuroscience research. 2021-08-17. PMID:34352294. |
body mass index (bmi), adiposity, fasting insulin, glucose, leptin as well as structural neuroimaing with automatic hippocampal subfield segmentation were performed. |
2021-08-17 |
2023-08-13 |
Not clear |
| Sophia Frangou, Fahim Abbasi, Katie Watson, Shalaila S Haas, Mathilde Antoniades, Amirhossein Modabbernia, Alison Myoraku, Thalia Robakis, Natalie Rasgo. Hippocampal volume reduction is associated with direct measure of insulin resistance in adults. Neuroscience research. 2021-08-17. PMID:34352294. |
data analysis using unsupervised machine learning (k-means clustering) identified two subgroups reflecting a pattern of more pronounced hippocampal volume reduction being concurrently associated with greater adiposity and insulin resistance; the hippocampal volume reductions were uniform across subfields. |
2021-08-17 |
2023-08-13 |
Not clear |
| Hilaree N Frazier, Adam O Ghoweri, Katie L Anderson, Ruei-Lung Lin, Gabriel J Popa, Michael D Mendenhall, Lawrence P Reagan, Rolf J Craven, Olivier Thibaul. Elevating Insulin Signaling Using a Constitutively Active Insulin Receptor Increases Glucose Metabolism and Expression of GLUT3 in Hippocampal Neurons. Frontiers in neuroscience. vol 14. 2021-08-12. PMID:32733189. |
elevating insulin signaling using a constitutively active insulin receptor increases glucose metabolism and expression of glut3 in hippocampal neurons. |
2021-08-12 |
2023-08-13 |
human |
| Hilaree N Frazier, Adam O Ghoweri, Katie L Anderson, Ruei-Lung Lin, Gabriel J Popa, Michael D Mendenhall, Lawrence P Reagan, Rolf J Craven, Olivier Thibaul. Elevating Insulin Signaling Using a Constitutively Active Insulin Receptor Increases Glucose Metabolism and Expression of GLUT3 in Hippocampal Neurons. Frontiers in neuroscience. vol 14. 2021-08-12. PMID:32733189. |
previously, our lab used a molecular approach to characterize the impact of insulin signaling on voltage-gated calcium channels and has also shown that acute insulin administration reduces calcium-induced calcium release in hippocampal neurons. |
2021-08-12 |
2023-08-13 |
human |
| José Gulfo, Joana Pérez de San Román, Angelo Ledda, Felix Junyent, María J Ramírez, Francisco J Gil-Bea, Montserrat Esteve, Mar Gras. Corticosteroid-binding-globulin (CBG)-deficient mice show high pY216-GSK3β and phosphorylated-Tau levels in the hippocampus. PloS one. vol 16. issue 2. 2021-08-04. PMID:33592009. |
we used cbg-/- mice, which display low total-corticosterone and high free-corticosterone blood levels at the nadir of corticosterone secretion (morning) and at rest to evaluate the hippocampus for total- and free-corticosterone levels; 11β-hydroxysteroid dehydrogenase expression and activity; the expression of key proteins involved in glucocorticoid activity and insulin signaling; microtubule-associated protein tau phosphorylation, and neuronal and synaptic function markers. |
2021-08-04 |
2023-08-13 |
mouse |
| Karlo Toljan, Jan Homola. Circadian changes in Alzheimer's disease: Neurobiology, clinical problems, and therapeutic opportunities. Handbook of clinical neurology. vol 179. 2021-07-28. PMID:34225969. |
the understanding of alzheimer's disease (ad) pathophysiology is an active area of research, and the traditional focus on hippocampus, amyloid and tau protein, and memory impairment has been expanded with components like neuroinflammation, insulin resistance, and circadian rhythm alterations. |
2021-07-28 |
2023-08-13 |
Not clear |
| Masoud Rahmati, Maryam Keshvari, Rahim Mirnasouri, Farzaneh Chehelcheragh. Exercise and Urtica dioica extract ameliorate hippocampal insulin signaling, oxidative stress, neuroinflammation, and cognitive function in STZ-induced diabetic rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 139. 2021-07-26. PMID:33839493. |
exercise and urtica dioica extract ameliorate hippocampal insulin signaling, oxidative stress, neuroinflammation, and cognitive function in stz-induced diabetic rats. |
2021-07-26 |
2023-08-13 |
rat |
| Qi-Chen Yuan, Han Gong, Min Du, Xue-Ying Ma. Supplementation of milk polar lipids to obese dams improves neurodevelopment and cognitive function in male offspring. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 35. issue 4. 2021-07-21. PMID:33749945. |
insulin resistance and aberrant brain-derived neurotrophic factor signaling were induced in the hippocampus of neonatal and adult offspring due to maternal and progeny hfd, but recovered by maternal mfgm-pl administration. |
2021-07-21 |
2023-08-13 |
rat |
| Qi-Chen Yuan, Han Gong, Min Du, Xue-Ying Ma. Supplementation of milk polar lipids to obese dams improves neurodevelopment and cognitive function in male offspring. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 35. issue 4. 2021-07-21. PMID:33749945. |
this study demonstrates that maternal mfgm-pl supplementation can promote neurodevelopment and exert long-term effects against hfd-induced cognitive impairment in offspring via alleviating hippocampal insulin resistance. |
2021-07-21 |
2023-08-13 |
rat |
| Kamil Ziarniak, Monika Dudek, Julia Matuszewska, Łukasz Bijoch, Marek Skrzypski, Jan Celichowski, Joanna H Sliwowsk. Two weeks of moderate intensity locomotor training increased corticosterone concentrations but did not alter the number of adropin-immunoreactive cells in the hippocampus of diabetic type 2 and control rats. Acta histochemica. vol 123. issue 5. 2021-07-16. PMID:34229193. |
we found that: 1) in dm2 animals, running decreased insulin and increased glucose concentrations; 2) in c rats, running decreased insulin concentrations and had no effect on glucose concentration in blood; 3) running increased corticosterone (cort) concentrations in dm2 and c rats; 4) adr-ir cells were detected in the hippocampus and adr-ir fibers in the arcuate nucleus of the hypothalamus, which is a novel location; 5) metabolic status and running, however, did not change number of these cells. |
2021-07-16 |
2023-08-13 |
rat |
| L P Reagan, H B Cowan, J L Woodruff, G G Piroli, J M Erichsen, A N Evans, H E Burzynski, N D Maxwell, F Z Loyo-Rosado, V A Macht, C A Grill. Hippocampal-specific insulin resistance elicits behavioral despair and hippocampal dendritic atrophy. Neurobiology of stress. vol 15. 2021-07-15. PMID:34258333. |
hippocampal-specific insulin resistance elicits behavioral despair and hippocampal dendritic atrophy. |
2021-07-15 |
2023-08-13 |
rat |
| L P Reagan, H B Cowan, J L Woodruff, G G Piroli, J M Erichsen, A N Evans, H E Burzynski, N D Maxwell, F Z Loyo-Rosado, V A Macht, C A Grill. Hippocampal-specific insulin resistance elicits behavioral despair and hippocampal dendritic atrophy. Neurobiology of stress. vol 15. 2021-07-15. PMID:34258333. |
in view of the increased risk for the development of neuropsychiatric disorders in patients with insulin resistance, the current study examined depressive and anxiety-like behaviors, as well as hippocampal structural plasticity in rats with hippocampal-specific insulin resistance. |
2021-07-15 |
2023-08-13 |
rat |
| L P Reagan, H B Cowan, J L Woodruff, G G Piroli, J M Erichsen, A N Evans, H E Burzynski, N D Maxwell, F Z Loyo-Rosado, V A Macht, C A Grill. Hippocampal-specific insulin resistance elicits behavioral despair and hippocampal dendritic atrophy. Neurobiology of stress. vol 15. 2021-07-15. PMID:34258333. |
rats with hippocampal insulin resistance exhibited anxiety-like behaviors and behavioral despair without differences in anhedonia, suggesting that some but not all components of depressive-like behaviors were affected. |
2021-07-15 |
2023-08-13 |
rat |