| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shaimaa Nasr Amin, Shaimaa Abdalaleem Abdalgeleel, Mubarak Ali Algahtany, Sherif Ahmed Shaltout, Walaa Bayoumie El Gazzar, Dalia Azmy Elberr. Effect of Allopregnanolone on Spatial Memory and Synaptic Proteins in Animal Model of Metabolic Syndrome. Brain sciences. vol 11. issue 5. 2021-06-15. PMID:34063474. |
biochemical evaluation of serum glucose, insulin, lipid profile, and hippocampal expression of synaptophysin and associated protein 43 (ga |
2021-06-15 |
2023-08-13 |
rat |
| Tracy L Fetterly, Max F Oginsky, Allison M Nieto, Yanaira Alonso-Caraballo, Zuleirys Santana-Rodriguez, Carrie R Ferrari. Insulin Bidirectionally Alters NAc Glutamatergic Transmission: Interactions between Insulin Receptor Activation, Endogenous Opioids, and Glutamate Release. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 41. issue 11. 2021-06-11. PMID:33514676. |
insulin receptors are expressed by nac medium spiny neurons (msns), and studies of cultured cortical and hippocampal neurons suggest that insulin influences excitatory transmission via presynaptic and postsynaptic mechanisms. |
2021-06-11 |
2023-08-13 |
human |
| Samira Rashtiani, Iran Goudarzi, Adele Jafari, Kambiz Rohampou. Adenosine monophosphate activated protein kinase (AMPK) is essential for the memory improving effect of adiponectin. Neuroscience letters. vol 749. 2021-06-03. PMID:33582189. |
apn is also able to boost insulin signaling by overexpression of irs-1 in the hippocampus. |
2021-06-03 |
2023-08-13 |
rat |
| Hui Lv, Lingjiao Tang, Canshou Guo, Yongming Jiang, Ce Gao, Yifan Wang, Chongdong Jia. Intranasal insulin administration may be highly effective in improving cognitive function in mice with cognitive dysfunction by reversing brain insulin resistance. Cognitive neurodynamics. vol 14. issue 3. 2021-06-02. PMID:32399074. |
following intranasal insulin treatment, the learning and memory functions of mice were significantly restored, the neurogenesis in the hippocampus was improved, the level of insulin in the brain increased, and the activation of the irs-1-pi3k-akt-gsk3β insulin signal pathway, but not the ras-raf-mek-mapk pathway, was markedly increased. |
2021-06-02 |
2023-08-13 |
mouse |
| Liang Liang, Yage Zheng, Yinping Xie, Ling Xiao, Gaohua Wan. Oridonin ameliorates insulin resistance partially through inhibition of inflammatory response in rats subjected to chronic unpredictable mild stress. International immunopharmacology. vol 91. 2021-05-26. PMID:33388733. |
ori was discovered to ameliorate insulin resistance as well as insulin signaling disturbance in the hippocampus. |
2021-05-26 |
2023-08-13 |
rat |
| Syed Obaidur Rahman, Madhu Kaundal, Mohd Salman, Apeksha Shrivastava, Suhel Parvez, Bibhu Prasad Panda, Mymoona Akhter, Mohd Akhtar, Abul Kalam Najm. Alogliptin reversed hippocampal insulin resistance in an amyloid-beta fibrils induced animal model of Alzheimer's disease. European journal of pharmacology. vol 889. 2021-05-14. PMID:32866503. |
alogliptin reversed hippocampal insulin resistance in an amyloid-beta fibrils induced animal model of alzheimer's disease. |
2021-05-14 |
2023-08-13 |
rat |
| Syed Obaidur Rahman, Madhu Kaundal, Mohd Salman, Apeksha Shrivastava, Suhel Parvez, Bibhu Prasad Panda, Mymoona Akhter, Mohd Akhtar, Abul Kalam Najm. Alogliptin reversed hippocampal insulin resistance in an amyloid-beta fibrils induced animal model of Alzheimer's disease. European journal of pharmacology. vol 889. 2021-05-14. PMID:32866503. |
in this study, we evaluated the efficacy of alogliptin (dpp-4 inhibitor) on hippocampal insulin resistance and associated ad complications. |
2021-05-14 |
2023-08-13 |
rat |
| Syed Obaidur Rahman, Madhu Kaundal, Mohd Salman, Apeksha Shrivastava, Suhel Parvez, Bibhu Prasad Panda, Mymoona Akhter, Mohd Akhtar, Abul Kalam Najm. Alogliptin reversed hippocampal insulin resistance in an amyloid-beta fibrils induced animal model of Alzheimer's disease. European journal of pharmacology. vol 889. 2021-05-14. PMID:32866503. |
alogliptin also significantly attenuated insulin level, irs-1ps307 expression, aβ (1-42) level, gsk-3β activity, tnf-α level and oxidative stress in the hippocampus. |
2021-05-14 |
2023-08-13 |
rat |
| Syed Obaidur Rahman, Madhu Kaundal, Mohd Salman, Apeksha Shrivastava, Suhel Parvez, Bibhu Prasad Panda, Mymoona Akhter, Mohd Akhtar, Abul Kalam Najm. Alogliptin reversed hippocampal insulin resistance in an amyloid-beta fibrils induced animal model of Alzheimer's disease. European journal of pharmacology. vol 889. 2021-05-14. PMID:32866503. |
the in-silico, behavioral, biochemical and histopathological analysis supports the protective effect of alogliptin against hippocampal insulin resistance and ad. |
2021-05-14 |
2023-08-13 |
rat |
| Cheng Lin, YanYan Lin, Ji Luo, JunRu Yu, YaNi Cheng, XiaoYun Wu, Lin Lin, YuanShao Li. Maternal High-Fat Diet Multigenerationally Impairs Hippocampal Synaptic Plasticity and Memory in Male Rat Offspring. Endocrinology. vol 162. issue 1. 2021-05-14. PMID:33211807. |
we observed that intranasal insulin replacement partially rescued hippocampal synaptic plasticity and cognitive deficits in f3 rats, suggesting central insulin resistance may play an important role in maternal diet-induced neuroplasticity impairment. |
2021-05-14 |
2023-08-13 |
rat |
| Cheng Lin, YanYan Lin, Ji Luo, JunRu Yu, YaNi Cheng, XiaoYun Wu, Lin Lin, YuanShao Li. Maternal High-Fat Diet Multigenerationally Impairs Hippocampal Synaptic Plasticity and Memory in Male Rat Offspring. Endocrinology. vol 162. issue 1. 2021-05-14. PMID:33211807. |
taken together, our data suggest that maternal hfd exposure multigenerationally influences adult male offspring hippocampal synaptic plasticity and cognitive performance, and central insulin resistance may serve as the cross-talk between maternal diet and cognitive impairment across generations. |
2021-05-14 |
2023-08-13 |
rat |
| Takashi Matsu. Exhaustive endurance exercise activates brain glycogen breakdown and lactate production more than insulin-induced hypoglycemia. American journal of physiology. Regulatory, integrative and comparative physiology. vol 320. issue 4. 2021-05-10. PMID:33533310. |
glycogen in the hypothalamus and cerebellum decreased similarly with the insulin challenge and exhaustive exercise; however, glycogen in the cortex, hippocampus, and brainstem of the exercise group were lower compared with the insulin group. |
2021-05-10 |
2023-08-13 |
rat |
| Takashi Matsu. Exhaustive endurance exercise activates brain glycogen breakdown and lactate production more than insulin-induced hypoglycemia. American journal of physiology. Regulatory, integrative and comparative physiology. vol 320. issue 4. 2021-05-10. PMID:33533310. |
brain lactate and camp levels in the hypothalamus and cerebellum increased similarly with the insulin challenge and exhaustive exercise, but those in the cortex, hippocampus, and brainstem of the exercise group were higher compared with the insulin group. |
2021-05-10 |
2023-08-13 |
rat |
| Takashi Matsu. Exhaustive endurance exercise activates brain glycogen breakdown and lactate production more than insulin-induced hypoglycemia. American journal of physiology. Regulatory, integrative and comparative physiology. vol 320. issue 4. 2021-05-10. PMID:33533310. |
blood glucose correlated positively with brain glycogen, but the slope of regression lines was greater in the exercise group compared with the insulin group in the cortex, hippocampus, and brainstem, but not the hypothalamus and cerebellum. |
2021-05-10 |
2023-08-13 |
rat |
| Mohammad Hossein Esmaeili, Mohsen Enayati, Farhad Khabbaz Abkenar, Fereshte Ebrahimian, Ali-Akbar Salar. Glibenclamide mitigates cognitive impairment and hippocampal neuroinflammation in rats with type 2 diabetes and sporadic Alzheimer-like disease. Behavioural brain research. vol 379. 2021-05-03. PMID:31733313. |
we measured glucose and insulin levels in the blood, and inflammatory cytokines such as tumor necrosis factor (tnf)-α and interleukin (il)-6 in the hippocampus of animals. |
2021-05-03 |
2023-08-13 |
rat |
| Mohammad Hossein Esmaeili, Mohsen Enayati, Farhad Khabbaz Abkenar, Fereshte Ebrahimian, Ali-Akbar Salar. Glibenclamide mitigates cognitive impairment and hippocampal neuroinflammation in rats with type 2 diabetes and sporadic Alzheimer-like disease. Behavioural brain research. vol 379. 2021-05-03. PMID:31733313. |
in contrast, gbc treatment improved memory impairment, increased insulin, and reduced glucose and hippocampal inflammation in rats with t2d and sporadic ad. |
2021-05-03 |
2023-08-13 |
rat |
| Rui-Fang Ji, Xue-Peng Bian, Bei-Bei Liu, Jing-Yun Hu, Xiang-Li Xue, Shu-Jie Lo. [Effects of resistance exercise on pyroptosis-related proteins in hippocampus of insulin resistant mice]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology. vol 36. issue 5. 2021-04-27. PMID:33629560. |
[effects of resistance exercise on pyroptosis-related proteins in hippocampus of insulin resistant mice]. |
2021-04-27 |
2023-08-13 |
mouse |
| Wenqing Xia, Yu-Chen Chen, Yong Luo, Danfeng Zhang, Huiyou Chen, Jianhua Ma, Xindao Yi. Alterations in effective connectivity within the Papez circuit are correlated with insulin resistance in T2DM patients without mild cognitive impairment. Brain imaging and behavior. vol 14. issue 4. 2021-04-27. PMID:30734918. |
insulin resistance (ir) can significantly affect the hippocampus, a component of a larger memory circuit called the papez circuit. |
2021-04-27 |
2023-08-13 |
Not clear |
| James W Daily, Suna Kang, Sunmin Par. Protection against Alzheimer's disease by luteolin: Role of brain glucose regulation, anti-inflammatory activity, and the gut microbiota-liver-brain axis. BioFactors (Oxford, England). vol 47. issue 2. 2021-04-20. PMID:33347668. |
the impairment of insulin/igf-1 signaling mainly in the hippocampus and brain insulin resistance is connected to signals originating in the liver and gut microbiota, known as the gut microbiota-liver-brain axis. |
2021-04-20 |
2023-08-13 |
human |
| Nicola J Lee, Herbert Herzo. Coordinated regulation of energy and glucose homeostasis by insulin and the NPY system. Journal of neuroendocrinology. vol 33. issue 4. 2021-04-19. PMID:33427385. |
in this review, we explore the recent advances that have been made to further the understanding of the hypothalamic insulin receptor-npy network, as well as provide insights from other lesser explored areas, such as the amygdala and hippocampus. |
2021-04-19 |
2023-08-13 |
Not clear |