| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rana Malekiyan, Alireza Abdanipour, Davood Sohrabi, Iraj Jafari Anarkool. Antioxidant and neuroprotective effects of lycopene and insulin in the hippocampus of streptozotocin-induced diabetic rats. Biomedical reports. vol 10. issue 1. 2020-10-01. PMID:30588303. |
the results indicated that lycopene and insulin, solely or in combination, prevented hippocampal neuronal cell death and improved learning and cognition by increasing tac and decreasing mda. |
2020-10-01 |
2023-08-13 |
rat |
| Rana Malekiyan, Alireza Abdanipour, Davood Sohrabi, Iraj Jafari Anarkool. Antioxidant and neuroprotective effects of lycopene and insulin in the hippocampus of streptozotocin-induced diabetic rats. Biomedical reports. vol 10. issue 1. 2020-10-01. PMID:30588303. |
collectively, the findings presented herein suggest that insulin and lycopene co-treatment has neuroprotective effect, and ameliorates stz-induced learning and memory impairment and apoptotic cell death in the hippocampal regions of diabetic rats. |
2020-10-01 |
2023-08-13 |
rat |
| Hyunhee Park, Kyung Min Chung, Hyun-Kyu An, Ji-Eun Gim, Jihyun Hong, Hanwoong Woo, Bongki Cho, Cheil Moon, Seong-Woon Y. Parkin Promotes Mitophagic Cell Death in Adult Hippocampal Neural Stem Cells Following Insulin Withdrawal. Frontiers in molecular neuroscience. vol 12. 2020-10-01. PMID:30853892. |
parkin promotes mitophagic cell death in adult hippocampal neural stem cells following insulin withdrawal. |
2020-10-01 |
2023-08-13 |
human |
| Hyunhee Park, Kyung Min Chung, Hyun-Kyu An, Ji-Eun Gim, Jihyun Hong, Hanwoong Woo, Bongki Cho, Cheil Moon, Seong-Woon Y. Parkin Promotes Mitophagic Cell Death in Adult Hippocampal Neural Stem Cells Following Insulin Withdrawal. Frontiers in molecular neuroscience. vol 12. 2020-10-01. PMID:30853892. |
we have previously demonstrated that adult rat hippocampal neural stem (hcn) cells undergo autophagy-dependent cell death (adcd) following insulin withdrawal. |
2020-10-01 |
2023-08-13 |
human |
| Yang Yang, Qi Chen, Quanfeng Zhao, Ying Luo, Ying Xu, Weimin Du, Hong Wang, Huan Li, Lu Yang, Congli Hu, Jiahua Zhang, Yuke Li, Hui Xia, Zhihao Chen, Jie Ma, Xiaoyan Tian, Junqing Yan. Inhibition of COX2/PGD2-Related Autophagy Is Involved in the Mechanism of Brain Injury in T2DM Rat. Frontiers in cellular neuroscience. vol 13. 2020-10-01. PMID:30873010. |
in model rats, we found that the body weight was significantly decreased, the blood glucose levels were significantly increased, the plasma insulin content was significantly decreased, the learning and memory functions were impaired and the cortex and hippocampus neurons showed significant nuclear pyknosis. |
2020-10-01 |
2023-08-13 |
rat |
| Yang Yang, Qi Chen, Quanfeng Zhao, Ying Luo, Ying Xu, Weimin Du, Hong Wang, Huan Li, Lu Yang, Congli Hu, Jiahua Zhang, Yuke Li, Hui Xia, Zhihao Chen, Jie Ma, Xiaoyan Tian, Junqing Yan. Inhibition of COX2/PGD2-Related Autophagy Is Involved in the Mechanism of Brain Injury in T2DM Rat. Frontiers in cellular neuroscience. vol 13. 2020-10-01. PMID:30873010. |
in meloxicam-treated rats, the body weight, blood glucose and the content of plasma insulin did not significantly change, the learning and memory functions were improved and nuclear pyknosis was improved in the cortex and hippocampus neurons. |
2020-10-01 |
2023-08-13 |
rat |
| S Galoi. NEW BLOOD PRESSURE TARGETS IN NON-DIABETIC PATIENTS AND INSULIN RESISTANCE IN BRAIN. Acta endocrinologica (Bucharest, Romania : 2005). vol 12. issue 1. 2020-10-01. PMID:31258812. |
in limited area of the human brain, insulin acts in modulation of body weight by food intake and modification of metabolism: hypothalamus (the central regulator of whole- body energy homeostasis and of food intake), prefrontal cortex (inhibitory control of eating), hippocampus (memory) and the fusiform gyrus (recognition of food, positive emotions, reward). |
2020-10-01 |
2023-08-13 |
human |
| Matteo Spinelli, Salvatore Fusco, Claudio Grass. Brain Insulin Resistance and Hippocampal Plasticity: Mechanisms and Biomarkers of Cognitive Decline. Frontiers in neuroscience. vol 13. 2020-10-01. PMID:31417349. |
brain insulin resistance and hippocampal plasticity: mechanisms and biomarkers of cognitive decline. |
2020-10-01 |
2023-08-13 |
Not clear |
| Matteo Spinelli, Salvatore Fusco, Claudio Grass. Brain Insulin Resistance and Hippocampal Plasticity: Mechanisms and Biomarkers of Cognitive Decline. Frontiers in neuroscience. vol 13. 2020-10-01. PMID:31417349. |
in particular, insulin signaling has been demonstrated to impact on molecular cascades underlying hippocampal plasticity, learning and memory. |
2020-10-01 |
2023-08-13 |
Not clear |
| Matteo Spinelli, Salvatore Fusco, Claudio Grass. Brain Insulin Resistance and Hippocampal Plasticity: Mechanisms and Biomarkers of Cognitive Decline. Frontiers in neuroscience. vol 13. 2020-10-01. PMID:31417349. |
here, we summarize the molecular evidence linking alteration of hippocampal insulin sensitivity with changes of both adult neurogenesis and synaptic plasticity. |
2020-10-01 |
2023-08-13 |
Not clear |
| Emily E Noble, Ted M Hsu, Scott E Kanosk. Gut to Brain Dysbiosis: Mechanisms Linking Western Diet Consumption, the Microbiome, and Cognitive Impairment. Frontiers in behavioral neuroscience. vol 11. 2020-09-30. PMID:28194099. |
recent findings also show that diet-induced alterations in gut microbiota impair peripheral insulin sensitivity, which is associated with hippocampal neuronal derrangements and associated mnemonic deficits. |
2020-09-30 |
2023-08-13 |
Not clear |
| Jeremy D Coplan, Anna V Rozenboym, Sasha L Fulton, Venkatesh Panthangi, Jean Tang, Lakshmi Thiramangalakdi, Tarique D Perera, Yang Liu, Haroon Kamran, Michael J Owens, Charles B Nemeroff, Leonard A Rosenblum, John G Kral, Louis Salciccioli, Jason Laza. Reduced left ventricular dimension and function following early life stress: A thrifty phenotype hypothesis engendering risk for mood and anxiety disorders. Neurobiology of stress. vol 8. 2020-09-30. PMID:29888314. |
for instance, els induces persistent increases in insulin resistance, hippocampal and corpus callosum atrophy and reduced "behavioral plasticity", which, taken together, engenders an increased risk for mood and anxiety disorders in humans but also a putative sparing of calories. |
2020-09-30 |
2023-08-13 |
Not clear |
| Jim R Fadel, Lawrence P Reaga. Stop signs in hippocampal insulin signaling: the role of insulin resistance in structural, functional and behavioral deficits. Current opinion in behavioral sciences. vol 9. 2020-09-29. PMID:26955646. |
stop signs in hippocampal insulin signaling: the role of insulin resistance in structural, functional and behavioral deficits. |
2020-09-29 |
2023-08-13 |
Not clear |
| Jim R Fadel, Lawrence P Reaga. Stop signs in hippocampal insulin signaling: the role of insulin resistance in structural, functional and behavioral deficits. Current opinion in behavioral sciences. vol 9. 2020-09-29. PMID:26955646. |
while insulin appears to play a minor role in the regulation of glucose uptake in the central nervous system (cns), insulin is known to play a major role in regulating synaptic plasticity in brain regions like the hippocampus. |
2020-09-29 |
2023-08-13 |
Not clear |
| Jim R Fadel, Lawrence P Reaga. Stop signs in hippocampal insulin signaling: the role of insulin resistance in structural, functional and behavioral deficits. Current opinion in behavioral sciences. vol 9. 2020-09-29. PMID:26955646. |
the concept that insulin regulates hippocampal neuroplasticity is further supported from animal models of type 2 diabetes (t2dm) and alzheimer's disease (ad). |
2020-09-29 |
2023-08-13 |
Not clear |
| Jim R Fadel, Lawrence P Reaga. Stop signs in hippocampal insulin signaling: the role of insulin resistance in structural, functional and behavioral deficits. Current opinion in behavioral sciences. vol 9. 2020-09-29. PMID:26955646. |
the goal of this review is to provide an overview of these studies, as well as the studies that have examined whether deficits in hippocampal insulin signaling are amenable to intervention strategies. |
2020-09-29 |
2023-08-13 |
Not clear |
| Junghyung Park, Jinyoung Won, Jincheol Seo, Hyeon-Gu Yeo, Keonwoo Kim, Yu Gyeong Kim, Chang-Yeop Jeon, Min Kyoung Kam, Young-Hyun Kim, Jae-Won Huh, Sang-Rae Lee, Dong-Seok Lee, Youngjeon Le. Streptozotocin Induces Alzheimer's Disease-Like Pathology in Hippocampal Neuronal Cells Frontiers in cellular neuroscience. vol 14. 2020-09-28. PMID:32903692. |
streptozotocin induces alzheimer's disease-like pathology in hippocampal neuronal cells aberrant brain insulin signaling plays a critical role in the pathology of alzheimer's disease (ad). |
2020-09-28 |
2023-08-13 |
Not clear |
| Junghyung Park, Jinyoung Won, Jincheol Seo, Hyeon-Gu Yeo, Keonwoo Kim, Yu Gyeong Kim, Chang-Yeop Jeon, Min Kyoung Kam, Young-Hyun Kim, Jae-Won Huh, Sang-Rae Lee, Dong-Seok Lee, Youngjeon Le. Streptozotocin Induces Alzheimer's Disease-Like Pathology in Hippocampal Neuronal Cells Frontiers in cellular neuroscience. vol 14. 2020-09-28. PMID:32903692. |
however, the molecular mechanisms underlying the progression of ad and mitochondrial fragmentation induced by aberrant brain insulin signaling in the hippocampal neurons are poorly understood. |
2020-09-28 |
2023-08-13 |
Not clear |
| Ying Fu, Jiangping Wei, Bin Li, Lijuan Gao, Peng Xia, Yueqiang Wen, Shijun X. CGA ameliorates cognitive decline by regulating the PI3K/AKT signaling pathway and neurotransmitter systems in rats with multi-infarct dementia. Experimental and therapeutic medicine. vol 20. issue 5. 2020-09-28. PMID:32963600. |
mitochondrial swelling and changes in the membrane potential in the hippocampus were detected using flow cytometry, and the changes in insulin, glutamate and γ-aminobutyric acid (gaba) content were detected using elisa. |
2020-09-28 |
2023-08-13 |
rat |
| Xue-Peng Bian, Rui-Fang Ji, Bei-Bei Liu, Jing-Yun Hu, Ming-Ming Li, Xiang-Li Xue, Shu-Jie Lo. [Aerobic exercise reduces the expression of pyroptosis-related proteins and inflammatory factors in hippocampus of mice with insulin resistance]. Sheng li xue bao : [Acta physiologica Sinica]. vol 72. issue 4. 2020-09-24. PMID:32820308. |
[aerobic exercise reduces the expression of pyroptosis-related proteins and inflammatory factors in hippocampus of mice with insulin resistance]. |
2020-09-24 |
2023-08-13 |
mouse |