| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wenqi Gao, Wei Wang, Jing Zhang, Pengyi Deng, Jun Hu, Jian Yang, Zhifang Den. Allicin ameliorates obesity comorbid depressive-like behaviors: involvement of the oxidative stress, mitochondrial function, autophagy, insulin resistance and NOX/Nrf2 imbalance in mice. Metabolic brain disease. vol 34. issue 5. 2020-04-30. PMID:31201726. |
allicin attenuated depressive-like behaviors triggered by long-term hfd consumption by inhibiting ros production and oxidative stress, improving mitochondrial function, regulating autophagy, and reducing insulin resistance in the hippocampus via optimization of nox/nrf2 imbalance. |
2020-04-30 |
2023-08-13 |
mouse |
| Claudia A Grillo, Jennifer L Woodruff, Victoria A Macht, Lawrence P Reaga. Insulin resistance and hippocampal dysfunction: Disentangling peripheral and brain causes from consequences. Experimental neurology. vol 318. 2020-03-02. PMID:31028829. |
insulin resistance and hippocampal dysfunction: disentangling peripheral and brain causes from consequences. |
2020-03-02 |
2023-08-13 |
Not clear |
| Claudia A Grillo, Jennifer L Woodruff, Victoria A Macht, Lawrence P Reaga. Insulin resistance and hippocampal dysfunction: Disentangling peripheral and brain causes from consequences. Experimental neurology. vol 318. 2020-03-02. PMID:31028829. |
the goals of this review are to provide an overview of the literature that have identified the neuroplasticity deficits observed in t2dm and obesity, as well as to discuss the potential causes and consequences of insulin resistance in the cns, with a particular focus on how insulin resistance impacts hippocampal neuroplasticity. |
2020-03-02 |
2023-08-13 |
Not clear |
| Joanne M Gladding, Kirsten N Abbott, Christopher P Antoniadis, Angela Stuart, Denovan P Beg. The Effect of Intrahippocampal Insulin Infusion on Spatial Cognitive Function and Markers of Neuroinflammation in Diet-induced Obesity. Frontiers in endocrinology. vol 9. 2020-02-25. PMID:30619085. |
the present study investigated whether hippocampal-dependent spatial memory impairments in a dietary induced mouse model of obesity could be improved by the direct administration of insulin into the hippocampus and whether this was associated with markers of hippocampal inflammation. |
2020-02-25 |
2023-08-13 |
mouse |
| Joanne M Gladding, Kirsten N Abbott, Christopher P Antoniadis, Angela Stuart, Denovan P Beg. The Effect of Intrahippocampal Insulin Infusion on Spatial Cognitive Function and Markers of Neuroinflammation in Diet-induced Obesity. Frontiers in endocrinology. vol 9. 2020-02-25. PMID:30619085. |
insulin infusion into the hippocampus reversed the deficit of high fat diet consumption on both of the tasks. |
2020-02-25 |
2023-08-13 |
mouse |
| Joanne M Gladding, Kirsten N Abbott, Christopher P Antoniadis, Angela Stuart, Denovan P Beg. The Effect of Intrahippocampal Insulin Infusion on Spatial Cognitive Function and Markers of Neuroinflammation in Diet-induced Obesity. Frontiers in endocrinology. vol 9. 2020-02-25. PMID:30619085. |
increased expression of inflammatory markers was detected in the hippocampus in the high fat diet group and expression of these markers was ameliorated in insulin infused mice. |
2020-02-25 |
2023-08-13 |
mouse |
| Joanne M Gladding, Kirsten N Abbott, Christopher P Antoniadis, Angela Stuart, Denovan P Beg. The Effect of Intrahippocampal Insulin Infusion on Spatial Cognitive Function and Markers of Neuroinflammation in Diet-induced Obesity. Frontiers in endocrinology. vol 9. 2020-02-25. PMID:30619085. |
this demonstrates that cns insulin can improve hippocampal-dependent memory and that hippocampal inflammation may be a factor in the development of cognitive deficits associated with diet-induced obesity. |
2020-02-25 |
2023-08-13 |
mouse |
| Soheila Maghami, Homeira Zardooz, Fariba Khodagholi, Fatemeh Binayi, Roya Ranjbar Saber, Mehdi Hedayati, Hedayat Sahraei, Mohammad Ali Ansar. Correction: Maternal separation blunted spatial memory formation independent of peripheral and hippocampal insulin content in young adult male rats. PloS one. vol 14. issue 1. 2020-02-25. PMID:30629701. |
correction: maternal separation blunted spatial memory formation independent of peripheral and hippocampal insulin content in young adult male rats. |
2020-02-25 |
2023-08-13 |
rat |
| Zhao Wohua, Xu Weimin. Glutaredoxin 2 (GRX2) deficiency exacerbates high fat diet (HFD)-induced insulin resistance, inflammation and mitochondrial dysfunction in brain injury: A mechanism involving GSK-3β. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 118. 2020-02-13. PMID:31382130. |
furthermore, grx2 knockout markedly enhanced hfd-triggered insulin resistance in hippocampus of mice through down-regulating the protein levels of p-insulin receptor substrate 1 (irs1) (y632) and p-akt (s473). |
2020-02-13 |
2023-08-13 |
mouse |
| Ming-Yu Chou, Ying-Ju Chen, Liang-Hung Lin, Yoshihiro Nakao, Ai Lin Lim, Ming-Fu Wang, Shan May Yon. Protective Effects of Hydrolyzed Chicken Extract (Probeptigen®/Cmi-168) on Memory Retention and Brain Oxidative Stress in Senescence-Accelerated Mice. Nutrients. vol 11. issue 8. 2020-02-07. PMID:31408929. |
microarray analysis of hippocampus revealed several processes that may be involved in the improvement of cognitive ability by probeptigen, including heme binding, insulin growth factor (igf) regulation, carboxylic metabolic process, oxidation-reduction process and endopeptidase inhibition. |
2020-02-07 |
2023-08-13 |
mouse |
| Fangli Zhao, Jason J Siu, Wei Huang, Candice Askwith, Lei Ca. Insulin Modulates Excitatory Synaptic Transmission and Synaptic Plasticity in the Mouse Hippocampus. Neuroscience. vol 411. 2020-02-04. PMID:31146008. |
insulin modulates excitatory synaptic transmission and synaptic plasticity in the mouse hippocampus. |
2020-02-04 |
2023-08-13 |
mouse |
| Fangli Zhao, Jason J Siu, Wei Huang, Candice Askwith, Lei Ca. Insulin Modulates Excitatory Synaptic Transmission and Synaptic Plasticity in the Mouse Hippocampus. Neuroscience. vol 411. 2020-02-04. PMID:31146008. |
the administration of exogenous insulin into the hippocampus has the potential to enhance cognitive function and exert other beneficial effects. |
2020-02-04 |
2023-08-13 |
mouse |
| Fangli Zhao, Jason J Siu, Wei Huang, Candice Askwith, Lei Ca. Insulin Modulates Excitatory Synaptic Transmission and Synaptic Plasticity in the Mouse Hippocampus. Neuroscience. vol 411. 2020-02-04. PMID:31146008. |
here, we used extracellular field recordings in mouse hippocampal slices to investigate how insulin acutely modulates synaptic transmission and synaptic plasticity, both of which are correlated with learning and memory processes. |
2020-02-04 |
2023-08-13 |
mouse |
| Fangli Zhao, Jason J Siu, Wei Huang, Candice Askwith, Lei Ca. Insulin Modulates Excitatory Synaptic Transmission and Synaptic Plasticity in the Mouse Hippocampus. Neuroscience. vol 411. 2020-02-04. PMID:31146008. |
our data demonstrate that insulin application inhibited basal excitatory synaptic transmission and promoted long-term potentiation (ltp) induction at hippocampal schaffer collateral-ca1 synapses. |
2020-02-04 |
2023-08-13 |
mouse |
| Manpreet K Singh, Sara M Leslie, Mary Melissa Packer, Yevgeniya V Zaiko, Owen R Phillips, Elizabeth F Weisman, Danielle M Wall, Booil Jo, Natalie Rasgo. Brain and behavioral correlates of insulin resistance in youth with depression and obesity. Hormones and behavior. vol 108. 2020-01-22. PMID:29596854. |
we posit that, in the context of depressive symptoms, insulin resistance is associated with aberrant structure and functional connectivity in the anterior cingulate cortex (acc) and hippocampus. |
2020-01-22 |
2023-08-13 |
Not clear |
| Manpreet K Singh, Sara M Leslie, Mary Melissa Packer, Yevgeniya V Zaiko, Owen R Phillips, Elizabeth F Weisman, Danielle M Wall, Booil Jo, Natalie Rasgo. Brain and behavioral correlates of insulin resistance in youth with depression and obesity. Hormones and behavior. vol 108. 2020-01-22. PMID:29596854. |
using acc and hippocampus structural and seed-based regions of interest, we investigated associations between insulin resistance, depression, structure (acc thickness, and acc and hippocampal area), and resting-state functional connectivity (rsfc). |
2020-01-22 |
2023-08-13 |
Not clear |
| Manpreet K Singh, Sara M Leslie, Mary Melissa Packer, Yevgeniya V Zaiko, Owen R Phillips, Elizabeth F Weisman, Danielle M Wall, Booil Jo, Natalie Rasgo. Brain and behavioral correlates of insulin resistance in youth with depression and obesity. Hormones and behavior. vol 108. 2020-01-22. PMID:29596854. |
we found that youth with greater insulin resistance had higher levels of anhedonia and more food seeking behaviors, reduced hippocampal and acc volumes, and greater levels of acc and hippocampal dysconnectivity to fronto-limbic reward networks at rest. |
2020-01-22 |
2023-08-13 |
Not clear |
| Manpreet K Singh, Sara M Leslie, Mary Melissa Packer, Yevgeniya V Zaiko, Owen R Phillips, Elizabeth F Weisman, Danielle M Wall, Booil Jo, Natalie Rasgo. Brain and behavioral correlates of insulin resistance in youth with depression and obesity. Hormones and behavior. vol 108. 2020-01-22. PMID:29596854. |
for youth with high levels of insulin resistance, thinner acc and smaller hippocampal volumes were associated with more severe depressive symptoms, whereas the opposite was true for youth with low levels of insulin resistance. |
2020-01-22 |
2023-08-13 |
Not clear |
| Salvatore Fusco, Matteo Spinelli, Sara Cocco, Cristian Ripoli, Alessia Mastrodonato, Francesca Natale, Marco Rinaudo, Giulia Livrizzi, Claudio Grass. Maternal insulin resistance multigenerationally impairs synaptic plasticity and memory via gametic mechanisms. Nature communications. vol 10. issue 1. 2020-01-16. PMID:31641124. |
hfd downregulates bdnf and insulin signaling in maternal tissues and epigenetically inhibits bdnf expression in both germline and hippocampus of progeny. |
2020-01-16 |
2023-08-13 |
mouse |
| Jiqu Xu, Hui Gao, Li Zhang, Shuang Rong, Wei Yang, Congcong Ma, Meng Chen, Qingde Huang, Qianchun Deng, Fenghong Huan. Melatonin alleviates cognition impairment by antagonizing brain insulin resistance in aged rats fed a high-fat diet. Journal of pineal research. vol 67. issue 2. 2020-01-09. PMID:31050371. |
results showed that mlt supplementation attenuated peripheral insulin resistance and lowered hippocampal oxidative stress levels. |
2020-01-09 |
2023-08-13 |
rat |