| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sunmin Park, Da Sol Kim, Suna Kang, Hyun Jin Ki. The combination of luteolin and l-theanine improved Alzheimer disease-like symptoms by potentiating hippocampal insulin signaling and decreasing neuroinflammation and norepinephrine degradation in amyloid-β-infused rats. Nutrition research (New York, N.Y.). vol 60. 2019-05-24. PMID:30527255. |
the combination of luteolin and l-theanine prevented alzheimer disease-like symptom, possibly by improving hippocampal insulin signaling, norepinephrine metabolisms, and decreasing neuroinflammation. |
2019-05-24 |
2023-08-13 |
rat |
| Marion Soto, Weikang Cai, Masahiro Konishi, C Ronald Kah. Insulin signaling in the hippocampus and amygdala regulates metabolism and neurobehavior. Proceedings of the National Academy of Sciences of the United States of America. vol 116. issue 13. 2019-05-20. PMID:30765523. |
insulin signaling in the hippocampus and amygdala regulates metabolism and neurobehavior. |
2019-05-20 |
2023-08-13 |
mouse |
| Ragitha Chruvattil, Shreya Banerjee, Sarmi Nath, Jatin Machhi, Gitika Kharkwal, Mange Ram Yadav, Sarita Gupt. Dexamethasone Alters the Appetite Regulation via Induction of Hypothalamic Insulin Resistance in Rat Brain. Molecular neurobiology. vol 54. issue 9. 2019-05-08. PMID:27822713. |
immunoblotting of insulin receptor (insr)-pi3kinase-akt demonstrated reduced insulin signaling in hypothalamus but no change in hippocampus, cortex, and cerebellum in dexamethasone-treated rats as compared to vehicle-treated rats, signifying the diversity of distribution and function of insulin in different brain regions. |
2019-05-08 |
2023-08-13 |
rat |
| Suping Qin, Dexu Sun, Jingjing Mu, Daifu Ma, Renxian Tang, Yuanlin Zhen. Purple sweet potato color improves hippocampal insulin resistance via down-regulating SOCS3 and galectin-3 in high-fat diet mice. Behavioural brain research. vol 359. 2019-04-23. PMID:30465813. |
purple sweet potato color improves hippocampal insulin resistance via down-regulating socs3 and galectin-3 in high-fat diet mice. |
2019-04-23 |
2023-08-13 |
mouse |
| Suping Qin, Dexu Sun, Jingjing Mu, Daifu Ma, Renxian Tang, Yuanlin Zhen. Purple sweet potato color improves hippocampal insulin resistance via down-regulating SOCS3 and galectin-3 in high-fat diet mice. Behavioural brain research. vol 359. 2019-04-23. PMID:30465813. |
hippocampal insulin resistance is the key factor in cognitive deficits. |
2019-04-23 |
2023-08-13 |
mouse |
| Suping Qin, Dexu Sun, Jingjing Mu, Daifu Ma, Renxian Tang, Yuanlin Zhen. Purple sweet potato color improves hippocampal insulin resistance via down-regulating SOCS3 and galectin-3 in high-fat diet mice. Behavioural brain research. vol 359. 2019-04-23. PMID:30465813. |
the insulin signaling molecules including the p-irs1 (tyr608), pi3k p110α and p-akt (ser473) were detected and the pspc treatment improved the insulin resistance in hippocampus of hfd mice. |
2019-04-23 |
2023-08-13 |
mouse |
| Syed Obaidur Rahman, Bibhu Prasad Panda, Suhel Parvez, Madhu Kaundal, Salman Hussain, Mohd Akhtar, Abul Kalam Najm. Neuroprotective role of astaxanthin in hippocampal insulin resistance induced by Aβ peptides in animal model of Alzheimer's disease. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 110. 2019-04-18. PMID:30463045. |
neuroprotective role of astaxanthin in hippocampal insulin resistance induced by aβ peptides in animal model of alzheimer's disease. |
2019-04-18 |
2023-08-13 |
rat |
| Syed Obaidur Rahman, Bibhu Prasad Panda, Suhel Parvez, Madhu Kaundal, Salman Hussain, Mohd Akhtar, Abul Kalam Najm. Neuroprotective role of astaxanthin in hippocampal insulin resistance induced by Aβ peptides in animal model of Alzheimer's disease. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 110. 2019-04-18. PMID:30463045. |
our study concludes preventive action of astaxanthin against hippocampal insulin resistance and alzheimer's disease complications, supporting potential role of hippocampal insulin resistance targeting against ad. |
2019-04-18 |
2023-08-13 |
rat |
| Qing-Hua Yang, Ling Guo, Qing Chen, Kai-Hui Wu, Yan-Jun Wu, Yan Jia, Shu-Juan Zhu, Cheng-Lin Tang, Hua-Jun Shen. [Kidney-reinforcing and Governor Vessel-regulating EA Intervention May Improve Learningmemory Possibly by Suppressing Formation of Senile Plaques in Hippocampus in APP/PS 1 Double Transgenic Alzheimer's Disease Mice]. Zhen ci yan jiu = Acupuncture research. vol 43. issue 4. 2019-04-03. PMID:29888573. |
to observe the effect of electroacupuncture (ea) intervention on learning-memory ability and the expression of senile plaques (sp), amyloid precursor protein (app), β-secretase 1(bace 1) and insulin degrading enzyme (ide) in the hippocampus in app/presenilin 1 (ps 1) double transgenic alzheimer's disease (ad) mice, so as to reveal its mechanisms underlying improvement of ad. |
2019-04-03 |
2023-08-13 |
mouse |
| Manuel Rodriguez-Perdigon, Maite Solas, Maria Jesús Moreno-Aliaga, Maria Javier Ramire. Lipoic acid improves neuronal insulin signalling and rescues cognitive function regulating VGlut1 expression in high-fat-fed rats: Implications for Alzheimer's disease. Biochimica et biophysica acta. vol 1862. issue 4. 2019-03-28. PMID:26769360. |
the present work hypothesizes that ketosis associated to insulin resistance could interfere with the normal activity of vglut1 and its role in the release of glutamate in the hippocampus, which might ultimately lead to cognitive deficits. |
2019-03-28 |
2023-08-13 |
rat |
| Manuel Rodriguez-Perdigon, Maite Solas, Maria Jesús Moreno-Aliaga, Maria Javier Ramire. Lipoic acid improves neuronal insulin signalling and rescues cognitive function regulating VGlut1 expression in high-fat-fed rats: Implications for Alzheimer's disease. Biochimica et biophysica acta. vol 1862. issue 4. 2019-03-28. PMID:26769360. |
high fat diet (hfd) rats showed memory impairments and both peripheral (as shown by increased fasting plasma insulin levels and homa index) and hippocampal (as shown by decreased activation of insulin receptor, irs-1 and pakt) insulin pathway alterations, accompanied by increased ketone bodies production. |
2019-03-28 |
2023-08-13 |
rat |
| Manuel Rodriguez-Perdigon, Maite Solas, Maria Jesús Moreno-Aliaga, Maria Javier Ramire. Lipoic acid improves neuronal insulin signalling and rescues cognitive function regulating VGlut1 expression in high-fat-fed rats: Implications for Alzheimer's disease. Biochimica et biophysica acta. vol 1862. issue 4. 2019-03-28. PMID:26769360. |
altogether, the present results suggest that hfd induced alterations in central insulin signalling could switch metabolism to produce ketone bodies, which in turn, in the hippocampus, might lead to a decreased expression of vglut1, and therefore to a decreased release of glutamate and hence, to the glutamatergic deficit described in ad. |
2019-03-28 |
2023-08-13 |
rat |
| Lan Luo, Jinyu Ma, Yue Li, Zongkang Hu, Chengfeng Jiang, Hao Cai, Cheng Su. Cystatin C Induces Insulin Resistance in Hippocampal Neurons and Promotes Cognitive Dysfunction in Rodents. Neuroscience bulletin. vol 34. issue 3. 2019-03-20. PMID:29667002. |
cystatin c induces insulin resistance in hippocampal neurons and promotes cognitive dysfunction in rodents. |
2019-03-20 |
2023-08-13 |
Not clear |
| A Lotan, T Lifschytz, G Wolf, S Keller, H Ben-Ari, P Tatarsky, N Pillar, K Oved, J Sharabany, T K Merzel, T Matsumoto, Y Yamawaki, B Mernick, E Avidan, S Yamawaki, A Weller, N Shomron, B Lere. Differential effects of chronic stress in young-adult and old female mice: cognitive-behavioral manifestations and neurobiological correlates. Molecular psychiatry. vol 23. issue 6. 2019-03-18. PMID:29257131. |
these phenotypes were paralleled by differential changes in the expression of hypothalamic insulin and melanocortin-4 receptors and were consistent with an age-dependent reduction in the dynamic range of stress-related changes in the hippocampal transcriptome. |
2019-03-18 |
2023-08-13 |
mouse |
| Soheila Maghami, Homeira Zardooz, Fariba Khodagholi, Fatemeh Binayi, Roya Ranjbar Saber, Mehdi Hedayati, Hedayat Sahraei, Mohammad Ali Ansar. Maternal separation blunted spatial memory formation independent of peripheral and hippocampal insulin content in young adult male rats. PloS one. vol 13. issue 10. 2019-03-14. PMID:30332425. |
maternal separation blunted spatial memory formation independent of peripheral and hippocampal insulin content in young adult male rats. |
2019-03-14 |
2023-08-13 |
rat |
| Soheila Maghami, Homeira Zardooz, Fariba Khodagholi, Fatemeh Binayi, Roya Ranjbar Saber, Mehdi Hedayati, Hedayat Sahraei, Mohammad Ali Ansar. Maternal separation blunted spatial memory formation independent of peripheral and hippocampal insulin content in young adult male rats. PloS one. vol 13. issue 10. 2019-03-14. PMID:30332425. |
this study explores the effects of maternal separation as a chronic early life stress (els) on pancreatic islets insulin content and secretion, and their potential relationship with the hippocampus insulin content and spatial memory in young adulthood. |
2019-03-14 |
2023-08-13 |
rat |
| Soheila Maghami, Homeira Zardooz, Fariba Khodagholi, Fatemeh Binayi, Roya Ranjbar Saber, Mehdi Hedayati, Hedayat Sahraei, Mohammad Ali Ansar. Maternal separation blunted spatial memory formation independent of peripheral and hippocampal insulin content in young adult male rats. PloS one. vol 13. issue 10. 2019-03-14. PMID:30332425. |
maternal separation did not change the plasma levels of insulin but increased plasma corticosterone levels from pnd-21 to young adulthood and also reduced the islets insulin content but did not affect insulin secretion and the hippocampus insulin content and insulin receptor protein amount. |
2019-03-14 |
2023-08-13 |
rat |
| Soheila Maghami, Homeira Zardooz, Fariba Khodagholi, Fatemeh Binayi, Roya Ranjbar Saber, Mehdi Hedayati, Hedayat Sahraei, Mohammad Ali Ansar. Maternal separation blunted spatial memory formation independent of peripheral and hippocampal insulin content in young adult male rats. PloS one. vol 13. issue 10. 2019-03-14. PMID:30332425. |
the islets insulin content and secretion, and the plasma insulin concentration were not significantly correlated with the hippocampus insulin content. |
2019-03-14 |
2023-08-13 |
rat |
| Soheila Maghami, Homeira Zardooz, Fariba Khodagholi, Fatemeh Binayi, Roya Ranjbar Saber, Mehdi Hedayati, Hedayat Sahraei, Mohammad Ali Ansar. Maternal separation blunted spatial memory formation independent of peripheral and hippocampal insulin content in young adult male rats. PloS one. vol 13. issue 10. 2019-03-14. PMID:30332425. |
moreover, due to the reduction of the body weight and length of offspring belonging to the str group, it should be further considered that both maternal separation and early life malnutrition are directly (and mechanistically) linked to cognitive alterations later in life in ways that are not dependent on peripheral and hippocampal insulin content. |
2019-03-14 |
2023-08-13 |
rat |
| Qingzhi Wang, Jing Yuan, Zhanyang Yu, Li Lin, Yinghua Jiang, Zeyuan Cao, Pengwei Zhuang, Michael J Whalen, Bo Song, Xiao-Jie Wang, Xiaokun Li, Eng H Lo, Yuming Xu, Xiaoying Wan. FGF21 Attenuates High-Fat Diet-Induced Cognitive Impairment via Metabolic Regulation and Anti-inflammation of Obese Mice. Molecular neurobiology. vol 55. issue 6. 2019-02-26. PMID:28712011. |
our experimental findings support our hypothesis that rfgf21 is protective to hfd-induced cognitive impairment, at least in part by metabolic regulation in glucose tolerance impairment, insulin resistance, and hyperlipidemia; potent systemic pro-inflammation inhibition; and improvement of hippocampal dysfunction, particularly by inhibiting pro-neuroinflammation and neurogenesis deficit. |
2019-02-26 |
2023-08-13 |
mouse |