| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gabriel Keine Kuga, Vitor Rosetto Muñoz, Rafael Calais Gaspar, Susana Castelo Branco Ramos Nakandakari, Adelino Sanchez Ramos da Silva, José Diego Botezelli, José Alexandre Curiacos de Almeida Leme, Ricardo José Gomes, Leandro Pereira de Moura, Dennys Esper Cintra, Eduardo Rochete Ropelle, José Rodrigo Paul. Impaired insulin signaling and spatial learning in middle-aged rats: The role of PTP1B. Experimental gerontology. vol 104. 2019-02-19. PMID:29421605. |
the insulin and brain-derived neurotrophic factor (bdnf) signaling in the hippocampus promotes synaptic plasticity and memory formation. |
2019-02-19 |
2023-08-13 |
rat |
| Gabriel Keine Kuga, Vitor Rosetto Muñoz, Rafael Calais Gaspar, Susana Castelo Branco Ramos Nakandakari, Adelino Sanchez Ramos da Silva, José Diego Botezelli, José Alexandre Curiacos de Almeida Leme, Ricardo José Gomes, Leandro Pereira de Moura, Dennys Esper Cintra, Eduardo Rochete Ropelle, José Rodrigo Paul. Impaired insulin signaling and spatial learning in middle-aged rats: The role of PTP1B. Experimental gerontology. vol 104. 2019-02-19. PMID:29421605. |
in this context, our study aims to investigate the age-related changes in ptp1b content, insulin signaling, β-amyloid content, and tau phosphorylation in the hippocampus of middle-aged rats. |
2019-02-19 |
2023-08-13 |
rat |
| Gabriel Keine Kuga, Vitor Rosetto Muñoz, Rafael Calais Gaspar, Susana Castelo Branco Ramos Nakandakari, Adelino Sanchez Ramos da Silva, José Diego Botezelli, José Alexandre Curiacos de Almeida Leme, Ricardo José Gomes, Leandro Pereira de Moura, Dennys Esper Cintra, Eduardo Rochete Ropelle, José Rodrigo Paul. Impaired insulin signaling and spatial learning in middle-aged rats: The role of PTP1B. Experimental gerontology. vol 104. 2019-02-19. PMID:29421605. |
young (3 months) and middle-aged (17 months) wistar rats were submitted to morris-water maze (mwm) test, insulin tolerance test, and molecular analysis in the hippocampus. |
2019-02-19 |
2023-08-13 |
rat |
| Nathalie Marissal-Arvy, Marie-Neige Campas, Audrey Semont, Céline Ducroix-Crepy, Marie-Christine Beauvieux, Julie Brossaud, Jean-Benoit Corcuff, Jean-Christophe Helbling, Sylvie Vancassel, Anne-Karine Bouzier-Sore, Katia Touyarot, Guillaume Ferreira, Pascal Barat, Marie-Pierre Moisa. Insulin treatment partially prevents cognitive and hippocampal alterations as well as glucocorticoid dysregulation in early-onset insulin-deficient diabetic rats. Psychoneuroendocrinology. vol 93. 2019-02-19. PMID:29702445. |
insulin treatment partially prevents cognitive and hippocampal alterations as well as glucocorticoid dysregulation in early-onset insulin-deficient diabetic rats. |
2019-02-19 |
2023-08-13 |
rat |
| Nathalie Marissal-Arvy, Marie-Neige Campas, Audrey Semont, Céline Ducroix-Crepy, Marie-Christine Beauvieux, Julie Brossaud, Jean-Benoit Corcuff, Jean-Christophe Helbling, Sylvie Vancassel, Anne-Karine Bouzier-Sore, Katia Touyarot, Guillaume Ferreira, Pascal Barat, Marie-Pierre Moisa. Insulin treatment partially prevents cognitive and hippocampal alterations as well as glucocorticoid dysregulation in early-onset insulin-deficient diabetic rats. Psychoneuroendocrinology. vol 93. 2019-02-19. PMID:29702445. |
although insulin restored basal corticosterone and 11β-hsd1 activity (in hippocampus and plasma), the negative feedback regulation of corticosterone secretion after stress was still impaired in insulin-treated diabetic rats. |
2019-02-19 |
2023-08-13 |
rat |
| Nathalie Marissal-Arvy, Marie-Neige Campas, Audrey Semont, Céline Ducroix-Crepy, Marie-Christine Beauvieux, Julie Brossaud, Jean-Benoit Corcuff, Jean-Christophe Helbling, Sylvie Vancassel, Anne-Karine Bouzier-Sore, Katia Touyarot, Guillaume Ferreira, Pascal Barat, Marie-Pierre Moisa. Insulin treatment partially prevents cognitive and hippocampal alterations as well as glucocorticoid dysregulation in early-onset insulin-deficient diabetic rats. Psychoneuroendocrinology. vol 93. 2019-02-19. PMID:29702445. |
further characterization of insulin control on glucocorticoid regulation and availability within hippocampus is awaited. |
2019-02-19 |
2023-08-13 |
rat |
| Joao Tomé-Carneiro, M Carmen Crespo, Emma Burgos-Ramos, Cristina Tomas-Zapico, Alba García-Serrano, Pilar Castro-Gómez, Cesar Venero, Inmaculada Pereda-Pérez, Shishir Baliyan, Azucena Valencia, Javier Fontecha, Alberto Dávalos, Francesco Visiol. Buttermilk and Krill Oil Phospholipids Improve Hippocampal Insulin Resistance and Synaptic Signaling in Aged Rats. Molecular neurobiology. vol 55. issue 9. 2019-02-04. PMID:29397560. |
buttermilk and krill oil phospholipids improve hippocampal insulin resistance and synaptic signaling in aged rats. |
2019-02-04 |
2023-08-13 |
rat |
| Joao Tomé-Carneiro, M Carmen Crespo, Emma Burgos-Ramos, Cristina Tomas-Zapico, Alba García-Serrano, Pilar Castro-Gómez, Cesar Venero, Inmaculada Pereda-Pérez, Shishir Baliyan, Azucena Valencia, Javier Fontecha, Alberto Dávalos, Francesco Visiol. Buttermilk and Krill Oil Phospholipids Improve Hippocampal Insulin Resistance and Synaptic Signaling in Aged Rats. Molecular neurobiology. vol 55. issue 9. 2019-02-04. PMID:29397560. |
we studied insulin signaling, mitochondrial activity and biogenesis, and synaptic signaling in the hippocampus and cortex following dietary supplementation with bioactive phospholipid concentrates of krill oil (koc), buttermilk fat globule membranes (bmfc), and a combination of both in aged rats. |
2019-02-04 |
2023-08-13 |
rat |
| Hye-Sang Park, Han-Sam Cho, Tae-Woon Ki. Physical exercise promotes memory capability by enhancing hippocampal mitochondrial functions and inhibiting apoptosis in obesity-induced insulin resistance by high fat diet. Metabolic brain disease. vol 33. issue 1. 2019-01-31. PMID:29185193. |
physical exercise promotes memory capability by enhancing hippocampal mitochondrial functions and inhibiting apoptosis in obesity-induced insulin resistance by high fat diet. |
2019-01-31 |
2023-08-13 |
mouse |
| Hye-Sang Park, Han-Sam Cho, Tae-Woon Ki. Physical exercise promotes memory capability by enhancing hippocampal mitochondrial functions and inhibiting apoptosis in obesity-induced insulin resistance by high fat diet. Metabolic brain disease. vol 33. issue 1. 2019-01-31. PMID:29185193. |
a high-fat diet induces obesity in mice, leading to insulin resistance, decreased mitochondrial function, and increased apoptosis in the hippocampus, which eventually result in memory loss. |
2019-01-31 |
2023-08-13 |
mouse |
| Hye-Sang Park, Han-Sam Cho, Tae-Woon Ki. Physical exercise promotes memory capability by enhancing hippocampal mitochondrial functions and inhibiting apoptosis in obesity-induced insulin resistance by high fat diet. Metabolic brain disease. vol 33. issue 1. 2019-01-31. PMID:29185193. |
the present study investigated the effect of physical exercise on memory, hippocampal mitochondrial function, and apoptosis in mice with in insulin resistance caused by obesity due to high-fat diet. |
2019-01-31 |
2023-08-13 |
mouse |
| Hye-Sang Park, Han-Sam Cho, Tae-Woon Ki. Physical exercise promotes memory capability by enhancing hippocampal mitochondrial functions and inhibiting apoptosis in obesity-induced insulin resistance by high fat diet. Metabolic brain disease. vol 33. issue 1. 2019-01-31. PMID:29185193. |
insulin resistance also caused a decrease in mitochondrial function in the hippocampus by reducing ca |
2019-01-31 |
2023-08-13 |
mouse |
| Carrie R Ferrario, Lawrence P Reaga. Insulin-mediated synaptic plasticity in the CNS: Anatomical, functional and temporal contexts. Neuropharmacology. vol 136. issue Pt B. 2019-01-17. PMID:29217283. |
this neuroplasticity continuum can be conceptualized by the mechanisms through which insulin promotes cognitive function through its actions in brain regions like the hippocampus, as well as the ability of insulin to modulate motivated behaviors through actions in brain regions like the nucleus accumbens and the ventral tegmental area. |
2019-01-17 |
2023-08-13 |
Not clear |
| Lisa Schmitz, Rebecca Kuglin, Inga Bae-Gartz, Ruth Janoschek, Sarah Appel, Andrea Mesaros, Igor Jakovcevski, Christina Vohlen, Marion Handwerk, Regina Ensenauer, Jörg Dötsch, Eva Hucklenbruch-Rothe. Hippocampal insulin resistance links maternal obesity with impaired neuronal plasticity in adult offspring. Psychoneuroendocrinology. vol 89. 2018-12-31. PMID:29324300. |
hippocampal insulin resistance links maternal obesity with impaired neuronal plasticity in adult offspring. |
2018-12-31 |
2023-08-13 |
Not clear |
| Stephanie Kullmann, Martin Heni, Ralf Veit, Klaus Scheffler, Jürgen Machann, Hans-Ulrich Häring, Andreas Fritsche, Hubert Preiss. Intranasal insulin enhances brain functional connectivity mediating the relationship between adiposity and subjective feeling of hunger. Scientific reports. vol 7. issue 1. 2018-12-11. PMID:28487570. |
insulin compared to placebo administration resulted in increased functional connectivity between the prefrontal regions of the default-mode network and the hippocampus as well as the hypothalamus. |
2018-12-11 |
2023-08-13 |
human |
| Stephanie Kullmann, Martin Heni, Ralf Veit, Klaus Scheffler, Jürgen Machann, Hans-Ulrich Häring, Andreas Fritsche, Hubert Preiss. Intranasal insulin enhances brain functional connectivity mediating the relationship between adiposity and subjective feeling of hunger. Scientific reports. vol 7. issue 1. 2018-12-11. PMID:28487570. |
the change in hippocampal functional connectivity significantly correlated with visceral adipose tissue and the change in subjective feeling of hunger after intranasal insulin. |
2018-12-11 |
2023-08-13 |
human |
| Stephanie Kullmann, Martin Heni, Ralf Veit, Klaus Scheffler, Jürgen Machann, Hans-Ulrich Häring, Andreas Fritsche, Hubert Preiss. Intranasal insulin enhances brain functional connectivity mediating the relationship between adiposity and subjective feeling of hunger. Scientific reports. vol 7. issue 1. 2018-12-11. PMID:28487570. |
mediation analysis revealed that the intranasal insulin induced hippocampal functional connectivity increase served as a mediator, suppressing the relationship between visceral adipose tissue and hunger. |
2018-12-11 |
2023-08-13 |
human |
| Pamela V Martino Adami, Pablo Galeano, Marina L Wallinger, Celia Quijano, Alejandro Rabossi, Eleonora S Pagano, Natividad Olivar, Carlos Reyes Toso, Daniel Cardinali, Luis I Brusco, Sonia Do Carmo, Rafael Radi, Goar Gevorkian, Eduardo M Castaño, A Claudio Cuello, Laura Morell. Worsening of memory deficit induced by energy-dense diet in a rat model of early-Alzheimer's disease is associated to neurotoxic Aβ species and independent of neuroinflammation. Biochimica et biophysica acta. Molecular basis of disease. vol 1863. issue 3. 2018-11-26. PMID:28039031. |
results from peripheral and hippocampal biochemical analysis and in situ respirometry showed that wd induced a metabolic syndrome and decreased presynaptic bioenergetic parameters without alterations in hippocampal insulin signaling or lipid composition. |
2018-11-26 |
2023-08-13 |
rat |
| J M Kasper, A J Milton, A E Smith, F Laezza, G Taglialatela, J D Hommel, N Abat. Cognitive deficits associated with a high-fat diet and insulin resistance are potentiated by overexpression of ecto-nucleotide pyrophosphatase phosphodiesterase-1. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 64. 2018-11-15. PMID:28373023. |
this finding was then reviewed in the context of the greater literature to explore potential mechanisms including triglyceride storage, adiponectin, lipid composition, insulin signaling, oxidative stress, and hippocampal signaling. |
2018-11-15 |
2023-08-13 |
mouse |
| Fang Chen, Yingkun He, Pengwen Wang, Peng Wei, Huili Feng, Yingxue Rao, Jing Shi, Jinzhou Tia. Banxia Xiexin decoction ameliorated cognition via the regulation of insulin pathways and glucose transporters in the hippocampus of APPswe/PS1dE9 mice. International journal of immunopathology and pharmacology. vol 32. 2018-10-31. PMID:29873261. |
banxia xiexin decoction ameliorated cognition via the regulation of insulin pathways and glucose transporters in the hippocampus of appswe/ps1de9 mice. |
2018-10-31 |
2023-08-13 |
mouse |