| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fang Chen, Yingkun He, Pengwen Wang, Peng Wei, Huili Feng, Yingxue Rao, Jing Shi, Jinzhou Tia. Banxia Xiexin decoction ameliorated cognition via the regulation of insulin pathways and glucose transporters in the hippocampus of APPswe/PS1dE9 mice. International journal of immunopathology and pharmacology. vol 32. 2018-10-31. PMID:29873261. |
this research aimed to investigate the effects of banxia xiexin decoction (bxd) on cognitive deficits in appswe/ps1de9 double transgenic mice and verify the hypothesis that bxd treatment improves cognitive function via improving insulin signalling, glucose metabolism and synaptic plasticity in the hippocampus of appswe/ps1de9 double transgenic mice. |
2018-10-31 |
2023-08-13 |
mouse |
| Fang Chen, Yingkun He, Pengwen Wang, Peng Wei, Huili Feng, Yingxue Rao, Jing Shi, Jinzhou Tia. Banxia Xiexin decoction ameliorated cognition via the regulation of insulin pathways and glucose transporters in the hippocampus of APPswe/PS1dE9 mice. International journal of immunopathology and pharmacology. vol 32. 2018-10-31. PMID:29873261. |
proteins involved in insulin signalling pathways and glucose transports in the hippocampus were assessed through immunohistochemical staining and western blot. |
2018-10-31 |
2023-08-13 |
mouse |
| Kun Han, Ning Jia, Yi Zhong, Xiuli Shan. S14G-humanin alleviates insulin resistance and increases autophagy in neurons of APP/PS1 transgenic mouse. Journal of cellular biochemistry. vol 119. issue 4. 2018-10-25. PMID:29058763. |
our results demonstrated that hng could improve the learning ability and memory in app/ps1 transgenic mice, possibly through decreasing irs-1 ser636 phosphorylation and mtor protein expression in the hippocampus, thus improving insulin resistance in the brain. |
2018-10-25 |
2023-08-13 |
mouse |
| Kun Han, Ning Jia, Yi Zhong, Xiuli Shan. S14G-humanin alleviates insulin resistance and increases autophagy in neurons of APP/PS1 transgenic mouse. Journal of cellular biochemistry. vol 119. issue 4. 2018-10-25. PMID:29058763. |
taken together, our results suggest that through the regulation of irs-1/mtor insulin signaling in the hippocampus, hng increases the activity of autophagy and decreases aβ deposition in the brain, and improves learning ability and memory of ad mice. |
2018-10-25 |
2023-08-13 |
mouse |
| Hanwoong Woo, Caroline Jeeyeon Hong, Seonghee Jung, Seongwon Choe, Seong-Woon Y. Chronic restraint stress induces hippocampal memory deficits by impairing insulin signaling. Molecular brain. vol 11. issue 1. 2018-10-22. PMID:29970188. |
chronic restraint stress induces hippocampal memory deficits by impairing insulin signaling. |
2018-10-22 |
2023-08-13 |
mouse |
| Hanwoong Woo, Caroline Jeeyeon Hong, Seonghee Jung, Seongwon Choe, Seong-Woon Y. Chronic restraint stress induces hippocampal memory deficits by impairing insulin signaling. Molecular brain. vol 11. issue 1. 2018-10-22. PMID:29970188. |
insulin signaling is important for the development and cognitive function of the hippocampus. |
2018-10-22 |
2023-08-13 |
mouse |
| Hanwoong Woo, Caroline Jeeyeon Hong, Seonghee Jung, Seongwon Choe, Seong-Woon Y. Chronic restraint stress induces hippocampal memory deficits by impairing insulin signaling. Molecular brain. vol 11. issue 1. 2018-10-22. PMID:29970188. |
here, we show that chronic stress impairs insulin signaling in vitro and in vivo, and thereby induces deficits in hippocampal spatial working memory and neurobehavior. |
2018-10-22 |
2023-08-13 |
mouse |
| Hanwoong Woo, Caroline Jeeyeon Hong, Seonghee Jung, Seongwon Choe, Seong-Woon Y. Chronic restraint stress induces hippocampal memory deficits by impairing insulin signaling. Molecular brain. vol 11. issue 1. 2018-10-22. PMID:29970188. |
intranasal insulin delivery restored insulin signaling and rescued hippocampal deficits. |
2018-10-22 |
2023-08-13 |
mouse |
| Hanwoong Woo, Caroline Jeeyeon Hong, Seonghee Jung, Seongwon Choe, Seong-Woon Y. Chronic restraint stress induces hippocampal memory deficits by impairing insulin signaling. Molecular brain. vol 11. issue 1. 2018-10-22. PMID:29970188. |
our data suggest that psychological stress impairs insulin signaling and results in hippocampal deficits, and these effects can be prevented by intranasal insulin delivery. |
2018-10-22 |
2023-08-13 |
mouse |
| Elmira Beirami, Shahrbanoo Oryan, Seyedeh Masoumeh Seyedhosseini Tamijani, Abolhassan Ahmadiani, Leila Dargah. Intranasal insulin treatment restores cognitive deficits and insulin signaling impairment induced by repeated methamphetamine exposure. Journal of cellular biochemistry. vol 119. issue 2. 2018-10-15. PMID:28884876. |
the expression of components involved in insulin signaling (ir/irs2/pi3k/akt/gsk3β) and mitochondrial biogenesis (pgc-1α, nrf1, and tfam) was measured in the hippocampus. |
2018-10-15 |
2023-08-13 |
rat |
| Matteo Spinelli, Salvatore Fusco, Marco Mainardi, Federico Scala, Francesca Natale, Rosita Lapenta, Andrea Mattera, Marco Rinaudo, Domenica Donatella Li Puma, Cristian Ripoli, Alfonso Grassi, Marcello D'Ascenzo, Claudio Grass. Brain insulin resistance impairs hippocampal synaptic plasticity and memory by increasing GluA1 palmitoylation through FoxO3a. Nature communications. vol 8. issue 1. 2018-10-01. PMID:29222408. |
brain insulin resistance impairs hippocampal synaptic plasticity and memory by increasing glua1 palmitoylation through foxo3a. |
2018-10-01 |
2023-08-13 |
mouse |
| Matteo Spinelli, Salvatore Fusco, Marco Mainardi, Federico Scala, Francesca Natale, Rosita Lapenta, Andrea Mattera, Marco Rinaudo, Domenica Donatella Li Puma, Cristian Ripoli, Alfonso Grassi, Marcello D'Ascenzo, Claudio Grass. Brain insulin resistance impairs hippocampal synaptic plasticity and memory by increasing GluA1 palmitoylation through FoxO3a. Nature communications. vol 8. issue 1. 2018-10-01. PMID:29222408. |
here, we demonstrate that hfd increases palmitic acid deposition in the hippocampus and induces hippocampal insulin resistance leading to foxo3a-mediated overexpression of the palmitoyltransferase zdhhc3. |
2018-10-01 |
2023-08-13 |
mouse |
| Noriyasu Kamei, Ai Yamaoka, Yukiko Fukuyama, Rei Itokazu, Mariko Takeda-Morishit. Noncovalent Strategy with Cell-Penetrating Peptides to Facilitate the Brain Delivery of Insulin through the Blood-Brain Barrier. Biological & pharmaceutical bulletin. vol 41. issue 4. 2018-09-11. PMID:29607927. |
furthermore, an in vivo study with rats showed that the accumulation of insulin in the deeper region of the brain, i.e., hippocampus, significantly increased after the intravenous coadministration of insulin with d-r8 without altering the insulin disposition in plasma. |
2018-09-11 |
2023-08-13 |
rat |
| Archontia Kaminari, Nikolas Giannakas, Athina Tzinia, Effie C Tsilibar. Overexpression of matrix metalloproteinase-9 (MMP-9) rescues insulin-mediated impairment in the 5XFAD model of Alzheimer's disease. Scientific reports. vol 7. issue 1. 2018-08-30. PMID:28386117. |
in the present study, we examined the role of mmp-9 on the insulin survival pathway in primary hippocampal cultures and hippocampal cell extracts from 3 month-old wild type, ad (5xfad), mmp-9-overexpressing (tgmmp-9), and double transgenic mice (5xfad/tgmmp-9). |
2018-08-30 |
2023-08-13 |
mouse |
| Maria Elizabeth de Sousa Rodrigues, Mandakh Bekhbat, Madelyn C Houser, Jianjun Chang, Douglas I Walker, Dean P Jones, Claudia M P Oller do Nascimento, Christopher J Barnum, Malú G Tanse. Chronic psychological stress and high-fat high-fructose diet disrupt metabolic and inflammatory gene networks in the brain, liver, and gut and promote behavioral deficits in mice. Brain, behavior, and immunity. vol 59. 2018-08-23. PMID:27592562. |
psychological stress and hfhf diet promoted changes in intestinal tight junctions proteins and increases in insulin resistance and plasma cholesterol, and impacted the rna expression of inflammatory factors in the hippocampus. |
2018-08-23 |
2023-08-13 |
mouse |
| Tsai-Teng Tzeng, Chien-Chih Chen, Chin-Chu Chen, Huey-Jen Tsay, Li-Ya Lee, Wan-Ping Chen, Chien-Chang Shen, Young-Ji Shia. The Cyanthin Diterpenoid and Sesterterpene Constituents of Hericium erinaceus Mycelium Ameliorate Alzheimer's Disease-Related Pathologies in APP/PS1 Transgenic Mice. International journal of molecular sciences. vol 19. issue 2. 2018-08-17. PMID:29463001. |
our results indicated the benefit effects of both erinacine a and s in cerebrum of appswe/ps1de9 mice, including: (1) attenuating cerebral plaque loading by inhibiting plaque growth; (2) diminishing the activation of glial cells; (3) raising the level of insulin degrading enzyme; and (4) promoting hippocampal neurogenesis. |
2018-08-17 |
2023-08-13 |
mouse |
| Frédéric Canini, Bolin Qin, Nathalie Arvy, Laurent Poulet, Cécile Batandier, Anne-Marie Roussel, Richard A Anderso. Stress exposure alters brain mRNA expression of the genes involved in insulin signalling, an effect modified by a high fat/high fructose diet and cinnamon supplement. PloS one. vol 13. issue 5. 2018-08-13. PMID:29813096. |
the insulin signalling in hippocampus and frontal cortex was studied through the mrna expression of the following genes: insulin receptor (ir), insulin receptor substrate (irs1), glucose transporters (glut1 and glut3), glycogen synthase (gys1) and their modulators, akt1 and pten. |
2018-08-13 |
2023-08-13 |
rat |
| Sophie Calderari, Massimiliano Ria, Christelle Gérard, Tatiane C Nogueira, Olatz Villate, Stephan C Collins, Helen Neil, Nicolas Gervasi, Christophe Hue, Nicolas Suarez-Zamorano, Cécilia Prado, Miriam Cnop, Marie-Thérèse Bihoreau, Pamela J Kaisaki, Jean-Baptiste Cazier, Cécile Julier, Mark Lathrop, Michel Werner, Decio L Eizirik, Dominique Gauguie. Molecular genetics of the transcription factor GLIS3 identifies its dual function in beta cells and neurons. Genomics. vol 110. issue 2. 2018-08-10. PMID:28911974. |
naturally-occurring coding polymorphisms in glis3 in the goto-kakizaki rat model of type 2 diabetes were associated with increased insulin production in vitro and in vivo, suggestive alteration of autophagy in pc12 and ins1 and abnormal neurogenesis in hippocampus neurons. |
2018-08-10 |
2023-08-13 |
rat |
| Kelly A Hamilton, Yue Wang, Sophia M Raefsky, Sean Berkowitz, Ryan Spangler, Caitlin N Suire, Simonetta Camandola, Robert H Lipsky, Mark P Mattso. Mice lacking the transcriptional regulator Bhlhe40 have enhanced neuronal excitability and impaired synaptic plasticity in the hippocampus. PloS one. vol 13. issue 5. 2018-07-30. PMID:29715265. |
of the validated genes identified from mrna expression analysis, insulin degrading enzyme (ide) had the most significantly altered expression in hippocampus and was significantly downregulated on the rna and protein levels; although bhlhe40 did not occupy the ide gene by chip-seq. |
2018-07-30 |
2023-08-13 |
mouse |
| João Paulo Almeida Dos Santos, Adriana Vizuete, Fernanda Hansen, Regina Biasibetti, Carlos-Alberto Gonçalve. Early and Persistent O-GlcNAc Protein Modification in the Streptozotocin Model of Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 61. issue 1. 2018-07-13. PMID:29154269. |
we investigated hippocampal metabolic changes in wistar rats, particularly ogt levels and insulin resistance, as well as related astroglial activities, immediately after icv stz administration (first week) and later on (fourth week). |
2018-07-13 |
2023-08-13 |
rat |