| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Elizabeth S Chan, Mahesh Shivarama Shetty, Sreedharan Sajikumar, Christopher Chen, Tuck Wah Soong, Boon-Seng Won. ApoE4 expression accelerates hippocampus-dependent cognitive deficits by enhancing Aβ impairment of insulin signaling in an Alzheimer's disease mouse model. Scientific reports. vol 6. 2018-03-27. PMID:27189808. |
insulin treatment was only able to stimulate insulin signaling and increased ampa-glur1 phosphorylation in forskolin pre-treated hippocampal slices from apoe3xapp mice. |
2018-03-27 |
2023-08-13 |
mouse |
| Elizabeth S Chan, Mahesh Shivarama Shetty, Sreedharan Sajikumar, Christopher Chen, Tuck Wah Soong, Boon-Seng Won. ApoE4 expression accelerates hippocampus-dependent cognitive deficits by enhancing Aβ impairment of insulin signaling in an Alzheimer's disease mouse model. Scientific reports. vol 6. 2018-03-27. PMID:27189808. |
using dissociated hippocampal neuron in vitro, we showed that insulin response in apoe3 and apoe4 neurons increased ampa receptor-mediated miniature excitatory postsynaptic current (mepsc) amplitudes and glur1-subunit insertion. |
2018-03-27 |
2023-08-13 |
mouse |
| Alberto Jiménez-Maldonado, Zhe Ying, Hyae Ran Byun, Fernando Gomez-Pinill. Short-term fructose ingestion affects the brain independently from establishment of metabolic syndrome. Biochimica et biophysica acta. Molecular basis of disease. vol 1864. issue 1. 2018-03-26. PMID:29017895. |
we report that the fructose treatment had no effect on liver/body weight ratio, weight gain, glucose tolerance and insulin sensitivity, was sufficient to reduce several aspects of hippocampal plasticity. |
2018-03-26 |
2023-08-13 |
Not clear |
| Wen-Chung Liu, Chih-Wei Wu, You-Lin Tain, Mu-Hui Fu, Chun-Ying Hung, I-Chun Chen, Lee-Wei Chen, Kay L H W. Oral pioglitazone ameliorates fructose-induced peripheral insulin resistance and hippocampal gliosis but not restores inhibited hippocampal adult neurogenesis. Biochimica et biophysica acta. Molecular basis of disease. vol 1864. issue 1. 2018-03-26. PMID:29054390. |
oral pioglitazone ameliorates fructose-induced peripheral insulin resistance and hippocampal gliosis but not restores inhibited hippocampal adult neurogenesis. |
2018-03-26 |
2023-08-13 |
rat |
| Wen-Chung Liu, Chih-Wei Wu, You-Lin Tain, Mu-Hui Fu, Chun-Ying Hung, I-Chun Chen, Lee-Wei Chen, Kay L H W. Oral pioglitazone ameliorates fructose-induced peripheral insulin resistance and hippocampal gliosis but not restores inhibited hippocampal adult neurogenesis. Biochimica et biophysica acta. Molecular basis of disease. vol 1864. issue 1. 2018-03-26. PMID:29054390. |
diet-associated insulin resistance (ir) is intimately correlated with the progression of metabolic syndrome and hippocampal dysfunction. |
2018-03-26 |
2023-08-13 |
rat |
| Wen-Chung Liu, Chih-Wei Wu, You-Lin Tain, Mu-Hui Fu, Chun-Ying Hung, I-Chun Chen, Lee-Wei Chen, Kay L H W. Oral pioglitazone ameliorates fructose-induced peripheral insulin resistance and hippocampal gliosis but not restores inhibited hippocampal adult neurogenesis. Biochimica et biophysica acta. Molecular basis of disease. vol 1864. issue 1. 2018-03-26. PMID:29054390. |
we evaluated the levels of peripheral and hippocampal ir via the homeostatic model assessment of insulin resistance and hippocampal irs-1/akt phosphorylation, respectively, of wistar kyoto rats fed with a regular chew or high fructose diet (hfd) for 12weeks. |
2018-03-26 |
2023-08-13 |
rat |
| S Madhavadas, S Subramanian, B M Kutt. Environmental enrichment improved cognitive deficits more in peri-adolescent than in adult rats after postnatal monosodium glutamate treatment. Physiology international. vol 104. issue 4. 2018-03-09. PMID:29278027. |
unless treated, msg rats exhibited peripheral insulin resistance, cognitive deficits, and a reduction in the total hippocampal volume with decreased neuron count in the dg, ca3, and ca1 subfields. |
2018-03-09 |
2023-08-13 |
rat |
| S Madhavadas, S Subramanian, B M Kutt. Environmental enrichment improved cognitive deficits more in peri-adolescent than in adult rats after postnatal monosodium glutamate treatment. Physiology international. vol 104. issue 4. 2018-03-09. PMID:29278027. |
ee exposure has improved insulin sensitivity, yielded a significant increase in total hippocampal volume along with increase in neuron number in the ca1 subfield of the hippocampus in both age groups. |
2018-03-09 |
2023-08-13 |
rat |
| Madhavan Nampoothiri, Nitesh Kumar, Grandhi Venkata Ramalingayya, Nampurath Gopalan Kutty, Nandakumar Krishnadas, Chamallamudi Mallikarjuna Ra. Effect of insulin on spatial memory in aluminum chloride-induced dementia in rats. Neuroreport. vol 28. issue 9. 2018-03-05. PMID:28498150. |
thus, the present study aimed to evaluate the prophylactic role of insulin and its combination with glucose and its possible mechanism(s) in an aluminum chloride (alcl3)-induced cognitive dysfunction model in rodents, with a special focus on memory centers namely, the hippocampus and the frontal cortex. |
2018-03-05 |
2023-08-13 |
rat |
| Madhavan Nampoothiri, Nitesh Kumar, Grandhi Venkata Ramalingayya, Nampurath Gopalan Kutty, Nandakumar Krishnadas, Chamallamudi Mallikarjuna Ra. Effect of insulin on spatial memory in aluminum chloride-induced dementia in rats. Neuroreport. vol 28. issue 9. 2018-03-05. PMID:28498150. |
insulin alone and its combination with glucose could not inhibit aluminum-induced oxidative stress and impaired cholinergic transmission in the hippocampus and frontal cortex regions. |
2018-03-05 |
2023-08-13 |
rat |
| Madhavan Nampoothiri, Nitesh Kumar, Grandhi Venkata Ramalingayya, Nampurath Gopalan Kutty, Nandakumar Krishnadas, Chamallamudi Mallikarjuna Ra. Effect of insulin on spatial memory in aluminum chloride-induced dementia in rats. Neuroreport. vol 28. issue 9. 2018-03-05. PMID:28498150. |
the study suggests the inability of prophylactic insulin administration against cognitive dysfunction induced by environmental toxin (alcl3) in the hippocampus and the frontal cortex. |
2018-03-05 |
2023-08-13 |
rat |
| Z Chen, Y-Y Xu, R Wu, Y-X Han, Y Yu, J-F Ge, F-H Che. Impaired learning and memory in rats induced by a high-fat diet: Involvement with the imbalance of nesfatin-1 abundance and copine 6 expression. Journal of neuroendocrinology. vol 29. issue 4. 2018-02-26. PMID:28211103. |
the plasma levels of nesfatin-1, leptin and insulin were measured via enzyme-linked immunosorbent assay, and the protein expressions of p-glycogen synthase kinase-3β (gsk-3β), gsk-3β, p-β-catenin, β-catenin, cyclind and copine 6 in the hippocampus and prefrontal cortex (pfc) were detected using western blotting. |
2018-02-26 |
2023-08-13 |
rat |
| Xiaoxu Sun, Shanshan Li, Lixing Xu, Hao Wang, Zhanqiang Ma, Qiang Fu, Rong Qu, Shiping M. Paeoniflorin ameliorates cognitive dysfunction via regulating SOCS2/IRS-1 pathway in diabetic rats. Physiology & behavior. vol 174. 2018-02-26. PMID:28322909. |
current evidences support that inflammatory reaction, oxidative stress, as well as abnormal insulin signaling in the hippocampus are potential causes of tau hyperphosphorylation and finally induce cognitive dysfunction. |
2018-02-26 |
2023-08-13 |
rat |
| Sisi Yang, Zhe Chen, Ming Cao, Renjie Li, Zhigang Wang, Muxun Zhan. Pioglitazone ameliorates Aβ42 deposition in rats with diet-induced insulin resistance associated with AKT/GSK3β activation. Molecular medicine reports. vol 15. issue 5. 2018-02-16. PMID:28447730. |
plasma glucose and insulin levels, and cerebrospinal fluid insulin levels were measured; in addition, hippocampal tissues were collected for immunohistochemical analysis of aβ42 expression. |
2018-02-16 |
2023-08-13 |
rat |
| Yvonne F Brünner, Rea Rodriguez-Raecke, Smiljana Mutic, Christian Benedict, Jessica Freiher. Neural correlates of olfactory and visual memory performance in 3D-simulated mazes after intranasal insulin application. Neurobiology of learning and memory. vol 134 Pt B. 2018-02-09. PMID:27492601. |
however, we did not observe an enhancement of declarative memory performance in our behavioral data or hippocampal activity in response to insulin application in the fmri analysis. |
2018-02-09 |
2023-08-13 |
human |
| J Pearson-Leary, V Jahagirdar, J Sage, E C McNa. Insulin modulates hippocampally-mediated spatial working memory via glucose transporter-4. Behavioural brain research. vol 338. 2018-02-07. PMID:28943428. |
we previously showed that insulin signaling within the hippocampus is required for processing this task, and that administration of exogenous insulin enhances performance. |
2018-02-07 |
2023-08-13 |
rat |
| J Pearson-Leary, V Jahagirdar, J Sage, E C McNa. Insulin modulates hippocampally-mediated spatial working memory via glucose transporter-4. Behavioural brain research. vol 338. 2018-02-07. PMID:28943428. |
at baseline levels of hippocampal insulin, inhibition of glut4-mediated glucose uptake did not affect sa performance. |
2018-02-07 |
2023-08-13 |
rat |
| J Pearson-Leary, V Jahagirdar, J Sage, E C McNa. Insulin modulates hippocampally-mediated spatial working memory via glucose transporter-4. Behavioural brain research. vol 338. 2018-02-07. PMID:28943428. |
conversely, when a memory-enhancing dose of insulin was delivered to the hippocampus prior to sa-testing, inhibition of glut4-mediated glucose transport prevented cognitive enhancement. |
2018-02-07 |
2023-08-13 |
rat |
| J Pearson-Leary, V Jahagirdar, J Sage, E C McNa. Insulin modulates hippocampally-mediated spatial working memory via glucose transporter-4. Behavioural brain research. vol 338. 2018-02-07. PMID:28943428. |
these data suggest that baseline hippocampal cognitive processing does not require functional hippocampal glut4, but that cognitive enhancement by supra-baseline insulin does. |
2018-02-07 |
2023-08-13 |
rat |
| J Pearson-Leary, V Jahagirdar, J Sage, E C McNa. Insulin modulates hippocampally-mediated spatial working memory via glucose transporter-4. Behavioural brain research. vol 338. 2018-02-07. PMID:28943428. |
collectively, these data demonstrate a key role for glut4 in transducing the procognitive effects of elevated hippocampal insulin. |
2018-02-07 |
2023-08-13 |
rat |