| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Amanda Brondani Mucellini, Natasha Kim de Oliveira da Fonseca, Gisele Gus Manfro, Patrícia Pelufo Silveir. Hippocampal insulin resistance and altered food decision-making as players on obesity risk. Neuroscience and biobehavioral reviews. vol 77. 2017-10-26. PMID:28342765. |
hippocampal insulin resistance and altered food decision-making as players on obesity risk. |
2017-10-26 |
2023-08-13 |
Not clear |
| Amanda Brondani Mucellini, Natasha Kim de Oliveira da Fonseca, Gisele Gus Manfro, Patrícia Pelufo Silveir. Hippocampal insulin resistance and altered food decision-making as players on obesity risk. Neuroscience and biobehavioral reviews. vol 77. 2017-10-26. PMID:28342765. |
insulin also has been linked to brain functions such as feeding behavior and the imbalance of its mechanism of action on hippocampus is being related to cognitive dysfunction. |
2017-10-26 |
2023-08-13 |
Not clear |
| Amanda Brondani Mucellini, Natasha Kim de Oliveira da Fonseca, Gisele Gus Manfro, Patrícia Pelufo Silveir. Hippocampal insulin resistance and altered food decision-making as players on obesity risk. Neuroscience and biobehavioral reviews. vol 77. 2017-10-26. PMID:28342765. |
the discussion here is whether changes in insulin action could contribute to intake dysregulation and obesogenic behavior as a primary consequence of impairing hippocampal functioning, aside from the role of this hormone on obesity development through peripheral metabolic pathways. |
2017-10-26 |
2023-08-13 |
Not clear |
| Amanda Brondani Mucellini, Natasha Kim de Oliveira da Fonseca, Gisele Gus Manfro, Patrícia Pelufo Silveir. Hippocampal insulin resistance and altered food decision-making as players on obesity risk. Neuroscience and biobehavioral reviews. vol 77. 2017-10-26. PMID:28342765. |
excess intake of high-fat and high-sugar diets leads to insulin resistance, which disrupts hippocampal function. |
2017-10-26 |
2023-08-13 |
Not clear |
| Maud Gratuze, Emmanuel Plane. Regulation of brain insulin signaling: A new function for tau. The Journal of experimental medicine. vol 214. issue 8. 2017-10-26. PMID:28652305. |
they find that tau deletion impairs hippocampal response to insulin through irs-1 and pten dysregulation and suggest that, in alzheimer's disease, impairment of brain insulin signaling might occur via tau loss of function. |
2017-10-26 |
2023-08-13 |
Not clear |
| Noriyasu Kamei, Misa Tanaka, Hayoung Choi, Nobuyuki Okada, Takamasa Ikeda, Rei Itokazu, Mariko Takeda-Morishit. Effect of an Enhanced Nose-to-Brain Delivery of Insulin on Mild and Progressive Memory Loss in the Senescence-Accelerated Mouse. Molecular pharmaceutics. vol 14. issue 3. 2017-10-24. PMID:28094952. |
immunohistological examination of hippocampal regions of samples from samp8 in the progressive stage suggested that accelerated nose-to-brain insulin delivery had a partial neuroprotective function but unexpectedly increased aβ plaque deposition in the hippocampus. |
2017-10-24 |
2023-08-13 |
mouse |
| Dongmei Wang, Xiaozhuan Liu, Yumei Liu, Guomin Shen, Xiaoying Zhu, Sanqiang L. Treatment effects of Cardiotrophin-1 (CT-1) on streptozotocin-induced memory deficits in mice. Experimental gerontology. vol 92. 2017-10-04. PMID:28285145. |
moreover, ct-1 significantly enhanced insulin signaling pathway in the hippocampus of icv-stz-treated mice when compared with the control. |
2017-10-04 |
2023-08-13 |
mouse |
| Farzaneh Rostami, Mohammad Javan, Ali Moghimi, Aliakbar Haddad-Mashadrizeh, Masoud Fereidon. Streptozotocin-induced hippocampal astrogliosis and insulin signaling malfunction as experimental scales for subclinical sporadic Alzheimer model. Life sciences. vol 188. 2017-09-29. PMID:28867578. |
streptozotocin-induced hippocampal astrogliosis and insulin signaling malfunction as experimental scales for subclinical sporadic alzheimer model. |
2017-09-29 |
2023-08-13 |
rat |
| Piangkwan Sa-Nguanmoo, Pongpan Tanajak, Sasiwan Kerdphoo, Pattarapong Satjaritanun, Xiaojie Wang, Guang Liang, Xiaokun Li, Chao Jiang, Wasana Pratchayasakul, Nipon Chattipakorn, Siriporn C Chattipakor. FGF21 improves cognition by restored synaptic plasticity, dendritic spine density, brain mitochondrial function and cell apoptosis in obese-insulin resistant male rats. Hormones and behavior. vol 85. 2017-09-26. PMID:27566237. |
fgf21-treated obese-insulin resistant rats had improved peripheral insulin sensitivity, increased hippocampal synaptic plasticity, increased dendritic spine density, restored brain mitochondrial function, attenuated brain cells apoptosis and increased brain fgf21 signaling, leading to a prevention of cognitive decline. |
2017-09-26 |
2023-08-13 |
human |
| Elodie Marciniak, Antoine Leboucher, Emilie Caron, Tariq Ahmed, Anne Tailleux, Julie Dumont, Tarik Issad, Ellen Gerhardt, Patrick Pagesy, Margaux Vileno, Clément Bournonville, Malika Hamdane, Kadiombo Bantubungi, Steve Lancel, Dominique Demeyer, Sabiha Eddarkaoui, Emmanuelle Vallez, Didier Vieau, Sandrine Humez, Emilie Faivre, Benjamin Grenier-Boley, Tiago F Outeiro, Bart Staels, Philippe Amouyel, Detlef Balschun, Luc Buee, David Blu. Tau deletion promotes brain insulin resistance. The Journal of experimental medicine. vol 214. issue 8. 2017-09-26. PMID:28652303. |
we found that tau deletion leads to an impaired hippocampal response to insulin, caused by altered irs-1 and pten (phosphatase and tensin homologue on chromosome 10) activities. |
2017-09-26 |
2023-08-13 |
mouse |
| Fiona Brabazon, Colin M Wilson, Shalini Jaiswal, John Reed, William H Frey, Kimberly R Byrne. Intranasal insulin treatment of an experimental model of moderate traumatic brain injury. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 37. issue 9. 2017-09-19. PMID:28058996. |
intranasal insulin also resulted in a significant decrease in hippocampus lesion volume and significantly less microglial immunolabeling in the hippocampus. |
2017-09-19 |
2023-08-13 |
rat |
| Fiona Brabazon, Colin M Wilson, Shalini Jaiswal, John Reed, William H Frey, Kimberly R Byrne. Intranasal insulin treatment of an experimental model of moderate traumatic brain injury. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 37. issue 9. 2017-09-19. PMID:28058996. |
these data show that intranasal insulin improves memory, increases cerebral glucose uptake and decreases neuroinflammation and hippocampal lesion volume, and may therefore be a viable therapy for tbi. |
2017-09-19 |
2023-08-13 |
rat |
| Xiaoqing Wang, Lai Wang, Yizheng Sun, Ruiping Li, Jinbo Deng, Jiexin Den. DNA methylation and histone deacetylation regulating insulin sensitivity due to chronic cold exposure. Cryobiology. vol 74. 2017-09-07. PMID:27988168. |
the results showed: ① chronic cold exposure could reduce the insulin resistance index (p < 0.01) and increase the number of irs2 positive cells and ob-r positive cells in hippocampus (p < 0.01). |
2017-09-07 |
2023-08-13 |
mouse |
| Shinwon Ha, Seol-Hwa Jeong, Kyungrim Yi, Kyung Min Chung, Caroline Jeeyeon Hong, Seong Who Kim, Eun-Kyoung Kim, Seong-Woon Y. Phosphorylation of p62 by AMP-activated protein kinase mediates autophagic cell death in adult hippocampal neural stem cells. The Journal of biological chemistry. vol 292. issue 33. 2017-09-05. PMID:28655770. |
previously, we have reported that adult rat hippocampal neural (hcn) stem cells undergo autophagic cell death (acd) following insulin withdrawal. |
2017-09-05 |
2023-08-13 |
human |
| Vineet Mehta, Arun Parashar, Arun Sharma, Tiratha Raj Singh, Malairaman Udayaban. Quercetin ameliorates chronic unpredicted stress-mediated memory dysfunction in male Swiss albino mice by attenuating insulin resistance and elevating hippocampal GLUT4 levels independent of insulin receptor expression. Hormones and behavior. vol 89. 2017-09-04. PMID:28025042. |
quercetin ameliorates chronic unpredicted stress-mediated memory dysfunction in male swiss albino mice by attenuating insulin resistance and elevating hippocampal glut4 levels independent of insulin receptor expression. |
2017-09-04 |
2023-08-13 |
mouse |
| Vineet Mehta, Arun Parashar, Arun Sharma, Tiratha Raj Singh, Malairaman Udayaban. Quercetin ameliorates chronic unpredicted stress-mediated memory dysfunction in male Swiss albino mice by attenuating insulin resistance and elevating hippocampal GLUT4 levels independent of insulin receptor expression. Hormones and behavior. vol 89. 2017-09-04. PMID:28025042. |
hippocampal insulin signaling was determined by immunofluorescence staining. |
2017-09-04 |
2023-08-13 |
mouse |
| Vineet Mehta, Arun Parashar, Arun Sharma, Tiratha Raj Singh, Malairaman Udayaban. Quercetin ameliorates chronic unpredicted stress-mediated memory dysfunction in male Swiss albino mice by attenuating insulin resistance and elevating hippocampal GLUT4 levels independent of insulin receptor expression. Hormones and behavior. vol 89. 2017-09-04. PMID:28025042. |
these results suggest that intact insulin functioning in the hippocampus is essential for cognitive functions and quercetin improves cus-mediated cognitive dysfunction by modulating hippocampal insulin signaling. |
2017-09-04 |
2023-08-13 |
mouse |
| Éva A Csajbók, Gábor Tamá. Cerebral cortex: a target and source of insulin? Diabetologia. vol 59. issue 8. 2017-08-28. PMID:27207082. |
recent results suggest that insulin is synthesised by a subpopulation of neurons in the cerebral cortex and neural progenitor cells of the hippocampus. |
2017-08-28 |
2023-08-13 |
Not clear |
| Jiah Pearson-Leary, Ewan C McNa. Novel Roles for the Insulin-Regulated Glucose Transporter-4 in Hippocampally Dependent Memory. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 47. 2017-08-18. PMID:27881773. |
several established molecular modulators of memory processing regulate hippocampal glut4 trafficking and hippocampal memory formation is limited by both glucose metabolism and insulin signaling. |
2017-08-18 |
2023-08-13 |
rat |
| Jiah Pearson-Leary, Ewan C McNa. Novel Roles for the Insulin-Regulated Glucose Transporter-4 in Hippocampally Dependent Memory. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 47. 2017-08-18. PMID:27881773. |
unexpectedly, we found that prolonged hippocampal blockade of glucose transport through glut4-upregulated markers of hippocampal insulin signaling prevented task-associated depletion of hippocampal glucose and enhanced both working and short-term memory while also impairing long-term memory. |
2017-08-18 |
2023-08-13 |
rat |