| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kyung Min Chung, Hyunhee Park, Seonghee Jung, Shinwon Ha, Seung-Jun Yoo, Hanwoong Woo, Hyang Ju Lee, Seong Who Kim, Eun-Kyoung Kim, Cheil Moon, Seong-Woon Y. Calpain Determines the Propensity of Adult Hippocampal Neural Stem Cells to Autophagic Cell Death Following Insulin Withdrawal. Stem cells (Dayton, Ohio). vol 33. issue 10. 2016-07-06. PMID:26086870. |
calpain determines the propensity of adult hippocampal neural stem cells to autophagic cell death following insulin withdrawal. |
2016-07-06 |
2023-08-13 |
rat |
| Kyung Min Chung, Hyunhee Park, Seonghee Jung, Shinwon Ha, Seung-Jun Yoo, Hanwoong Woo, Hyang Ju Lee, Seong Who Kim, Eun-Kyoung Kim, Cheil Moon, Seong-Woon Y. Calpain Determines the Propensity of Adult Hippocampal Neural Stem Cells to Autophagic Cell Death Following Insulin Withdrawal. Stem cells (Dayton, Ohio). vol 33. issue 10. 2016-07-06. PMID:26086870. |
we have previously reported that adult rat hippocampal neural stem (hcn) cells underwent autophagic cell death (acd) rather than apoptosis following insulin withdrawal despite their intact apoptotic capabilities. |
2016-07-06 |
2023-08-13 |
rat |
| Catrina Sims-Robinson, Anna Bakeman, Rebecca Glasser, Janet Boggs, Crystal Pacut, Eva L Feldma. The role of endoplasmic reticulum stress in hippocampal insulin resistance. Experimental neurology. vol 277. 2016-06-27. PMID:26775176. |
the role of endoplasmic reticulum stress in hippocampal insulin resistance. |
2016-06-27 |
2023-08-13 |
mouse |
| Catrina Sims-Robinson, Anna Bakeman, Rebecca Glasser, Janet Boggs, Crystal Pacut, Eva L Feldma. The role of endoplasmic reticulum stress in hippocampal insulin resistance. Experimental neurology. vol 277. 2016-06-27. PMID:26775176. |
the role of er stress in the development of insulin resistance in hippocampal neurons is not known. |
2016-06-27 |
2023-08-13 |
mouse |
| Catrina Sims-Robinson, Anna Bakeman, Rebecca Glasser, Janet Boggs, Crystal Pacut, Eva L Feldma. The role of endoplasmic reticulum stress in hippocampal insulin resistance. Experimental neurology. vol 277. 2016-06-27. PMID:26775176. |
similarly, we also demonstrate that impaired insulin signaling is only present in the hf and apoe 3ko mice, which suggests that er stress may play a role in insulin resistance in the hippocampus. |
2016-06-27 |
2023-08-13 |
mouse |
| Catrina Sims-Robinson, Anna Bakeman, Rebecca Glasser, Janet Boggs, Crystal Pacut, Eva L Feldma. The role of endoplasmic reticulum stress in hippocampal insulin resistance. Experimental neurology. vol 277. 2016-06-27. PMID:26775176. |
we demonstrate for the first time that thapsigargin leads to er stress and impaired insulin signaling in human hippocampal neurons. |
2016-06-27 |
2023-08-13 |
mouse |
| Dongmei Wang, Junqiang Yan, Jing Chen, Wenlan Wu, Xiaoying Zhu, Yong Wan. Naringin Improves Neuronal Insulin Signaling, Brain Mitochondrial Function, and Cognitive Function in High-Fat Diet-Induced Obese Mice. Cellular and molecular neurobiology. vol 35. issue 7. 2016-06-24. PMID:25939427. |
then the protein levels of insulin signaling pathway and the amp-activated protein kinase (ampk) in the hippocampus were detected by western blot method. |
2016-06-24 |
2023-08-13 |
mouse |
| Dongmei Wang, Junqiang Yan, Jing Chen, Wenlan Wu, Xiaoying Zhu, Yong Wan. Naringin Improves Neuronal Insulin Signaling, Brain Mitochondrial Function, and Cognitive Function in High-Fat Diet-Induced Obese Mice. Cellular and molecular neurobiology. vol 35. issue 7. 2016-06-24. PMID:25939427. |
moreover, naringin significantly enhanced insulin signaling pathway as indicated by a 34.5% increase in the expression levels of irs-1, a 47.8% decrease in the p-irs-1, a 1.43-fold increase in the p-akt, and a 1.89-fold increase in the p-gsk-3β in the hippocampus of the hfdn mice versus hfd mice. |
2016-06-24 |
2023-08-13 |
mouse |
| Nicolas Kunath, Thomas van Groen, David B Allison, Ashish Kumar, Monique Dozier-Sharpe, Inga Kadis. Ghrelin agonist does not foster insulin resistance but improves cognition in an Alzheimer's disease mouse model. Scientific reports. vol 5. 2016-06-07. PMID:26090621. |
immunoassay results showed a beneficial impact of long-term treatment on insulin signaling pathways in hippocampal tissue. |
2016-06-07 |
2023-08-13 |
mouse |
| Hiranya Pintana, Wasana Pratchayasakul, Piangkwan Sa-nguanmoo, Wanpitak Pongkan, Rungroj Tawinvisan, Nipon Chattipakorn, Siriporn C Chattipakor. Testosterone deprivation has neither additive nor synergistic effects with obesity on the cognitive impairment in orchiectomized and/or obese male rats. Metabolism: clinical and experimental. vol 65. issue 2. 2016-05-24. PMID:26773929. |
this study investigated the effects of obesity on brain insulin sensitivity, brain mitochondrial function, hippocampal synaptic plasticity and cognitive function in testosterone-deprived male rats. |
2016-05-24 |
2023-08-13 |
rat |
| Kyung Min Chung, Eun-Ji Jeong, Hyunhee Park, Hyun-Kyu An, Seong-Woon Y. Mediation of Autophagic Cell Death by Type 3 Ryanodine Receptor (RyR3) in Adult Hippocampal Neural Stem Cells. Frontiers in cellular neuroscience. vol 10. 2016-05-20. PMID:27199668. |
here we investigated the intracellular ca(2+)-mediated regulation of survival and death of adult hippocampal neural stem (hcn) cells utilizing an insulin withdrawal model of autophagic cell death (acd). |
2016-05-20 |
2023-08-13 |
Not clear |
| Sara L Hargrave, Terry L Davidson, Tien-Jui Lee, Kimberly P Kinzi. Brain and behavioral perturbations in rats following Western diet access. Appetite. vol 93. 2016-05-18. PMID:25862980. |
we assessed the effect of 10, 40 and 90 days wd, kd and chow maintenance on spontaneous alternation (sa) and vicarious trial and error (vte) behaviors in male rats, then analyzed blood glucose, insulin, and ketone levels; and hippocampal glut1 and mct1 mrna. |
2016-05-18 |
2023-08-13 |
rat |
| N M Pathak, V Pathak, A M Lynch, N Irwin, V A Gault, P R Flat. Stable oxyntomodulin analogues exert positive effects on hippocampal neurogenesis and gene expression as well as improving glucose homeostasis in high fat fed mice. Molecular and cellular endocrinology. vol 412. 2016-05-17. PMID:26048772. |
hippocampal gene expression and histology were assessed together with evaluation of energy intake, body weight, non-fasting glucose and insulin, glucose tolerance, insulin sensitivity and lipids. |
2016-05-17 |
2023-08-13 |
mouse |
| N M Pathak, V Pathak, A M Lynch, N Irwin, V A Gault, P R Flat. Stable oxyntomodulin analogues exert positive effects on hippocampal neurogenesis and gene expression as well as improving glucose homeostasis in high fat fed mice. Molecular and cellular endocrinology. vol 412. 2016-05-17. PMID:26048772. |
these data demonstrate potential of stable oxm analogues, and particularly (ds(2))oxm(k-γ-glu-pal) to improve metabolic function and enhance neurogenesis, synaptic plasticity, insulin signalling and exert protective effects against oxidative damage in hippocampus and cortex brain regions in hf mice. |
2016-05-17 |
2023-08-13 |
mouse |
| Hiranya Pintana, Wanpitak Pongkan, Wasana Pratchayasakul, Nipon Chattipakorn, Siriporn C Chattipakor. Testosterone replacement attenuates cognitive decline in testosterone-deprived lean rats, but not in obese rats, by mitigating brain oxidative stress. Age (Dordrecht, Netherlands). vol 37. issue 5. 2016-05-17. PMID:26277724. |
we hypothesized that testosterone replacement improves cognitive function in testosterone-deprived obese rats by restoring brain insulin sensitivity, brain mitochondrial function, and hippocampal synaptic plasticity. |
2016-05-17 |
2023-08-13 |
rat |
| Hiranya Pintana, Wanpitak Pongkan, Wasana Pratchayasakul, Nipon Chattipakorn, Siriporn C Chattipakor. Testosterone replacement attenuates cognitive decline in testosterone-deprived lean rats, but not in obese rats, by mitigating brain oxidative stress. Age (Dordrecht, Netherlands). vol 37. issue 5. 2016-05-17. PMID:26277724. |
at the end of this protocol, cognitive function, metabolic parameters, brain insulin sensitivity, hippocampal synaptic plasticity, and brain mitochondrial function were determined. |
2016-05-17 |
2023-08-13 |
rat |
| Hiranya Pintana, Wanpitak Pongkan, Wasana Pratchayasakul, Nipon Chattipakorn, Siriporn C Chattipakor. Testosterone replacement attenuates cognitive decline in testosterone-deprived lean rats, but not in obese rats, by mitigating brain oxidative stress. Age (Dordrecht, Netherlands). vol 37. issue 5. 2016-05-17. PMID:26277724. |
these findings suggest that testosterone replacement improved peripheral insulin sensitivity and decreased oxidative stress levels, but failed to restore hippocampal synaptic plasticity and cognitive function in testosterone-deprived obese rats. |
2016-05-17 |
2023-08-13 |
rat |
| Gui-Hai Chen, Jing-Jing Tong, Fang Wang, Xue-Qin Hu, Xue-Wei Li, Fei Tao, Zhao-Jun We. Chronic adjunction of 1-deoxynojirimycin protects from age-related behavioral and biochemical changes in the SAMP8 mice. Age (Dordrecht, Netherlands). vol 37. issue 5. 2016-05-17. PMID:26400487. |
the old controls exhibited significant declines in sensorimotor ability, open-field anxiety, spatial and nonspatial memory abilities, and age-related biochemical changes, including decreased serum insulin level; increased levels of insulin-like growth factor 1 receptor, presynaptic protein synaptotagmin-1, and astrocyte activation; and decreased levels of insulin receptor, brain-derived neurotrophic factor, presynaptic protein syntaxin-1, and acetylation of histones h4 at lysine 8 in the dorsal hippocampus. |
2016-05-17 |
2023-08-13 |
mouse |
| A R Chandna, N Kuhlmann, C A Bryce, Q Greba, V A Campanucci, J G Howlan. Chronic maternal hyperglycemia induced during mid-pregnancy in rats increases RAGE expression, augments hippocampal excitability, and alters behavior of the offspring. Neuroscience. vol 303. 2016-05-10. PMID:26151680. |
insulin replacement with an implantable pellet in the dams reversed the effects of maternal diabetes on rage expression, hippocampal excitability, prepulse inhibition and object-place memory, but not anxiety-like behavior or set-shifting. |
2016-05-10 |
2023-08-13 |
rat |
| M R King, N J Anderson, C Liu, E Law, M Cundiff, T M Mixcoatl-Zecuatl, C G Jolival. Activation of the insulin-signaling pathway in sciatic nerve and hippocampus of type 1 diabetic rats. Neuroscience. vol 303. 2016-05-06. PMID:26149351. |
fresh sciatic nerve and hippocampus from control and diabetic rats were incubated with varied ex vivo concentrations of insulin and phosphorylation levels of insulin receptor and glycogen synthase kinase-3 (gsk3β) were assessed by western blot analysis. |
2016-05-06 |
2023-08-13 |
rat |