| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shinwon Ha, Hye Young Ryu, Kyung Min Chung, Seung-Hoon Baek, Eun-Kyoung Kim, Seong-Woon Y. Regulation of autophagic cell death by glycogen synthase kinase-3β in adult hippocampal neural stem cells following insulin withdrawal. Molecular brain. vol 8. 2016-01-19. PMID:25986948. |
regulation of autophagic cell death by glycogen synthase kinase-3β in adult hippocampal neural stem cells following insulin withdrawal. |
2016-01-19 |
2023-08-13 |
Not clear |
| Konstantin Bloch, Irit Gil-Ad, Igor Tarasenko, Alexey Vanichkin, Michal Taler, Shay Henry Hornfeld, Pnina Vardi, Abraham Weizma. Intracranial pancreatic islet transplantation increases islet hormone expression in the rat brain and attenuates behavioral dysfunctions induced by MK-801 (dizocilpine). Hormones and behavior. vol 72. 2016-01-11. PMID:25943974. |
significantly higher levels of insulin were detected in the hippocampus and prefrontal cortex of transplanted animals compared to the non-transplanted rats. |
2016-01-11 |
2023-08-13 |
rat |
| Wasana Pratchayasakul, Piangkwan Sa-Nguanmoo, Sivaporn Sivasinprasasn, Hiranya Pintana, Rungroj Tawinvisan, Jirapas Sripetchwandee, Sirinart Kumfu, Nipon Chattipakorn, Siriporn C Chattipakor. Obesity accelerates cognitive decline by aggravating mitochondrial dysfunction, insulin resistance and synaptic dysfunction under estrogen-deprived conditions. Hormones and behavior. vol 72. 2016-01-11. PMID:25989597. |
we hypothesized that estrogen deprivation causes brain insulin resistance, brain mitochondrial dysfunction, hippocampal synaptic dysfunction and cognitive impairment, and that consumption of a hf accelerates these impairments in an estrogen-deprived condition. |
2016-01-11 |
2023-08-13 |
rat |
| Wasana Pratchayasakul, Piangkwan Sa-Nguanmoo, Sivaporn Sivasinprasasn, Hiranya Pintana, Rungroj Tawinvisan, Jirapas Sripetchwandee, Sirinart Kumfu, Nipon Chattipakorn, Siriporn C Chattipakor. Obesity accelerates cognitive decline by aggravating mitochondrial dysfunction, insulin resistance and synaptic dysfunction under estrogen-deprived conditions. Hormones and behavior. vol 72. 2016-01-11. PMID:25989597. |
obesity, peripheral insulin resistance, increased brain oxidative stress and hippocampal synaptic dysfunction were observed at the eighth week in the ndo, hfs and hfo rats. |
2016-01-11 |
2023-08-13 |
rat |
| Wasana Pratchayasakul, Piangkwan Sa-Nguanmoo, Sivaporn Sivasinprasasn, Hiranya Pintana, Rungroj Tawinvisan, Jirapas Sripetchwandee, Sirinart Kumfu, Nipon Chattipakorn, Siriporn C Chattipakor. Obesity accelerates cognitive decline by aggravating mitochondrial dysfunction, insulin resistance and synaptic dysfunction under estrogen-deprived conditions. Hormones and behavior. vol 72. 2016-01-11. PMID:25989597. |
either estrogen deprivation or hf appears to cause peripheral insulin resistance, increased brain oxidative stress, hippocampal synaptic dysfunction, brain mitochondrial dysfunction and brain insulin resistance, which together can lead to cognitive impairment. |
2016-01-11 |
2023-08-13 |
rat |
| De-Lin Ma, Fu-Qiong Chen, Wei-Jie Xu, Wen-Zhu Yue, Gang Yuan, Yan Yan. Early intervention with glucagon-like peptide 1 analog liraglutide prevents tau hyperphosphorylation in diabetic db/db mice. Journal of neurochemistry. vol 135. issue 2. 2016-01-11. PMID:26183127. |
we found that db/db mice treated with saline exhibited an age-dependent decrease in csf insulin and an increase in hippocampal tau phosphorylation. |
2016-01-11 |
2023-08-13 |
mouse |
| Hiranya Pintana, Wanpitak Pongkan, Wasana Pratchayasakul, Nipon Chattipakorn, Siriporn C Chattipakor. Dipeptidyl peptidase 4 inhibitor improves brain insulin sensitivity, but fails to prevent cognitive impairment in orchiectomy obese rats. The Journal of endocrinology. vol 226. issue 2. 2015-12-29. PMID:26016746. |
it is unclear whether the dipeptidyl peptidase 4 (dpp4) inhibitor can counteract brain insulin resistance, brain mitochondrial dysfunction, impairment of hippocampal synaptic plasticity and cognitive decline in testosterone-deprived obese rats. |
2015-12-29 |
2023-08-13 |
human |
| Hiranya Pintana, Wanpitak Pongkan, Wasana Pratchayasakul, Nipon Chattipakorn, Siriporn C Chattipakor. Dipeptidyl peptidase 4 inhibitor improves brain insulin sensitivity, but fails to prevent cognitive impairment in orchiectomy obese rats. The Journal of endocrinology. vol 226. issue 2. 2015-12-29. PMID:26016746. |
we hypothesized that dpp4 inhibitor vildagliptin improves cognitive function in testosterone-deprived obese rats by restoring brain insulin sensitivity, brain mitochondrial function and hippocampal synaptic plasticity. |
2015-12-29 |
2023-08-13 |
human |
| Hiranya Pintana, Wanpitak Pongkan, Wasana Pratchayasakul, Nipon Chattipakorn, Siriporn C Chattipakor. Dipeptidyl peptidase 4 inhibitor improves brain insulin sensitivity, but fails to prevent cognitive impairment in orchiectomy obese rats. The Journal of endocrinology. vol 226. issue 2. 2015-12-29. PMID:26016746. |
after treatment, cognitive function, metabolic parameters, brain insulin sensitivity, hippocampal synaptic plasticity and brain mitochondrial function were determined in each rat. |
2015-12-29 |
2023-08-13 |
human |
| Hiranya Pintana, Wanpitak Pongkan, Wasana Pratchayasakul, Nipon Chattipakorn, Siriporn C Chattipakor. Dipeptidyl peptidase 4 inhibitor improves brain insulin sensitivity, but fails to prevent cognitive impairment in orchiectomy obese rats. The Journal of endocrinology. vol 226. issue 2. 2015-12-29. PMID:26016746. |
we found that hfo rats exhibited peripheral and brain insulin resistance, brain mitochondrial dysfunction, impaired hippocampal synaptic plasticity and cognitive decline. |
2015-12-29 |
2023-08-13 |
human |
| Hiranya Pintana, Wanpitak Pongkan, Wasana Pratchayasakul, Nipon Chattipakorn, Siriporn C Chattipakor. Dipeptidyl peptidase 4 inhibitor improves brain insulin sensitivity, but fails to prevent cognitive impairment in orchiectomy obese rats. The Journal of endocrinology. vol 226. issue 2. 2015-12-29. PMID:26016746. |
these findings suggest that vildagliptin could not counteract the impairment of hippocampal synaptic plasticity and cognitive decline in testosterone-deprived subjects, despite its effects on improved peripheral and brain insulin sensitivity as well as brain mitochondrial function. |
2015-12-29 |
2023-08-13 |
human |
| Guohui Jiang, Wei Wang, Qingqing Cao, Juan Gu, Xiujuan Mi, Kewei Wang, Guojun Chen, Xuefeng Wan. Insulin growth factor-1 (IGF-1) enhances hippocampal excitatory and seizure activity through IGF-1 receptor-mediated mechanisms in the epileptic brain. Clinical science (London, England : 1979). vol 129. issue 12. 2015-12-22. PMID:26286172. |
insulin growth factor-1 (igf-1) enhances hippocampal excitatory and seizure activity through igf-1 receptor-mediated mechanisms in the epileptic brain. |
2015-12-22 |
2023-08-13 |
human |
| J Osmanovic Barilar, A Knezovic, E Grünblatt, P Riederer, M Salkovic-Petrisi. Nine-month follow-up of the insulin receptor signalling cascade in the brain of streptozotocin rat model of sporadic Alzheimer's disease. Journal of neural transmission (Vienna, Austria : 1996). vol 122. issue 4. 2015-12-16. PMID:25503661. |
we have investigated insulin signalling in the rat hippocampus at five time points in periods ≤9 months after stz-icv treatment. |
2015-12-16 |
2023-08-13 |
rat |
| Lina Ma, Zhimin Shao, Rong Wang, Zhiwei Zhao, Xu Zhang, Zhijuan Ji, Shuli Sheng, Baolei Xu, Wen Dong, Jingshuang Zhan. The β-amyloid precursor protein analog P165 improves impaired insulin signal transduction in type 2 diabetic rats. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 36. issue 4. 2015-12-09. PMID:25380623. |
after 8 weeks of treatment, the animals were killed and the expression of insulin signaling-related proteins was examined in the hippocampus by western blot and immunohistochemical staining. |
2015-12-09 |
2023-08-13 |
rat |
| Wen-Wen Yan, Gui-Hai Chen, Fang Wang, Jing-Jing Tong, Fei Ta. Long-term acarbose administration alleviating the impairment of spatial learning and memory in the SAMP8 mice was associated with alleviated reduction of insulin system and acetylated H4K8. Brain research. vol 1603. 2015-12-07. PMID:25645154. |
compared to the young controls (3-month-old, n=11), the old group (9-month-old, n=8) had declined abilities of spatial learning and memory and levels of serum insulin, hippocampal insulin receptors (insrs) and h4k8ac. |
2015-12-07 |
2023-08-13 |
mouse |
| Jing-Jing Tong, Gui-Hai Chen, Fang Wang, Xue-Wei Li, Lei Cao, Xu Sui, Fei Tao, Wen-Wen Yan, Zhao-Jun We. Chronic acarbose treatment alleviates age-related behavioral and biochemical changes in SAMP8 mice. Behavioural brain research. vol 284. 2015-12-07. PMID:25698601. |
the results showed that the aged controls exhibited declines in sensorimotor ability, open field anxiety, spatial and non-spatial memory abilities, decreased serum insulin levels, increased igf-1 receptor and synaptotagmin 1 (syt1) levels and decreased insulin receptor, brain-derived neurotrophic factor (bdnf) and syntaxin 1 (stx1) levels in the hippocampal layers. |
2015-12-07 |
2023-08-13 |
mouse |
| Fang Wang, Yan-Feng Song, Jie Yin, Zi-Hua Liu, Xiao-Dan Mo, De-Gui Wang, Li-Ping Gao, Yu-Hong Jin. Spatial memory impairment is associated with hippocampal insulin signals in ovariectomized rats. PloS one. vol 9. issue 8. 2015-11-30. PMID:25099767. |
spatial memory impairment is associated with hippocampal insulin signals in ovariectomized rats. |
2015-11-30 |
2023-08-13 |
rat |
| Fang Wang, Yan-Feng Song, Jie Yin, Zi-Hua Liu, Xiao-Dan Mo, De-Gui Wang, Li-Ping Gao, Yu-Hong Jin. Spatial memory impairment is associated with hippocampal insulin signals in ovariectomized rats. PloS one. vol 9. issue 8. 2015-11-30. PMID:25099767. |
this phenomenon was accompanied by decreased insulin level and glut4 expression in the hippocampus. |
2015-11-30 |
2023-08-13 |
rat |
| Fang Wang, Yan-Feng Song, Jie Yin, Zi-Hua Liu, Xiao-Dan Mo, De-Gui Wang, Li-Ping Gao, Yu-Hong Jin. Spatial memory impairment is associated with hippocampal insulin signals in ovariectomized rats. PloS one. vol 9. issue 8. 2015-11-30. PMID:25099767. |
the female rats were neutralized with hippocampal insulin with insulin antibody, which also impaired memory and local glucose consumption. |
2015-11-30 |
2023-08-13 |
rat |
| Fang Wang, Yan-Feng Song, Jie Yin, Zi-Hua Liu, Xiao-Dan Mo, De-Gui Wang, Li-Ping Gao, Yu-Hong Jin. Spatial memory impairment is associated with hippocampal insulin signals in ovariectomized rats. PloS one. vol 9. issue 8. 2015-11-30. PMID:25099767. |
the mechanisms by which estrogen blockade impaired memory partially contributed to the decline in hippocampal insulin signals, which diminished glucose consumption. |
2015-11-30 |
2023-08-13 |
rat |