| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M R King, N J Anderson, C Liu, E Law, M Cundiff, T M Mixcoatl-Zecuatl, C G Jolival. Activation of the insulin-signaling pathway in sciatic nerve and hippocampus of type 1 diabetic rats. Neuroscience. vol 303. 2016-05-06. PMID:26149351. |
both the sciatic nerve and hippocampus from type 1 diabetic rats were highly responsive to exogenous insulin with a significantly increased phosphorylation of insulin receptor and gsk3 compared to tissues from control rats. |
2016-05-06 |
2023-08-13 |
rat |
| John G Mielke, Geoffrey A R Mealin. A profile of the insulin receptor in cultured hippocampal slices. Neuro endocrinology letters. vol 33. issue 1. 2016-04-23. PMID:22467113. |
to assess ohscs as a model for the study of hippocampal irs, ligand-binding and the expression and cellular distribution of the β-subunit (which transduces the insulin signal) were examined over time in culture. |
2016-04-23 |
2023-08-12 |
Not clear |
| Raheleh Kheirbakhsh, Maryam Chinisaz, Saeed Khodayari, Saeid Amanpour, Ahmad-Reza Dehpour, Ahad Muhammadnejad, Bagher Larijani, Azadeh Ebrahim-Habib. Injection of insulin amyloid fibrils in the hippocampus of male Wistar rats: report on memory impairment and formation of amyloid plaques. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 36. issue 8. 2016-04-19. PMID:25787810. |
injection of insulin amyloid fibrils in the hippocampus of male wistar rats: report on memory impairment and formation of amyloid plaques. |
2016-04-19 |
2023-08-13 |
rat |
| Raheleh Kheirbakhsh, Maryam Chinisaz, Saeed Khodayari, Saeid Amanpour, Ahmad-Reza Dehpour, Ahad Muhammadnejad, Bagher Larijani, Azadeh Ebrahim-Habib. Injection of insulin amyloid fibrils in the hippocampus of male Wistar rats: report on memory impairment and formation of amyloid plaques. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 36. issue 8. 2016-04-19. PMID:25787810. |
the experimental group was bilaterally injected with insulin amyloid in the hippocampus. |
2016-04-19 |
2023-08-13 |
rat |
| Shaniya Maimaiti, Katie L Anderson, Chris DeMoll, Lawrence D Brewer, Benjamin A Rauh, John C Gant, Eric M Blalock, Nada M Porter, Olivier Thibaul. Intranasal Insulin Improves Age-Related Cognitive Deficits and Reverses Electrophysiological Correlates of Brain Aging. The journals of gerontology. Series A, Biological sciences and medical sciences. vol 71. issue 1. 2016-04-14. PMID:25659889. |
we also explored insulin effects on the ca(2+)-dependent hippocampal afterhyperpolarization (ahp), a well-characterized neurophysiological marker of aging which is increased in the aged, memory impaired animal. |
2016-04-14 |
2023-08-13 |
rat |
| Lin Li, Ke Liu, Juan Zhao, Christian Holscher, Guang-Lai Li, Yue-Ze Li. Neuroprotective role of (Val(8))GLP-1-Glu-PAL in an in vitro model of Parkinson's disease. Neural regeneration research. vol 11. issue 2. 2016-04-13. PMID:27073388. |
here, we analyzed the neuroprotective effects of a novel protease-resistant glp-1 analogue, (val(8))glp-1-glu-pal, which has advantages over older analogues, such as improvement of hippocampal neurogenesis, glucose homeostasis, and insulin secretion. |
2016-04-13 |
2023-08-13 |
mouse |
| Nilmini Viswaprakash, Thirumalini Vaithianathan, Ajitan Viswaprakash, Robert Judd, Kodeeswaran Parameshwaran, Vishnu Suppiramania. Insulin treatment restores glutamate (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptor function in the hippocampus of diabetic rats. Journal of neuroscience research. vol 93. issue 9. 2016-04-12. PMID:25807926. |
insulin treatment restores glutamate (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptor function in the hippocampus of diabetic rats. |
2016-04-12 |
2023-08-13 |
rat |
| Nilmini Viswaprakash, Thirumalini Vaithianathan, Ajitan Viswaprakash, Robert Judd, Kodeeswaran Parameshwaran, Vishnu Suppiramania. Insulin treatment restores glutamate (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptor function in the hippocampus of diabetic rats. Journal of neuroscience research. vol 93. issue 9. 2016-04-12. PMID:25807926. |
these findings suggest that stz-induced diabetes may result in functional deteriorations in glutamatergic synapses in the hippocampus of rats and that these effects may be reduced by insulin treatment. |
2016-04-12 |
2023-08-13 |
rat |
| Rosita Dangman. An insulin based model to explain changes and interactions in human breath-holding. Medical hypotheses. vol 84. issue 6. 2016-03-28. PMID:25801485. |
freedivers that go over the breakpoint of breath-holding could exhibit seizures and thus the effect of insulin, blood glucose levels and corticosteroids in hippocampal seizures is highlighted. |
2016-03-28 |
2023-08-13 |
human |
| Gemma McGregor, Yasaman Malekizadeh, Jenni Harve. Minireview: Food for thought: regulation of synaptic function by metabolic hormones. Molecular endocrinology (Baltimore, Md.). vol 29. issue 1. 2016-03-24. PMID:25470238. |
the hippocampus in particular expresses high levels of both insulin and leptin receptors as well as key components of their associated signaling cascades. |
2016-03-24 |
2023-08-13 |
Not clear |
| Gemma McGregor, Yasaman Malekizadeh, Jenni Harve. Minireview: Food for thought: regulation of synaptic function by metabolic hormones. Molecular endocrinology (Baltimore, Md.). vol 29. issue 1. 2016-03-24. PMID:25470238. |
indeed, it has been demonstrated that both leptin and insulin markedly influence key cellular events that underlie hippocampal learning and memory including activity-dependent synaptic plasticity and the trafficking of glutamate receptors to and away from hippocampal synapses. |
2016-03-24 |
2023-08-13 |
Not clear |
| Gemma McGregor, Yasaman Malekizadeh, Jenni Harve. Minireview: Food for thought: regulation of synaptic function by metabolic hormones. Molecular endocrinology (Baltimore, Md.). vol 29. issue 1. 2016-03-24. PMID:25470238. |
thus, the capacity of the metabolic hormones, leptin and insulin, to regulate hippocampal synaptic function has significant implications for normal brain function and also central nervous system-driven disease. |
2016-03-24 |
2023-08-13 |
Not clear |
| Linda Adzovic, Ashley E Lynn, Heather M D'Angelo, Alexis M Crockett, Roxanne M Kaercher, Sarah E Royer, Sarah C Hopp, Gary L Wen. Insulin improves memory and reduces chronic neuroinflammation in the hippocampus of young but not aged brains. Journal of neuroinflammation. vol 12. 2016-03-07. PMID:25889938. |
insulin improves memory and reduces chronic neuroinflammation in the hippocampus of young but not aged brains. |
2016-03-07 |
2023-08-13 |
rat |
| Geert Jan Biessels, Lawrence P Reaga. Hippocampal insulin resistance and cognitive dysfunction. Nature reviews. Neuroscience. vol 16. issue 11. 2016-02-10. PMID:26462756. |
hippocampal insulin resistance and cognitive dysfunction. |
2016-02-10 |
2023-08-13 |
Not clear |
| Geert Jan Biessels, Lawrence P Reaga. Hippocampal insulin resistance and cognitive dysfunction. Nature reviews. Neuroscience. vol 16. issue 11. 2016-02-10. PMID:26462756. |
this review highlights these observations and discusses intervention studies which suggest that the restoration of insulin activity in the hippocampus may be an effective strategy to alleviate the cognitive decline associated with t2dm and ad. |
2016-02-10 |
2023-08-13 |
Not clear |
| Claudia A Grillo, Gerardo G Piroli, Robert C Lawrence, Shayna A Wrighten, Adrienne J Green, Steven P Wilson, Randall R Sakai, Sandra J Kelly, Marlene A Wilson, David D Mott, Lawrence P Reaga. Hippocampal Insulin Resistance Impairs Spatial Learning and Synaptic Plasticity. Diabetes. vol 64. issue 11. 2016-02-02. PMID:26216852. |
hippocampal insulin resistance impairs spatial learning and synaptic plasticity. |
2016-02-02 |
2023-08-13 |
rat |
| Claudia A Grillo, Gerardo G Piroli, Robert C Lawrence, Shayna A Wrighten, Adrienne J Green, Steven P Wilson, Randall R Sakai, Sandra J Kelly, Marlene A Wilson, David D Mott, Lawrence P Reaga. Hippocampal Insulin Resistance Impairs Spatial Learning and Synaptic Plasticity. Diabetes. vol 64. issue 11. 2016-02-02. PMID:26216852. |
to elucidate the functional role of hippocampal irs independent of metabolic function, we generated a model of hippocampal-specific insulin resistance using a lentiviral vector expressing an ir antisense sequence (lv-iras). |
2016-02-02 |
2023-08-13 |
rat |
| Claudia A Grillo, Gerardo G Piroli, Robert C Lawrence, Shayna A Wrighten, Adrienne J Green, Steven P Wilson, Randall R Sakai, Sandra J Kelly, Marlene A Wilson, David D Mott, Lawrence P Reaga. Hippocampal Insulin Resistance Impairs Spatial Learning and Synaptic Plasticity. Diabetes. vol 64. issue 11. 2016-02-02. PMID:26216852. |
importantly, these learning deficits are strikingly similar to the impairments in complex task performance observed in patients with diabetes, which strengthens the hypothesis that hippocampal insulin resistance is a key mediator of cognitive deficits independent of glycemic control. |
2016-02-02 |
2023-08-13 |
rat |
| Erica L Underwood, Lucien T Thompso. High-fat diet impairs spatial memory and hippocampal intrinsic excitability and sex-dependently alters circulating insulin and hippocampal insulin sensitivity. Biology of sex differences. vol 7. 2016-01-29. PMID:26823968. |
high-fat diet impairs spatial memory and hippocampal intrinsic excitability and sex-dependently alters circulating insulin and hippocampal insulin sensitivity. |
2016-01-29 |
2023-08-13 |
rat |
| b' Andrea \\xc5\\xa0polcov\\xc3\\xa1, Barbora Mikul\\xc3\\xa1\\xc5\\xa1kov\\xc3\\xa1, Martina Holubov\\xc3\\xa1, Veronika Nagelov\\xc3\\xa1, Zdenko Pirnik, Jana Zemenov\\xc3\\xa1, Martin Haluz\\xc3\\xadk, Blanka \\xc5\\xbdelezn\\xc3\\xa1, Marie-Christine Galas, Lenka Malet\\xc3\\xadnsk\\xc3\\xa. Anorexigenic lipopeptides ameliorate central insulin signaling and attenuate tau phosphorylation in hippocampi of mice with monosodium glutamate-induced obesity. Journal of Alzheimer\'s disease : JAD. vol 45. issue 3. 2016-01-19. PMID:25624414.' |
we identified tau hyperphosphorylation in the obesity-induced pre-diabetes state in msg-obese mice and demonstrated the beneficial effects of palm-prrp31 and liraglutide, both of known central anorexigenic effects, on hippocampal insulin signaling and on tau phosphorylation. |
2016-01-19 |
2023-08-13 |
mouse |