| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yue-Bi Li, Wei-Hua Zhang, Hua-Dong Liu, Zhou Liu, Shi-Ping M. Protective effects of Huanglian Wendan Decoction aganist cognitive deficits and neuronal damages in rats with diabetic encephalopathy by inhibiting the release of inflammatory cytokines and repairing insulin signaling pathway in hippocampus. Chinese journal of natural medicines. vol 14. issue 11. 2017-01-31. PMID:27914525. |
protective effects of huanglian wendan decoction aganist cognitive deficits and neuronal damages in rats with diabetic encephalopathy by inhibiting the release of inflammatory cytokines and repairing insulin signaling pathway in hippocampus. |
2017-01-31 |
2023-08-13 |
rat |
| S Nugent, C A Castellano, C Bocti, I Dionne, T Fulop, S C Cunnan. Relationship of metabolic and endocrine parameters to brain glucose metabolism in older adults: do cognitively-normal older adults have a particular metabolic phenotype? Biogerontology. vol 17. issue 1. 2016-10-19. PMID:26364049. |
these data show that compared to a healthy younger adult, the metabolic phenotype of a cognitively-normal 72 year old person includes similar plasma glucose, insulin, cholesterol, triglycerides and tsh, higher hemoglobin a1c and percent body fat, lower cmrg in the superior frontal cortex and caudate, but the same cmrg in the hippocampus and white matter. |
2016-10-19 |
2023-08-13 |
Not clear |
| Sara L Hargrave, Terry L Davidson, Wei Zheng, Kimberly P Kinzi. Western diets induce blood-brain barrier leakage and alter spatial strategies in rats. Behavioral neuroscience. vol 130. issue 1. 2016-10-17. PMID:26595878. |
insulin, glucose, and bbb permeability throughout several loci in the hippocampus, striatum, and cerebellum were evaluated in relation to duration of wd exposure, obesity phenotype, and type of strategy used. |
2016-10-17 |
2023-08-13 |
rat |
| Bo Kyoung Yeo, Caroline Jeeyeon Hong, Kyung Min Chung, Hanwoong Woo, Kyungchan Kim, Seonghee Jung, Eun-Kyoung Kim, Seong-Woon Y. Valosin-containing protein is a key mediator between autophagic cell death and apoptosis in adult hippocampal neural stem cells following insulin withdrawal. Molecular brain. vol 9. 2016-10-14. PMID:27000202. |
valosin-containing protein is a key mediator between autophagic cell death and apoptosis in adult hippocampal neural stem cells following insulin withdrawal. |
2016-10-14 |
2023-08-13 |
Not clear |
| Yan Yang, Delin Ma, Weijie Xu, Fuqiong Chen, Tingting Du, Wenzhu Yue, Shiying Shao, Gang Yua. Exendin-4 reduces tau hyperphosphorylation in type 2 diabetic rats via increasing brain insulin level. Molecular and cellular neurosciences. vol 70. 2016-10-13. PMID:26640240. |
we found that peripheral ex-4 injection in t2d rats reduced hyperphosphorylation of tau protein in rat hippocampus, probably via increasing hippocampal insulin which activated insulin signaling. |
2016-10-13 |
2023-08-13 |
rat |
| Fang Chen, Rong Rong Dong, Kai Long Zhong, Arijit Ghosh, Su Su Tang, Yan Long, Mei Hu, Ming Xing Miao, Jian Min Liao, Hong Bing Sun, Ling Yi Kong, Hao Hon. Antidiabetic drugs restore abnormal transport of amyloid-β across the blood-brain barrier and memory impairment in db/db mice. Neuropharmacology. vol 101. 2016-09-22. PMID:26211973. |
however, insulin glargine or glibenclamide, but not metformin, restored hippocampal synaptic plasticity characterized by enhancing in vivo long-term potentiation (ltp). |
2016-09-22 |
2023-08-13 |
mouse |
| Sita Sharan Patel, Vineet Mehta, Harish Changotra, Malairaman Udayaban. Depression mediates impaired glucose tolerance and cognitive dysfunction: A neuromodulatory role of rosiglitazone. Hormones and behavior. vol 78. 2016-09-15. PMID:26631485. |
the effect of rosi on insulin signaling, autophagy and apoptosis were evaluated in the hippocampus. |
2016-09-15 |
2023-08-13 |
mouse |
| Sita Sharan Patel, Vineet Mehta, Harish Changotra, Malairaman Udayaban. Depression mediates impaired glucose tolerance and cognitive dysfunction: A neuromodulatory role of rosiglitazone. Hormones and behavior. vol 78. 2016-09-15. PMID:26631485. |
cus significantly impaired hippocampal insulin signaling, membrane translocation of glucose transporter type 4 (glut4) as well as decreased the expression of autophagy5, autophagy7, b-cell lymphoma 2 and apoptosis inhibitory protein 2. |
2016-09-15 |
2023-08-13 |
mouse |
| Sita Sharan Patel, Vineet Mehta, Harish Changotra, Malairaman Udayaban. Depression mediates impaired glucose tolerance and cognitive dysfunction: A neuromodulatory role of rosiglitazone. Hormones and behavior. vol 78. 2016-09-15. PMID:26631485. |
moreover, rosi treatment effectively improved hippocampal insulin signaling, glut4 membrane translocation and cognitive performance in depressed mice. |
2016-09-15 |
2023-08-13 |
mouse |
| Qiong Xiang, Jie Zhang, Chun-Yan Li, Yan Wang, Mao-Jun Zeng, Zhi-Xin Cai, Rong-Bo Tian, Wei Jia, Xian-Hui L. Insulin resistance-induced hyperglycemia decreased the activation of Akt/CREB in hippocampus neurons: Molecular evidence for mechanism of diabetes-induced cognitive dysfunction. Neuropeptides. vol 54. 2016-09-13. PMID:26344332. |
insulin resistance-induced hyperglycemia decreased the activation of akt/creb in hippocampus neurons: molecular evidence for mechanism of diabetes-induced cognitive dysfunction. |
2016-09-13 |
2023-08-13 |
rat |
| Jose Morales-Corraliza, Harrison Wong, Matthew J Mazzella, Shaoli Che, Sang Han Lee, Eva Petkova, Janice D Wagner, Scott E Hemby, Stephen D Ginsberg, Paul M Mathew. Brain-Wide Insulin Resistance, Tau Phosphorylation Changes, and Hippocampal Neprilysin and Amyloid-β Alterations in a Monkey Model of Type 1 Diabetes. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 15. 2016-09-08. PMID:27076423. |
brain-wide insulin resistance, tau phosphorylation changes, and hippocampal neprilysin and amyloid-β alterations in a monkey model of type 1 diabetes. |
2016-09-08 |
2023-08-13 |
human |
| Rasoul Ghasemi, Maryam Moosavi, Asadollah Zarifkar, Karim Rastegar, Nader Maghsoud. The Interplay of Akt and ERK in Aβ Toxicity and Insulin-Mediated Protection in Primary Hippocampal Cell Culture. Journal of molecular neuroscience : MN. vol 57. issue 3. 2016-08-10. PMID:26266487. |
it is not known if insulin prevents aβ-induced cell death, mapk, and akt activity in isolated hippocampal cell culture. |
2016-08-10 |
2023-08-13 |
Not clear |
| Rasoul Ghasemi, Maryam Moosavi, Asadollah Zarifkar, Karim Rastegar, Nader Maghsoud. The Interplay of Akt and ERK in Aβ Toxicity and Insulin-Mediated Protection in Primary Hippocampal Cell Culture. Journal of molecular neuroscience : MN. vol 57. issue 3. 2016-08-10. PMID:26266487. |
this study was aimed to explore the effect of insulin on aβ-induced cell death and erk and akt signaling alteration in isolated hippocampal cell culture. |
2016-08-10 |
2023-08-13 |
Not clear |
| Rasoul Ghasemi, Maryam Moosavi, Asadollah Zarifkar, Karim Rastegar, Nader Maghsoud. The Interplay of Akt and ERK in Aβ Toxicity and Insulin-Mediated Protection in Primary Hippocampal Cell Culture. Journal of molecular neuroscience : MN. vol 57. issue 3. 2016-08-10. PMID:26266487. |
this study showed, for the first time, that insulin protects against aβ toxicity in isolated hippocampal cell culture via modulating akt and erk phosphorylation and also revealed an interaction between those signals in aβ toxicity and insulin-mediated protection. |
2016-08-10 |
2023-08-13 |
Not clear |
| Elizabeth S Chan, Christopher Chen, Gregory M Cole, Boon-Seng Won. Differential interaction of Apolipoprotein-E isoforms with insulin receptors modulates brain insulin signaling in mutant human amyloid precursor protein transgenic mice. Scientific reports. vol 5. 2016-08-03. PMID:26346625. |
using primary hippocampal neurons, we showed that apoe3 and apoe4 neurons are equally sensitive to physiological levels of insulin. |
2016-08-03 |
2023-08-13 |
mouse |
| Elizabeth S Chan, Christopher Chen, Gregory M Cole, Boon-Seng Won. Differential interaction of Apolipoprotein-E isoforms with insulin receptors modulates brain insulin signaling in mutant human amyloid precursor protein transgenic mice. Scientific reports. vol 5. 2016-08-03. PMID:26346625. |
however, in the presence of aβ42, insulin failed to elicit a downstream response only in apoe4 hippocampal neurons. |
2016-08-03 |
2023-08-13 |
mouse |
| Hui-Wen Wu, Lai-Feng Ren, Xing Zhou, De-Wu Ha. A high-fructose diet induces hippocampal insulin resistance and exacerbates memory deficits in male Sprague-Dawley rats. Nutritional neuroscience. vol 18. issue 7. 2016-07-20. PMID:24856097. |
a high-fructose diet induces hippocampal insulin resistance and exacerbates memory deficits in male sprague-dawley rats. |
2016-07-20 |
2023-08-13 |
rat |
| Hui-Wen Wu, Lai-Feng Ren, Xing Zhou, De-Wu Ha. A high-fructose diet induces hippocampal insulin resistance and exacerbates memory deficits in male Sprague-Dawley rats. Nutritional neuroscience. vol 18. issue 7. 2016-07-20. PMID:24856097. |
eight months later, peripheral insulin sensitivity, the activity of the hippocampal insulin pathway, and memory tasks were assessed. |
2016-07-20 |
2023-08-13 |
rat |
| Hui-Wen Wu, Lai-Feng Ren, Xing Zhou, De-Wu Ha. A high-fructose diet induces hippocampal insulin resistance and exacerbates memory deficits in male Sprague-Dawley rats. Nutritional neuroscience. vol 18. issue 7. 2016-07-20. PMID:24856097. |
in addition, insulin signaling in the hippocampus was attenuated in the high fructose group. |
2016-07-20 |
2023-08-13 |
rat |
| Hui-Wen Wu, Lai-Feng Ren, Xing Zhou, De-Wu Ha. A high-fructose diet induces hippocampal insulin resistance and exacerbates memory deficits in male Sprague-Dawley rats. Nutritional neuroscience. vol 18. issue 7. 2016-07-20. PMID:24856097. |
these results suggested that a high-fructose diet induced peripheral insulin resistance and an abnormal insulin-signaling pathway in the hippocampus which exacerbated memory deficits in the rats. |
2016-07-20 |
2023-08-13 |
rat |