| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nona Abolhassani, Julio Leon, Zijing Sheng, Sugako Oka, Hideomi Hamasaki, Toru Iwaki, Yusaku Nakabepp. Molecular pathophysiology of impaired glucose metabolism, mitochondrial dysfunction, and oxidative DNA damage in Alzheimer's disease brain. Mechanisms of ageing and development. vol 161. issue Pt A. 2017-08-07. PMID:27233446. |
in normal brain, neurons in the cortex and hippocampus produce insulin, which modulates glucose metabolism and cognitive functions. |
2017-08-07 |
2023-08-13 |
mouse |
| Zhuo Fu, Jing Wu, Tanseli Nesil, Ming D Li, Kevin W Aylor, Zhenqi Li. Long-term high-fat diet induces hippocampal microvascular insulin resistance and cognitive dysfunction. American journal of physiology. Endocrinology and metabolism. vol 312. issue 2. 2017-06-26. PMID:27899343. |
long-term high-fat diet induces hippocampal microvascular insulin resistance and cognitive dysfunction. |
2017-06-26 |
2023-08-13 |
rat |
| Zhuo Fu, Jing Wu, Tanseli Nesil, Ming D Li, Kevin W Aylor, Zhenqi Li. Long-term high-fat diet induces hippocampal microvascular insulin resistance and cognitive dysfunction. American journal of physiology. Endocrinology and metabolism. vol 312. issue 2. 2017-06-26. PMID:27899343. |
insulin action on hippocampus improves cognitive function, and obesity and type 2 diabetes are associated with decreased cognitive function. |
2017-06-26 |
2023-08-13 |
rat |
| Zhuo Fu, Jing Wu, Tanseli Nesil, Ming D Li, Kevin W Aylor, Zhenqi Li. Long-term high-fat diet induces hippocampal microvascular insulin resistance and cognitive dysfunction. American journal of physiology. Endocrinology and metabolism. vol 312. issue 2. 2017-06-26. PMID:27899343. |
cerebral microvasculature plays a critical role in maintaining cerebral vitality and function by supplying nutrients, oxygen, and hormones such as insulin to cerebral parenchyma, including hippocampus. |
2017-06-26 |
2023-08-13 |
rat |
| Zhuo Fu, Jing Wu, Tanseli Nesil, Ming D Li, Kevin W Aylor, Zhenqi Li. Long-term high-fat diet induces hippocampal microvascular insulin resistance and cognitive dysfunction. American journal of physiology. Endocrinology and metabolism. vol 312. issue 2. 2017-06-26. PMID:27899343. |
to examine insulin's action on hippocampal microvasculature and parenchyma and the impact of diet-induced obesity, we determined cognitive function and microvascular insulin responses, parenchyma insulin responses, and capillary density in the hippocampus in 2- and 8-mo-old rats on chow diet and 8-mo-old rats on a long-term high-fat diet (6 mo). |
2017-06-26 |
2023-08-13 |
rat |
| Zhuo Fu, Jing Wu, Tanseli Nesil, Ming D Li, Kevin W Aylor, Zhenqi Li. Long-term high-fat diet induces hippocampal microvascular insulin resistance and cognitive dysfunction. American journal of physiology. Endocrinology and metabolism. vol 312. issue 2. 2017-06-26. PMID:27899343. |
insulin infusion increased hippocampal microvascular perfusion in rats on chow diet by ~80-90%. |
2017-06-26 |
2023-08-13 |
rat |
| Zhuo Fu, Jing Wu, Tanseli Nesil, Ming D Li, Kevin W Aylor, Zhenqi Li. Long-term high-fat diet induces hippocampal microvascular insulin resistance and cognitive dysfunction. American journal of physiology. Endocrinology and metabolism. vol 312. issue 2. 2017-06-26. PMID:27899343. |
as the microvasculature provides the needed endothelial surface area for delivery of nutrients, oxygen, and insulin to hippocampal parenchyma, we conclude that hippocampal microvascular insulin resistance may play a critical role in the development of cognitive impairment seen in obesity and diabetes. |
2017-06-26 |
2023-08-13 |
rat |
| Zhuo Fu, Jing Wu, Tanseli Nesil, Ming D Li, Kevin W Aylor, Zhenqi Li. Long-term high-fat diet induces hippocampal microvascular insulin resistance and cognitive dysfunction. American journal of physiology. Endocrinology and metabolism. vol 312. issue 2. 2017-06-26. PMID:27899343. |
our results suggest that improvement in hippocampal microvascular insulin sensitivity might help improve or reverse cognitive function in the insulin-resistant states. |
2017-06-26 |
2023-08-13 |
rat |
| Shanti Diwakarla, Erik Nylander, Alfhild Grönbladh, Sudarsana Reddy Vanga, Yasmin Shamsudin Khan, Hugo Gutiérrez-de-Terán, Jonas Sävmarker, Leelee Ng, Vi Pham, Thomas Lundbäck, Annika Jenmalm-Jensen, Richard Svensson, Per Artursson, Sofia Zelleroth, Karin Engen, Ulrika Rosenström, Mats Larhed, Johan Åqvist, Siew Yeen Chai, Mathias Hallber. Aryl Sulfonamide Inhibitors of Insulin-Regulated Aminopeptidase Enhance Spine Density in Primary Hippocampal Neuron Cultures. ACS chemical neuroscience. vol 7. issue 10. 2017-06-21. PMID:27501164. |
the zinc metallopeptidase insulin regulated aminopeptidase (irap), which is highly expressed in the hippocampus and other brain regions associated with cognitive function, has been identified as a high-affinity binding site of the hexapeptide angiotensin iv (ang iv). |
2017-06-21 |
2023-08-13 |
human |
| Ania M Jastreboff, Rajita Sinha, Jagriti Arora, Cosimo Giannini, Jessica Kubat, Saima Malik, Michelle A Van Name, Nicola Santoro, Mary Savoye, Elvira J Duran, Bridget Pierpont, Gary Cline, R Todd Constable, Robert S Sherwin, Sonia Capri. Altered Brain Response to Drinking Glucose and Fructose in Obese Adolescents. Diabetes. vol 65. issue 7. 2017-06-05. PMID:27207544. |
in addition, obese adolescents demonstrated attenuated suppression of serum acyl-ghrelin and increased circulating insulin level after glucose ingestion; furthermore, the change in acyl-ghrelin and insulin levels after both glucose and fructose ingestion was associated with increased hypothalamic, thalamic, and hippocampal blood flow in obese relative to lean adolescents. |
2017-06-05 |
2023-08-13 |
human |
| Yan-Fang Mao, Zhangyu Guo, Tingting Zheng, Yasi Jiang, Yaping Yan, Xinzhen Yin, Yanxing Chen, Baorong Zhan. Intranasal insulin alleviates cognitive deficits and amyloid pathology in young adult APPswe/PS1dE9 mice. Aging cell. vol 15. issue 5. 2017-06-05. PMID:27457264. |
in addition, intranasal insulin effectively promotes hippocampal neurogenesis in app/ps1 mice. |
2017-06-05 |
2023-08-13 |
mouse |
| Caroline Jeeyeon Hong, Hyunhee Park, Seong-Woon Y. Autophagy for the quality control of adult hippocampal neural stem cells. Brain research. vol 1649. issue Pt B. 2017-05-16. PMID:26969409. |
acd plays a primary role in the death of adult hippocampal neural stem (hcn) cells following insulin withdrawal. |
2017-05-16 |
2023-08-13 |
Not clear |
| Karen A Nunley, Regina L Leckie, Trevor J Orchard, Tina Costacou, Howard J Aizenstein, J Richard Jennings, Kirk I Erickson, Caterina Rosan. Physical activity and hippocampal volume in middle-aged patients with type 1 diabetes. Neurology. vol 88. issue 16. 2017-05-02. PMID:28283592. |
to examine the cross-sectional association between physical activity (pa) and hippocampal volume in middle-aged adults with childhood-onset type 1 diabetes (t1d), and whether hyperglycemia and insulin sensitivity contribute to this relationship. |
2017-05-02 |
2023-08-13 |
Not clear |
| Yu-Fei Han, Christian Holscher, Zhao-Jun Wang, Jun Zhang, Li Yuan, Jia-Qing Tong, Dan-Dan Wang, Mei-Na Wu, Jin-Shun Q. [Neuroprotective effects of a novel antidiabetic drug (D-Ser2)Oxm on amyloid β protein-induced cytotoxicity]. Sheng li xue bao : [Acta physiologica Sinica]. vol 68. issue 3. 2017-05-01. PMID:27350199. |
according to a most recent study, (d-ser2) oxm, a new antidiabetic drug, not only improves the disorders in plasma glucose and insulin in type 2 diabetes mellitus (t2dm) rats, but also exerts positive effects on hippocampal neurogenesis and synaptogenesis. |
2017-05-01 |
2023-08-13 |
rat |
| Yuki Matsunaga, Takayuki Negishi, Akinori Hatakeyama, Yuta Kawagoe, Erika Sawano, Tomoko Tashir. Impairment of synaptic development in the hippocampus of diabetic Goto-Kakizaki rats. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 53. 2017-03-27. PMID:27444810. |
alterations in insulin receptor signaling and signs of insulin resistance were detected in the gk rat hippocampus at 3 weeks, as early as in other insulin-responsive peripheral tissues. |
2017-03-27 |
2023-08-13 |
rat |
| Sunmin Park, Suna Kang, Da Sol Kim, Bo Rerum Moo. Agrimonia pilosa Ledeb., Cinnamomum cassia Blume, and Lonicera japonica Thunb. protect against cognitive dysfunction and energy and glucose dysregulation by reducing neuroinflammation and hippocampal insulin resistance in β-amyloid-infused rats. Nutritional neuroscience. vol 20. issue 2. 2017-03-13. PMID:26842885. |
protect against cognitive dysfunction and energy and glucose dysregulation by reducing neuroinflammation and hippocampal insulin resistance in β-amyloid-infused rats. |
2017-03-13 |
2023-08-13 |
rat |
| Krista Minéia Wartchow, Ana Carolina Tramontina, Daniela F de Souza, Regina Biasibetti, Larissa D Bobermin, Carlos-Alberto Gonçalve. Insulin Stimulates S100B Secretion and These Proteins Antagonistically Modulate Brain Glucose Metabolism. Neurochemical research. vol 41. issue 6. 2017-03-06. PMID:26875731. |
herein, we investigated the effect of s100b on glucose metabolism, measuring d-(3)h-glucose incorporation in two preparations, c6 glioma cells and acute hippocampal slices, and we also investigated the effect of insulin on s100b secretion. |
2017-03-06 |
2023-08-13 |
Not clear |
| Vedrana Ivić, Senka Blažetić, Irena Labak, Marta Balog, Luka Vondrak, Robert Blažeković, Sandor G Vari, Marija Heffe. Ovariectomy and chronic stress lead toward leptin resistance in the satiety centers and insulin resistance in the hippocampus of Sprague-Dawley rats. Croatian medical journal. vol 57. issue 2. 2017-02-23. PMID:27106360. |
ovariectomy and chronic stress lead toward leptin resistance in the satiety centers and insulin resistance in the hippocampus of sprague-dawley rats. |
2017-02-23 |
2023-08-13 |
rat |
| Takashi Kawano, Hideki Iwata, Bun Aoyama, Atsushi Nishigaki, Daiki Yamanaka, Hiroki Tateiwa, Satoru Eguchi, Fabricio M Locatelli, Masataka Yokoyam. The role of hippocampal insulin signaling on postoperative cognitive dysfunction in an aged rat model of abdominal surgery. Life sciences. vol 162. 2017-02-17. PMID:27561842. |
the role of hippocampal insulin signaling on postoperative cognitive dysfunction in an aged rat model of abdominal surgery. |
2017-02-17 |
2023-08-13 |
rat |
| Jing Li, Yixin Wang, Fangfang Fang, Donglong Chen, Yue Gao, Jingli Liu, Rong Gao, Jun Wang, Hang Xia. Bisphenol A disrupts glucose transport and neurophysiological role of IR/IRS/AKT/GSK3β axis in the brain of male mice. Environmental toxicology and pharmacology. vol 43. 2017-02-09. PMID:26923231. |
mice were treated with subcutaneous injection of 100μg/kg/d bpa or vehicle for 30 days, then the insulin signaling and glucose transporters in the hippocampus and prefrontal cortex were detected by western blot. |
2017-02-09 |
2023-08-13 |
mouse |