| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Meha Fatima Aftab, Shabbir Khan Afridi, Uzma Rasool Mughal, Aneela Karim, Darakhshan Jabeen Haleem, Nurul Kabir, Khalid M Khan, Rahman M Hafizur, Rizwana S Waraic. New isatin derivative inhibits neurodegeneration by restoring insulin signaling in brain. Journal of chemical neuroanatomy. vol 81. 2018-02-06. PMID:28093241. |
histological analysis showed reduced nfts in ca3 hippocampal region and restoration of insulin signaling in hippocampii of diabetic mice. |
2018-02-06 |
2023-08-13 |
mouse |
| Prapimpun Wongchitrat, Niyada Lansubsakul, Utcharaporn Kamsrijai, Kwankanit Sae-Ung, Sujira Mukda, Piyarat Govitrapon. Melatonin attenuates the high-fat diet and streptozotocin-induced reduction in rat hippocampal neurogenesis. Neurochemistry international. vol 100. 2018-01-31. PMID:27620814. |
our data suggested that the dysfunction of insulin signaling pathway occurred in the diabetes may provide a convergent mechanism of hippocampal impaired neurogenesis and synaptogenesis lead to impair memory while melatonin reverses these effects, suggesting that melatonin may reduce the pathogenesis of diabetes. |
2018-01-31 |
2023-08-13 |
rat |
| Miren Ettcheto, Dmitry Petrov, Ignacio Pedrós, Norma Alva, Teresa Carbonell, Carlos Beas-Zarate, Merce Pallas, Carme Auladell, Jaume Folch, Antoni Camin. Evaluation of Neuropathological Effects of a High-Fat Diet in a Presymptomatic Alzheimer's Disease Stage in APP/PS1 Mice. Journal of Alzheimer's disease : JAD. vol 54. issue 1. 2018-01-29. PMID:27567882. |
the results showed that the hippocampus from app/ps1 mice fed with a hfd had an early significant decrease in aβ signaling pathway specifically in the insulin degrading enzyme protein levels, an enzyme involved in (aβ) metabolism, and α-secretase. |
2018-01-29 |
2023-08-13 |
mouse |
| Clarissa B Haas, Eduardo Kalinine, Eduardo R Zimmer, Gisele Hansel, Andressa W Brochier, Jean P Oses, Luis V Portela, Alexandre P Mulle. Brain Insulin Administration Triggers Distinct Cognitive and Neurotrophic Responses in Young and Aged Rats. Molecular neurobiology. vol 53. issue 9. 2018-01-15. PMID:26497034. |
interestingly, insulin treatment increased the expression of the brain-derived neurotrophic factor (bdnf) and tropomyosin receptor kinase b (trkb) receptors in the hippocampus of young rats, but not of aged rats. |
2018-01-15 |
2023-08-13 |
rat |
| Katarzyna Głombik, Joanna Ślusarczyk, Ewa Trojan, Katarzyna Chamera, Bogusława Budziszewska, Władysław Lasoń, Agnieszka Basta-Kai. Regulation of insulin receptor phosphorylation in the brains of prenatally stressed rats: New insight into the benefits of antidepressant drug treatment. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 27. issue 2. 2018-01-15. PMID:28063625. |
in the frontal cortex and hippocampus, the mrna and protein expression of insulin, insulin receptor, insulin receptor substrates (irs-1,irs-2) and adaptor proteins (shc1, grb2) before and after drugs administration were measured.rats exposed prenatally to stressful stimuli displayed depressive-like disturbances, which were attenuated by antidepressant drug administration. |
2018-01-15 |
2023-08-13 |
rat |
| Sita Sharan Patel, Sahil Gupta, Malairaman Udayaban. Urtica dioica modulates hippocampal insulin signaling and recognition memory deficit in streptozotocin induced diabetic mice. Metabolic brain disease. vol 31. issue 3. 2018-01-12. PMID:26767366. |
urtica dioica modulates hippocampal insulin signaling and recognition memory deficit in streptozotocin induced diabetic mice. |
2018-01-12 |
2023-08-13 |
mouse |
| Sita Sharan Patel, Sahil Gupta, Malairaman Udayaban. Urtica dioica modulates hippocampal insulin signaling and recognition memory deficit in streptozotocin induced diabetic mice. Metabolic brain disease. vol 31. issue 3. 2018-01-12. PMID:26767366. |
stz induced diabetic mice showed significant decrease in hippocampal insulin signaling and translocation of glucose transporter type 4 (glut4) to neuronal membrane resulting in cognitive dysfunction and hypolocomotion. |
2018-01-12 |
2023-08-13 |
mouse |
| Sita Sharan Patel, Sahil Gupta, Malairaman Udayaban. Urtica dioica modulates hippocampal insulin signaling and recognition memory deficit in streptozotocin induced diabetic mice. Metabolic brain disease. vol 31. issue 3. 2018-01-12. PMID:26767366. |
ud treatment effectively improved hippocampal insulin signaling, glucose tolerance and recognition memory performance in diabetic mice, which was comparable to rosi. |
2018-01-12 |
2023-08-13 |
mouse |
| Ming Cai, Hong Wang, Jing-Jing Li, Yun-Li Zhang, Lei Xin, Feng Li, Shu-Jie Lo. The signaling mechanisms of hippocampal endoplasmic reticulum stress affecting neuronal plasticity-related protein levels in high fat diet-induced obese rats and the regulation of aerobic exercise. Brain, behavior, and immunity. vol 57. 2018-01-11. PMID:27189035. |
additionally, hfd that is associated with hyperglycemia could induce hippocampal ers, thus impairing insulin signaling and cognitive health in hfd mice. |
2018-01-11 |
2023-08-13 |
mouse |
| Fernanda Prieto-Almeida, Ana Carolina Panveloski-Costa, Fernanda Crunfli, Silvania da Silva Teixeira, Maria Tereza Nunes, Andréa da Silva Torrã. Thyroid hormone improves insulin signaling and reduces the activation of neurodegenerative pathway in the hippocampus of diabetic adult male rats. Life sciences. vol 192. 2018-01-08. PMID:29132997. |
thyroid hormone improves insulin signaling and reduces the activation of neurodegenerative pathway in the hippocampus of diabetic adult male rats. |
2018-01-08 |
2023-08-13 |
rat |
| FangFang, Hongyan Li, Tingting Qin, Min Li, Shiping M. Thymol improves high-fat diet-induced cognitive deficits in mice via ameliorating brain insulin resistance and upregulating NRF2/HO-1 pathway. Metabolic brain disease. vol 32. issue 2. 2018-01-05. PMID:27761760. |
in conclusion, thymol exhibited beneficial effects on hfd-induced cognitive deficits through improving hippocampal insulin resistance, and activating nrf2/ho-1 signaling. |
2018-01-05 |
2023-08-13 |
mouse |
| G I Godahewa, N C N Perera, Jehee Le. Insights into the multifunctional role of natural killer enhancing factor-A (NKEF-A/Prx1) in big-belly seahorse (Hippocampus abdominalis): DNA protection, insulin reduction, H Gene. vol 642. 2017-12-26. PMID:29155258. |
insights into the multifunctional role of natural killer enhancing factor-a (nkef-a/prx1) in big-belly seahorse (hippocampus abdominalis): dna protection, insulin reduction, h natural killer enhancing factor a (nkef-a), also known as peroxiredoxin 1 (prx1), is a well-known antioxidant involved in innate immunity. |
2017-12-26 |
2023-08-13 |
Not clear |
| María Sol Kruse, Lucas Gabriel Suarez, Héctor Coirin. Regulation of the expression of LXR in rat hypothalamic and hippocampal explants. Neuroscience letters. vol 639. 2017-12-19. PMID:28038938. |
here, we further characterized the effects of glucose, insulin, cholesterol and cholic acid on the expression of lxrα and lxrβ in hypothalamus and hippocampus explants as in vitro models. |
2017-12-19 |
2023-08-13 |
rat |
| María Sol Kruse, Lucas Gabriel Suarez, Héctor Coirin. Regulation of the expression of LXR in rat hypothalamic and hippocampal explants. Neuroscience letters. vol 639. 2017-12-19. PMID:28038938. |
in contrast, insulin treatment decreased lxrβ in the hypothalamus while having no effects on the hippocampus. |
2017-12-19 |
2023-08-13 |
rat |
| Elif Tunc-Ozcan, Adriana B Ferreira, Eva E Rede. Modeling Fetal Alcohol Spectrum Disorder: Validating an Ex Vivo Primary Hippocampal Cell Culture System. Alcoholism, clinical and experimental research. vol 40. issue 6. 2017-12-08. PMID:27162054. |
the insulin signaling pathways are known to be involved in hippocampal functions. |
2017-12-08 |
2023-08-13 |
Not clear |
| Elif Tunc-Ozcan, Adriana B Ferreira, Eva E Rede. Modeling Fetal Alcohol Spectrum Disorder: Validating an Ex Vivo Primary Hippocampal Cell Culture System. Alcoholism, clinical and experimental research. vol 40. issue 6. 2017-12-08. PMID:27162054. |
therefore, we compared the expression of insulin signaling pathway genes between fetal hippocampi (in vivo) and primary hippocampal culture (ex vivo). |
2017-12-08 |
2023-08-13 |
Not clear |
| Angeles Vinuesa, Carlos Pomilio, Martin Menafra, Maria Marta Bonaventura, Laura Garay, María Florencia Mercogliano, Roxana Schillaci, Victoria Lux Lantos, Fernando Brites, Juan Beauquis, Flavia Saravi. Juvenile exposure to a high fat diet promotes behavioral and limbic alterations in the absence of obesity. Psychoneuroendocrinology. vol 72. 2017-12-08. PMID:27337091. |
these phenomena were accompanied by a neuroinflammatory and insulin-resistant state in the hippocampus, depicted by a reactive phenotype in iba1+ microglia cells (increased in number and soma size) and an impaired response to insulin given by decreased phosphorylated akt levels and increased levels of inhibitory phosphorylation of irs1. |
2017-12-08 |
2023-08-13 |
mouse |
| Madhavan Nampoothiri, Grandhi Venkata Ramalingayya, Nampurath Gopalan Kutty, Nandakumar Krishnadas, Chamallamudi Mallikarjuna Ra. Insulin Combined with Glucose Improves Spatial Learning and Memory in Aluminum Chloride-Induced Dementia in Rats. Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer. vol 36. issue 2. 2017-12-07. PMID:29199596. |
the combination corrected the diminished level of antioxidant enzymes such as catalase and gsh in the hippocampus and frontal cortex.combined administration of insulin and glucose to aluminum-treated rats did not inhibit the aluminum action on the acetylcholinesterase enzyme. |
2017-12-07 |
2023-08-13 |
rat |
| Noriyasu Kame. Nose-to-Brain Delivery of Peptide Drugs Enhanced by Coadministration of Cell-penetrating Peptides: Therapeutic Potential for Dementia. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. vol 137. issue 10. 2017-11-16. PMID:28966266. |
in both mice and rats, we found that direct transport of insulin into the brain was significantly facilitated when coadministered with amphipathic cpp penetratin, and eventually insulin reached the deeper regions of the brain such as the hippocampus. |
2017-11-16 |
2023-08-13 |
mouse |
| Noriyasu Kame. Nose-to-Brain Delivery of Peptide Drugs Enhanced by Coadministration of Cell-penetrating Peptides: Therapeutic Potential for Dementia. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. vol 137. issue 10. 2017-11-16. PMID:28966266. |
the immunohistological examination of the hippocampus suggested that enhanced nose-to-brain delivery of insulin had a partial neuroprotective effect but unexpectedly increased amyloid β plaque deposition. |
2017-11-16 |
2023-08-13 |
mouse |