| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yong Tang, Chonglin Yu, Jianming Wu, Haixia Chen, Yuan Zeng, Xiuling Wang, Le Yang, Qibing Mei, Shousong Cao, Dalian Qi. Lychee seed extract protects against neuronal injury and improves cognitive function in rats with type II diabetes mellitus with cognitive impairment. International journal of molecular medicine. vol 41. issue 1. 2018-07-09. PMID:29138799. |
the levels of glucose, insulin, aβ, ages, tau protein and acetylcholinesterase in the blood and/or hippocampus of rats were determined by blood‑glucose meter, radioimmunoassay, chemical chromatometry, enzyme‑linked immunosorbent assay (elisa) and immunohistochemical analysis, respectively. |
2018-07-09 |
2023-08-13 |
rat |
| Yong Tang, Chonglin Yu, Jianming Wu, Haixia Chen, Yuan Zeng, Xiuling Wang, Le Yang, Qibing Mei, Shousong Cao, Dalian Qi. Lychee seed extract protects against neuronal injury and improves cognitive function in rats with type II diabetes mellitus with cognitive impairment. International journal of molecular medicine. vol 41. issue 1. 2018-07-09. PMID:29138799. |
the levels of glucose, insulin, aβ, ages and tau protein were significantly increased in the blood and/or hippocampus of t2dm rats, while lse remarkably decreased their levels compared to vehicle treatment (p<0.01). |
2018-07-09 |
2023-08-13 |
rat |
| Ângela G Batista, Edilene S Soares, Monique C P Mendonça, Juliana K da Silva, Ana Paula Dionísio, Cesar R Sartori, Maria Alice da Cruz-Höfling, Mário R Maróstica Júnio. Jaboticaba berry peel intake prevents insulin-resistance-induced tau phosphorylation in mice. Molecular nutrition & food research. vol 61. issue 10. 2018-07-02. PMID:28544198. |
the hyperphosphorylation of microtubule-associated protein tau (tau) in the hippocampus can be caused by central and peripheral insulin resistance and these alterations are related to the development of tauopathies, such as alzheimer's disease. |
2018-07-02 |
2023-08-13 |
mouse |
| Ângela G Batista, Edilene S Soares, Monique C P Mendonça, Juliana K da Silva, Ana Paula Dionísio, Cesar R Sartori, Maria Alice da Cruz-Höfling, Mário R Maróstica Júnio. Jaboticaba berry peel intake prevents insulin-resistance-induced tau phosphorylation in mice. Molecular nutrition & food research. vol 61. issue 10. 2018-07-02. PMID:28544198. |
in this study, we used a high-fat diet to induce obesity and insulin resistance in adult swiss mice and checked whether supplementation with myrciaria jaboticaba berry peel for 10 weeks could improve insulin sensitivity, learning/memory performance, and prevent tau phosphorylation in the hippocampus. |
2018-07-02 |
2023-08-13 |
mouse |
| Masahiro Konishi, Masaji Sakaguchi, Samuel M Lockhart, Weikang Cai, Mengyao Ella Li, Erica P Homan, Christian Rask-Madsen, C Ronald Kah. Endothelial insulin receptors differentially control insulin signaling kinetics in peripheral tissues and brain of mice. Proceedings of the National Academy of Sciences of the United States of America. vol 114. issue 40. 2018-06-26. PMID:28923931. |
using mice with endothelial-specific inactivation of the ir gene (endoirko), we find that in response to systemic insulin stimulation, loss of endothelial irs caused delayed onset of insulin signaling in skeletal muscle, brown fat, hypothalamus, hippocampus, and prefrontal cortex but not in liver or olfactory bulb. |
2018-06-26 |
2023-08-13 |
mouse |
| Elmira Beirami, Shahrbanoo Oryan, Seyedeh Masoumeh Seyedhosseini Tamijani, Abolhassan Ahmadiani, Leila Dargah. Intranasal insulin treatment alleviates methamphetamine induced anxiety-like behavior and neuroinflammation. Neuroscience letters. vol 660. 2018-06-11. PMID:28917981. |
in insulin treatment (0.5iu/day, for 7days after ma discontinuation) attenuated ma-induced anxiety-like behavior in the elevated plus maze task, and significantly decreased the levels of glial cell markers (gfap and iba1), pro-inflammatory cytokines (tnf-α and il-6) as well as cox2 and nf-κb players of neuroinflammation, in the hippocampus of ma-treated animals. |
2018-06-11 |
2023-08-13 |
rat |
| Vineet Mehta, Tiratha Raj Singh, Malairaman Udayaban. Quercetin ameliorates chronic unpredicted stress-induced behavioral dysfunction in male Swiss albino mice by modulating hippocampal insulin signaling pathway. Physiology & behavior. vol 182. 2018-06-11. PMID:28939429. |
quercetin ameliorates chronic unpredicted stress-induced behavioral dysfunction in male swiss albino mice by modulating hippocampal insulin signaling pathway. |
2018-06-11 |
2023-08-13 |
mouse |
| Vineet Mehta, Tiratha Raj Singh, Malairaman Udayaban. Quercetin ameliorates chronic unpredicted stress-induced behavioral dysfunction in male Swiss albino mice by modulating hippocampal insulin signaling pathway. Physiology & behavior. vol 182. 2018-06-11. PMID:28939429. |
in the present study, we aimed to investigate whether chronic unpredicted stress (cus) mediated neurological alterations are associated with impaired hippocampal insulin signaling or not, and studied the effect of quercetin in this scenario. |
2018-06-11 |
2023-08-13 |
mouse |
| Vineet Mehta, Tiratha Raj Singh, Malairaman Udayaban. Quercetin ameliorates chronic unpredicted stress-induced behavioral dysfunction in male Swiss albino mice by modulating hippocampal insulin signaling pathway. Physiology & behavior. vol 182. 2018-06-11. PMID:28939429. |
further, hippocampal insulin signaling was evaluated in terms of protein expression of insulin, insulin receptor (ir) and glucose transporter 4 (glut-4) and neurogenesis was evaluated in terms of doublecortin (dcx) expression. |
2018-06-11 |
2023-08-13 |
mouse |
| Vineet Mehta, Tiratha Raj Singh, Malairaman Udayaban. Quercetin ameliorates chronic unpredicted stress-induced behavioral dysfunction in male Swiss albino mice by modulating hippocampal insulin signaling pathway. Physiology & behavior. vol 182. 2018-06-11. PMID:28939429. |
we observed significantly higher ir expression and significantly lower glut-4 expression in the hippocampus of stressed animals, despite of nonsignificant difference in insulin levels. |
2018-06-11 |
2023-08-13 |
mouse |
| Vineet Mehta, Tiratha Raj Singh, Malairaman Udayaban. Quercetin ameliorates chronic unpredicted stress-induced behavioral dysfunction in male Swiss albino mice by modulating hippocampal insulin signaling pathway. Physiology & behavior. vol 182. 2018-06-11. PMID:28939429. |
quercetin treatment significantly lowered insulin and ir expression and significantly enhanced glut-4 and dcx expression in the hippocampus, when compared to cus. |
2018-06-11 |
2023-08-13 |
mouse |
| Vineet Mehta, Tiratha Raj Singh, Malairaman Udayaban. Quercetin ameliorates chronic unpredicted stress-induced behavioral dysfunction in male Swiss albino mice by modulating hippocampal insulin signaling pathway. Physiology & behavior. vol 182. 2018-06-11. PMID:28939429. |
in conclusion, quercetin treatment efficiently alleviated stress mediated behavioral dysfunction by modulating hippocampal insulin signaling and neurogenesis. |
2018-06-11 |
2023-08-13 |
mouse |
| Shaniya Maimaiti, Hilaree N Frazier, Katie L Anderson, Adam O Ghoweri, Lawrence D Brewer, Nada M Porter, Olivier Thibaul. Novel calcium-related targets of insulin in hippocampal neurons. Neuroscience. vol 364. 2018-06-08. PMID:28939258. |
novel calcium-related targets of insulin in hippocampal neurons. |
2018-06-08 |
2023-08-13 |
Not clear |
| b' Ana Djordjevic, Biljana Bursa\\xc4\\x87, Nata\\xc5\\xa1a Veli\\xc4\\x8dkovi\\xc4\\x87, Ljupka Gligorovska, Djurdjica Ignjatovi\\xc4\\x87, Mirko Tomi\\xc4\\x87, Gordana Mati\\xc4\\x8. Disturbances of systemic and hippocampal insulin sensitivity in macrophage migration inhibitory factor (MIF) knockout male mice lead to behavioral changes associated with decreased PSA-NCAM levels. Hormones and behavior. vol 96. 2018-05-22. PMID:28919555.' |
disturbances of systemic and hippocampal insulin sensitivity in macrophage migration inhibitory factor (mif) knockout male mice lead to behavioral changes associated with decreased psa-ncam levels. |
2018-05-22 |
2023-08-13 |
mouse |
| b' Ana Djordjevic, Biljana Bursa\\xc4\\x87, Nata\\xc5\\xa1a Veli\\xc4\\x8dkovi\\xc4\\x87, Ljupka Gligorovska, Djurdjica Ignjatovi\\xc4\\x87, Mirko Tomi\\xc4\\x87, Gordana Mati\\xc4\\x8. Disturbances of systemic and hippocampal insulin sensitivity in macrophage migration inhibitory factor (MIF) knockout male mice lead to behavioral changes associated with decreased PSA-NCAM levels. Hormones and behavior. vol 96. 2018-05-22. PMID:28919555.' |
however, a growing body of evidence is emerging on its role in energy metabolism in insulin sensitive tissues such as hippocampus, a brain region implicated in cognition, learning and memory. |
2018-05-22 |
2023-08-13 |
mouse |
| b' Ana Djordjevic, Biljana Bursa\\xc4\\x87, Nata\\xc5\\xa1a Veli\\xc4\\x8dkovi\\xc4\\x87, Ljupka Gligorovska, Djurdjica Ignjatovi\\xc4\\x87, Mirko Tomi\\xc4\\x87, Gordana Mati\\xc4\\x8. Disturbances of systemic and hippocampal insulin sensitivity in macrophage migration inhibitory factor (MIF) knockout male mice lead to behavioral changes associated with decreased PSA-NCAM levels. Hormones and behavior. vol 96. 2018-05-22. PMID:28919555.' |
we hypothesized that genetic deletion of mif may result in the specific behavioral changes, which may be linked tо impairments in brain or systemic insulin sensitivity by possible changes of the hippocampal synaptic plasticity. |
2018-05-22 |
2023-08-13 |
mouse |
| P Zanini, B D Arbo, G Niches, D Czarnabay, F Benetti, M F Ribeiro, A L Cecconell. Diet-induced obesity alters memory consolidation in female rats. Physiology & behavior. vol 180. 2018-05-14. PMID:28821446. |
however, no significant differences were found in the serum levels of insulin, tnf-α and il-1β, in the index of insulin resistance (homa), in the hippocampal levels of insulin, tnf-α and il-1β, as well as on akt expression or activation in the hippocampus. |
2018-05-14 |
2023-08-13 |
rat |
| Masoume Soleymaninejad, Seyed Gholamali Joursaraei, Farideh Feizi, Iraj Jafari Anarkool. The Effects of Lycopene and Insulin on Histological Changes and the Expression Level of Bcl-2 Family Genes in the Hippocampus of Streptozotocin-Induced Diabetic Rats. Journal of diabetes research. vol 2017. 2018-04-11. PMID:28656152. |
the effects of lycopene and insulin on histological changes and the expression level of bcl-2 family genes in the hippocampus of streptozotocin-induced diabetic rats. |
2018-04-11 |
2023-08-13 |
rat |
| Elizabeth S Chan, Mahesh Shivarama Shetty, Sreedharan Sajikumar, Christopher Chen, Tuck Wah Soong, Boon-Seng Won. ApoE4 expression accelerates hippocampus-dependent cognitive deficits by enhancing Aβ impairment of insulin signaling in an Alzheimer's disease mouse model. Scientific reports. vol 6. 2018-03-27. PMID:27189808. |
to investigate insulin response in the ageing mouse hippocampus, we crossed the human apoe-targeted replacement mice with the mutant human amyloid precursor protein (app) mice (apoexapp). |
2018-03-27 |
2023-08-13 |
mouse |
| Elizabeth S Chan, Mahesh Shivarama Shetty, Sreedharan Sajikumar, Christopher Chen, Tuck Wah Soong, Boon-Seng Won. ApoE4 expression accelerates hippocampus-dependent cognitive deficits by enhancing Aβ impairment of insulin signaling in an Alzheimer's disease mouse model. Scientific reports. vol 6. 2018-03-27. PMID:27189808. |
while hippocampal aβ levels were comparable between apoe3xapp and apoe4xapp mice at 26 weeks, insulin response was impaired in the apoe4xapp hippocampus. |
2018-03-27 |
2023-08-13 |
mouse |