| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ewan McNa. Your Brain on Insulin: From Heresy to Dogma. Perspectives on psychological science : a journal of the Association for Psychological Science. vol 9. issue 1. 2015-07-17. PMID:26173246. |
today insulin is established as a key regulator of hippocampal fuel supply and a critical component of memory formation and storage within the hippocampus. |
2015-07-17 |
2023-08-13 |
Not clear |
| Heather M Wilkins, Janna L Harris, Steven M Carl, Lezi E, Jianghua Lu, J Eva Selfridge, Nairita Roy, Lewis Hutfles, Scott Koppel, Jill Morris, Jeffrey M Burns, Mary L Michaelis, Elias K Michaelis, William M Brooks, Russell H Swerdlo. Oxaloacetate activates brain mitochondrial biogenesis, enhances the insulin pathway, reduces inflammation and stimulates neurogenesis. Human molecular genetics. vol 23. issue 24. 2015-07-09. PMID:25027327. |
in mice, oaa promotes brain mitochondrial biogenesis, activates the insulin signaling pathway, reduces neuroinflammation and activates hippocampal neurogenesis. |
2015-07-09 |
2023-08-13 |
mouse |
| Sarah A Stern, Dillon Y Chen, Cristina M Alberin. The effect of insulin and insulin-like growth factors on hippocampus- and amygdala-dependent long-term memory formation. Learning & memory (Cold Spring Harbor, N.Y.). vol 21. issue 10. 2015-05-27. PMID:25227250. |
we found that a bilateral injection of insulin into the dorsal hippocampus transiently enhances hippocampal-dependent memory and an injection of igf1 has no effect. |
2015-05-27 |
2023-08-13 |
rat |
| Hanaa S Sallam, Batbayar Tumurbaatar, Wen-Ru Zhang, Demidmaa Tuvdendorj, Manisha Chandalia, Filippo Tempia, Fernanda Laezza, Giulio Taglialatela, Nicola Abat. Peripheral adipose tissue insulin resistance alters lipid composition and function of hippocampal synapses. Journal of neurochemistry. vol 133. issue 1. 2015-05-27. PMID:25640170. |
peripheral adipose tissue insulin resistance alters lipid composition and function of hippocampal synapses. |
2015-05-27 |
2023-08-13 |
mouse |
| Sun Shin Y. Effects of exercise on brain functions in diabetic animal models. World journal of diabetes. vol 6. issue 4. 2015-05-19. PMID:25987956. |
additionally, many physiopathologic alterations are caused in the brain by dm such as increased adiposity, inflammation, hormonal dysregulation, uncontrolled hyperphagia, insulin and leptin resistance, and dysregulation of neurotransmitters and declined neurogenesis in the hippocampus and we describe how exercise corrects these alterations in animal models. |
2015-05-19 |
2023-08-13 |
human |
| Weiwei Dai, Jiajia Yang, Ting Chen, Zhuo Yan. Protective effects of bexarotene against amyloid-β25-35-induced dysfunction in hippocampal neurons through the insulin signaling pathway. Neuro-degenerative diseases. vol 14. issue 2. 2015-05-11. PMID:24802415. |
protective effects of bexarotene against amyloid-β25-35-induced dysfunction in hippocampal neurons through the insulin signaling pathway. |
2015-05-11 |
2023-08-13 |
mouse |
| Takuya Kishi, Yoshitaka Hirooka, Tomomi Nagayama, Kengo Isegawa, Masato Katsuki, Ko Takesue, Kenji Sunagaw. Calorie restriction improves cognitive decline via up-regulation of brain-derived neurotrophic factor: tropomyosin-related kinase B in hippocampus ofobesity-induced hypertensive rats. International heart journal. vol 56. issue 1. 2015-05-01. PMID:25503654. |
after treatment for 28 days, body weight, insulin, fasting blood glucose, adiponectin, systolic blood pressure, and oxidative stress in the hippocampus were significantly lower, and bdnf expression in the hippocampus was significantly higher in cr and cr+a than in hf. |
2015-05-01 |
2023-08-13 |
rat |
| Hui Zhang, Ying Hao, Bradley Manor, Peter Novak, William Milberg, Jue Zhang, Jing Fang, Vera Nova. Intranasal insulin enhanced resting-state functional connectivity of hippocampal regions in type 2 diabetes. Diabetes. vol 64. issue 3. 2015-04-22. PMID:25249577. |
intranasal insulin enhanced resting-state functional connectivity of hippocampal regions in type 2 diabetes. |
2015-04-22 |
2023-08-13 |
human |
| Hui Zhang, Ying Hao, Bradley Manor, Peter Novak, William Milberg, Jue Zhang, Jing Fang, Vera Nova. Intranasal insulin enhanced resting-state functional connectivity of hippocampal regions in type 2 diabetes. Diabetes. vol 64. issue 3. 2015-04-22. PMID:25249577. |
following insulin administration, diabetic patients demonstrated increased resting-state connectivity between the hippocampal regions and the medial frontal cortex (mfc) as compared with placebo (cluster size: right, p = 0.03) and other dmn regions. |
2015-04-22 |
2023-08-13 |
human |
| Hui Zhang, Ying Hao, Bradley Manor, Peter Novak, William Milberg, Jue Zhang, Jing Fang, Vera Nova. Intranasal insulin enhanced resting-state functional connectivity of hippocampal regions in type 2 diabetes. Diabetes. vol 64. issue 3. 2015-04-22. PMID:25249577. |
on placebo, the diabetes group had lower connectivity between the hippocampal region and the mfc as compared with control subjects (cluster size: right, p = 0.02), but on insulin, mfc connectivity was similar to control subjects. |
2015-04-22 |
2023-08-13 |
human |
| Hui Zhang, Ying Hao, Bradley Manor, Peter Novak, William Milberg, Jue Zhang, Jing Fang, Vera Nova. Intranasal insulin enhanced resting-state functional connectivity of hippocampal regions in type 2 diabetes. Diabetes. vol 64. issue 3. 2015-04-22. PMID:25249577. |
a single dose of intranasal insulin increases resting-state functional connectivity between the hippocampal regions and multiple dmn regions in older adults with t2dm. |
2015-04-22 |
2023-08-13 |
human |
| Javad Hami, Fatemeh Shojae, Saeed Vafaee-Nezhad, Nasim Lotfi, Hamed Kheradmand, Hossein Haghi. Some of the experimental and clinical aspects of the effects of the maternal diabetes on developing hippocampus. World journal of diabetes. vol 6. issue 3. 2015-04-21. PMID:25897352. |
insulin and igf-1 receptors (ir and igf1r, respectively) are distributed in a highly specific pattern with the high density in some brain regions such as hippocampus. |
2015-04-21 |
2023-08-13 |
rat |
| Richard A Anderson, Bolin Qin, Frederic Canini, Laurent Poulet, Anne Marie Rousse. Cinnamon counteracts the negative effects of a high fat/high fructose diet on behavior, brain insulin signaling and Alzheimer-associated changes. PloS one. vol 8. issue 12. 2015-03-30. PMID:24349472. |
increased peripheral insulin sensitivity was also associated with increased glycogen synthase in both hippocampus and cortex in the control and hf/hfr diet animals fed cn. |
2015-03-30 |
2023-08-12 |
rat |
| Ming Lu, Jing-Zhe Yang, Fan Geng, Jian-Hua Ding, Gang H. Iptakalim confers an antidepressant effect in a chronic mild stress model of depression through regulating neuro-inflammation and neurogenesis. The international journal of neuropsychopharmacology. vol 17. issue 9. 2015-03-30. PMID:24621884. |
we further found that ipt reversed the cms-induced reduction of the adult hippocampal neurogenesis and improved cerebral insulin signalling in the cms mice. |
2015-03-30 |
2023-08-12 |
mouse |
| Rasoul Ghasemi, Asadollah Zarifkar, Karim Rastegar, Nader maghsoudi, Maryam Moosav. Insulin protects against Aβ-induced spatial memory impairment, hippocampal apoptosis and MAPKs signaling disruption. Neuropharmacology. vol 85. 2015-03-30. PMID:24881967. |
insulin protects against aβ-induced spatial memory impairment, hippocampal apoptosis and mapks signaling disruption. |
2015-03-30 |
2023-08-13 |
rat |
| Rasoul Ghasemi, Asadollah Zarifkar, Karim Rastegar, Nader maghsoudi, Maryam Moosav. Insulin protects against Aβ-induced spatial memory impairment, hippocampal apoptosis and MAPKs signaling disruption. Neuropharmacology. vol 85. 2015-03-30. PMID:24881967. |
therefore this study was designed to investigate if intrahippocampal insulin hinders aβ-related memory deterioration, hippocampal apoptosis and mapks signaling alteration induced by aβ. |
2015-03-30 |
2023-08-13 |
rat |
| Rasoul Ghasemi, Asadollah Zarifkar, Karim Rastegar, Nader maghsoudi, Maryam Moosav. Insulin protects against Aβ-induced spatial memory impairment, hippocampal apoptosis and MAPKs signaling disruption. Neuropharmacology. vol 85. 2015-03-30. PMID:24881967. |
this study disclosed that intrahippocampal insulin treatment averts not only aβ-induced memory deterioration but also hippocampal caspase-3, erk and p38 activation. |
2015-03-30 |
2023-08-13 |
rat |
| Brandon H Cline, Joao P Costa-Nunes, Raymond Cespuglio, Natalyia Markova, Ana I Santos, Yury V Bukhman, Aslan Kubatiev, Harry W M Steinbusch, Klaus-Peter Lesch, Tatyana Strekalov. Dicholine succinate, the neuronal insulin sensitizer, normalizes behavior, REM sleep, hippocampal pGSK3 beta and mRNAs of NMDA receptor subunits in mouse models of depression. Frontiers in behavioral neuroscience. vol 9. 2015-03-13. PMID:25767439. |
dicholine succinate, the neuronal insulin sensitizer, normalizes behavior, rem sleep, hippocampal pgsk3 beta and mrnas of nmda receptor subunits in mouse models of depression. |
2015-03-13 |
2023-08-13 |
mouse |
| b' Andrea \\xc5\\xa0polcov\\xc3\\xa1, Barbora Mikul\\xc3\\xa1\\xc5\\xa1kov\\xc3\\xa1, Katar\\xc3\\xadna Kr\\xc5\\xa1kov\\xc3\\xa1, Lucia Gajdo\\xc5\\xa1echov\\xc3\\xa1, \\xc5\\xa0tefan Z\\xc3\\xb3rad, Rafa\\xc5\\x82 Olszanecki, Maciej Suski, Beata Bujak-Gi\\xc5\\xbcycka, Blanka \\xc5\\xbdelezn\\xc3\\xa1, Lenka Malet\\xc3\\xadnsk\\xc3\\xa. Deficient hippocampal insulin signaling and augmented Tau phosphorylation is related to obesity- and age-induced peripheral insulin resistance: a study in Zucker rats. BMC neuroscience. vol 15. 2015-03-12. PMID:25257559.' |
deficient hippocampal insulin signaling and augmented tau phosphorylation is related to obesity- and age-induced peripheral insulin resistance: a study in zucker rats. |
2015-03-12 |
2023-08-13 |
rat |
| Wenqing Yang, Jing Ma, Zheng Liu, Yongliang Lu, Bin Hu, Huarong Y. Effect of naringenin on brain insulin signaling and cognitive functions in ICV-STZ induced dementia model of rats. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 35. issue 5. 2015-01-27. PMID:24337945. |
in addition, nar reversed icv-stz induced tau hyper-phosphorylation in both hippocampus and cerebral cortex through downregulation of glycogen synthase kinase-3β (gsk-3β) activity, a key kinase in the insulin signaling. |
2015-01-27 |
2023-08-12 |
rat |