| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wen-Juan Gu, Di Liu, Meng-Ren Zhang, Hong Zhan. [Effect of ginsenoside Rb1 on insulin signal transduction pathway in hippocampal neurons of high-glucose-fed rats]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 39. issue 6. 2014-07-07. PMID:24956852. |
[effect of ginsenoside rb1 on insulin signal transduction pathway in hippocampal neurons of high-glucose-fed rats]. |
2014-07-07 |
2023-08-13 |
rat |
| Olivier Thibault, Katie L Anderson, Chris DeMoll, Lawrence D Brewer, Philip W Landfield, Nada M Porte. Hippocampal calcium dysregulation at the nexus of diabetes and brain aging. European journal of pharmacology. vol 719. issue 1-3. 2014-07-02. PMID:23872402. |
we have been testing predictions of the ca(2+) dysregulation/diabetes/brain aging hypothesis and have found that insulin and insulin-sensitizers (thiazolidinediones) target several hippocampal ca(2+)-related processes affected by aging. |
2014-07-02 |
2023-08-12 |
Not clear |
| Y F Brünner, C Benedict, J Freiher. [Targeting the brain through the nose. Effects of intranasally administered insulin]. Der Nervenarzt. vol 84. issue 8. 2014-06-30. PMID:23760596. |
accordingly, in animal studies an increased insulin level in the central nervous system leads to an improvement of hippocampal memory function and a decrease of food intake. |
2014-06-30 |
2023-08-12 |
human |
| Wei Sun, Jin-Bao Ban, Ni Zhang, Yu-Kun Zu, Wen-Xiao Su. Perinatal exposure to Di-(2-ethylhexyl)-Phthalate leads to cognitive dysfunction and phospho-tau level increase in aged rats. Environmental toxicology. vol 29. issue 5. 2014-06-17. PMID:22610992. |
our results suggested that perinatal exposure to dehp can affect the expression of insulin and insulin-akt- gsk-3β signal pathway in hippocampus. |
2014-06-17 |
2023-08-12 |
rat |
| Wei Sun, Jin-Bao Ban, Ni Zhang, Yu-Kun Zu, Wen-Xiao Su. Perinatal exposure to Di-(2-ethylhexyl)-Phthalate leads to cognitive dysfunction and phospho-tau level increase in aged rats. Environmental toxicology. vol 29. issue 5. 2014-06-17. PMID:22610992. |
the present study demonstrates that perinatal exposure to dehp may be a potential risk factor for ad pathogenesis associated with insulin resistance and insulin metabolism disorder in the hippocampus. |
2014-06-17 |
2023-08-12 |
rat |
| A Perianes-Cachero, E Burgos-Ramos, L Puebla-Jiménez, S Canelles, L M Frago, A Hervás-Aguilar, S de Frutos, M V Toledo-Lobo, V Mela, M P Viveros, J Argente, J A Chowen, E Arilla-Ferreiro, V Barrio. Acute up-regulation of the rat brain somatostatin receptor-effector system by leptin is related to activation of insulin signaling and may counteract central leptin actions. Neuroscience. vol 252. 2014-06-11. PMID:23973620. |
these changes in sst2 mrna levels were concomitant with increased activation of the insulin signaling, c-jun and cyclic amp response element-binding protein (creb); however, activation of signal transducer and activator of transcription 3 was reduced in the cortex and unchanged in the hippocampus and suppressor of cytokine signaling 3 remained unchanged in these areas. |
2014-06-11 |
2023-08-12 |
rat |
| Yulian Miao, Jianmin Ren, Ling Jiang, Jinbo Liu, Bei Jiang, Xiaoli Zhan. α-Lipoic acid attenuates obesity-associated hippocampal neuroinflammation and increases the levels of brain-derived neurotrophic factor in ovariectomized rats fed a high-fat diet. International journal of molecular medicine. vol 32. issue 5. 2014-05-09. PMID:24008266. |
these findings demonstrate that α-la significantly increases the expression of bdnf in the hippocampus of obese ovariectomized rats fed hfd, possibly by improving lipid metabolism, enhancing insulin sensitivity and reversing central inflammation. |
2014-05-09 |
2023-08-12 |
rat |
| E Soares, R D Prediger, S Nunes, A A Castro, S D Viana, C Lemos, C M De Souza, P Agostinho, R A Cunha, E Carvalho, C A Fontes Ribeiro, F Reis, F C Pereir. Spatial memory impairments in a prediabetic rat model. Neuroscience. vol 250. 2014-04-04. PMID:23912035. |
hsu rats displayed a poorer performance in hippocampal-dependent short- and long-term spatial memory performance, assessed with the modified y-maze and morris water maze tasks, respectively; this was accompanied by a reduction of insulin receptor-β density with normal levels of insulin receptor substrate-1 pser636/639, and decreased hippocampal glucocorticoid receptor levels without changes of the plasma corticosterone levels. |
2014-04-04 |
2023-08-12 |
rat |
| Maite Solas, Bárbara Aisa, Rosa M Tordera, María C Mugueta, María J Ramíre. Stress contributes to the development of central insulin resistance during aging: implications for Alzheimer's disease. Biochimica et biophysica acta. vol 1832. issue 12. 2014-02-20. PMID:24090692. |
in addition, cms aged mice displayed both peripheral insulin resistance, as shown by homa index, and decreased hippocampal levels of pirs and downstream intracellular signaling (pakt, pgsk and perk1/2). |
2014-02-20 |
2023-08-12 |
mouse |
| Jessica Freiherr, Manfred Hallschmid, William H Frey, Yvonne F Brünner, Colin D Chapman, Christian Hölscher, Suzanne Craft, Fernanda G De Felice, Christian Benedic. Intranasal insulin as a treatment for Alzheimer's disease: a review of basic research and clinical evidence. CNS drugs. vol 27. issue 7. 2014-02-03. PMID:23719722. |
these results, in conjunction with the finding that insulin mitigates hippocampal synapse vulnerability to beta amyloid, a peptide thought to be causative in the development of ad, provide a strong rationale for hypothesizing that pharmacological strategies bolstering brain insulin signaling, such as intranasal administration of insulin, could have significant potential in the treatment and prevention of ad. |
2014-02-03 |
2023-08-12 |
Not clear |
| Jessica Freiherr, Manfred Hallschmid, William H Frey, Yvonne F Brünner, Colin D Chapman, Christian Hölscher, Suzanne Craft, Fernanda G De Felice, Christian Benedic. Intranasal insulin as a treatment for Alzheimer's disease: a review of basic research and clinical evidence. CNS drugs. vol 27. issue 7. 2014-02-03. PMID:23719722. |
finally, we will provide an overview of neuroimaging studies indicating that disturbances in insulin metabolism--such as insulin resistance in obesity, type 2 diabetes and ad--and altered brain responses to insulin are linked to decreased cerebral volume and especially to hippocampal atrophy. |
2014-02-03 |
2023-08-12 |
Not clear |
| Jim R Fadel, Corinne G Jolivalt, Lawrence P Reaga. Food for thought: the role of appetitive peptides in age-related cognitive decline. Ageing research reviews. vol 12. issue 3. 2014-01-21. PMID:23416469. |
the neurological activities of insulin, orexin and leptin also include facilitation of hippocampal synaptic plasticity and enhancement of cognitive performance. |
2014-01-21 |
2023-08-12 |
Not clear |
| Jim R Fadel, Corinne G Jolivalt, Lawrence P Reaga. Food for thought: the role of appetitive peptides in age-related cognitive decline. Ageing research reviews. vol 12. issue 3. 2014-01-21. PMID:23416469. |
collectively, these studies support the hypothesis that leptin and insulin resistance, concepts normally associated with the hypothalamus, are also applicable to the hippocampus. |
2014-01-21 |
2023-08-12 |
Not clear |
| Sunmin Park, Da Sol Kim, Suna Kang, Na Rang Moo. β-Amyloid-induced cognitive dysfunction impairs glucose homeostasis by increasing insulin resistance and decreasing β-cell mass in non-diabetic and diabetic rats. Metabolism: clinical and experimental. vol 62. issue 12. 2014-01-08. PMID:24050268. |
the present study investigated whether β-amyloid deposition in the hippocampus impairs glucose homeostasis by altering insulin sensitivity, glucose-stimulated insulin secretion or β-cell mass. |
2014-01-08 |
2023-08-12 |
rat |
| Andrea Mazzatenta, Mieczyslaw Pokorski, Camillo Di Giuli. Real-time breath analysis in type 2 diabetes patients during cognitive effort. Advances in experimental medicine and biology. vol 788. 2014-01-07. PMID:23835985. |
t2dm is associated with cognitive impairment and neural deficits, because of insulin resistance and high expression of insulin receptors in the hippocampus. |
2014-01-07 |
2023-08-12 |
human |
| Li-Na Liang, Shou-Yu Hu, Li-Bin Zha. [Effects of zibu piyin recipe on the insulin resistance in the hippocampus of pi-yin deficiency diabetic rats]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine. vol 32. issue 3. 2014-01-02. PMID:22686083. |
[effects of zibu piyin recipe on the insulin resistance in the hippocampus of pi-yin deficiency diabetic rats]. |
2014-01-02 |
2023-08-12 |
rat |
| Li-Na Liang, Shou-Yu Hu, Li-Bin Zha. [Effects of zibu piyin recipe on the insulin resistance in the hippocampus of pi-yin deficiency diabetic rats]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine. vol 32. issue 3. 2014-01-02. PMID:22686083. |
to study the protection of zibu piyin recipe (zbpyr) on the insulin signal pathway in the hippocampus of pi-yin deficiency diabetic encephalopathy rats and to explore its possible mechanisms. |
2014-01-02 |
2023-08-12 |
rat |
| Amer Kamal, Geert M J Ramakers, Willem Hendrik Gispen, Geert Jan Biessels, Amer Al Ansar. Hyperinsulinemia in rats causes impairment of spatial memory and learning with defects in hippocampal synaptic plasticity by involvement of postsynaptic mechanisms. Experimental brain research. vol 226. issue 1. 2013-12-27. PMID:23371746. |
in addition to its peripheral metabolic functions, insulin acts as a central neuromodulator and affects synaptic plasticity of the hippocampal neurons. |
2013-12-27 |
2023-08-12 |
rat |
| María E Bernis, Mariana Oksdath, Sebastián Dupraz, Alvaro Nieto Guil, Marisa M Fernández, Emilio L Malchiodi, Silvana B Rosso, Santiago Quirog. Wingless-type family member 3A triggers neuronal polarization via cross-activation of the insulin-like growth factor-1 receptor pathway. Frontiers in cellular neuroscience. vol 7. 2013-12-03. PMID:24298236. |
we used cultured hippocampal neurons and growth cone particles (gcps) isolated from fetal rat brain to show that stimulation with the wingless family factor 3a (wnt3a) was sufficient to promote neuronal polarization in the absence of igf-1 or high insulin. |
2013-12-03 |
2023-08-12 |
rat |
| Yun-Qing Ma, Dong-Ke Wu, Jian-Kun Li. mTOR and tau phosphorylated proteins in the hippocampal tissue of rats with type 2 diabetes and Alzheimer's disease. Molecular medicine reports. vol 7. issue 2. 2013-11-04. PMID:23165862. |
t2dm may excessively activate mtor in the hippocampal tissue by impairing insulin signaling, thereby increasing the extent of tau hyperphosphorylation and promoting the occurrence of ad. |
2013-11-04 |
2023-08-12 |
rat |