| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ewan C McNay, Leslie A Sandusky, Jiah Pearson-Lear. Hippocampal insulin microinjection and in vivo microdialysis during spatial memory testing. Journal of visualized experiments : JoVE. issue 71. 2013-03-17. PMID:23354340. |
substances such as insulin can be delivered to the hippocampus via the same microdialysis probe used to measure metabolites. |
2013-03-17 |
2023-08-12 |
Not clear |
| Larry A Denner, Jennifer Rodriguez-Rivera, Sigmund J Haidacher, Jordan B Jahrling, J Russ Carmical, Caterina M Hernandez, Yingxin Zhao, Rovshan G Sadygov, Jonathan M Starkey, Heidi Spratt, Bruce A Luxon, Thomas G Wood, Kelly T Dinele. Cognitive enhancement with rosiglitazone links the hippocampal PPARγ and ERK MAPK signaling pathways. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 47. 2013-02-01. PMID:23175826. |
since extracellular signal-regulated protein kinase mitogen-activated protein kinase (erk mapk) is required for many forms of learning and memory that are affected in ad, and since both pparγ and erk mapk are key mediators of insulin signaling, the current study tested the hypothesis that rsg-mediated cognitive improvement induces a hippocampal pparγ pattern of gene and protein expression that converges with the erk mapk signaling axis in tg2576 ad mice. |
2013-02-01 |
2023-08-12 |
mouse |
| Helgi B Schiöth, Suzanne Craft, Samantha J Brooks, William H Frey, Christian Benedic. Brain insulin signaling and Alzheimer's disease: current evidence and future directions. Molecular neurobiology. vol 46. issue 1. 2013-01-31. PMID:22205300. |
using the intranasal method, which effectively bypasses the blood-brain barrier to deliver and target insulin directly from the nose to the brain, a series of experiments involving healthy humans has shown that increased central nervous system (cns) insulin action enhances learning and memory processes associated with the hippocampus. |
2013-01-31 |
2023-08-12 |
Not clear |
| Helgi B Schiöth, Suzanne Craft, Samantha J Brooks, William H Frey, Christian Benedic. Brain insulin signaling and Alzheimer's disease: current evidence and future directions. Molecular neurobiology. vol 46. issue 1. 2013-01-31. PMID:22205300. |
considering that insulin mitigates hippocampal synapse vulnerability to amyloid beta and inhibits the phosphorylation of tau, pharmacological strategies bolstering brain insulin signaling, such as intranasal insulin, could have significant therapeutic potential to deter ad pathogenesis. |
2013-01-31 |
2023-08-12 |
Not clear |
| David Heras-Sandoval, Patricia Ferrera, Clorinda Aria. Amyloid-β protein modulates insulin signaling in presynaptic terminals. Neurochemical research. vol 37. issue 9. 2012-11-20. PMID:22638775. |
we found that insulin increased mitochondrial activity and ir/akt phosphorylation in synaptosomes taken from both hippocampus and cortex. |
2012-11-20 |
2023-08-12 |
Not clear |
| David Heras-Sandoval, Patricia Ferrera, Clorinda Aria. Amyloid-β protein modulates insulin signaling in presynaptic terminals. Neurochemical research. vol 37. issue 9. 2012-11-20. PMID:22638775. |
also, pretreatment with aβ antagonized insulin's effect on hippocampal synaptosomes, but not vice versa. |
2012-11-20 |
2023-08-12 |
Not clear |
| Masataka Suzuki, Jumpei Sasabe, Shigeki Furuya, Masashi Mita, Kenji Hamase, Sadakazu Ais. Type 1 diabetes mellitus in mice increases hippocampal D-serine in the acute phase after streptozotocin injection. Brain research. vol 1466. 2012-11-20. PMID:22652304. |
in vivo, subcutaneous insulin implants into stz-treated mice restored the elevated d-serine levels in the hippocampus. |
2012-11-20 |
2023-08-12 |
mouse |
| Masataka Suzuki, Jumpei Sasabe, Shigeki Furuya, Masashi Mita, Kenji Hamase, Sadakazu Ais. Type 1 diabetes mellitus in mice increases hippocampal D-serine in the acute phase after streptozotocin injection. Brain research. vol 1466. 2012-11-20. PMID:22652304. |
these results indicate that dm pathology caused by insulin deficiency triggers transient d-serine increase and l-glutamate alteration in the hippocampus. |
2012-11-20 |
2023-08-12 |
mouse |
| Amer Kamal, Geert M J Ramakers, Willem Hendrik Gispen, Geert Jan Biessel. Effect of chronic intracerebroventricular insulin administration in rats on the peripheral glucose metabolism and synaptic plasticity of CA1 hippocampal neurons. Brain research. vol 1435. 2012-11-07. PMID:22206925. |
effect of chronic intracerebroventricular insulin administration in rats on the peripheral glucose metabolism and synaptic plasticity of ca1 hippocampal neurons. |
2012-11-07 |
2023-08-12 |
rat |
| Amer Kamal, Geert M J Ramakers, Willem Hendrik Gispen, Geert Jan Biessel. Effect of chronic intracerebroventricular insulin administration in rats on the peripheral glucose metabolism and synaptic plasticity of CA1 hippocampal neurons. Brain research. vol 1435. 2012-11-07. PMID:22206925. |
in this study we examined the effects of sustained intracerebroventricular insulin infusion on hippocampal synaptic plasticity in rats. |
2012-11-07 |
2023-08-12 |
rat |
| Yonghui Lu, Shangcheng Xu, Mindi He, Chunhai Chen, Lei Zhang, Chuan Liu, Fang Chu, Zhengping Yu, Zhou Zhou, Min Zhon. Glucose administration attenuates spatial memory deficits induced by chronic low-power-density microwave exposure. Physiology & behavior. vol 106. issue 5. 2012-11-07. PMID:22564535. |
hippocampal glucose uptake was also reduced by mw exposure in the absence or presence of insulin, but the levels of blood glucose and insulin were not affected. |
2012-11-07 |
2023-08-12 |
rat |
| Alexandra Ursache, William Wedin, Aziz Tirsi, Antonio Convi. Preliminary evidence for obesity and elevations in fasting insulin mediating associations between cortisol awakening response and hippocampal volumes and frontal atrophy. Psychoneuroendocrinology. vol 37. issue 8. 2012-11-05. PMID:22265870. |
preliminary evidence for obesity and elevations in fasting insulin mediating associations between cortisol awakening response and hippocampal volumes and frontal atrophy. |
2012-11-05 |
2023-08-12 |
Not clear |
| Alexandra Ursache, William Wedin, Aziz Tirsi, Antonio Convi. Preliminary evidence for obesity and elevations in fasting insulin mediating associations between cortisol awakening response and hippocampal volumes and frontal atrophy. Psychoneuroendocrinology. vol 37. issue 8. 2012-11-05. PMID:22265870. |
mediation analyses indicated pathways whereby a smaller car was associated with higher bmi which was in turn associated with fasting insulin levels, which in turn was related to smaller hippocampal volume and greater frontal lobe atrophy. |
2012-11-05 |
2023-08-12 |
Not clear |
| Gail Musen, Alan M Jacobson, Nicolas R Bolo, Donald C Simonson, Martha E Shenton, Richard L McCartney, Veronica L Flores, Wouter S Hoogenboo. Resting-state brain functional connectivity is altered in type 2 diabetes. Diabetes. vol 61. issue 9. 2012-11-05. PMID:22664957. |
we also evaluated hippocampal volume, cognition, and insulin sensitivity by homeostasis model assessment of insulin resistance (homa-ir). |
2012-11-05 |
2023-08-12 |
human |
| G A Werther, A Hogg, B J Oldfield, M J McKinley, R Figdor, F A Mendelsoh. Localization and Characterization of Insulin-Like Growth Factor-I Receptors in Rat Brain and Pituitary Gland Using in vitro Autoradiography and Computerized Densitometry* A Distinct Distribution from Insulin Receptors. Journal of neuroendocrinology. vol 1. issue 5. 2012-10-02. PMID:19210430. |
in contrast, in the hippocampus, insulin binding was high in the ca1 field, and low in ca2, ca3, ca4 while for igf-i binding the converse was seen. |
2012-10-02 |
2023-08-12 |
rat |
| Takayuki Masaki, Futoshi Anan, Tsuyoshi Shimomura, Minoru Fujiki, Tetsunori Saikawa, Hironobu Yoshimats. Association between hippocampal volume and serum adiponectin in patients with type 2 diabetes mellitus. Metabolism: clinical and experimental. vol 61. issue 8. 2012-10-01. PMID:22405025. |
the aim of the present study was to test the hypothesis that the level of the adipocytokine adiponectin correlates with hippocampus volume and insulin resistance in patients with type 2 dm. |
2012-10-01 |
2023-08-12 |
Not clear |
| Masanao Machida, Shin Fujimaki, Ryo Hidaka, Makoto Asashima, Tomoko Kuwabar. The insulin regulatory network in adult hippocampus and pancreatic endocrine system. Stem cells international. vol 2012. 2012-09-19. PMID:22988465. |
the insulin regulatory network in adult hippocampus and pancreatic endocrine system. |
2012-09-19 |
2023-08-12 |
Not clear |
| Jiah Pearson-Leary, Ewan C McNa. Intrahippocampal administration of amyloid-β(1-42) oligomers acutely impairs spatial working memory, insulin signaling, and hippocampal metabolism. Journal of Alzheimer's disease : JAD. vol 30. issue 2. 2012-09-18. PMID:22430529. |
intrahippocampal administration of amyloid-β(1-42) oligomers acutely impairs spatial working memory, insulin signaling, and hippocampal metabolism. |
2012-09-18 |
2023-08-12 |
rat |
| Jiah Pearson-Leary, Ewan C McNa. Intrahippocampal administration of amyloid-β(1-42) oligomers acutely impairs spatial working memory, insulin signaling, and hippocampal metabolism. Journal of Alzheimer's disease : JAD. vol 30. issue 2. 2012-09-18. PMID:22430529. |
we previously showed that endogenous insulin signaling is an obligatory component of normal hippocampal function, and that disrupting this signaling led to a rapid impairment of spatial working memory, while delivery of exogenous insulin to the hippocampus enhanced both memory and metabolism; diet-induced insulin resistance both impaired spatial memory and prevented insulin from increasing metabolism or cognitive function. |
2012-09-18 |
2023-08-12 |
rat |
| Jiah Pearson-Leary, Ewan C McNa. Intrahippocampal administration of amyloid-β(1-42) oligomers acutely impairs spatial working memory, insulin signaling, and hippocampal metabolism. Journal of Alzheimer's disease : JAD. vol 30. issue 2. 2012-09-18. PMID:22430529. |
these data show in vivo that aβ(1-42) oligomers can rapidly impair hippocampal cognitive and metabolic processes, and provide support for the hypothesis that elevated aβ(1-42) leads to cognitive impairment via interference with hippocampal insulin signaling. |
2012-09-18 |
2023-08-12 |
rat |