| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alexandre P Muller, Jussânia Gnoatto, Julia D Moreira, Eduardo R Zimmer, Clarissa B Haas, Francisco Lulhier, Marcos L S Perry, Diogo O Souza, Ignácio Torres-Aleman, Luis V Portel. Exercise increases insulin signaling in the hippocampus: physiological effects and pharmacological impact of intracerebroventricular insulin administration in mice. Hippocampus. vol 21. issue 10. 2012-04-02. PMID:20824731. |
in the hippocampus, insulin improves synaptic plasticity, memory formation, and learning via direct modulation of gabaergic and glutamatergic receptors. |
2012-04-02 |
2023-08-12 |
mouse |
| Alexandre P Muller, Jussânia Gnoatto, Julia D Moreira, Eduardo R Zimmer, Clarissa B Haas, Francisco Lulhier, Marcos L S Perry, Diogo O Souza, Ignácio Torres-Aleman, Luis V Portel. Exercise increases insulin signaling in the hippocampus: physiological effects and pharmacological impact of intracerebroventricular insulin administration in mice. Hippocampus. vol 21. issue 10. 2012-04-02. PMID:20824731. |
we here use cf1 mice to investigate (i) the effects of voluntary exercise on hippocampal insulin signaling and memory performance and (ii) whether central insulin administration alters the effects of exercise on hippocampal insulin signaling and memory performance. |
2012-04-02 |
2023-08-12 |
mouse |
| Alexandre P Muller, Jussânia Gnoatto, Julia D Moreira, Eduardo R Zimmer, Clarissa B Haas, Francisco Lulhier, Marcos L S Perry, Diogo O Souza, Ignácio Torres-Aleman, Luis V Portel. Exercise increases insulin signaling in the hippocampus: physiological effects and pharmacological impact of intracerebroventricular insulin administration in mice. Hippocampus. vol 21. issue 10. 2012-04-02. PMID:20824731. |
hippocampal tissue was measured for [u-(14)c] glucose oxidation and the immunocontent of insulin receptor/signaling (ir, ptyr, paktser473). |
2012-04-02 |
2023-08-12 |
mouse |
| Alexandre P Muller, Jussânia Gnoatto, Julia D Moreira, Eduardo R Zimmer, Clarissa B Haas, Francisco Lulhier, Marcos L S Perry, Diogo O Souza, Ignácio Torres-Aleman, Luis V Portel. Exercise increases insulin signaling in the hippocampus: physiological effects and pharmacological impact of intracerebroventricular insulin administration in mice. Hippocampus. vol 21. issue 10. 2012-04-02. PMID:20824731. |
exercise significantly increased insulin peripheral sensitivity, spatial learning, and hippocampal ir/ptyrir/paktser473 immunocontent. |
2012-04-02 |
2023-08-12 |
mouse |
| Alexandre P Muller, Jussânia Gnoatto, Julia D Moreira, Eduardo R Zimmer, Clarissa B Haas, Francisco Lulhier, Marcos L S Perry, Diogo O Souza, Ignácio Torres-Aleman, Luis V Portel. Exercise increases insulin signaling in the hippocampus: physiological effects and pharmacological impact of intracerebroventricular insulin administration in mice. Hippocampus. vol 21. issue 10. 2012-04-02. PMID:20824731. |
in conclusion, physical exercise thus increased hippocampal insulin signaling and improved water maze performance. |
2012-04-02 |
2023-08-12 |
mouse |
| Tomoko Kuwabara, Mohamedi N Kagalwala, Yasuko Onuma, Yuzuru Ito, Masaki Warashina, Kazuyuki Terashima, Tsukasa Sanosaka, Kinichi Nakashima, Fred H Gage, Makoto Asashim. Insulin biosynthesis in neuronal progenitors derived from adult hippocampus and the olfactory bulb. EMBO molecular medicine. vol 3. issue 12. 2012-03-21. PMID:21984534. |
insulin biosynthesis in neuronal progenitors derived from adult hippocampus and the olfactory bulb. |
2012-03-21 |
2023-08-12 |
Not clear |
| Tomoko Kuwabara, Mohamedi N Kagalwala, Yasuko Onuma, Yuzuru Ito, Masaki Warashina, Kazuyuki Terashima, Tsukasa Sanosaka, Kinichi Nakashima, Fred H Gage, Makoto Asashim. Insulin biosynthesis in neuronal progenitors derived from adult hippocampus and the olfactory bulb. EMBO molecular medicine. vol 3. issue 12. 2012-03-21. PMID:21984534. |
in the present study, we demonstrated that insulin is produced not only in the mammalian pancreas but also in adult neuronal cells derived from the hippocampus and olfactory bulb (ob). |
2012-03-21 |
2023-08-12 |
Not clear |
| Tomoko Kuwabara, Mohamedi N Kagalwala, Yasuko Onuma, Yuzuru Ito, Masaki Warashina, Kazuyuki Terashima, Tsukasa Sanosaka, Kinichi Nakashima, Fred H Gage, Makoto Asashim. Insulin biosynthesis in neuronal progenitors derived from adult hippocampus and the olfactory bulb. EMBO molecular medicine. vol 3. issue 12. 2012-03-21. PMID:21984534. |
paracrine wnt3 plays an essential role in promoting the active expression of insulin in both hippocampal and ob-derived neural stem cells. |
2012-03-21 |
2023-08-12 |
Not clear |
| Wenchao Zhao, Xiaomei Wu, Hui Xie, Ya Ke, Wing-Ho Yun. Permissive role of insulin in the expression of long-term potentiation in the hippocampus of immature rats. Neuro-Signals. vol 18. issue 4. 2012-03-09. PMID:21346324. |
permissive role of insulin in the expression of long-term potentiation in the hippocampus of immature rats. |
2012-03-09 |
2023-08-12 |
rat |
| Wenchao Zhao, Xiaomei Wu, Hui Xie, Ya Ke, Wing-Ho Yun. Permissive role of insulin in the expression of long-term potentiation in the hippocampus of immature rats. Neuro-Signals. vol 18. issue 4. 2012-03-09. PMID:21346324. |
here we show that while insulin pretreatment did not affect ltp magnitude in the adult rat hippocampus, it facilitated ltp expression in the immature hippocampus. |
2012-03-09 |
2023-08-12 |
rat |
| Noppamas Pipatpiboon, Wasana Pratchayasakul, Nipon Chattipakorn, Siriporn C Chattipakor. PPARγ agonist improves neuronal insulin receptor function in hippocampus and brain mitochondria function in rats with insulin resistance induced by long term high-fat diets. Endocrinology. vol 153. issue 1. 2012-03-05. PMID:22109891. |
pparγ agonist improves neuronal insulin receptor function in hippocampus and brain mitochondria function in rats with insulin resistance induced by long term high-fat diets. |
2012-03-05 |
2023-08-12 |
human |
| Ewan C McNay, Andrew K Recknage. Brain insulin signaling: a key component of cognitive processes and a potential basis for cognitive impairment in type 2 diabetes. Neurobiology of learning and memory. vol 96. issue 3. 2012-02-22. PMID:21907815. |
understanding of the role of insulin in the brain has gradually expanded, from initial conceptions of the brain as insulin-insensitive through identification of a role in regulation of feeding, to recent demonstration of insulin as a key component of hippocampal memory processes. |
2012-02-22 |
2023-08-12 |
Not clear |
| Patrícia Pelufo Silveira, André Krumel Portella, Carla da Silva Benetti, Alexandra Ioppi Zugno, Emilene Barros da Silva Scherer, Cristiane Bastos Mattos, Angela T S Wyse, Aldo Bolten Lucion, Carla Dalma. Association between Na⁺,K⁺-ATPase activity and the vulnerability/resilience to mood disorders induced by early life experience. Neurochemical research. vol 36. issue 11. 2012-01-27. PMID:21695394. |
when the animals reached adulthood, the groups were subdivided and the rats were submitted or not to cvs, which consisted of daily exposure to different stressors for 40 days, followed by a period of behavioral tasks, biochemical (plasma corticosterone and insulin sensitivity) and neurochemical (na⁺,k⁺-atpase activity in hippocampus, amygdala and parietal cortex) measurements. |
2012-01-27 |
2023-08-12 |
rat |
| Yoshiaki Miichi, Takashi Sakurai, Taichi Akisaki, Koichi Yokon. Effects of insulin and amyloid β(1-42) oligomers on glucose incorporation and mitochondrial function in cultured rat hippocampal neurons. Geriatrics & gerontology international. vol 11. issue 4. 2012-01-26. PMID:21592272. |
effects of insulin and amyloid β(1-42) oligomers on glucose incorporation and mitochondrial function in cultured rat hippocampal neurons. |
2012-01-26 |
2023-08-12 |
rat |
| Yoshiaki Miichi, Takashi Sakurai, Taichi Akisaki, Koichi Yokon. Effects of insulin and amyloid β(1-42) oligomers on glucose incorporation and mitochondrial function in cultured rat hippocampal neurons. Geriatrics & gerontology international. vol 11. issue 4. 2012-01-26. PMID:21592272. |
we tested whether insulin and amyloid (a)β(1-42) oligomers would regulate glucose metabolism and energy homeostasis directly in cultured rat hippocampal neurons and evaluated possible interactions between insulin signaling and aβ(1-42) oligomers. |
2012-01-26 |
2023-08-12 |
rat |
| Natalie L Rasgon, Heather A Kenna, Tonita E Wroolie, Ryan Kelley, Daniel Silverman, John Brooks, Katherine E Williams, Bevin N Powers, Joachim Hallmayer, Allan Reis. Insulin resistance and hippocampal volume in women at risk for Alzheimer's disease. Neurobiology of aging. vol 32. issue 11. 2012-01-18. PMID:20031276. |
insulin resistance and hippocampal volume in women at risk for alzheimer's disease. |
2012-01-18 |
2023-08-12 |
Not clear |
| Wasana Pratchayasakul, Nipon Chattipakorn, Siriporn C Chattipakor. Effects of estrogen in preventing neuronal insulin resistance in hippocampus of obese rats are different between genders. Life sciences. vol 89. issue 19-20. 2011-12-02. PMID:21925187. |
effects of estrogen in preventing neuronal insulin resistance in hippocampus of obese rats are different between genders. |
2011-12-02 |
2023-08-12 |
rat |
| Wasana Pratchayasakul, Nipon Chattipakorn, Siriporn C Chattipakor. Effects of estrogen in preventing neuronal insulin resistance in hippocampus of obese rats are different between genders. Life sciences. vol 89. issue 19-20. 2011-12-02. PMID:21925187. |
the effects of estrogen on the prevention of impaired insulin-induced long-term depression in the hippocampus and neuronal insulin signaling caused by high-fat diet (hf) were studied in male and female rats. |
2011-12-02 |
2023-08-12 |
rat |
| Dingzhen Luo, Xunyao Hou, Liang Hou, Meixia Wang, Song Xu, Chuanfang Dong, Xueping Li. Effect of pioglitazone on altered expression of Aβ metabolism-associated molecules in the brain of fructose-drinking rats, a rodent model of insulin resistance. European journal of pharmacology. vol 664. issue 1-3. 2011-10-06. PMID:21549699. |
we found that diet-induced insulin resistance induced aβ overproduction with altered expression of aβ metabolism-associated molecules, which corresponded with increased β-secretase-1 (bace1), γ-secretase (ps-1) activities and decreased insulin degrading enzyme (ide) activities, but not neprilysin in the cortex and hippocampus. |
2011-10-06 |
2023-08-12 |
rat |
| Xin Liu, Yi-na Zhang, Zong-yan Teng, Li-hong Jian. [Abnormal expression of insulin receptor induced by Aβ(1-42) in rat hippocampus neuron]. Zhonghua yi xue za zhi. vol 90. issue 41. 2011-09-15. PMID:21211393. |
to detect the expression change of insulin receptor under the induction of aβ(1-42) in rat hippocampus neuron and thus from the receptor level explore the disorder of central nervous insulin signaling and molecular mechanism of alzheimer's disease. |
2011-09-15 |
2023-08-12 |
rat |