| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sabrina D Robertson, Heinrich J G Matthies, W Anthony Owens, Vidiya Sathananthan, Nicole S Bibus Christianson, J Phillip Kennedy, Craig W Lindsley, Lynette C Daws, Aurelio Gall. Insulin reveals Akt signaling as a novel regulator of norepinephrine transporter trafficking and norepinephrine homeostasis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 34. 2010-09-16. PMID:20739551. |
here, we show that acute insulin treatment, through the downstream kinase protein kinase b (akt), significantly decreases net surface expression in mouse hippocampal slices and superior cervical ganglion neuron boutons (sites of synaptic ne release). |
2010-09-16 |
2023-08-12 |
mouse |
| Chiung-Chun Huang, Cheng-Che Lee, Kuei-Sen Hs. The role of insulin receptor signaling in synaptic plasticity and cognitive function. Chang Gung medical journal. vol 33. issue 2. 2010-08-06. PMID:20438663. |
several lines of work in both laboratory animals and humans suggest that when neurons in cognitive brain regions such as the hippocampus and cerebral cortex do not make enough insulin or cannot respond to insulin properly, everything from very mild memory loss to severe neurodegenerative diseases can result. |
2010-08-06 |
2023-08-12 |
Not clear |
| Ewan C McNay, Cecilia T Ong, Rory J McCrimmon, James Cresswell, Jonathan S Bogan, Robert S Sherwi. Hippocampal memory processes are modulated by insulin and high-fat-induced insulin resistance. Neurobiology of learning and memory. vol 93. issue 4. 2010-07-30. PMID:20176121. |
hippocampal memory processes are modulated by insulin and high-fat-induced insulin resistance. |
2010-07-30 |
2023-08-12 |
rat |
| Ewan C McNay, Cecilia T Ong, Rory J McCrimmon, James Cresswell, Jonathan S Bogan, Robert S Sherwi. Hippocampal memory processes are modulated by insulin and high-fat-induced insulin resistance. Neurobiology of learning and memory. vol 93. issue 4. 2010-07-30. PMID:20176121. |
the machinery for transduction of insulin signaling is also present in other brain areas, particularly in the hippocampus, but a physiological role for brain insulin outside the hypothalamus has not been established. |
2010-07-30 |
2023-08-12 |
rat |
| Ewan C McNay, Cecilia T Ong, Rory J McCrimmon, James Cresswell, Jonathan S Bogan, Robert S Sherwi. Hippocampal memory processes are modulated by insulin and high-fat-induced insulin resistance. Neurobiology of learning and memory. vol 93. issue 4. 2010-07-30. PMID:20176121. |
here we report that local delivery of insulin to the rat hippocampus enhances spatial memory, in a pi-3-kinase dependent manner, and that intrahippocampal insulin also increases local glycolytic metabolism. |
2010-07-30 |
2023-08-12 |
rat |
| Ewan C McNay, Cecilia T Ong, Rory J McCrimmon, James Cresswell, Jonathan S Bogan, Robert S Sherwi. Hippocampal memory processes are modulated by insulin and high-fat-induced insulin resistance. Neurobiology of learning and memory. vol 93. issue 4. 2010-07-30. PMID:20176121. |
further, a rodent model of type 2 diabetes mellitus produced by a high-fat diet impairs basal cognitive function and attenuates both cognitive and metabolic responses to hippocampal insulin administration. |
2010-07-30 |
2023-08-12 |
rat |
| Ewan C McNay, Cecilia T Ong, Rory J McCrimmon, James Cresswell, Jonathan S Bogan, Robert S Sherwi. Hippocampal memory processes are modulated by insulin and high-fat-induced insulin resistance. Neurobiology of learning and memory. vol 93. issue 4. 2010-07-30. PMID:20176121. |
our data demonstrate that insulin is required for optimal hippocampal memory processing. |
2010-07-30 |
2023-08-12 |
rat |
| Donald J Roohk, Krista A Varady, Scott M Turner, Claire L Emson, Richard W Gelling, Mahalakshmi Shankaran, Glen Lindwall, Lauren E Shipp, Thomas S Scanlan, Jen-Chywan Wang, Marc K Hellerstei. Differential in vivo effects on target pathways of a novel arylpyrazole glucocorticoid receptor modulator compared with prednisolone. The Journal of pharmacology and experimental therapeutics. vol 333. issue 1. 2010-04-22. PMID:20065017. |
in contrast, l5 was a more rapid and potent inhibitor of hippocampal neurogenesis than prednisolone, and l5 and prednisolone induced insulin resistance equally. |
2010-04-22 |
2023-08-12 |
mouse |
| George Boukouvalas, Kyriaki Gerozissis, Efthimia Kitrak. Fat feeding of rats during pubertal growth leads to neuroendocrine alterations in adulthood. Cellular and molecular neurobiology. vol 30. issue 1. 2010-04-13. PMID:19649701. |
the neuroendocrine endpoints studied were the levels of circulating leptin, insulin and corticosterone, as well as their receptors in the hypothalamus and hippocampus. |
2010-04-13 |
2023-08-12 |
rat |
| Elaine S Coleman, John C Dennis, Timothy D Braden, Robert L Judd, Phil Posne. Insulin treatment prevents diabetes-induced alterations in astrocyte glutamate uptake and GFAP content in rats at 4 and 8 weeks of diabetes duration. Brain research. vol 1306. 2010-02-03. PMID:19822133. |
we determined by immunoblotting and immunohistochemistry that insulin treatment prevented the decrease of gfap expression detected in the cerebral cortex, hippocampus, and cerebellum of untreated, diabetic rats. |
2010-02-03 |
2023-08-12 |
rat |
| Savitha Balakrishnan, Peeyush Kumar T, C S Paulos. Glutamate (mGluR-5) gene expression in brain regions of streptozotocin induced diabetic rats as a function of age: role in regulation of calcium release from the pancreatic islets in vitro. Journal of biomedical science. vol 16. 2010-01-18. PMID:19903331. |
in this study, we have analysed the expression pattern of group-i metabotropic glutamate receptor (mglu-5) in cerebral cortex, corpus striatum, brainstem and hippocampus of streptozotocin induced and insulin treated diabetic rats (d+i) as a function of age. |
2010-01-18 |
2023-08-12 |
rat |
| Karen E Inouye, Owen Chan, Jessica T Y Yue, Marcus Andrews, Qifu Li, Stephen G Matthews, Mladen Vrani. The effect of long-term insulin treatment with and without antecedent hypoglycemia on neuropeptide and corticosteroid receptor expression in the brains of diabetic rats. Brain research bulletin. vol 77. issue 4. 2010-01-05. PMID:18672033. |
these data suggest that (1) recurrent hypoglycemia, much like uncontrolled diabetes, has a pronounced effect on hippocampal mineralocorticoid receptor mrna expression that may prevent it, and presumably also the stress axis, from responding properly to a subsequent bout of hypoglycemia, and (2) while long-term insulin treatment was sufficient to restore some of these responses in diabetic animals, tighter glycemic control may be necessary to see full restoration of the stress response. |
2010-01-05 |
2023-08-12 |
rat |
| V Haj-ali, G Mohaddes, S H Babr. Intracerebroventricular insulin improves spatial learning and memory in male Wistar rats. Behavioral neuroscience. vol 123. issue 6. 2010-01-05. PMID:20001114. |
the high density of insulin/insulin receptor in brain areas such as the hippocampus and cerebral cortex have shown to play an important role in higher cognitive functions, suggesting that insulin might be involved in the modulation of memory. |
2010-01-05 |
2023-08-12 |
rat |
| Futoshi Anan, Takayuki Masaki, Tsuyoshi Shimomura, Minoru Fujiki, Yoshikazu Umeno, Nobuoki Eshima, Tetsunori Saikawa, Hironobu Yoshimats. Abdominal visceral fat accumulation is associated with hippocampus volume in non-dementia patients with type 2 diabetes mellitus. NeuroImage. vol 49. issue 1. 2010-01-04. PMID:19683583. |
we tested the hypothesis that an elevated level of visceral fat accumulation (vfa) correlates with hippocampus volume and insulin resistance in non-dementia patients with type 2 diabetes. |
2010-01-04 |
2023-08-12 |
human |
| Futoshi Anan, Takayuki Masaki, Tsuyoshi Shimomura, Minoru Fujiki, Yoshikazu Umeno, Nobuoki Eshima, Tetsunori Saikawa, Hironobu Yoshimats. Abdominal visceral fat accumulation is associated with hippocampus volume in non-dementia patients with type 2 diabetes mellitus. NeuroImage. vol 49. issue 1. 2010-01-04. PMID:19683583. |
our results indicate that the elevated level of vfa in japanese non-dementia patients with type 2 diabetes is characterized by increased hippocampus volume and insulin resistance, and that the z-score and homa index are independent predictors of vfa. |
2010-01-04 |
2023-08-12 |
human |
| C A Grillo, G G Piroli, R M Hendry, L P Reaga. Insulin-stimulated translocation of GLUT4 to the plasma membrane in rat hippocampus is PI3-kinase dependent. Brain research. vol 1296. 2009-12-29. PMID:19679110. |
the cognitive enhancing effects of insulin are proposed to be mediated through activation of insulin receptors in the hippocampus, an important integration center for learning and memory in the mammalian brain. |
2009-12-29 |
2023-08-12 |
rat |
| C A Grillo, G G Piroli, R M Hendry, L P Reaga. Insulin-stimulated translocation of GLUT4 to the plasma membrane in rat hippocampus is PI3-kinase dependent. Brain research. vol 1296. 2009-12-29. PMID:19679110. |
since less is known regarding insulin signaling events in the hippocampus, the aim of the current study was to determine whether insulin stimulates similar signaling cascades and glut4 translocation in the rat hippocampus as has been described in peripheral tissues. |
2009-12-29 |
2023-08-12 |
rat |
| C A Grillo, G G Piroli, R M Hendry, L P Reaga. Insulin-stimulated translocation of GLUT4 to the plasma membrane in rat hippocampus is PI3-kinase dependent. Brain research. vol 1296. 2009-12-29. PMID:19679110. |
intracerebroventricular administration of insulin increases hippocampal insulin levels and also stimulates the phosphorylation of akt in a time-dependent manner. |
2009-12-29 |
2023-08-12 |
rat |
| C A Grillo, G G Piroli, R M Hendry, L P Reaga. Insulin-stimulated translocation of GLUT4 to the plasma membrane in rat hippocampus is PI3-kinase dependent. Brain research. vol 1296. 2009-12-29. PMID:19679110. |
insulin also stimulates the translocation of glut4 to hippocampal plasma membranes in a time course that mirrors the increases in glucose uptake observed during the performance of hippocampal-dependent tasks. |
2009-12-29 |
2023-08-12 |
rat |
| C A Grillo, G G Piroli, R M Hendry, L P Reaga. Insulin-stimulated translocation of GLUT4 to the plasma membrane in rat hippocampus is PI3-kinase dependent. Brain research. vol 1296. 2009-12-29. PMID:19679110. |
confocal immunofluorescence determined that insulin stimulated phosphorylation of akt was localized to neurons and colocalized with the insulin receptor and glut4 in the rat hippocampus, thereby identifying the functional anatomical substrates of insulin signaling in the hippocampus. |
2009-12-29 |
2023-08-12 |
rat |