| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| V Jahagirdar, E C McNa. Thyroid hormone's role in regulating brain glucose metabolism and potentially modulating hippocampal cognitive processes. Metabolic brain disease. vol 27. issue 2. 2012-09-07. PMID:22437199. |
insulin, which regulates systemic glucose metabolism, has been recently shown both to regulate hippocampal metabolism and to be a mandatory component of hippocampally-mediated cognitive performance. |
2012-09-07 |
2023-08-12 |
Not clear |
| Javad Hami, Ariane Sadr-Nabavi, Mojtaba Sankian, Hossein Haghi. Sex differences and left-right asymmetries in expression of insulin and insulin-like growth factor-1 receptors in developing rat hippocampus. Brain structure & function. vol 217. issue 2. 2012-09-04. PMID:22042446. |
sex differences and left-right asymmetries in expression of insulin and insulin-like growth factor-1 receptors in developing rat hippocampus. |
2012-09-04 |
2023-08-12 |
human |
| Derek A Costello, Marc Claret, Hind Al-Qassab, Florian Plattner, Elaine E Irvine, Agharul I Choudhury, K Peter Giese, Dominic J Withers, Paola Pedarzan. Brain deletion of insulin receptor substrate 2 disrupts hippocampal synaptic plasticity and metaplasticity. PloS one. vol 7. issue 2. 2012-08-27. PMID:22383997. |
to elucidate the specific role of brain insulin signalling in neuronal functions that are relevant for cognitive processes we have investigated the behaviour of neurons and synaptic plasticity in the hippocampus of mice lacking the insulin receptor substrate protein 2 (irs-2). |
2012-08-27 |
2023-08-12 |
mouse |
| Artur F Schuh, Carlos M Rieder, Liara Rizzi, Márcia Chaves, Matheus Roriz-Cru. Mechanisms of brain aging regulation by insulin: implications for neurodegeneration in late-onset Alzheimer's disease. ISRN neurology. vol 2011. 2012-08-23. PMID:22389813. |
insulin and insulin receptors are diffusely found in the brain, especially so in the hippocampus. |
2012-08-23 |
2023-08-12 |
human |
| David Porter, Emilie Faivre, Peter R Flatt, Christian Hölscher, Victor A Gaul. Actions of incretin metabolites on locomotor activity, cognitive function and in vivo hippocampal synaptic plasticity in high fat fed mice. Peptides. vol 35. issue 1. 2012-08-07. PMID:22465882. |
therefore, the present study investigated effects of glp-1(9-36)amide and gip(3-42) on locomotor activity, cognitive function and hippocampal synaptic plasticity in mice with diet-induced obesity and insulin resistance. |
2012-08-07 |
2023-08-12 |
mouse |
| A P Ross, E C Bruggeman, A W Kasumu, J G Mielke, M B Paren. Non-alcoholic fatty liver disease impairs hippocampal-dependent memory in male rats. Physiology & behavior. vol 106. issue 2. 2012-07-27. PMID:22280920. |
the aims of the present study were to test whether diet-induced nafld impairs hippocampal-dependent memory and to determine whether any observed deficits are associated with changes in hippocampal insulin signaling or concentrations of brain-derived neurotrophic factor (bdnf) and insulin-like growth factor-1 (igf-1). |
2012-07-27 |
2023-08-12 |
rat |
| A P Ross, E C Bruggeman, A W Kasumu, J G Mielke, M B Paren. Non-alcoholic fatty liver disease impairs hippocampal-dependent memory in male rats. Physiology & behavior. vol 106. issue 2. 2012-07-27. PMID:22280920. |
thus, these data indicate that nafld impairs hippocampal-dependent memory function and that the deficit does not appear attributable to alterations in hippocampal insulin signaling or hippocampal bdnf or igf-1 concentrations. |
2012-07-27 |
2023-08-12 |
rat |
| William S Stone, Xiaolu Hs. Declarative memory deficits and schizophrenia: problems and prospects. Neurobiology of learning and memory. vol 96. issue 4. 2012-07-19. PMID:21527348. |
the third section views problems in declarative memory and hippocampal function from the perspective of elevated rates of common medical disorders in schizophrenia, with a focus on insulin insensitivity/diabetes. |
2012-07-19 |
2023-08-12 |
Not clear |
| Ewan C McNay, Andrew K Recknage. Reprint of: 'Brain insulin signaling: A key component of cognitive processes and a potential basis for cognitive impairment in type 2 diabetes'. Neurobiology of learning and memory. vol 96. issue 4. 2012-07-19. PMID:22085799. |
understanding of the role of insulin in the brain has gradually expanded, from initial conceptions of the brain as insulin-insensitive through identification of a role in regulation of feeding, to recent demonstration of insulin as a key component of hippocampal memory processes. |
2012-07-19 |
2023-08-12 |
Not clear |
| Auriel A Willette, Barbara B Bendlin, Ricki J Colman, Erik K Kastman, Aaron S Field, Andrew L Alexander, Aadhavi Sridharan, David B Allison, Rozalyn Anderson, Mary-Lou Voytko, Joseph W Kemnitz, Richard H Weindruch, Sterling C Johnso. Calorie restriction reduces the influence of glucoregulatory dysfunction on regional brain volume in aged rhesus monkeys. Diabetes. vol 61. issue 5. 2012-06-28. PMID:22415875. |
insulin signaling dysregulation is related to neural atrophy in hippocampus and other areas affected by neurovascular and neurodegenerative disorders. |
2012-06-28 |
2023-08-12 |
monkey |
| Auriel A Willette, Barbara B Bendlin, Ricki J Colman, Erik K Kastman, Aaron S Field, Andrew L Alexander, Aadhavi Sridharan, David B Allison, Rozalyn Anderson, Mary-Lou Voytko, Joseph W Kemnitz, Richard H Weindruch, Sterling C Johnso. Calorie restriction reduces the influence of glucoregulatory dysfunction on regional brain volume in aged rhesus monkeys. Diabetes. vol 61. issue 5. 2012-06-28. PMID:22415875. |
an insulin sensitivity × dietary condition interaction indicated that cr animals had more gray matter in hippocampus and other areas per unit increase relative to controls, suggesting a beneficial effect. |
2012-06-28 |
2023-08-12 |
monkey |
| Auriel A Willette, Barbara B Bendlin, Ricki J Colman, Erik K Kastman, Aaron S Field, Andrew L Alexander, Aadhavi Sridharan, David B Allison, Rozalyn Anderson, Mary-Lou Voytko, Joseph W Kemnitz, Richard H Weindruch, Sterling C Johnso. Calorie restriction reduces the influence of glucoregulatory dysfunction on regional brain volume in aged rhesus monkeys. Diabetes. vol 61. issue 5. 2012-06-28. PMID:22415875. |
finally, bilateral hippocampal volume adjusted by insulin sensitivity, but not volume itself, was significantly associated with mmap learning and performance. |
2012-06-28 |
2023-08-12 |
monkey |
| Sarah M Rothman, Nathan Herdener, Simonetta Camandola, Sarah J Texel, Mohamed R Mughal, Wei-Na Cong, Bronwen Martin, Mark P Mattso. 3xTgAD mice exhibit altered behavior and elevated Aβ after chronic mild social stress. Neurobiology of aging. vol 33. issue 4. 2012-06-15. PMID:21855175. |
a triple-transgenic mouse model of ad (3xtgad mice) and nontransgenic control mice were used to test for an affect of chronic mild social stress on blood glucose, plasma glucocorticoids, plasma insulin, anxiety, and hippocampal amyloid β-particle (aβ), phosphorylated tau (ptau), and brain-derived neurotrophic factor (bdnf) levels. |
2012-06-15 |
2023-08-12 |
mouse |
| Boon Wan Wang, Vincent Hok, Andrea Della-Chiesa, Charlotte Callaghan, Sally Barlow, Marian Tsanov, Ranya Bechara, Elaine Irving, David J Virley, Neil Upton, Shane M O'Mar. Rosiglitazone enhances learning, place cell activity, and synaptic plasticity in middle-aged rats. Neurobiology of aging. vol 33. issue 4. 2012-06-15. PMID:21975308. |
rosi treatment reversed basal plasma insulin abnormalities and increased hippocampal glucose transporter (glut)-3 expression in middle-aged rats. |
2012-06-15 |
2023-08-12 |
rat |
| André Apostolatos, Shijie Song, Sandra Acosta, Mishka Peart, James E Watson, Paula Bickford, Denise R Cooper, Niketa A Pate. Insulin promotes neuronal survival via the alternatively spliced protein kinase CδII isoform. The Journal of biological chemistry. vol 287. issue 12. 2012-06-12. PMID:22275369. |
finally, we demonstrate in vivo that intranasal insulin promotes cognitive function in mice with concomitant increases in pkcδii expression in the hippocampus. |
2012-06-12 |
2023-08-12 |
mouse |
| Cheng-Che Lee, Chiung-Chun Huang, Kuei-Sen Hs. Insulin promotes dendritic spine and synapse formation by the PI3K/Akt/mTOR and Rac1 signaling pathways. Neuropharmacology. vol 61. issue 4. 2012-05-25. PMID:21683721. |
here we report that insulin promotes dendritic spine formation in primary cultures of rat hippocampal neurons. |
2012-05-25 |
2023-08-12 |
rat |
| Omar Abdul-Rahman, Maria Sasvari-Szekely, Agota Ver, Klara Rosta, Bernadett K Szasz, Eva Kereszturi, Gergely Keszle. Altered gene expression profiles in the hippocampus and prefrontal cortex of type 2 diabetic rats. BMC genomics. vol 13. 2012-05-23. PMID:22369239. |
for a better understanding of the insulin effect on the central nervous system, we performed microarray-based global gene expression profiling in the hippocampus, striatum and prefrontal cortex of streptozotocin-induced and spontaneously diabetic goto-kakizaki rats as model animals for type 1 and type 2 diabetes, respectively. |
2012-05-23 |
2023-08-12 |
rat |
| Raquel Alvarez-Nölting, Emma Arnal, Jorge M Barcia, Maria Miranda, Francisco J Romer. Protection by DHA of early hippocampal changes in diabetes: possible role of CREB and NF-κB. Neurochemical research. vol 37. issue 1. 2012-05-09. PMID:21909958. |
administration of dha as well as insulin prevented the changes induced by diabetes in hippocampus. |
2012-05-09 |
2023-08-12 |
rat |
| Nancy Ho, Darrick T Balu, Monica R F Hilario, Julie A Blendy, Irwin Luck. Depressive phenotypes evoked by experimental diabetes are reversed by insulin. Physiology & behavior. vol 105. issue 3. 2012-04-16. PMID:21945451. |
insulin treatment, on the other hand, reduced hyperglycemia, reversed the behavioral effects, and returned hippocampal cell proliferation and corticosterone to levels comparable to the control group. |
2012-04-16 |
2023-08-12 |
mouse |
| Alexandre P Muller, Jussânia Gnoatto, Julia D Moreira, Eduardo R Zimmer, Clarissa B Haas, Francisco Lulhier, Marcos L S Perry, Diogo O Souza, Ignácio Torres-Aleman, Luis V Portel. Exercise increases insulin signaling in the hippocampus: physiological effects and pharmacological impact of intracerebroventricular insulin administration in mice. Hippocampus. vol 21. issue 10. 2012-04-02. PMID:20824731. |
exercise increases insulin signaling in the hippocampus: physiological effects and pharmacological impact of intracerebroventricular insulin administration in mice. |
2012-04-02 |
2023-08-12 |
mouse |